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In the News (Fri 18 Dec 09)

  
  A Mutant of Human Papillomavirus Type 16 E6 Deficient in Binding {alpha}-Helix Partners Displays Reduced Oncogenic ...
vitro with an affinity <5% of that of wild-type E6 (25).
BrdU was injected 1 h prior to sacrifice and detected as described in the Fig.
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes.
jvi.asm.org /cgi/content/full/76/24/13039   (4759 words)

  
 Update: Outbreak of Severe Acute Respiratory Syndrome --- Worldwide, 2003
Beginning on March 11, an increase in acute pneumonia cases among health-care workers (HCWs) at hospital 1 in Hong Kong was reported to DH.
One of these clusters involved suspected cases in patients L and M (Figure 1), who had stayed together at hotel M during March 1--6, when other hotel guests were symptomatic.
The new coronavirus was isolated in Vero E6 cells from clinical specimens of two patients in Thailand and Hong Kong with suspected SARS.
www.cdc.gov /mmwr/preview/mmwrhtml/mm5212a1.htm   (2613 words)

  
 TB #502: Published siRNA Target Sequences
Shang Y and Brown M. Molecular determinants for the tissue specificity of SERMs.
Hirai H and Wang H-G. A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex.
EMBO J. Tsuneoka M, Koda Y, Soejima M, Teye K, and Kimura H. A novel Myc target gene, mina53, that is involved in cell proliferation.
www.ambion.com /techlib/tb/tb_502.html   (1104 words)

  
 Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase ...
E6 is mediated by both Myc and Sp1 cis elements.
E6 correlated strongly with the induction of hTERT expression.
E6 and E7 may be due to the synergistic action of these two proteins.
jvi.asm.org /cgi/content/full/75/12/5559   (5185 words)

  
 Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase ...
Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen -- Escalante-Alcalde et al.
A fragment (0.8 kb) containing the HPV-16 E6 and E7 oncogenes was inserted between a 9.8-kb fragment of the bK6 gene promoter and regulatory region and a fragment containing the SV40 polyadenylation signal.
Münger K., Phelps W. C., Bubb V., Howley P. M., Schlegel R. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes.
cgd.aacrjournals.org /cgi/content/full/11/10/527   (8424 words)

  
 Identification of an alpha  Helical Motif Sufficient for Association with Papillomavirus E6 -- Chen et al. 273 (22): ...
pSPBPVE6 encodes BPV-1 E6 in a pSP65 vector.
Previous studies of E6AP defined a span of 18 amino acids that is necessary for interaction with E6 (2).
The E6 binding peptides of E6bd (residues 18-29), the 18 amino acids (amino acids 391-408) of E6AP (2), and the sequence of LD1 from paxillin (amino acids 3-15) (3) are aligned.
www.jbc.org /cgi/content/full/273/22/13537   (5037 words)

  
 Program Files\Netscape\Communicator\Program\nshsalg\MoreExponential
= 1 + 1 + 1/2 + 1/6 = 2.666666....
= 1 + 1 + 1/2 + 1/6 + 1/24 = 2.70833...
= 1 + 1 + 1/2 + 1/6 + 1/24 + 1/120 = 2.7166...
www.ii.uib.no /~wagner/hsalg/MoreExponential.htm   (456 words)

  
 Identification of Enteroviruses by Using Monoclonal Antibodies against a Putative Common Epitope -- Shin et al. 41 (7): ...
1, 31 of 61 clones were concentrated on the
E6, CVB3, and CVB5 at the dilution factor of 10
40 to 53 in the N terminus of VP1.
jcm.asm.org /cgi/content/full/41/7/3028   (4306 words)

  
 Human Papillomavirus Oncoprotein E6 Inactivates the Transcriptional Coactivator Human ADA3 -- Kumar et al. 22 (16): ...
S-labeled E6 proteins were generated by in vitro translation with wheat germ lysate, and aliquots were allowed to bind to GST, GST-hADA3 (aa 75 to 432), GST-E6AP (as a positive control), or GST-NES1 (as a negative control) coated on glutathione-Sepharose beads.
Whole-cell lysates (10% input, lanes 1 to 4) were directly blotted with anti-myc antibody (upper panel) or anti-FLAG antibody (lower panel) to assess the expression of HPV16 E6 and hADA3, respectively.
The immortalizing versus nonimmortalizing designation of each E6 mutant is derived from a mammary epithelial cell immortalization assay reported previously (12, 47).
mcb.asm.org /cgi/content/full/22/16/5801   (7833 words)

