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Topic: 3,4-Methylenedioxyamphetamine

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Methylenedioxymethamphetamine - Wikipedia, the free encyclopedia The chemical structure of MDMA is similar to those of Mescaline and methamphetamine, but the phenyl ring is substituted with a methylenedioxy group in position 3,4. It should be noted that the Expert Committee held extensive discussions concerning therapeutic usefulness of 3,4 Methylenedioxymethamphetamine. It is a member of the phenethylamine family, a group of substances typically having pronounced biological activity. en.wikipedia.org /wiki/MDMA   (4654 words)

MDMA as Title Word in search TI  - Simultaneous determination of amphetamine, methamphetamine, methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methylenedioxyethylamphetamine (MDEA) enantiomers by GC-MS - A method is described for the simultaneous determination of the ratio of l- and d-enantiomers of amphetamine, methamphetamine, 3,4- methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) in urine. The peak effect and duration of hyperthermia of a dose of MDEA of 35 mg/kg intraperitoneally was similar to a dose of 3,4- methylenedioxymethamphetamine (MDMA or "ecstasy") of 15 mg/kg intraperitoneally. The effects of acute administration of 3,4- methylenedioxymethamphetamine (MDMA; "ecstasy") on anxiety tested in the light/dark box were examined in albino male mice of the OF.1 strain. www.doctordeluca.com /Library/References/MDMA_title.htm   (7356 words)

Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity -- O'Hearn et al. 8 (8): 2788 -- Journal of Neuroscience Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity -- O'Hearn et al. Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity www.jneurosci.org /cgi/content/abstract/8/8/2788   (1130 words)

The hyperthermic and neurotoxic effects of 'Ecstasy' ( MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype.1. The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. The effect of administration of 3,4- methylenedioxymethamphetamine (MDMA or 'Ecstasy') and its N-demethylated product, 3,4-methylenedioxyamphetamine (MDA) on both rectal temperature and long term neurotoxic loss of cerebral 5-hydroxytryptamine (5-HT) has been studied in male and female Dark Agouti (DA) rats. www.ihop-net.org /UniPub/iHOP/gp/394529.html   (289 words)

The Lycaeum Research Collection - 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites In contrast, neither MDMA nor MDA caused any widespread or long-term changes in the content of the catecholaminergic markers (i.e., norepinephrine, dopamine, 3,4 dihydroxyphenylacetic acid and homovanillic acid) or in the number of [3H]mazindol-labeled norepinephrine or dopamine uptake sites in the brain regions examined. In addition, both MDMA and MDA caused comparable and substantial reductions (50-75%) in the density of [3H]paroxetine-labeled 5-HT uptake sites in all brain regions examined. research.lycaeum.org /index.rbx?id=443   (210 words)

Medical Dictionary: 3,4 methylenedioxyamphetamine - WrongDiagnosis.com 3,4 methylenedioxyamphetamine : abused, controlled, serotonergic hallucinogen of the "designer drug" class; probably the active metabolite of MDMA ("ecstasy"). The description of 3,4 methylenedioxyamphetamine may also be used for the following terms: www.wrongdiagnosis.com /medical/3_4_methylenedioxyamphetamine.htm   (119 words)

mdma.neurotoxic.refs 581: 237-243 O'Hearn E, Battaglia G, DeSouza EB, Kuhar MJ, Molliver ME (1988) Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence for neurotoxicity. 39: 569-574 McBean DE, Sharkey J, Ritchie IM, Kelly PAT (1990) Chronic effects of the selective serotoninergic neurotoxin, methylenedioxyamphetamine, upon cerebral function. >O'Hearn E, Battaglia G, DeSouza EB, Kuhar MJ, Molliver ME (1988) >Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) >cause selective ablation of serotonergic axon terminals in forebrain: >Immunocytochemical evidence for neurotoxicity. paranoia.lycaeum.org /mdma/mdma.neurotoxic.refs   (2256 words)

E is for Ecstasy, Appendix 4, Biochemistry Section Stone, D.M., Johnson, M., Hanson, G.R. and Gibb, J.W. A Comparison of the Neurotoxic Potential of Methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated Derivatives. The neurotoxicity of MDMA (in the rat) was protected against by GABA-transaminase inhibitors. Multiple doses of MDA and MDMA decreases the level of brain tryptophan hydroxylase (TPH). www.ecstasy.org /books/e4x/e4x.ap.04/e4x.ap.04.02.html   (1244 words)

SongMeanings lyrics Green Day - Sassafras Roots Active Constituents: Safrole (non-amine precursor of MDA [3,4- www.songmeanings.net /lyric.php?lid=2174   (586 words)

STEREOCHEMICAL ANALYSIS OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE AND ITS MAIN METABOLITES IN HUMAN SAMPLES INCLUDING THE CATECHOL-TYPE METABOLITE (3,4-DIHYDROXYMETHAMPHETAMINE) -- Pizarro et al. 32 (9): 1001 -- Drug Metabolism and Disposition Hensley D and Cody JT (1999) Simultaneous determination of amphetamine, methamphetamine, methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA) and methylenedioxyethylamphetamine (MDEA) enantiomers by GC-MS. Johnson MP, Hoffman AJ, and Nichols DE (1986) Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices. dmd.aspetjournals.org /cgi/content/full/32/9/1001   (3668 words)

Stereospecific Analysis and Enantiomeric Disposition of 3,4-Methylenedioxymethamphetamine (Ecstasy) in Humans -- Fallon et al. 45 (7): 1058 -- Clinical Chemistry similar at 10.5 ± 2.9 and 10.2 ± 3.4 L/h for (R)- of ingestion time [Fish and Tilstone, 1979, cited in Ref. (34)] However, this approach is limited by the number of commercially www.clinchem.org /cgi/content/full/45/7/1058   (5834 words)

The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs -- Kalant 165 (7): 917 -- Canadian Medical Association Journal Tehan B, Hardern R, Bodenham A. Hyperthermia associated with 3,4- methylenedioxyethamphetamine ('eve'). Ecstasy intoxication: an overlap between serotonin syndrome and neuroleptic malignant syndrome. www.cmaj.ca /cgi/content/full/165/7/917   (7919 words)

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