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Topic: 2,3,7,8-tetrachlorodibenzo-p-dioxin

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Viktor Yushchenko was a victim of dioxin poisoning, say doctors Dioxins are formed as a result of combustion processes such as commercial or municipal waste incineration and from burning fuels (like wood, coal or oil). Dioxins can also be formed when household trash is burned and as a result of natural processes such as forest fires. Dioxins decompose very slowly in the environment and can be deposited on plants and taken up by animals and aquatic organisms. www.medicalnewstoday.com /medicalnews.php?newsid=17661&nfid=mnf

Ovarian Tumors in Rats Induced by Chronic 2,3,7,8-Tetrachlorodibenzo-p- Dioxin Treatment -- Davis et al. 60 (19): 5414 -- Cancer Research Ovarian Tumors in Rats Induced by Chronic 2,3,7,8-Tetrachlorodibenzo-p- Dioxin Treatment -- Davis et al. Laboratory of Women’s Health [B. M.] and Laboratory of Computational Biology and Risk Analysis [B. L.], National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, and Nestlé Research Center, CH-1000 Lausanne 26, Switzerland [A. 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) is a multispecies Ovarian Tumors in Rats Induced by Chronic 2,3,7,8-Tetrachlorodibenzo- p - Dioxin Treatment cancerres.aacrjournals.org /cgi/content/abstract/60/19/5414

Liver Tumor-promoting Activity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant Rat Strains -- Viluksela et al. 60 (24): 6911 -- Cancer Research Pohjanvirta R., Unkila M., Tuomisto J. Comparative acute lethality of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo- p -dioxin and 1,2,3,4,7,8-hexachlorodibenzo- p -dioxin in the most TCDD-susceptible and the most TCDD-resistant rat strain. Stinchcombe S., Buchmann A., Bock K. W., Schwarz M. Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo- p -dioxin-mediated tumor promotion in rat liver. CDD, chlorinated dibenzo- p -dioxin; AHR, aryl hydrocarbon receptor; cancerres.aacrjournals.org /cgi/content/full/60/24/6911

NAP Skim View of: Appendix B: Total Diet Study Report: Dioxin Considerations in Foods Dioxin TEQ for skim milk was estimated assuming that all dioxin congeners concentrate in milk fat, that whole milk contains 3.34% fat, and that skim milk contains 0.18% fat. APPENDIX B ales,Consumers' Dioxin Toxic Equivalents (TEQ) Intake (pa/kg body weight/d) APPENDIX B males,Consumers' Dioxin Toxic Equivalents (TEQ) Intake (pa/kg body weight/d) www.nap.edu /nap-cgi/skimit.cgi?isbn=0309089611&chap=281-308

P&G Health Sciences Institute - Members Bjerke, D.L., Shinomiya, K., Hess, R.A., Cooke, P.S., Zucker, R.M., and Peterson, R.E.: Investigations into the mechanism by which in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure inhibits spermatogenesis in adult rats. Shinomiya, K., Bjerke, D.L., Moore, R.W., Hess, R.A., Cooke, P.S., Zucker, R.W., and Peterson, R.E.: Effects of in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on spermatogenesis in rats. In: Banbury Report 35: Biological Basis for Risk Assessment of Dioxins and Related Compounds (M. Gallo, R.J. Scheuplein, and C.A. van der Heijden, eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. www.pghsi.com /member/bjerke_d.htm

Population Analysis of a Toxicokinetic Model for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Using Bayesian Techniques (ResearchIndex) Abstract: Introduction The object of the analysis is to understand the temporal behaviour of the concentration of 2,3,7,8-- tetracholoribenzo--p--dioxin (TCDD) in a group of Vietnam veterans. In particular, interest focuses on the parameters controlling the dioxin kinetics, as they are an essential ingredient for a cancer dose--response study for TCDD. Typically, pharmacokinetic applications rely on a known test dose of the compound and several repeated concentration measures. citeseer.ist.psu.edu /404809.html

Alliance for Safe Alternatives Dioxin is the name given to a group of persistent, very toxic chemicals. Dioxin released from these and other sources has been found to travel long distances in the atmosphere. Dioxin can also disrupt the normal function of hormones—chemical messengers that the body uses for growth and regulation. www.safealternatives.org /whatisdioxin.html

Uncertainty in Estimating Exposure Using a Toxicokinetic Model: The Example of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin -- SALVAN et al. 895 (1): 125 -- Annals of the New York Academy of Sciences Uncertainty in Estimating Exposure Using a Toxicokinetic Model: The Example of 2,3,7,8-Tetrachlorodibenzo- p -Dioxin www.annalsnyas.org /cgi/content/abstract/895/1/125

