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	Zomig Tablets :: AstraZeneca (Site not responding. Last check: 2007-11-01)
		In all five studies, the percentage of patients achieving headache response 2 hours after treatment was significantly greater among patients receiving ZOMIG Tablets at all doses (except for the 1 mg dose in the smallest study) compared to those who received placebo.
		In the two studies that evaluated the 1 mg dose, there was a statistically significant greater percentage of patients with headache response at 2 hours in the higher dose groups (2.5 and/or 5 mg) compared to the 1 mg dose group.
		In controlled clinical trials, single doses of 1, 2.5 and 5 mg of zolmitriptan were effective for the acute treatment of migraines in adults.
	www.painhealth.com /product/zomig-tablets^9865.asp (5587 words)

	Serotonin type 1
		5HT1A_CANFA : HTR1A -- 5-hydroxytryptamine 1A receptor (5-HT-1A) (Serotonin receptor 1A) (5- HT1A).
		5HT1A_MOUSE : Htr1a -- 5-hydroxytryptamine 1A receptor (5-HT-1A) (Serotonin receptor 1A) (5- HT1A).
		5HT1A_RAT : Htr1a -- 5-hydroxytryptamine 1A receptor (5-HT-1A) (Serotonin receptor 1A) (5- HT1A).
	www.gpcr.org /7tm/seq/001_001_005_001/001_001_005_001.CDNA.html (609 words)

	Maxalt - Maxalt Side Effects - Maxalt Information - Canada Pharmacy - Canada Drugs
		The long-term efficacy of rizatriptan tablets 5 and 10 mg was investigated in a total of 1854 patients in optional extension phases of 3 Phase III studies.
		Approximately 16 150 attacks were treated with rizatriptan tablets 5 mg and approximately 24 043 with rizatriptan tablets 10 mg over a period of up to 12 months (median number of attacks treated per patient was approximately 17).
		Event frequencies are calculated as the number of patients who used rizatriptan 5 mg and 10 mg tablets in Phase II and III studies (n=3716) and reported an event divided by the total number of patients exposed to rizatriptan.
	www.rxcarecanada.com /Maxalt.asp?currency=GBP&page=/Maxalt.asp&q= (6167 words)

	Zomig - Zomig Side Effects - Zomig Information - Canada Pharmacy - Canada Drugs (Site not responding. Last check: 2007-11-01)
		Therapeutic Clinical Trials: The efficacy of zolmitriptan conventional tablets in the acute treatment of migraine attacks was evaluated in 5 randomized, double blind, placebo controlled studies, of which 2 utilized the 1 mg dose, 2 utilized the 2.5 mg dose and 4 utilized the 5 mg dose.
		In Study 3, which directly compared the 1, 2.5 and 5 mg doses, there was a statistically significant greater proportion of patients with headache response at 2 and 4 hours in the higher dose groups (2.5 or 5 mg) than in the 1 mg group.
		Increases in Blood Pressure: In pharmacodynamic studies, an increase of 1 and 5 mmHg in the systolic and diastolic blood pressure, respectively, was seen in volunteers with 5 mg zolmitriptan.
	www.rxcarecanada.com /Zomig.asp?prodid=1908 (5638 words)

	BioMed Central \| Full text \| Arterial expression of 5-HT2Band 5-HT1Breceptors during development of DOCA-salt ...
		On days 1, 3, 5 and 7 after surgery the rats were weighed and the systolic blood pressure was measured.
		In contrast to the data obtained on days 1, 3, 5 and 7, after 28 days of DOCA-high salt hypertension the 5-HT and 5-HT receptors are upregulated approximately 2-fold in the aorta from DOCA-high salt hypertensive rats [13].
		A baseline blood pressure and on days 1, 3, 5 and 7 the systolic blood pressures were measured using the standard tail cuff method.
	www.biomedcentral.com /1471-2210/3/12 (4618 words)

	5-HT1B Receptors and Aggression / Impulsivity -- Neurotransmitter.net
		Serotonin 1B (5HT-1B) receptor mediates aggressive behavior in mice models and was proposed to be involved in the control of aggression and impulsivity in humans.
		Little is known to what extent behavioral history influences subsequent behavior in mice, therefore the present study investigated the effects of lever-pressing under a fixed-ratio 5 schedule of reinforcement on subsequent differential-reinforcement-of-low-rate (DRL) 36 s performance in wild type mice compared to the behavior of 5-HT1B receptor knockout mice.
		All doses caused a significant down-regulation of the 5HT(1B) receptor density in the hippocampal CA(1) and in the medial globus pallidus and a significant up-regulation of the 5HT(2) receptor density in the nucleus accumbens shell.
	www.neurotransmitter.net /onebaggression.html (7261 words)

