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| | Patent 6,495,591 (Site not responding. Last check: 2007-10-09) |
 | | 40:2300-2305), the BEN or BenR pump (MF-family, Benyaakov et al., 1994; Fling et al., 1991, Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate, Mol. |
 | | The homologs of cdr1 and benR were cloned from C. glabrata (cgcdr and cgben, respectively) (Sanglard et al, 1997, Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug AB transporter gene, Microbiology 20 143:405-416) |
 | | In connection with this invention, it was determined that the efflux pumps cdr1, cdr2, BenR, and Flu1 and homologs of these pumps can be used to perform useful screening for efflux pump inhibitors active on these pumps. |
| www.pharmcast.com /Patents/Yr2002/December2002/121702/6495591_Fungal121702.htm (3496 words) |
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