DHHS (NIOSH) Publication No. 84-104 Because of the recent attention given to human exposure to 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD, "dioxin") contaminated materials and published reports on the toxicity of TCDD, NIOSH staff consider it necessary to present a review of the pertinent data and a summary of findings related to the human hazard potential of TCDD. Proceedings of an international symposium on chlorinated dioxins and related compounds, held October 25-29, 198l, in Arlington, Virginia. TCDD is one of a family of isomers known chemically as dibenzo- p -dioxins. www.cdc.gov /niosh/84104_40.html

Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin -- Bodner et al. 60 (9): 672 -- Occupational and Environmental Medicine Dioxin exposure and cancer risk: a 15-year mortality study after the "Seveso accident". Update of mortality among chemical workers with potential exposure to the higher chlorinated dioxins. Update of the mortality experience of workers exposed to chlorinated dioxins. oem.bmjjournals.com /cgi/content/full/60/9/672

Risk Assessment for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) based on an Epidemiologic Study -- Steenland et al. 154 (5): 451 -- American Journal of Epidemiology Abbreviations: TCDD, 2,3,7,8-tetrachlorodibenzo- p -dioxin • TEQ, toxic equivalent. Risk Assessment for 2,3,7,8-Tetrachlorodibenzo- p -Dioxin (TCDD) based on an Epidemiologic Study From the Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH. aje.oupjournals.org /cgi/content/abstract/154/5/451

In Utero and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and 2,3,4,7,8-Pentachlorodibenzofuran Reduces Growth and Disrupts Reproductive Parameters in Female Rats -- Salisbury and Marcinkiewicz 66 (6): 1621 -- Biology of Reproduction Bandiera S, Sawyer T, Romkes M. Polychlorinated dibenzofurans (PCDF): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Schecter A, Papke O, Ball M, Lis A, Brandt-Rauf P. Dioxin concentrations in the blood of workers at municipal waste incinerators. Nakagawa R, Hirakawa H, Matsueda T, Nagayama J. Maternal body burden of organochloride pesticides and dioxins. www.biolreprod.org /cgi/content/full/66/6/1621

SitoWeb1\biblio Analysis of 2,3,7,8 - TCDD tumor promotion activity and its relationship to cancer. Dioxin levels in raw and cooked liver, loioin steaks, round, and patties from beef fed technical grade pentachlorophenol. Dioxin intoxication from chronic exposure of horses to pentachlorophenol-contaminated wood shavings. users.libero.it /ubik.ubik/biblio.htm

Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice -- Lahvis et al. 97 (19): 10442 -- Proceedings of the National Academy of Sciences dioxins, can result in cancer ( 8), immunosuppression ( 9), Carmeliet, P., Dor, Y., Herbert, J. M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. Fernandez-Salguero, P. M., Hilbert, D. M., Rudikoff, S., Ward, J. & Gonzalez, F. Toxicol. www.pnas.org /cgi/content/full/97/19/10442

Dose and Inducer-Dependent Induction of Cytochrome P450 1A in Endothelia of the Eel, including in the Swimbladder Rete Mirabile, a Model Microvascular Structure -- Schlezinger and Stegeman 28 (6): 701 -- Drug Metabolism and Disposition -naphthoflavone; CYP, cytochrome P450; CYP1A, cytochrome P450 1A; CPR, cytochrome P450 reductase; PAH, polynuclear aromatic hydrocarbon; TCB, 3,3',4,4'-tetrachlorobiphenyl; TCDD, 2,3,7,8-tetrachlorodibenzo- p -dioxin; TCDF, 2,3,7,8-tetrachlorodibenzofuran; PCB, polychlorinated biphenyl; mAb, monoclonal antibody; EROD, ethoxyresorufin O -deethylase. I]2-Iodo-3,7,8-trichlorodibenzo- p -dioxin-binding species in mouse liver induced by agonists for the Ah receptor: Characterization and identification. Diliberto JJ (1997) Role of CYP1A2 in hepatic sequestration of dioxin: Studies using CYP1A2 knock-out mice. www.dmd.org /cgi/content/full/28/6/701

Dioxin and the Prostate Page 2 Soderkvist P, Poellinger L, Gustafsson JA Cancer Res 1986 Feb;46(2):651-7 The polychlorinated dibenzodioxin [3H]-2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and the carcinogens [3H]benzo(a)pyrene and [3H]-3-methylcholanthrene bound to saturable binding sites in cytosol from the rat ventral prostate. After 2 h of incubation, a complete in vitro transfer of ligand from PSP to the rat hepatic dioxin receptor was observed, as assessed by velocity sedimentation analysis of specific dioxin binding. These results indicate that a high abundance carcinogen-binding protein, such as PSP, may be of importance in the cellular transfer of dioxin receptor ligands, thereby eliciting a receptor-mediated biochemical and/or toxic response. www.bphata.com /AO_Pros2.htm

