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Follicle.com - Methods and compositions for inhibiting 5 alpha -reductase activity A prototype for 5 alpha -reductase inhibitors is 17 beta -N,N-diethylcarbamoyl-4-methyl-4-aza-5 alpha -androstan-3-one (4-MA), which behaves as an inhibitor of 5 alpha -reductase in vivo, decreasing the prostatic concentration of 5 alpha -DHT in intact male rats or in castrated male rats given testosterone propionate. The ability of gamma -linolenic acid to inhibit 5 alpha -reductase in solubilized microsomes indicates that the gamma -linolenic acid inhibition may not be rigidly dependent on the native source of endoplasmic reticulum membranes. 5 alpha -reductase inhibition using compositions of the present invention may also be utilized in such methods to provide a baseline control for determining the efficacy of a candidate substance, as well as to test such a candidate substance for synergistically enhancing the 5 alpha -reductase inhibitory activity of the compositions disclosed herein. www.follicle.com /section3/3_4_2.html   (16857 words)

Immunocytochemical localization of 4-ene steroid 5 alpha-reductase type 1 along the rat epididymis during postnatal ...   (Site not responding. Last check: 2007-11-02) In the epididymis, the maturation and storage of spermatozoa are dependent on the presence of 5 alpha-reduced androgens. We have raised rabbit polyclonal antibodies to a 24-mer synthetic peptide whose sequence was determined from the predicted amino acid sequence for rat 5 alpha-reductase type 1 to immunolocalize the 5 alpha-reductase type 1 protein in the rat epididymis during postnatal development. Finally, the pattern of immunolocalization of 5 alpha-reductase type 1 protein was different in the epididymis of rats of different postnatal ages. www.arclab.org /medlineupdates/abstract_8156933.html   (443 words)

5 alpha-reductase and finasteride in pattern alopecia and acne Journal of Drugs in Dermatology - Find Articles Females with pattern alopecia have lower levels of 5 alpha-reductase in scalp hair than their male counterparts, and accordingly, do not achieve as much success with finasteride therapy. Even in men, normal activity of 5 alpha-reductase is diminished with age, and it is anticipated that the drug will diminish in efficacy in males over 60 years of age. 5 alpha-Reductase levels appear to be reduced in female acne patients, suggesting that inhibitors of this enzyme would not be promising as acne therapy (14). www.findarticles.com /p/articles/mi_m0PDG/is_4_3/ai_n12417026   (753 words)

Gamma Linolenic Acid and Alpha Linolenic Acid - Revivogen Research Inhibitors of 5 alpha-reductase are useful for the selective treatment of prostatic cancer, benign prostate hyperplasia, acne, baldness and female hirsuitism, without affecting spermatogenesis, sexual behavior and smooth muscle growth, that do not require the conversion of testosterone to 5 alpha-dihydrotestosterone. Human or rat microsomal 5 alpha-reductase activity, as measured by enzymatic conversion of testosterone into 5 alpha-dihydrotestosterone or by binding of a competitive inhibitor, [3H]17 beta-NN-diethulcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one ([3H]4-MA) to the reductase, is inhibited by low concentrations (less than 10 microM) of certain polyunsaturated fatty acids. The results of the binding assay and the enzymatic assay correlated well except for elaidic acid and linolelaidic acid, the trans isomers of oleic acid and linoleic acid respectively, which were much less active than their cis isomers in the binding assay but were as potent in the enzymatic assay. www.revivogen.com /research/gla.html   (778 words)

Developmental pattern of 5 alpha-reductase activity in the rat gubernaculum.   (Site not responding. Last check: 2007-11-02) Aromatase activity was measured by the stereospecific release of tritium into the incubation medium, and 5 alpha-reductase was assessed by measuring the amount of 5 alpha-reduced steroids produced during the same incubations. 5 alpha-Reductase activity was relatively high in day 18 fetal gubernaculum (approximately 115 pmol/h.mg protein), but 2 days later in development (fetal day 20), 5 alpha-reductase activity had declined to approximately 21 pmol/h.mg protein. The administration of a 5 alpha-reductase inhibitor to pregnant rats from days 14-22 of gestation inhibited the normal growth rate of the gubernaculum, as assessed by measuring the protein content of the gubernaculum in control and treated rats, but did not have any profound effect on the histological development of the gubernaculum. www.arclab.org /medlineupdates/abstract_2912697.html   (289 words)

