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	Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal ...
		To establish the dose response in humans for perchlorate inhibition of thyroidal iodide uptake and any short-term effects on thyroid hormones, we gave perchlorate in drinking water at 0.007, 0.02, 0.1, or 0.5 mg/kg-day to 37 male and female volunteers for 14 days.
		On both E2 and E14, the dose response was a negative linear function of the logarithm of dose.
		Based on the dose response for inhibition of the 8- and 24-hr RAIU on E14 in all subjects, we derived estimates of the true no-effect level: 5.2 and 6.4 [micro]g/kg-day, respectively.
	findarticles.com /p/articles/mi_m0CYP/is_9_110/ai_94261107?lstpn=article_results&lstpc=search&lstpr=external&lstprs=other&lstwid=1&lstwn=search_results&lstwp=body_middle (882 words)

	Global Data Assimilation System (GDAS1) Archive Information
		NCEP post-processing of the GDAS converts the data from spectral coefficient form to 1 degree latitude-longitude (360 by 181) grids and from sigma levels to mandatory pressure levels.
		Record 1 consists of a four character string that identifies the source of the meteorological data.
		The packed values are one byte unsigned integers, where values from 0 to 126 represent -127 to -1, 127 represents zero, and values of 128 to 254 represent 1 to 127.
	www.arl.noaa.gov /ss/transport/gdas1.html (1543 words)

	USGS CFC Lab
		Figure 1 on this sheet is a plot of the air mixing ratios (Table 13.2-1) that were used to calculate the ground water ages.
		On Figure 1, the piston flow recharge dates can be obtained at the intersection of the horizontal dashed-lines with the air curves of the same color.
		On Figure 1 of this sheet, the ratio age is obtained at the intersection of the horizontal dashed-lines with the ratio curves of the same color.
	water.usgs.gov /lab/software/USGS_CFC (1731 words)

	BioMed Central \| Full text \| NF-κB DNA-binding activity in embryos responding to a teratogen, cyclophosphamide
		Supershift analysis was performed with nuclear extracts from the brain of E13 and E14 as well as from the liver of E13 and E14.
		Our previous studies [21] have shown that 14 day embryos of females exposed to this dose of CP were severely growth retarded but the size of their liver did not visually differ from that of age-matching control embryos.
		In this study we observed that the size of the liver of E14 exposed to 40 mg/kg CP and NaSAL was obviously smaller than that of embryos exposed to the teratogen alone.
	www.biomedcentral.com /1471-213X/2/2 (5893 words)

	[No title]
		References to positions within a sequence are made using sequential numbering, beginning with 1 at the N-terminal end of the sequence.
		Except for initiator N-terminal methionine residues, which are not included in a sequence when their absence from the mature sequence has been proven, the sequence data correspond to the precursor form of a protein before posttranslational modifications and processing.
		[1] For the 'CATALYTIC ACTIVITY' topic: To describe the catalytic activity of an enzyme we have used, whenever possible, the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) as published in Enzyme Nomenclature, NC-IUBMB, Academic Press, New-York, (1992).
	www.expasy.org /sprot/userman.html (9466 words)

	General Recommendations on Immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP) and ...
		However, by chronological age 1 month, all premature infants, regardless of initial birth weight or gestational age are as likely to respond as adequately as older and larger infants (120--122).
		Premature infants discharged from the hospital before chronological age 1 month can also be administered hepatitis B vaccine at discharge, if they are medically stable and have gained weight consistently.
		The program, which became operational on October 1, 1988, is intended as an alternative to civil litigation under the traditional tort system in that negligence need not be proven.
	www.cdc.gov /mmwr/preview/mmwrhtml/rr5102a1.htm (16938 words)

	Drug Information: Anti-inflammatory Drugs, Nonsteroidal (Systemic) (Print Version)
		At first, a total of 30 to 40 mg per kg (about 13.6 to 18 mg per pound) of body weight a day, divided into smaller amounts that are taken three or four times a day.
		At first, 1.5 to 2.5 mg per kilogram (kg) (about 0.7 to 1.1 mg per pound) of body weight a day, divided into smaller amounts that are taken three or four times a day.
		At first, 20 mg per kilogram (kg) (about 9 mg per pound) of body weight a day, divided into smaller amounts that are taken three or four times a day.
	www.nlm.nih.gov /medlineplus/print/druginfo/uspdi/202743.html (7480 words)

