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| | Birthdates of neurons in Microgyria |
 | | Rat pups from mothers who were injected with S-phase markers on E15, E17, E19, and E21 were subjected to freezing injury of the cortex to induce microgyria on postnatal day (P) 1. |
 | | In the regions of the cortex unaffected by the freezing lesion, neurons labeled at E15 were located, as expected, predominantly in layers IV, V, and VI with the greatest concentrations being in layer V. In contrast, there were few heavily labeled E15-injected neurons in the microgyric regions (Fig, 2). |
 | | It could be, however, that the reason E17 and E19 neurons, but not E15 neurons, arrive in the microgyria from adjacent areas is because by the time the region is reorganized (P5), the infragranular neurons have already established substantial local connectivity thereby precluding their move to adjacent areas. |
| www.nervenet.org /netpapers/Rosen/MGBirth96/MGBirthMain.html (3324 words) |
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