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The human cathelicidin hCAP-18 The sorting of granule proteins in the different granule subsets has been proposed to be regulated by timing (also called the "targeting by timing hypothesis"), i.e. Since the various subpopulations of granules are mobilized to varying degrees, the differences in subcellular localization might have functional implications for the different members of the cathelicidin family. Cathelicidins from peroxidase negative granules of bovine and porcine neutrophils are processed to the active antimicrobial peptides following exposure to the proteases from azurophil granules (23, 24) following degranulation either to the exterior (23, 24) or to the phagolysosome (23). www.danmedbul.dk /DMB_2005/0105/0105-disputatser/DMB3708.htm   (7800 words)

Loss of the Zymogen Granule Protein Syncollin Affects Pancreatic Protein Synthesis and Transport but Not Secretion -- ... Zymogen granules (20 µg/lane) from adult wild-type (+/+) mice and heterozygous (+/-) or homozygous (-/-) mice derived from three independent stem cell clones (syl6, syl8, and syl7) were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting using antibodies specific for SCAMP as a marker for zymogen granules and syncollin (syc). in the stimulus-evoked exocytosis of mature zymogen granules. of condensing vacuoles and/or the maturation of secretory granules. mcb.asm.org /cgi/content/full/22/5/1545   (4974 words)

Kinase Pathways in Chemoattractant-Induced Degranulation of Neutrophils: The Role of p38 Mitogen-Activated Protein ... Release of the primary granule marker ß-GU (A; n = 8), the secondary granule marker Lfr (B; n = 9–10), and the secretory vesicle marker HSA (C; n = 10) is shown. Release of the primary granule marker ß-GU (A; n = 3), the secondary granule marker Lfr (B; n = 4), and the secretory vesicle marker HSA (C; n = 4) is shown. degranulation of the secondary granules in murine neutrophils www.jimmunol.org /cgi/content/full/164/8/4321   (7828 words)

Caspase Dependence of Target Cell Damage Induced by Cytotoxic Lymphocytes -- Sarin et al. 161 (6): 2810 -- The Journal ... granule exocytosis pathway is predicted because the granule PS exposure on target cells induced by CTL granule exocytosis is not blocked by peptide caspase inhibitors. by CTL granule exocytosis is not inhibited by peptide-FMK caspase inhibitors. www.jimmunol.org /cgi/content/full/161/6/2810   (6123 words)

Spontaneous Release of Neuropeptide Y Tonically Inhibits Recurrent Mossy Fiber Synaptic Transmission in Epileptic Brain ... Mossy fiber-like Timm staining is present in the inner third of the dentate molecular layer, where recurrent mossy fibers innervate granule cell dendrites. Bottom, Grouped data (means ± SEM) from eight granule cells demonstrated a significant reduction in the percentage of response failures. Makiura Y, Suzuki F, Chevalier E, Onténiente B (1999) Excitatory granule cells of the dentate gyrus exhibit a double inhibitory neurochemical content after intrahippocampal administration of kainate in adult mice. www.jneurosci.org /cgi/content/full/25/7/1718   (7389 words)

Expression Profiling Reveals Novel Innate and Inflammatory Responses in the Jejunal Epithelial Compartment during ... Granule proteinases define mast cell heterogeneity in the serosa and the gastrointestinal mucosa of the mouse. Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Histochemical and ultrastructural modification of mucosal mast cell granules in parasitized mice lacking the beta-chymase, mouse mast cell protease-1. iai.asm.org /cgi/content/full/72/10/6076   (6608 words)

Priess Lab Publications Schisa, J. A., Pitt, J. N., and Priess, J. Analysis of RNA associated with P granules in germ cells of C. Pitt, J. N., Schisa, J. A., and Priess, J. P granules in the germ cells of Caenorhabditis elegans adults are associated with clusters of nuclear pores and contain RNA. Wolf, N., Priess, J., and Hirsh, D. Segregation of germline granules in early embryos of Caenorhabditis elegans: an electron microscopic analysis. www.fhcrc.org /science/labs/priess/priess-pubs.html   (1282 words)

Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis ... syntaxin-3 to the granule membrane, syntaxin-4 to the basolateral Redistribution of a Rab3-like GTP-binding protein from secretory granules to the Golgi complex in pancreatic acinar cells during regulated exocytosis. Valentijn, J.A., Valentijn, K., Pastore, L.M., and Jamieson,.J.D. Actin coating of secretory granules during regulated exocytosis correlates with release of rab3D. www.jci.org /cgi/content/full/108/11/1597   (9658 words)

