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Jason Chen, Ph.D. - Faculty - Medicine - UMass Medical School |
 | | Induction of genomic instability by HPV oncogenes E6 and E7 Polyploidy occurs as an early event during cervical carcinogenesis and predisposes cells to aneuploidy and chromosomal instability. |
 | | Expression of the HPV E6 and E7 oncogenes in human keratinocytes leads to polyploidy in response to mitotic stress and DNA damage. |
 | | Previously, it was thought that E6 and E7 induce polyploidy after microtubule disruption by abrogating the spindle checkpoint through degradation of the tumor suppressor p53 and pRb, respectively. |
| www.umassmed.edu /cfar/members/chen.cfm?start=0& (1183 words) |