	Divergent Expression Patterns for Hypoxia-Inducible Factor-1{beta} and Aryl Hydrocarbon Receptor Nuclear Transporter-2 ...
		examined: 1 d, 7 d, and 8 wk of age (Figure 1A).
		E12 mouse metanephroi were dissected and cultured for 4 d in 20% oxygen and then shifted to a hypoxic environment (2% oxygen) for 1 d (left) or were cultured for 5 d in 5% oxygen (right).
		protein expression at E14 was nearly ubiquitous and uniformly intense.
	jasn.asnjournals.org /cgi/content/full/15/10/2569 (4517 words)

	Health Effects Assessment for Environmental Perchlorate Contamination: The Dose Response for Inhibition of Thyroidal ...
		Figure 1 shows the relationship between the 24-hr relative uptakes on E2 and E14 for all subjects (and doses) tested at both time points (r = 0.824, n = 24); we observed a similar relationship for the 8-hr relative uptakes on E2 and E14 (r = 0.782, n = 24).
		For each E14 uptake measurement in the three studies, we calculated an effect parameter (analogous to the slope of the dose-response relationship) by dividing the uptake as a percentage of baseline by the logarithm of the body-weight-adjusted dose.
		Assuming a body weight of 70 kg and a drinking-water intake of 2 L/day, a perchlorate dose of 5.2 or 6.4 µg/kg-day would be consumed if drinking-water supplies contained perchlorate at a concentration of approximately 180 or 220 µg/L (ppb), respectively.
	www.ehponline.org /members/2002/110p927-937greer/greer-full.html (9743 words)

	Allergy & Asthma Disease Management Center: Ask the Expert
		Improvements in visual acuity and central retinal thickness measurements were evident by week 1 and continued through month 3.
		RESULTS: The majority of adverse events attributable to VEGF Trap were mild to moderate in severity, but 2 of 5 patients treated with 3.0 mg/kg experienced dose-limiting toxicity (1 with grade 4 hypertension and 1 with grade 2 proteinuria); therefore, all patients in the 3.0 mg/kg-dose group were withdrawn from the study.
		Although it is true that many asthmatics would be younger individuals without cardiac problems, one has to be selective when seeing patients in a very acute situation; 2) one can raise the question why epinephrine was not tried by the IM route first (apparently not done in these patients).
	www.aaaai.org /aadmc/ate/category.asp?cat=1042 (8176 words)

	wave/mass ratios: Any ideas ?
		certainly the energy of 1 electron compared to the energy of these various energies of EM spectrum will yield the technical frequency of electrons, assuming that 3e8 is the total mass and there is some kind of relationship between the frequency and the total energy.
		Potential velocity/wave decompression of wave length seems to be exactly equal to the frequency, in some odd respect, while the longer the wave, the more massive the wave, and the more “energy” can be produced by this expansion.
		There seems to be a factor of roughly “2” between the “total mass” of an electron using my system, and the technical mass of an electron as listed in books.
	www.physicsforums.com /showthread.php?t=15558 (806 words)

	The Pharmacokinetics of Escitalopram in Patients With Hepatic Impairment
		Alcoholic beverages were not allowed from 48 hours prior to dosing until completion of blood sampling; furthermore, the subjects with alcohol-induced liver cirrhosis abstained from alcohol for at least 1 week prior to escitalopram administration and during the entire study period.
		Blood samples (5 mL) for drug analysis were drawn from an antecubital vein 5 minutes predose and at 1, 2, 3, 4, 6, 8, 12, 24, 48, 72, 96, 120, 144, and 168 hours after escitalopram intake.
		After clotting, the samples were centrifuged and the serum was frozen in glass tubes at –20°C. Escitalopram in serum was analyzed using an enantioselective HPLC method with tandem mass spectroscopy (MS/MS) detection after liquid-liquid extraction.
	www.aapspharmsci.org /view.asp?art=aapsj080102 (3119 words)