	Zomig-ZMT Tablets Drug Information Zomig-ZMT Tablets
		The efficacy of ZOMIG Tablets in the acute treatment of migraine headaches was demonstrated in five randomized, double-blind, placebo controlled studies, of which 2 utilized the 1 mg dose, 2 utilized the 2.5 mg dose and 4 utilized the 5 mg dose; all studies used the marketed formulation.
		In controlled clinical trials, single doses of 1, 2.5 and 5 mg of ZOMIG Tablets were effective for the acute treatment of migraines in adults.
		5 mg Orally Disintegrating Tablets - White, flat faced, round, uncoated, bevelled tablet containing 5.0 mg of zolmitriptan identified with a debossed "Z" and "5" on one side and plain on the other are supplied in cartons containing a blister pack of 3 tablets (NDC 0037-7213-21).
	www.drugs.com /PDR/Zomig_ZMT_Tablets.html (6982 words)

	Transgenic research citation list for Dr. R Hen (Site not responding. Last check: 2007-11-01)
		Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice.
		Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice.
		Serotonin releasers increase prepulse inhibition in serotonin 1B knockout mice.
	www.knockoutscience.com /showcitationlist.php?surname=Hen&initials=R (1526 words)

	5-HT1F Receptor Research -- Neurotransmitter.net
		We report a study of possible association between the polymorphisms in the 5-HT receptor genes (1A, 1B, 1F, and 2A) and suicidal behavior on a sample of 226 suicide victims and 225 healthy control subjects.
		We undertook a detailed analysis of expression mapping of the Gi/o-coupled 5-HT1 (5-HT1A, 1B, 1D and 1F) receptor subtypes in the fetal and early postnatal mouse forebrain.
		Using receptor subtype-specific riboprobes and in situ hybridization, we observed that all 5-HT1 receptor subtypes are expressed as early as embryonic day (E) 14.5 in the forebrain, typically in gradients within specific structures.
	www.neurotransmitter.net /onef.html (6144 words)

	Maxalt Tablets Drug Information Maxalt Tablets
		The efficacy of MAXALT Tablets (5 mg) in patients aged 12 to 17 years was not established in a randomized placebo-controlled trial of 291 adolescent migraineurs (see Clinical Studies).
		In controlled clinical trials, single doses of 5 and 10 mg of MAXALT Tablets or MAXALT-MLT were effective for the acute treatment of migraines in adults.
		3800--MAXALT-MLT Orally Disintegrating Tablets, 5 mg, are white to off-white, round lyophilized orally disintegrating tablets debossed with a modified triangle on one side, and measuring 10.0-11.5 mm (side-to-side) with a peppermint flavor.
	www.drugs.com /PDR/Maxalt_Tablets.html (7501 words)

	Temporal Regulation of Agonist Efficacy at 5-Hydroxytryptamine (5-HT)1A and 5-HT1B Receptors -- Berg et al. 304 (1): ...
		O) or 1 mM ATP for 5 min at 37°C, washed twice quickly, and further incubated (37°C) for 5, 15, and 30 min as indicated.
		ETOH (1%) or the secondary alcohol isopropanol (ISO, 1%) was present 5 min before ATP treatment, during the wash, and 5-min challenge interval.
		After incubation for 5 min (37°C) with or without 1% ETOH, cells were treated for 15 min (37°C) with or without the phorbol ester PDBu (1 µM).
	jpet.aspetjournals.org /cgi/content/full/304/1/200 (3875 words)

	APStracts 3:0057N, 1996. (Site not responding. Last check: 2007-11-01)
		This effect was not voltage dependent, as the eEPSC reversal potential was not altered (n = 5).
		These data indicate that the 5-HT effect is primarily 5-HT 1B receptor mediated.
		4) We conclude that 5-HT, acting through presynaptic 5-HT 1B receptors, inhibits glutamatergic synaptic transmission by reducing the probability of vesicle release.
	www.uth.tmc.edu /apstracts/1996/jn/March/57n.html (356 words)

	Maxalt Receives First European Approval (Site not responding. Last check: 2007-11-01)
		In The Netherlands, Maxalt, a potent, highly selective 5-HT 1B/1D agonist, will be available in 10 mg and 5 mg strengths in tablets and a convenient new formulation, a rapidly disintegrating tablet that dissolves on the tongue and can be swallowed without liquids.
		Maxalt was studied for the acute treatment of migraine attacks in four multi-centre, placebo-controlled trials that included more than 2,000 patients who received Maxalt 10 mg or 5 mg for up to one year.
		Results from these studies presented at scientific meetings last year showed that Maxalt 10 mg had a rapid onset of action, relieving pain as early as 30 minutes in some patients and providing consistently high rates of relief within two hours.
	www.docguide.com /dg.nsf/PrintPrint/494D7A9B1F09EE46852565B6004F9F8C (394 words)