Castle Lab - Recent Publications The minor regulated pathway, a rapid component of salivary secretion, may provide docking/fusion sites for granule exocytosis at the apical surface of acinar cells. Guo Z, Liu L, Cafiso D, Castle D. Perturbation of a very late step of regulated exocytosis by a secretory carrier membrane protein (SCAMP2)-derived peptide. Liu L, Guo Z, Tieu Q, Castle A, Castle D. Role of secretory carrier membrane protein SCAMP2 in granule exocytosis. faculty.virginia.edu /castlelab/publications.php   (167 words)

Antimicrobial peptides antibodies and nucleic acid molecules from bovine neutrophils (US5459235) Gennaro et al., "Potency of Bactericidal Proteins Purified from the Large Granules of Bovine Neutrophils" Infect. Gennaro et al., "A Novel Type of Cytoplasmic Granule in Bovine Neutrophils" J. Cell. Baggiolini et al., "Identification of Three Types of Granules in Neutrophils of Ruminants" Lab. www.delphion.com /details?pn10=US05459235   (918 words)

Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus -- Neumaier et al. 244 ... of dentate granule cells and CA1 pyramidal cells in the rat hippocampal on dentate granule cell excitability were similar to those of the gamma- J Neurophysiol, September 1, 1997; 78(3): 1651 - 1661. jpet.aspetjournals.org /cgi/content/abstract/244/2/564   (498 words)

Ant Rock The locking device is designed to be opened with a slotted screw driver. The stations have a locking device that's easily opened with a slotted screw driver, which makes servicing quick and easy. Can be used with a variety of baits, including, all types liquid baits, paste baits, and granule baits for the control of ants, cockroaches, crickets, silverfish, slugs or snails. www.treadwaypestcontrol.com /ant_rock.htm   (309 words)

Physiological Modulation of Rabphilin Phosphorylation -- Foletti et al. 21 (15): 5473 -- Journal of Neuroscience Fykse EM (1998) Depolarization of cerebellar granule cells increases phosphorylation of rabphilin-3A. Masumoto N, Sasaki T, Tahara M, Mammoto A, Ikebuchi Y, Tasaka K, Tokunaga M, Takai Y, Miyake A (1996) Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs. McQuinston AR, Madison DV (1999) Nicotinic receptor activation excites distinct subtypes of interneurons in the rat hippocampus. www.jneurosci.org /cgi/content/full/21/15/5473   (7357 words)

The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule ... The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes -- Joiner et al. The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes Fusion of Azurophil Granules with Phagosomes and Activation of the Tyrosine Kinase Hck Are Specifically Inhibited During Phagocytosis of Mycobacteria by Human Neutrophils www.jcb.org /cgi/content/abstract/109/6/2771   (771 words)

Brain-derived Neurotrophic Factor Activation of TrkB Protects Neuroblastoma Cells from Chemotherapy-induced Apoptosis ... and cerebellar granule neurons from metabolic and excitotoxic Courtney M. J., Akerman K. E., Coffey E. Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism. Skaper S. D., Floreani M., Negro A., Facci L., Giusti P. Neurotrophins rescue cerebellar granule neurons from oxidative stress-mediated apoptotic death: selective involvement of phosphatidylinositol 3-kinase and the mitogen-activated protein kinase pathway. cancerres.aacrjournals.org /cgi/content/full/62/22/6756   (5494 words)

Neuropeptide Y Suppresses Epileptiform Activity in Rat Hippocampus In Vitro -- Klapstein and Colmers 78 (3): 1651 -- ... granule cells, NPY also causes an inhibition of N-type Ca channels in acutely dissociated rat superior cervical ganglion , A. Neuropeptide Y1 receptors inhibit N-type calcium currents and reduce transient calcium increases in rat dentate granule cells. , K. Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings. jn.physiology.org /cgi/content/full/78/3/1651   (5815 words)

Role of Secretory Carrier Membrane Protein SCAMP2 in Granule Exocytosis -- Liu et al. 13 (12): 4266 -- Molecular ... Having established that E peptide of SCAMP2 blocks large dense-core vesicle release and that a portion of SCAMP2 is concentrated Guo, Z., Liu, L., Cafiso, D., and Castle, D. Perturbation of a very late step of regulated granule exocytosis by a secretory carrier membrane protein (SCAMP2)-derived peptide. Stinchcombe, J.C., and Huttner, W.B. Purification of Secretory Granules from PC12 Cells in Cell Biology, A Laboratory Handbook, Vol. www.molbiolcell.org /cgi/content/full/13/12/4266   (7579 words)

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