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Topic: 454 Life Sciences

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454 454 Life Sciences publishes breakthrough genome sequencing technique. 454 Life Sciences Secures $20 Million in Equity Financing to Initiate Commercialization of Whole Genome Sequencing Techn... academia, stated Richard F. Begley, Ph.D., President and CEO of 454 Life Sciences. enciclopedia.cc /454

Fantastic 454: Biotech Unveils Rapid Genome Sequencing Platform — Bio-IT World In a dramatic advance for alternative DNA sequencing technologies, scientists at 454 Life Sciences Corp. have essentially sequenced and assembled a complete bacterial genome sequence based on a mere 4-hour run on the company’s proprietary instrument. But in recent years, companies such as Solexa, Helicos, and 454 have been developing new approaches that rely heavily on computer algorithms to virtually assemble hundreds of thousands of relatively short (about 100 bases) DNA fragments to produce the final sequence. The 454 authors concede that there are still key improvements to be made in read length and accuracy. www.bio-itworld.com /newsitems/2005/Aug2005/08-01-05-news-454

CuraGen Corporation - 454 Life Sciences 454 Life Sciences is commercializing new technologies to rapidly and comprehensively determine the nucleotide sequence of whole genomes and perform ultra-deep sequencing of target genes. 454 Life Sciences' technology is expected to have broad application in genetics, agriculture, animal health, biodefense and human health care, including drug discovery and development, as well as disease diagnosis. 454 Life Sciences has developed proprietary methodologies for rapidly sequencing genomes using a massively parallel, scalable, single-operator platform that compresses the time, cost, and space required to interrogate whole genomes. www.curagen.com /rnd/454tech.asp

Worldwide Biotech: 454 Life Sciences Gets Genome License From Pyrosequencing Established in 2000, 454 Life Sciences develops technologies and tools to sequence whole genomes using a massively parallel, scalable platform that compresses the time, cost, sample preparation, and space required to determine the nucleotide sequence of whole genomes. This license makes 454 Life Sciences the only company allowed to produce instruments and kits, and provide services that utilize sequencing by synthesis or pyrophosphate based sequencing for whole genome sequencing, such as karyotyping, genotyping and determining sequence-based expression, in the United States, Canada, Europe, Japan, Australia and other countries around the world. Under the terms of the agreement, the license gives 454 Life Sciences the exclusive right to use this technology in whole genome analysis, while Pyrosequencing AB will retain the rights to its pyrophosphate- based sequencing technology for all applications not related to whole genome activities. www.findarticles.com /p/articles/mi_m0DHC/is_10_15/ai_107782556

Globeinvestor.com: 454 Life Sciences Receives $11.5 Million in Milestones from Roche The hallmark of 454 Life Sciences' technology is the nanotechnology-based approach to sequencing which allows a single instrument to produce over 20 million nucleotide bases per four hour run, totaling more than 100 times the capacity of instruments using the current macro-scale technology. 454 Life Sciences is commercializing novel instrumentation and services for rapidly and comprehensively conducting high-throughput nucleotide sequencing, with specific application to sequencing of whole genomes and ultra-deep sequencing of target genes. 454 Life Sciences' technology is based on integrating proprietary picoliter-technologies (a picoliter is one trillionth of a liter), patented light emitting sequencing chemistries, and state-of-the- art informatics. www.globeinvestor.com /servlet/ArticleNews/story/PRNEWS/20050726/2005_07_26_06_4205_1412692

The Biology of Life Span: A Quantitative Approach: Citation Record Arking, R; Novoseltsev, V; Novoseltseva, J The human life span is not that limited: The effect of multiple longevity phenotypes JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 59 (7): 697-704 JUL 2004 Bonsall, MB; Mangel, M Life-history trade-offs and ecological dynamics in the evolution of longevity PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 271 (1544): 1143-1150 JUN 7 2004 Weale, RA Biorepair mechanisms and longevity JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 59 (5): 449-454 MAY 2004 longevity-science.org /CitationRecord.html   (3286 words)