	C-Peptide Exerts Beneficial Effects on Myocardial Blood Flow and Function in Patients With Type 1 Diabetes -- Hansen et ...
		Heart, December 1, 2004; 90(12): 1483 - 1484.
		Rev., August 1, 2004; 25(4): 543 - 567.
		Am J Physiol Endocrinol Metab, January 1, 2004; 286(1): E14 - E19.
	diabetes.diabetesjournals.org /cgi/content/abstract/51/10/3077 (471 words)

	Relationship between Perlecan and Tropoelastin Gene Expression and Cell Replication in the Developing Rat Pulmonary ...
		Embryonic (Days e15 to e17), fetal (Days f18 to f21), and postpartum (ppd 1, 2, 4, 7, and 16; 1 and 3 mo) periods are shown.
		Sections of BrdU-treated Day f19 (perlecan message [a and b]) and ppd 1 (TE message [c and d]) lung tissues were examined with in situ hybridization to detect perlecan or TE mRNA (fl dots under brightfield magnification) concurrently with BrdU immunohistochemistry (brown nuclei) to detect DNA synthesis.
		Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan.
	ajrcmb.atsjournals.org /cgi/content/full/20/1/24 (5798 words)

	Isradipine and insulin sensitivity in hypertensive rats -- Gaudreault et al. 276 (6): E1038 -- AJP - Endocrinology and ...
		infusion of insulin in the presence of isradipine (0.15 mg · kg
		Glucose infusion rates necessary to maintain euglycemia during steady-state hyperinsulinemia are significantly higher in both groups of rats treated with isradipine than in control group.
		for the untreated rats (17.3 ± 1.7 mg · kg
	ajpendo.physiology.org /cgi/content/full/276/6/E1038 (6135 words)

	Functional Expression of the L-Type Calcium Channel in Mice Skeletal Muscle during Prenatal Myogenesis -- Strube et al. ...
		E14 and E18 for a depolarization reaching +10 mV.
		A linear regression of the data revealed a single-channel conductance of 13.0 pS (E14), 10.4 pS (E16), and 10.5 pS (E18).
		for 7 cells at E14 and for 7 cells at E18.
	www.biophysj.org /cgi/content/full/78/3/1282 (5415 words)

	Requirement of transcription factor NFAT in developing atrial myocardium -- Schubert et al. 161 (5): 861 -- The Journal ...
		At E14, NFAT was not detected in the nucleus (arrowheads) as indicated by the separated staining of NFAT (green) and the nuclei (red; see inset for higher magnification).
		At E16, nuclear NFAT was observed, as indicated by the overlapped staining of NFAT and the nuclei (yellow).
		Thinning of atrial walls was found in E16 hearts that were exposed to Dox, from E14 to E16, for even 2 d (A).
	www.jcb.org /cgi/content/full/161/5/861 (6918 words)

	Ablation of TR{alpha}2 and a Concomitant Overexpression of {alpha}1 Yields a Mixed Hypo- and Hyperthyroid Phenotype in ...
		The TR 1 and TR 2 RNAs are widely coexpressed early in development (10)
		In the latter mice the normal TR 1 RNA was undetectable.
		The primers for detection of total TR 1 or TR mRNAs gave the expected band in all the samples analyzed (upper bands in lanes 1–12); the TR 2- specific primers were only detected in +/- and +/+ animal tissues (lower bands in lanes 5–12).
	mend.endojournals.org /cgi/content/full/15/12/2115 (7843 words)

	Apical and Basal Regulation of the Permeability of the Retinal Pigment Epithelium -- Peng et al. 44 (2): 808 -- ...
		E7 (squares) or E14 (circles) RPE was cultured with SF2 in the basolateral chamber.
		RPE was isolated from E14 embryos and examined using the protocols described in the legend to Figure 1.
		RPE cells were isolated from E7 (A, B) or E14 (C, D) embryos and cultured with SF3 in the basolateral chamber and rcSF3 in the apical chamber.
	www.iovs.org /cgi/content/full/44/2/808 (6009 words)

	Science -- Löw et al. 290 (5489): 131
		Mutant allele 1 is obtained after gene targeting in mouse embryonic stem cells and introduced into the mouse germ line; breeding of these mice to EIIa-cre mice (16) results in excision of the neomycin resistance cassette (mutant allele 2).
		However, the potentiation by diazepam (1 µM) was reduced in cells
		Mice were given vehicle or increasing doses of diazepam (0.5, 1, and 2 mg/kg orally).
	www.usm.maine.edu /~psy/broida/366/anxietyattenuation.html (1649 words)

