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| | Health Effects Assessment for Environmental Perchlorate Contamination: The Dose Response for Inhibition of Thyroidal ... (Site not responding. Last check: 2007-10-09) |
 | | For the two subjects with respective TT values of 80 and 84 ng/dL at the screening visit, TT values on E1, E2, and E14 were 92, 91, and 95 ng/dL in the first subject and 100, 99, and 112 ng/dL in the second. |
 | | Assuming a body weight of 70 kg and a drinking-water intake of 2 L/day, a perchlorate dose of 5.2 or 6.4 µg/kg-day would be consumed if drinking-water supplies contained perchlorate at a concentration of approximately 180 or 220 µg/L (ppb), respectively. |
 | | Based on this crude calculation, 150 µg iodine daily would protect against goiter in a person whose perchlorate ingestion is 4 mg/day (0.057 mg/kg-day in a 70-kg adult), a dose that would inhibit iodide uptake by approximately 35%, according to the dose-response we observed in the present study. |
| ehp.niehs.nih.gov /members/2002/110p927-937greer/greer-full.html (9708 words) |
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