5-alpha reductase - Wikipedia, the free encyclopedia The second isoenzyme is deficient in 5-alpha-reductase deficiency which leads to a form of intersexualism. Inhibition of 5-alpha reductase results in decreased produciton of DHT, increased levels of testosterone and possibly increased levels of estradiol. Gynecomastia is a possible side effect of 5-alpha reductase inhibition. en.wikipedia.org /wiki/5-alpha_reductase   (187 words)

Natural Hair Gamma Linolenic Acid The concentration of gamma -linolenic acid was 5 mu M. Inhibition of [<3> H]4-MA binding to 5 alpha -reductase in intact rat liver microsomes by gamma -linolenic acid. Inhibition of [<3> H]4-MA binding to 5 alpha -reductase in detergent-solubilized rat liver microsomes by gamma -linolenic acid. The 5 alpha -reductase activity was measured by analyzing the extent of the conversion of [<3> H]testosterone to [<3> H]5 alpha -DHT. www.natural-hair.com /treatments_greentea_patent.html   (15626 words)

Notes from the Scientific Field The gene for the type 1 isoenzyme is located on the short arm of chromosome 5, while the gene for the type 2 isoenzyme is located on the short arm of chromosome 2. Patients with benign prostatic hyperplasia treated with the recommended dose of 5 mg daily reported impotence (3-4%) and ejaculation disorders (4.4%) [Dr. Felman is using 1mg doses with MUCH less incidence of side effects] Finasteride has no effects on serum lipids and bone density, and has no adverse hormonal effects in healthy men. Found that men treated with 5 mg/day of finasteride for 4 weeks had significantly decreased concentration of dihydrotestosterone in bald scalp, resulting in a mean level similar to the baseline levels found in hairy scalp. home.earthlink.net /~drfelman/notes.html   (981 words)

Steroid 5-alpha-reductase inhibitors - Patent 4910226 A solution of sodium ethoxide (680 mg, 10 mmol) in 5 ml ethanol is added to a mixture of androst-3,5-diene-17-one-3-carboxylic acid (942 mg, 3 mmol) prepared as in Example 14, and methyl diethylphosphonoacetate (2.12 g, 10 mmol) and the resulting mixture heated at reflux for 4 hours. After 5 hours, 300 ml of 10% hydrochloric acid is added and the mixture is filtered and concentrated to remove the organic solvents. A mixture of potassium t-butoxide (5 g) in 100 ml t-butanol is heated to reflux. www.freepatentsonline.com /4910226.html   (12263 words)

5 ALPHA-REDUCTASE INHIBITION: Is there a Rationale   (Site not responding. Last check: 2007-11-02) Male offspring are born with ambiguous genitalia, a microphallus, hypospadias and an underdeveloped prostate gland. The 5aR enzyme is a membrane bound NADPH dependent protein which metabolizes testosterone to DHT within androgen dependent target cells which then binds to the androgen receptor with greater affinity than testosterone. Finasteride is the first of a new class of 5aR inhibitors which allows selective androgen deprivation affecting DHT levels in target organs such as the prostate and scalp hair without affecting circulating levels of testosterone thus preserving in most patients the desired androgen mediated effects on muscle strength, bone density and sexual function. www.prostatepointers.org /prostate/proscar1.html   (1539 words)

5-alpha reductase inhibitors for benign prostatic hyperplasia - [Medication] 5-alpha reductase inhibitors interfere with the effect of certain male hormones (androgens) on the prostate. Most men who use 5-alpha reductase inhibitors report about a 3-point decrease in their American Urologic Association (AUA) symptom index. 5-alpha reductase inhibitors may be less effective than alpha-blockers in relieving symptoms. www.healthwise.org /kbase/topic/detail/drug/hw60748/detail.htm   (643 words)

Scientific Research Studies about thinning hair loss treatments HairGenesis DHT Blockers The ratio of sterol to sterolin varies in the plant kingdom ranging from 5% to 10% but in some cases being higher as in the case of potatoes. Importantly for the purposes of considering value in combating pattern hair loss; the Type 1 isoenzyme is present in high concentrations in the scalp, sebaceous glands, and the skin. Human or rat microsomal 5-Alpha-Reductase (5AR) activity, as measured by enzymatic conversion of testosterone into 5 alpha-DiHydroTestosterone or by binding of a competitive inhibitor, [3H] 17 beta-NN-diethulcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one ([3H] 4-MA) to the reductase, is inhibited by low concentrations (less than 10 microM) of certain polyunsaturated fatty acids. www.botanicalpharmacy.net /scientific_studies.html   (2943 words)