	Sunlight and Weight
		Photons have a spin of "1" and things with integral spin (as opposed to electrons and protons that have spin "1/2") can all occupy the same energy level.
		Multiplying this by the 4.2 x 10^9 kg burned by the sun every second and we obtain 2.5 kg/s as the mass of the photons (light) from the sun striking the earth every second.
		There is another way to guesstimate this number using the rough estimate of 1 kW/m^2 as the energy of the sunlight striking the earth.
	www.newton.dep.anl.gov /askasci/phy00/phy00644.htm (817 words)

	Virology Journal \| Full text \| Transplacental murine cytomegalovirus infection in the brain of SCID mice
		Cytomegalovirus (CMV), a double-stranded DNA β-herpesvirus, is the most common cause of human congenital infection, with a prevalence rate of approximately 1% for all live births in the United States (worldwide range 0.5–2.4%) [1].
		By stage E14, the youngest gestational age at which the brains and viscera were examined separately, 21% of the fetuses had MCMV nPCR positive brains, and 50% amplified MCMV DNA in either their brains or viscera.
		The rate of CMV vertical transmission in the brain or viscera at stage E16 was 25%, and at E18 the incidence of transplacental MCMV transmission in reached a maximum of 53%.
	www.virologyj.com /content/4/1/26 (7040 words)

	Prevention of Pediatric Overweight and Obesity -- Committee on Nutrition 112 (2): 424 -- AAP Policy
		Pediatrics, December 1, 2006; 118(6): 2290 - 2297.
		Pediatrics, September 1, 2006; 118(3): e594 - e601.
		Pediatrics, March 1, 2006; 117(3): 673 - 680.
	aappolicy.aappublications.org /cgi/content/full/pediatrics;112/2/424 (4306 words)

	Development of a Transgenic Green Fluorescent Protein Lineage Marker for Steroidogenic Factor 1 -- Stallings et al. 16 ...
		Ikeda Y, Luo X, Abbud R, Nilson JH, Parker KL 1995 The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.
		Sadovsky Y, Crawford P, Woodson KG, Polish JA, Clements MA, Tourtellotte LM, Simburger K, Milbrandt J 1995 Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids.
		Nomura M, Bartsch S, Nawata H, Omura T, Morohashi KI 1995 An E box element is required for the expression of the ad4bp gene, a mammalian homologue of the ftz-f1 gene, which is essential for adrenal and gonadal development.
	mend.endojournals.org /cgi/content/full/16/10/2360 (4797 words)

	Influence of Nitric Oxide Synthase and Adrenergic Inhibition on Adenosine-Induced Myocardial Hyperemia -- Buus et al. ...
		Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2006; 11(3): 197 - 202.
		Diabetes, February 1, 2006; 55(2): 511 - 516.
		Hypertension, October 1, 2004; 44(4): 465 - 470.
	circ.ahajournals.org /cgi/content/abstract/104/19/2305 (1369 words)

	Animal Protocols
		Alternatively: a 1 mm tail snip can be placed into a 96 well plate with 200ml Lysis buffer and incubated overnight, followed by 95oC heat inactivation for 10 minutes.
		With a 26G3/8 needle attached to a 1 ml syringe, gently nick the kidney capsule leaving a small hole at the anterior end.
		For the gestational ages referred to in Table 1 below, the morning on which the vaginal plug is found is counted as day one (E1) of gestation.
	www.uchsc.edu /misc/diabetes/derc/prot_animal.htm (6456 words)

	Chemokine Receptor CCR1 But Not CCR5 Mediates Leukocyte Recruitment and Subsequent Renal Fibrosis after Unilateral ...
		Levels of mRNA expression for CCR1 (gray) and CCR5 (fl) in UUO kidneys are expressed in relation to renal GAPDH mRNA expression and to the respective ratio of the unobstructed contralateral kidney.
		1 is expressed in relation to renal GAPDH mRNA expression as indicated under Materials and Methods.
		1 mRNA expression of wild-type mice was set as 1 and values represent means ± SD from 5 mice per group.
	jasn.asnjournals.org /cgi/content/full/15/2/337 (5419 words)

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