	3-substituted pyrido [3',4':4,5] Thieno [2,3-d] pyrimidine derivatives, and production and use of the same - Patent ...
		A method of increasing serotonin concentration in the brain of a patient in need of such treatment comprising administering an effective amount of a composition as claimed in claim 3.
		The method of claim 5, wherein serotonin reuptake inhibition and/or selective serotonin antagonism is effected.
		A method of treating mood disorders, psychogenic eating disorders, endocrine disorders, sexual disorders, gastrointestinal disorders, schizophrenia or manic depressive psychosis comprising administering an effective amount of a composition as claimed in claim 3.
	www.freepatentsonline.com /6159981.html (2418 words)

	MODULATION OF NERVE TERMINAL 5-HT-1B AUTORECEPTORS BY CHRONIC ANTIDEPRESSANT AND CORTICOSTERONE ADMINISTRATION IN THE ... (Site not responding. Last check: 2007-11-01)
		Recent evidence suggests that desensitization of the presynaptic 5-HT-1B autoreceptors situated at the nerve terminals may also be an important mechanism in the action of tricyclic drugs such as desipramine as well as SSRIs such as paroxetine.
		We investigated the sensitivity of nerve terminal 5-HT-1B autoreceptors by measuring the increase in 5-HT levels induced by peripheral injection of the 5-HT1B/1D antagonist GR 127935 (5 mg/kg s.c.), using in vivo microdialysis.
		In the presence of 10 mM citalopram in the perfusion medium, this agent induced a 2- to 3-fold rise in 5-HT levels.
	www.hadassah.org.il /Atarim/biopsych/abstracts/12.html (247 words)

	Maxalt - Maxalt Side Effects - Maxalt Information - Canada Pharmacy - Canada Drugs
		Phenylketonurics: Phenylketonuric patients should be informed that rizatriptan wafers contain phenylalanine (a component of aspartame).
		Each 5 mg wafer contains 1.05 mg phenylalanine, and each 10 mg wafer contains 2.10 mg phenylalanine.
		Adults: Rizatriptan Tablets and Wafers: The recommended single adult dose is 5 mg.
	www.rxcarecanada.com /Maxalt.asp?currency=GBP&page=/Maxalt.asp&q= (6167 words)

	Drug Profiles: Relpax® (eletriptan) for Migraines
		The triptan antimigraine drugs are derived from the serotonin molecule.
		They act on 5-hydroxytryptamine (HT) 1B/1D receptors on blood vessels, trigeminal neurons, and the trigeminal nucleus caudalis, causing constriction of extracerebral intracranial vessels, abolition of dural extravasation and neurogenic inflammation, and inhibition of trigeminal neuronal discharge.
		Relpax has more than a 6-fold higher affinity than sumatriptan at the 5-HT1D receptor and more than a 3-fold greater affinity at the 5-HT1B receptor.
	www.migraines.org /treatment/pro_rlpx.htm (650 words)

	Chronic Clomipramine and Triiodothyronine Increase Serotonin Levels in Rat Frontal Cortex In Vivo: Relationship to ...
		The extent of the decrease in hippocampus was not affected
		antagonist GR 127935 (5 mg/kg) resulted in an increase in 5-HT levels in both brain areas.
		injection of 5 mg/kg GR 127935 on 5-HT levels in frontal cortex.
	jpet.aspetjournals.org /cgi/content/full/288/1/81 (5697 words)

	Excessive Activation of Serotonin (5-HT) 1B Receptors Disrupts the Formation of Sensory Maps in Monoamine Oxidase A and ...
		Excessive Activation of Serotonin (5-HT) 1B Receptors Disrupts the Formation of Sensory Maps in Monoamine Oxidase A and 5-HT Transporter Knock-Out Mice -- Salichon et al.
		Constantine-Paton M, Cline HT, Debski E (1990) Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways.
		Cook PM, Prusky G, Ramoa AS (1999) The role of spontaneous retinal activity before eye opening in the maturation of form and function in the retinogeniculate pathway of the ferret.
	www.jneurosci.org /cgi/content/full/21/3/884 (8969 words)