2,3,7,8-Tetrachlorodibenzo-p-dioxin, an Exogenous Modulator of the 3'{alpha} Immunoglobulin Heavy Chain Enhancer in the CH12.LX Mouse Cell Line -- Sulentic et al. 309 (1): 71 -- Journal of Pharmacology And Experimental Therapeutics Articles by Sulentic, C. Articles by Kaminski, N. 2,3,7,8-Tetrachlorodibenzo- p -dioxin, an Exogenous Modulator of the 3' www.jpet.org /cgi/content/abstract/309/1/71

Teratogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Mice Lacking the Expression of EGF and/or TGF-{{alpha}} -- Bryant et al. 62 (1): 103 -- Toxicological Sciences (TCDD, dioxin) is the most potent and extensively studied member 0.005 vs. 0.91 ± 0.006, respectively, p < 0.001). expression by binding to the dioxin response element (Neubert toxsci.oupjournals.org /cgi/content/full/62/1/103

Constitutive Activation of the Aromatic Hydrocarbon Receptor -- Chang and Puga 18 (1): 525 -- Molecular and Cellular Biology Santiago-Josefat, B., Pozo-Guisado, E., Mulero-Navarro, S., Fernandez-Salguero, P. Proteasome Inhibition Induces Nuclear Translocation and Transcriptional Activation of the Dioxin Receptor in Mouse Embryo Primary Fibroblasts in the Absence of Xenobiotics. Casper, R. F., Quesne, M., Rogers, I. M., Shirota, T., Jolivet, A., Milgrom, E., Savouret, J.-F. Resveratrol Has Antagonist Activity on the Aryl Hydrocarbon Receptor: Implications for Prevention of Dioxin Toxicity. Lees, M. J., Whitelaw, M. Multiple Roles of Ligand in Transforming the Dioxin Receptor to an Active Basic Helix-Loop-Helix/PAS Transcription Factor Complex with the Nuclear Protein Arnt. mcb.asm.org /cgi/content/abstract/18/1/525

Lactational Exposure of Han/Wistar Rats to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Interferes with Enamel Maturation and Retards Dentin Mineralization -- Gao et al. 83 (2): 139 -- Journal of Dental Research Han/Wistar rats a single dose of 2,3,7,8-tetrachlorodibenzo -p- dioxin Exposure to environmental dioxins via mother’s milk may dioxins interfere with enamel maturation, we administered lactating jdr.iadrjournals.org /cgi/content/short/83/2/139

Dioxins R US The binding of these transformed heteromeric TCDD:AhR complexes to specific DNA sequences (Dioxin Responsive Elements (DREs)) adjacent to the cytochrome P4501A1 (CYP1A1) gene leads to DNA bending, chromatin disruption, increased promoter accessibility and increased rates of transcription initiation of the CYP1A1 gene with the subsequent accumulation of cytochrome P450IA1-specific mRNA (4,21-27). (1992) Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin, Proc. Wu,L. and Whitlock,J.P.Jr., (1992) Mechanism of dioxin action: Ah receptor-mediated increase in Promoter accessibility in vivo, Proc. dioxins-r-us.ucdavis.edu /TCDDAhR.HTML

T Cell-Specific Disruption of Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Gene Causes Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Thymic Involution -- Tomita et al. 171 (8): 4113 -- The Journal of Immunology Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo- p -dioxin of hepatocarcinogenesis from diethylnitrosamine. Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo- p -dioxin on thymocytes in vivo and its effect on apoptosis. Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo- p -dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells. www.jimmunol.org /cgi/content/full/171/8/4113

Eco-USA: Dioxin The one with four chlorine atoms at positions 2, 3, 7 and 8 of the dibenzo-p-dioxin chemical structure is called 2,3,7,8- tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). The chlorinated dibenzo-p-dioxins are a class of compounds that are loosely referred to as dioxins. It is a colorless solid with no known odor. www.eco-usa.net /toxics/dioxin.shtml

Antiestrogenic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Are Mediated by Direct Transcriptional Interference with the Liganded Estrogen Receptor -- Kharat and Saatcioglu 271 (18): 10533 -- Journal of Biological Chemistry The abbreviations used are: TCDD, 2,3,7,8-tetrachlorodibenzo- p -dioxin; Ah, aryl hydrocarbon; AhR, Ah receptor; Arnt, AhR nuclear translocator protein; XRE, xenobiotic response element; ER, estrogen receptor; cat D, cathepsin D; ERE, estrogen response element; CAT, chloramphenicol acetyltransferase. Antiestrogenic Effects of 2,3,7,8-Tetrachlorodibenzo- p -dioxin Are Mediated by Direct Transcriptional Interference with the Liganded Estrogen Receptor P., Lincoln, D. W., Schuetz, J. D., Schuetz, E. G., Johnson, J. Kaminsky, L. S., and Gierthy, J. Arch. www.jbc.org /cgi/content/full/271/18/10533