The Biology of Life Span: A Quantitative Approach: Citation Record Weale, RA Biorepair mechanisms and longevity JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 59 (5): 449-454 MAY 2004 Bonsall, MB; Mangel, M Life-history trade-offs and ecological dynamics in the evolution of longevity PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 271 (1544): 1143-1150 JUN 7 2004 Gerasimov, IG; Ignatov, DY Age dynamics of body mass and human lifespan JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY, 40 (3): 343-349 MAY-JUN 2004 longevity-science.org /CitationRecord.html   (3286 words)

Pyrosequencing technology gives fast, qualitative and quantitative sequencing data Pyrosequencng is the chosen detection method behind the Whole Genome Sequencing technology from 454 Life Sciences. Pyrosequencing is as easy and as fast as running a PCR reaction, and it produces real sequence information. A description of the Pyrosequencing reaction cascade, based on sequencing by synthesis, from the nucleotide incorporation event to the detection of light. www.pyrosequencing.com /DynPage.aspx?id=8726&mn1=1366   (233 words)

PYROSEQUENCING BIDRAR TILL SUPERSNABB DNA-ANALYS - Ny Teknik Pyrosequencing får 36,5 miljoner kronor för licensensen, som ger 454 Life Sciences ensamrätt under fem år att använda metoden för analys av hela arvsmassan. Pyrosequencing omsätter cirka 100 miljoner kronor om året. Uppsalaföretaget Pyrosequencings metod att analysera delar av DNA-kedjan kommer att ingå i ett amerikanskt projekt att dramatiskt korta tiden för analys av människans hela arvsmassa. www.nyteknik.se /art/29535   (1144 words)

Worldwide Biotech: 454 Life Sciences Gets Genome License From Pyrosequencing Under the terms of the agreement, the license gives 454 Life Sciences the exclusive right to use this technology in whole genome analysis, while Pyrosequencing AB will retain the rights to its pyrophosphate- based sequencing technology for all applications not related to whole genome activities. This license makes 454 Life Sciences the only company allowed to produce instruments and kits, and provide services that utilize sequencing by synthesis or pyrophosphate based sequencing for whole genome sequencing, such as karyotyping, genotyping and determining sequence-based expression, in the United States, Canada, Europe, Japan, Australia and other countries around the world. Worldwide Biotech: 454 Life Sciences Gets Genome License From Pyrosequencing www.findarticles.com /p/articles/mi_m0DHC/is_10_15/ai_107782556   (454 words)

The Genome Sequencer 20 DNA Sequencing System and Reagents - 454 Life Sciences The Genome Sequencer 20 System, developed by 454 Life Sciences, is an ultra-high-throughput automated DNA sequencing system capable of resolving hundreds of thousands of DNA sequences in one run. The Genome Sequencer 20 DNA Sequencing System and Reagents - 454 Life Sciences The basic chemistry utilizes the release of pyrophosphate (PPi) that occurs with each nucleotide addition during DNA-directed DNA synthesis to generate an amount of light commensurate with the amount of PPi released; this light is captured by a CCD camera and converted into a digital signal. www.454.com /products-and-reagents/genome-sequencer.asp   (369 words)

DNA Sequencing, Screening, and Analysis: Instrumentation & Services - 454 Life Sciences Through this technology 454 Life Sciences provides an enabling solution for ultra-high-throughput DNA sequencing. The Genome Sequencer 20 system provides many tools for ultra-high throughput DNA sequencing that were formerly available only at Genome Centers. Many biologically meaningful and complex regions of genomes can be analyzed with this system without the time or cost constraints of current DNA sequencing methods. www.454.com   (199 words)

Roche Research & Development Roche and 454 Life Sciences enter exclusive world-wide agreement Roche acquires Swiss based GlycArt Biotechnology to strengthen expertise in therapeutic antibody research Media Briefing: Roche – one of the world's leaders in biotech, Basel www.roche.com /home/science.htm   (199 words)

Consider_the_Cycler.html Scientists from 454 Life Sciences in Branford, Conn., announced in November 2003 the successful simultaneous amplification of approximately 300,000 discrete reactions using a novel platform called the PicoTiterPlate. In the future, perhaps the limitations of PCR--that it is reagent intensive, requires expensive equipment, is difficult to reproduce, and generally is not linear--will be surmounted by new technologies, HDA or otherwise. Moreover, HDA can be conducted at a single temperature, thus obviating the need for thermocycling. www.up.ac.za /organizations/societies/psana/Consider_the_Cycler.html   (199 words)

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