  
 Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its ...
E6 (53% of input) and lesser binding with GST-18 E6 (5% of input)
E6 was detected by Western analysis with the AU1 monoclonal antibody.
The E6 protein of Human Papillomavirus type 16 functions as a transcriptional repressor in a mechanism independent of the tumor suppressor protein, p53.
www.genesdev.org /cgi/content/full/12/13/2061   (6913 words)

  
 PKN Binds and Phosphorylates Human Papillomavirus E6 Oncoprotein -- Gao et al. 275 (20): 14824 -- Journal of Biological ...
S-Labeled PKN or p53 were incubated with water-primed lysate (control), HPV16 E6, or HPV6 E6 for 12 h at 30 °C; the PKN or p53 remaining at the end of degradation assay were fractionated by SDS-PAGE and visualized by fluorography.
Analysis of E6 Mutants Binding to PKN in Vitro-- Previous analyses of HPV16 E6 have identified immortalizing and non-immortalizing mutants of HPV16 E6 (21, 41, 48);
In vivo phosphorylation of HPV16 E6 in the presence of PKN.
www.jbc.org /cgi/content/full/275/20/14824   (5340 words)

  
 PRELIMINARY DESCRIPTION OF STONE VARIETIES USED IN MEDIEVAL ISLAMIC BUILDINGS OF CAIRO
NOTE 1:        Megascopic descriptions are provided for each stone variety based on examples seen in Cairo mosques.
E6        MC gneiss: Stone — medium-grained tonalite gneiss, speckled light gray and greenish fl.
References and Photos — M85 (p 57; 545 in pl 16), G88 (p 196-199; f 203), MSG89 (p 154-156; f 14a-14c), AN89 (1 on p 112), DW92 (p 156; a in pl 2), PB98 (p 15; pl 89-90) and R01 (pl 1: C5-C6).
www.eeescience.utoledo.edu /Faculty/Harrell/Egypt/Mosques/CAIRO_Rocks_1.htm   (6279 words)

  
 Lymphocytic Choriomeningitis Virus Infection in Organ Transplant Recipients --- Massachusetts, Rhode Island, 2005
In early April, in Rhode Island, a woman with a medical history remarkable only for hypertension and 1 week of headache had sudden onset of hemiplegia caused by a stroke, followed by brainstem herniation and brain death within 3 days.
When the cause of illness among the recipients was not identified through extensive diagnostic testing and suspicion of transplant-transmitted infection arose, tissue and blood samples from the donor and recipients were sent from the Rhode Island Department of Health and the Massachusetts Department of Public Health to CDC.
LCMV was identified as the cause of illness in all four organ recipients; diagnosis was made in tissues from multiple organs through immunohistochemical staining, reverse transcriptase-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assays (i.e., IgM capture and indirect IgG), and viral culture on Vero E6 cells.
www.cdc.gov /mmwr/preview/mmwrhtml/mm5421a4.htm   (1575 words)

  
 Crystal page   (Site not responding. Last check: 2007-11-03)
compute the restriction of an irreducible representation obtained in #1 to a simple subalgebra obtained by omitting one of the simple roots.
The simple Lie algebras are denoted by the strings A1, A2,..., B1, B2,..., C1, C2,..., D1, D2,..., E6, E7, E8, F4, and G2.
We may assume that L is a subset of the set of all n x n matrices, for some n.
web.usna.navy.mil /~wdj/crystal.htm   (1093 words)

  
 XML Path Language (XPath) 2.0
Sequences are never nested—for example, combining the values 1, (2, 3), and () into a single sequence results in the sequence (1, 2, 3).
1.) XPath is defined in terms of the data model, but it does not place any constraints on how XDM instances are constructed.
This case is treated as a type error and inhibits evaluation, even though the function call would have been successful for input data in which the optional element is present.
www.w3.org /TR/xpath20   (10822 words)

  
 Mammalian Copper Chaperone Cox17p Has an Essential Role in Activation of Cytochrome c Oxidase and Embryonic Development ...
Articles by Takahashi, Y. Articles by Munekata, E. Molecular and Cellular Biology, November 2002, p.
(1), it was not known whether copper binds to the mammalian
A homologue of pancreatic trypsin is localized in the acrosome of mammalian sperm and is released during acrosome reaction.
mcb.asm.org /cgi/content/full/22/21/7614   (3995 words)