Dioxin (2,3,7,8-TCDD) - toxicity, ecologicial toxicity and regulatory information 04068 (CA DPR Chem Code), 1746-01-6 (CAS Number), 1746016, 1746016 (CAS Number), 2,3,7,8-TCDD (as impurity or contaminant), 2,3,7,8-Tetrachlorodibenzo-1,4-dioxin, 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetraclorodibenzo-p-dioxin, 4068 (CA DPR Chem Code), 600000 (US EPA PC Code), Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-, Dibenzo-p-dioxin, 2,3,7,8-tetrachloro- (6CI, 7CI, 8CI), Dioxin (2,3,7,8-TCDD), Dioxin (as impurity or contaminant), Dioxin2378TCDD, Dioxins, Polychlorinated dibenzo-p-dioxins, TCDBD, TCDD Dioxin (2,3,7,8-TCDD) - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Dioxin (2,3,7,8-TCDD) - toxicity, ecologicial toxicity and regulatory information www.pesticideinfo.org /Detail_Chemical.jsp?Rec_Id=PC35857

Rat Thyroid Hyperplasia Induced by Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin -- Nishimura et al. 144 (5): 2075 -- Endocrinology Rat Thyroid Hyperplasia Induced by Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo- p -Dioxin Effects of gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo- p -dioxin Address all correspondence and requests for reprints to: Noriko Nishimura, Ph.D., Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan. endo.endojournals.org /cgi/content/abstract/144/5/2075

Flavone Antagonists Bind Competitively with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) to the Aryl Hydrocarbon Receptor But Inhibit Nuclear Uptake and Transformation -- Henry et al. 55 (4): 716 -- Molecular Pharmacology AhR, aryl hydrocarbon receptor; Arnt, Ah receptor nuclear translocator; DRE, dioxin responsive element; EMSA, electrophoretic mobility shift assay; hsp90, 90 kDa heat shock protein; TCDD, 2,3,7,8-tetrachlorodibenzo- p -dioxin; SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; Hepa, hepatoma cells (Hepa Flavone Antagonists Bind Competitively with 2,3,7,8-Tetrachlorodibenzo- p -Dioxin (TCDD) to the Aryl Hydrocarbon Receptor But Inhibit Nuclear Uptake and Transformation Gasiewicz TA and Neal RA (1982) The examination and quantitation of tissue cytosolic receptors for 2,3,7,8-tetrachlorodibenzo- p -dioxin using hydroxylapatite. www.molpharm.org /cgi/content/full/55/4/716

Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells -- Backlund et al. 261 (1): 66 -- European Journal of Biochemistry Ma, Q. and Whitlock Jr J.P. (1997) A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo- p- dioxin. Gillner, M., Bergman, J., Cambillau, C., Alexandersson, M., Fernstrom, B. and Gustafsson, J.A. (1993) Interactions of indolo[3,2-b]carbazoles and related polycyclic aromatic hydrocarbons with specific binding sites for 2,3,7,8-tetrachlorodibenzo- p- dioxin in rat liver. Daujat, M., Charrasse, S., Fabre, I., Lesca, P., Jounaidi, Y., Larroque, C., Poellinger, L. and Maurel, P. (1996) Induction of CYP1A1 gene by benzimidazole derivatives during Caco-2 cell differentiation. www.ejbiochem.org /cgi/content/full/261/1/66

EPA Dioxin Reassessment, Health Assessment, Volume III, References (1980) Time-dependent inhibition by 2,3,7,8-tetrachlorodibenzo- p -dioxin of skin tumorigenesis with polycyclic hydrocarbons. (1988) Dioxins and dibenzofurans in blood and adipose tissue of Agent Orange-exposed Vietnam veterens and matched controls. (1993) A mechanistic model of effects of dioxin on gene expression in the rat liver. www.cqs.com /dioxhref.htm

Hemopoietic Progenitor Cells Are Sensitive Targets of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in C57BL/6J Mice -- Murante and Gasiewicz 54 (2): 374 -- Toxicological Sciences Key Words: tetrachlorodibenzo- p -dioxin; TCDD; hemopoiesis; Sca-1; c-Kit; hemopoietic stem cells; flow cytometry. Tetrachlorodibenzo- p -dioxin (TCDD), which binds to the aromatic The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. toxsci.oupjournals.org /cgi/content/full/54/2/374

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