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| | 1,2,4-Triazol E-3-carboxamides as antiviral agents - United States Patent 3,976,545 |
 | | The principal bacterial sources are E. coli and yeast, while a variety of animal sources exist, including beef spleen, rat liver, calf liver, calf thymus, beef liver, monkey brain, horse liver, calf spleen, human erythrocytes, fish skin, and fish muscle. |
 | | Animals dying during the experiment were noted daily, and the lungs of all surviving mice were removed on day 25 and graded on a scale of 0 to 4 for the degree of viral consolidation occurring. |
 | | In animal toxicity experiments, Compound 1 was nontoxic to mice when used in concentrations as high as 1000 mg/kg/day administered intraperitoneally twice daily for 9 days, whereas Compound 2 was moderately toxic as evidenced by weight loss and death in concentrations as low as 250 mg/kg/day administered by the same treatment regimen. |
| xrint.com /patents/us/3976545 (3429 words) |
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