  
 Expression of the Nucleoprotein of the Puumala Virus from the Recombinant Semliki Forest Virus Replicon: ...
, SFV-1, or Vero E6 cells not infected (mock) or infected with Puumala virus (Puumala V) or Hantaan virus (HTN V) were analyzed in a 10% polyacrylamide gel, transferred to a membrane incubated with hamster anti-Puumala antibodies revealed with peroxidase-labeled secondary antibodies.
The positions of N proteins from Puumala and Hantaan virus (N Puu and N HTN, respectively) are indicated to the right of the blot.
Plyusnin, A., Y. Cheng, H. Lehvaslaiho, and A. Vaheri.
cdli.asm.org /cgi/content/full/10/4/658   (4122 words)

  
 Film Recommendations
Oh, and if you want to sound like a pro, refer to slide film as "E6" (after the Kodak process that is used to develop all slide film today except Kodachrome (K14) and infrared Ektachrome (E4)) or "chromes".
I used a lot of it at MIT's 1998 graduation ceremony and the results were pretty bad compared to those obtained with Fuji Astia shot on the same day.
Every 1 hour lab in the world knows how to print this film accurately, which is an important selling feature.
www.photo.net /equipment/film   (17078 words)

  
 Thrombospondin-1 and -2 Messenger RNA Expression in Invasive Cervical Cancer: Correlation with Angiogenesis and ...   (Site not responding. Last check: 2007-11-03)
Oshika Y., Masuda K., Tokunaga T., Hatanaka H., Kamiya T., Abe Y., Ozeki Y., Kijima H., Yamazaki H., Yamaoki N., Ueyama Y., Nakamura M. Thrombospondin 2 gene expression is correlated with decreased vascularity in non-small cell lung cancer.
Ohtani Y., Kijima H., Dowaki S., Kashiwagi H., Tobita K., Tsukui M., Tanaka Y., Tsuchida T., Tokunaga T., Yamazaki H., Nakamura M., Ueyama Y., Tanaka M., Tajima T., Makuuchi H. Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.
Tokunaga T., Nakamura M., Oshika Y., Abe Y., Ozeki Y., Fukushima Y., Hatanaka H., Sadahiro S., Kijima H., Tsuchida T., Yamazaki H., Tamaoki N., Ueyama Y. Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer.
clincancerres.aacrjournals.org /cgi/content/full/7/9/2826   (3120 words)

  
 Chess Notes by Edward Winter
Page 53 of Chess Pie (1922) stated, ‘Fink is a strong chessplayer and has drawn twice with Capablanca in simultaneous exhibitions’, but it seems that the other game has not been traced.
Our proposal is 1 e4 e5 2 Nf3 d5 3 exd5 Qxd5 4 Nc3 Qa5 5 Qe2 Nc6 6 d3 Bg4 7 Bd2 Nd4 8 Qxe5+ Qxe5 9 Nxe5 Nc2 mate.
Two coincidences in the games are striking: both were played in 1957 and both had the surprising advance of the bishop’s pawn at move 53.
www.chesshistory.com /winter/winter06.html   (7239 words)

  
 PS/2 Mouse Interfacing
The movement counters are 9-bit 2's complement integers, where the most significant bit appears as a sign bit in Byte 1 of the movement data packet.
Z0-Z3 is a 2's complement number which represents the amount of movement that has occurred since the last data report.
Enable = 1 if data reporting is enabled; 0 if data reporting is disabled.
www.computer-engineering.org /ps2mouse   (3132 words)

  
 UR Faculty: Nancy Wang
THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma.
Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins.
Abeysinghe HR, Cao Q, Pollock S, Veyberman Y, Guckert NL, Keng P, Wang N. Thy-1 expression is associated with tumor suppression of human ovarian cancer.
www.urmc.rochester.edu /gebs/faculty/nancy_wang.htm   (728 words)

  
 THE PERRON-FROBENIUS THEOREM
= 1 if there is an arc from vertex i to vertex j.
If the associated matrix is irreducible then one can get from any vertex to any other vertex (perhaps in several steps) whereas if it is reducible then (like the Markov Chain case), there are vertices from which one cannot travel to all other vertices.
In the case of the first graph, the eigenvalues are 1,i,-i, and -1 while in the second graph they are 1.221, -.248 +/-1.034i, and -.724, consistent with the gcd of paths for graph 1 being 4 and the gcd of paths for graph 2 being 1.
www.prenhall.com /divisions/esm/app/ph-linear/leon/html/perron.html   (2166 words)