Clearogen Acne Research The enzyme steroid 5 alpha-reductase (EC 1.3.99.5) catalyzes the NADPH-dependent reduction of the double bond of a variety of 3-oxo-Delta(4) steroids including the conversion of testosterone to 5 alpha-dihydrotestosterone. In humans, 5 alpha-reductase activity is critical for certain aspects of male sexual differentiation, and may be involved in the development of benign prostatic hyperplasia, alopecia, hirsutism, and prostate cancer. Replacement of the gallate ester in EGCG with long-chain fatty acids produced potent 5 alpha-reductase inhibitors that were active in both cell-free and whole-cell assay systems. www.clearogen.com /research.html   (1111 words)

eMedicine - 5-Alpha-Reductase Deficiency : Article Excerpt by: Bruce E Wilson, MD   (Site not responding. Last check: 2007-11-02) The conversion involves hydroxylation at the 5 carbon position of the A ring of the steroid molecule. The gene for 5-alpha-reductase type 1 has been determined to be on chromosome 5. Its product is expressed only in nongenital skin and liver at low levels from the time the individual is aged 3 years to puberty, at which time enzyme expression is measurable in sebaceous glands and scalp. www.emedicine.com /ped/byname/5-alpha-reductase-deficiency.htm   (601 words)

DG DISPATCH - BAUS: 5-Alpha Reductase Inhibitors Don’t Offer Much Help In BPH   (Site not responding. Last check: 2007-11-02) The doxazosin dose was titrated up to a maximum of 8 mg daily while finasteride was maintained at 5 mg daily throughout the study. The primary efficacy variables were the International Prostate Symptom Score (I-PSS) and the maximum urinary flow rate (Qmax), while safety was monitored by the incidence of acute urinary retention (AUR) and the need for TURP (transurethral resection of the prostate). The 5-alpha reductase inhibitor, finasteride, on its own does not seem to be of significant benefit in treating symptoms of BPH, although both drugs seem able to reduce the need for surgery. www.pslgroup.com /dg/10c326.htm   (406 words)

5 Alpha-Reductase Inhibition in Hair Transplants – Bernstein Medical, Center for Hair Restoration Testosterone is converted to DHT by the enzyme 5-α reductase in several organs including the prostate, hair follicles, skin, liver and sebaceous glands. 5-α reductase exists in two isoforms: type 1 and type 2. Because there is no human model for combined type I and II 5-alpha reductase inhibition (as there is with type II) long-term usage should be viewed cautiously. www.bernsteinmedical.com /resources/alpha-reductase-inhibition.php   (292 words)

Development of prostate drug based on UT Southwestern research Finasteride inhibits the conversion of testosterone to dihydrotestosterone by the enzyme 5-alpha reductase. By doing so, it reduces the level of dihydrotestosterone –; the primary androgen in the prostate that is involved in the development of prostate cancer – by 90 percent. The drug has shown to shrink the prostate by 20 percent to 30 percent and to significantly reduce the need for surgical intervention and the risk of acute urinary retention. www8.utsouthwestern.edu /utsw/cda/dept37389/files/83515.html   (704 words)

eMedicine - 5-Alpha-Reductase Deficiency : Article by Bruce E Wilson, MD   (Site not responding. Last check: 2007-11-02) Gad YZ, Nasr H, Mazen I, et al: 5 alpha-reductase deficiency in patients with micropenis. Vilchis F, Canto P, Chavez B, et al: Molecular analysis of the 5 alpha-steroid reductase type 2 gene in a family with deficiency of the enzyme. Wilson JD, Griffin JE, Russell DW: Steroid 5 alpha-reductase 2 deficiency. www.emedicine.com /ped/topic1980.htm   (4700 words)

Cationi di rame inibiscono la 5-alpha-reductase   (Site not responding. Last check: 2007-11-02) Previously, we showed that human type I 5 alpha-reductase is expressed mainly in the skin, whereas a type II 5 alpha-reductase is more specifically expressed in the prostate. The results showed that type I 5 alpha-reductase was strongly inhibited by Cd, Cu, and Zn and moderately inhibited by Ni and Fe, with 50% inhibitory concentration values of 0.9, 1.9, 2.0, 169.2, and 174.3 microM, respectively. In contrast, type II 5 alpha-reductase activity was inhibited only by Cu, with a 50% inhibitory concentration value of 19.2 microM. www.anagen.net /rame1.htm   (213 words)