	DaVinci: Sports> R> ht
		John and Alice Harden, David Harden, Edna Harden, David R. Harden Jr., Sherry Harden, Parcel 2792-06-47-0750, 24th Street SW; HT; to Richard and Susan Armstrong...
		A Higgins (M Stephenson 58), S Berne, O Barkley (R Davies 76), J Maddock; C Malone, A Williams (N Walshe ht); D Barnes (D Flatman 49), L Mears (R Hawkins 76...
		HT Sangliana, BJP MP for Bangalore North, referred to Mr.
	www.bluegrassdavinci.com /ODP/Sports/R/ht (296 words)

	Excess of Serotonin (5-HT) Alters the Segregation of Ispilateral and Contralateral Retinal Projections in Monoamine ...
		Fixed slices were mounted on gelatin-coated slides, air-dried for 5 min at room temperature, and dehydrated with P
		to pierce the skull and inject 0.1 µl of 5% fluorogold in H
		Bennett-Clarke CA, Leslie MJ, Chiaia NL, Rhoades RW (1993) Serotonin 1B receptors in the developing somatosensory and visual cortices are located on thalamocortical axons.
	www.jneurosci.org /cgi/content/full/19/16/7007 (9751 words)

	Spatial Learning in the 5-HT1B Receptor Knockout Mouse: Selective Facilitation/Impairment Depending on the Cognitive ...
		task in a radial-arm water maze with short (0 or 5 min) delays.
		with short (0, 1, 5 min) and long (60, 90 min) delays.
		Serotonin 1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin 1B knockout mice.
	www.learnmem.org /cgi/content/full/10/6/466 (8164 words)

	Pete Clifton's Home Page
		Research in my laboratory is currently, or has recently, been supported by the Biotechnology and Biological Sciences Research Council and Medical Research Councils, Vernalis Research, Eli Lilly, Cerebrus and Wyeth Research and by postgraduate studentships from the Medical Research Council and the Biotechnology and Biological Sciences Research Council.
		I contribute lectures to 5 courses at Sussex and students at the University will find support material for each course by logging in to LifeSci Interactive.
		I am Course Organiser for The Psychobioloy of Motivation and Emotion and will be very happy to field general enquiries from interested students at Sussex.
	www.lifesci.sussex.ac.uk /home/Pete_Clifton (708 words)

	Gene Expression Atlas: Text Query
		D10995 cds HUMHGCR Human gene for serotonin 1B receptor GenBank==D10995
		comments FUNCTION THIS IS ONE OF THE SEVERAL DIFFERENT RECEPTORS FOR 5- HYDROXYTRYPTAMINE (SEROTONIN), A BIOGENIC HORMONE THAT FUNCTIONS AS A NEUROTRANSMITTER, A HORMONE, AND A MITOGEN.
		THE ACTIVITY OF THIS RECEPTOR IS MEDIATED BY G PROTEINS THAT INHIBITS ADENYLATE CYCLASE ACTIVITY PTM PHOSPHORYLATED, AND PALMITOYLATED.
	expression.gnf.org /cgi-bin/index.cgi?chip=U95A&text=775_at (410 words)

	Major Depression - Online Tips Major Depression (Site not responding. Last check: 2007-11-01)
		September 2nd, a Category 5 hurricane, the most intense ever recorded in U. The imbalance between the rich and the poor, with 0.
		Dysthymic disorder is a chronic, low level depression, that continues for years.
		Major depression is a serious medical illness affecting 9.9 million American adults, or approximately 5 percent of the adult population in a given year...
	www.ydepression.com /majordepression (2216 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Energy Citations Database (ECD) Document #5131967 - Characterization of a (sub 3 H)-5-hydroxtyryptamine binding site in rabbit caudate nucleus that differs from the 5-HT sub 1A, 5-HT sub 1B, 5-HT sub 1C and 5-HT sub 1D subtypes
		Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
		Characterization of a (sub 3 H)-5-hydroxtyryptamine binding site in rabbit caudate nucleus that differs from the 5-HT sub 1A, 5-HT sub 1B, 5-HT sub 1C and 5-HT sub 1D subtypes
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=5131967 (178 words)

	Fibromyalgia Symptoms Treatments: January 2006 Archives
		METHODS AND RESULTS: A simple diagnostic approach was applied to 37 consecutive patients (21 female, age 61+/-12 years) with angina-like chest pain and normal coronary angiograms.
		Twenty-one patients were found to suffer from psychiatric disorders (combined anxiety (A) and depression (D): n = 10, D: n = 5, panic disorder (P): n = 3, somatization (S): n = 3) based on their Symptom Check List 90 scores and according to DSM IV-R criteria.
		Sixteen patients had an improvement of their chest pain after oral esomeprazole (40 mg for 7 days) and were therefore diagnosed with gastroesophageal reflux disease (GERD).
	www.fibromyalgia-symptoms-treatments.com /archives/2006/01 (7682 words)

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