  
 UM Developmental Biology Center
One focus of the laboratory is directed at understanding the cell and molecular basis of Spinocerebellar ataxia type 1 (SCA1), an autosomal dominant progressive neurodegenerative disorder caused by the expansion of an unstable CAG trinculeotide repeat within the SCA1 coding region.
Cummings, C.J., Reinstein, E., Sun, Y., Antalffy, B., Jiang, Y., Ciechanover, A., Orr, H.T., Beaudet, A.L., Zoghbi, H.Y. (1999) Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.
Banfi, S., Servadio, A., Chung, M.-y., Capozzoli, F., Duvick, L.A., Elde, R., Zoghbi, H.Y., and Orr, H.T. (1996) Cloning and developmental expression analysis of the murine homolog of the spinocerebellar ataxia type 1 gene (Sca1).
www.med.umn.edu /dbc/html/faculty/Orr.html   (852 words)

  
 The RBT Files
We concluded by cautioning that analysis at the population level does not characterize individual cases: When CSA is accompanied by factors such as force or close familial ties, it has the potential to produce significant harm.
Sobre los últimos 25 años un modelo de incesto, con su imagen de víctimas indefensas explotadas y traumatizadas por adultos poderosos, ha venido a ser dominante en las percepciones de casi todos los tipos de sexo entre adultos y menores.
Peter: Comment: The Journal of Psychology (2001, 135, 1, 17-36) carries a 'Meta-analysis of published research on the effects of child sexual abuse (CSA)' by Elizabeth Paolucci, Mark Genuis and Claudio Violato, which reviews 37 good-quality studies.
www.ipce.info /ipceweb/Library/rbt_files.htm   (6277 words)

  
 Xiaojiang Chen - PIBBS - Graduate Programs in Biomedical & Biological Sciences - University of Southern California
Tumor viruses use oncoproteins to transform normal cells into cancerous cells.
Among such oncogenes are large Tumor antigen (LTag) from SV40, E6 and E7 from papillomavirus, and E1A from Adenovirus.
We want to understand how these diverse group of oncoproteins regulate cellular targets to promote the uncontrolled cell growth as in tumors.
www.usc.edu /programs/pibbs/site/faculty/chen_x.htm   (662 words)

  
 [Frontiers in Bioscience 6, d222-238, February 1, 2001]
Due to variability in the transciption start site the size of the exon is indicated as starting at the initiator methionine
The length of exon 1 is indicated as the size starting in the 5' flanking region where the longest cDNA started.
Exons 11 and 12 and the corresponding intervening sequences have not been isolated
www.bioscience.org /2001/v6/d/sun/tables.htm   (208 words)

  
 Targeting cyclin-dependent kinases in Drosophila with peptide aptamers -- Kolonin and Finley 95 (24): 14266 -- ...
Genetics, September 1, 2004; 168(1): 199 - 214.
Genetics, March 1, 2003; 163(3): 1047 - 1060.
Interv., April 1, 2001; 1(1): 40 - 53.
www.pnas.org /cgi/content/abstract/95/24/14266   (1007 words)

  
 (GCF0E2) Duetzhofer Busch by Hedi und Roldomo   (Site not responding. Last check: 2007-11-03)
Den Hauptweg bei N50 42.966 E6 56.172 Richtung West verlassen.
3 Deko-Ostereier, 1 Ostereikerze, 2 mal 3 Glückskäfer, Delphin-Ohrstecker, Haarband, ein Porzelanschweinchen, ein Glücksschweinchen und natürlich das Logbuch mit Stift und Spitzer (bitte nicht entfernen).
Leave the main trail at N50 42.966 E6 56.172 in west direction.
www.geocaching.com /seek/cache_details.aspx?wp=gcf0e2&submit6=find&pf=y&log=y   (4886 words)

  
 Chess Notes by Edward Winter
El torneo se inicia el de marzo de 1948 en Holanda jugándose allí la mitad del torneo.
We believe, however, that Bachmann erred by putting as White’s 50th move Rd6-d1, rather than Rd6-d8, and that there was thus no blunder by Lasker at move 53.
Caption on the reverse side: ‘The most interesting of New Orleans’ historic burial places, the St Louis Cemetery No. 1 — there are three — has been in use for 175 years, with some of the inscriptions still decipherable dated 1800.
www.chesshistory.com /winter/winter12.html   (13596 words)

  
 Psychology Videos, 16 mm Films & Sound Recordings - UA Library
1−9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
DESCRIPTION 1 videocassette (VHS) (53 min.) + 1 teacher's guide.
SUMMARY Focuses on the impact of important psychological discoveries.
www.library.arizona.edu /help/how/find/films/psyc/l.html   (388 words)

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