5-Alpha-Reductase: Press Releases Alpha Hedged Strategies Fund adds Gabelli Asset Management and G2 Capital Management to its sub-advisory roster.White Plains, NY (PRWEB) May 9, 2005 -- www.aipfunds.com [Alternative Investment Partners, LLC] (AIP) is pleased to announce a number of... Alpha Golf has earned `Top Dog` status on the Long Drivers of America Tour with its elite Alpha Team of past and present Long Drive champions.Chatsworth, CA (PRWEB) July 21, 2004 -- With the Long Drivers of America (LDA) Tour at the mid-point of the... The Omicron Omega chapter of Alpha Kappa Alpha Sorority, Inc. is celebrating its 80th anniversary with a series of events planned throughout the month of October. www.press-library.com /search/5-alpha-reductase.htm   (1265 words)

Steroidic 5.alpha.-reductase inhibitors - Patent 4732897 To a solution of 24-N,N-diethylcarbamoyl-5-oxo-3,5-seco-4-nor-cholan-3-oic acid (3 g, 0.0067 mol) in ethanol (90 ml of 95% solvent), potassium hydroxide (60 ml of a 5% aqueous solution) and hydroxylamine hydrochloride (0.9 g, 0.0129 mol) were added. After filtration to remove the catalyst, the reaction mixture was concentrated under high vacuum and the residue dissolved in ethyl acetate and chromatographed. To a solution of 17.beta.-N,N-diethylcarbamoyl-5-oxo-3,5-seco-4-nor-androstan-3-oic acid (3 g, 0.0076 mol) in ethanol (95%), was added KOH (70 mol of 5% aqueous solution) followed by hydroxylamine hydrochloride (1.05 g, 0.015 mol). www.freepatentsonline.com /4732897.html   (5701 words)

Medical Dictionary: Testosterone 5 alpha reductase - WrongDiagnosis.com Testosterone 5 alpha reductase : EC 1.3.99.5; catalyzes the reduction of testosterone to 5 alphadihydrotestosterone. The term Testosterone 5 alpha reductase can be used for: The description of Testosterone 5 alpha reductase may also be used for the following terms: www.wrongdiagnosis.com /medical/testosterone_5_alpha_reductase.htm   (195 words)

Action of Saw Palmetto, DHT,  5-alpha reductase, erection and sexual orgasm It is not 5-alpha reductase, but the binding of DHT to the hormonal receptor site and the poor local blood circulation, causing the prostate or hair loss problem. During our adolescence, our liver is very powerful to synthesize 5-alpha reductase, but only a small amount of Aromatase, and there is no hair loss and no prostate problem during that years. On the other hand, when the production of 5-alpha reductase reduces, when the production of Aromatase (and Estradiol) increases, and when the endocrine function produces less testosterone and DHT after 30, men start to experience hair loss and prostate problem. www.actionlove.com /cases/case8965.htm   (1389 words)

Clinical Trial: The Effect of 5-Alpha Reductase on Testosterone in Men The enzyme 5-alpha reductase is present in small amounts in muscle and converts testosterone to dihydrotestosterone (DHT). The role of 5-alpha reductase in mediating testosterone's effects on muscle and sexual function remains unclear. The study will also evaluate the necessity of 5-alpha reductase for maintenance of androgen effects on sexual function (sexual desire, overall sexual activity, nocturnal penile tumescence [NPT], response to visual erotic stimulus, and penile rigidity) in men. www.clinicaltrials.gov /ct/gui/show/NCT00070733   (621 words)

UniProtKB/Swiss-Prot entry P31213 [S5A2_HUMAN] 3-oxo-5-alpha-steroid 4-dehydrogenase 2 Nakanishi J. Hibino T. "Transcription of type II 5 alpha-reductase is up-regulated by SRY in human dermal papilla cells."; Pearce C.L. Makridakis N.M. Ross R.K. Pike M.C. Kolonel L.N. Henderson B.E. Reichardt J.K.V. "Steroid 5-alpha reductase type II V89L substitution is not associated with risk of prostate cancer in a multiethnic population study."; Molecular function: sterol 5-alpha reductase activity (inferred from direct assay). www.expasy.org /uniprot/P31213   (1057 words)

Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism -- Moghetti et al. ... Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism -- Moghetti et al. Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism Hyperactivity of 5 alpha-reductase in the skin is considered a major jcem.endojournals.org /cgi/content/abstract/79/4/1115   (409 words)

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