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Topic: 5HT

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	A genetic approach to access serotonin neurons for in vivo and in vitro studies -- Scott et al. 102 (45): 16472 -- ...
		Serotonin (5HT) is a critical modulator of neural circuits that
		vivo and in vitro studies of 5HT neurons.
		This paper was submitted directly (Track II) to the PNAS office.
	www.pnas.org /cgi/content/short/102/45/16472 (487 words)

	Journal of Circadian Rhythms \| Full text \| Relationship between nocturnal serotonin surge and melatonin onset in ... (Site not responding. Last check: 2007-10-24)
		As shown in Figure 3A and 3B, the phase angles of both 5HT-on and MT-on for either PVG rats or LEW rats are remarkably consistent between individuals of the same strain.
		For LEW rats (Figure 3B), the 5HT-on ranged from 130 to 172 min (upper panel), and the MT-on spanned from 159 to 179 min (lower panel).
		The strain-specific phase angles of 5HT-on and MT-on for PVG and LEW rats represent the extreme types of 5HT-on and MT-on found in SD rats, and are much earlier than those of the Wistar rats (Figure 3D).
	www.jcircadianrhythms.com /content/4/1/12 (4818 words)

	Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons -- Zhang et al. 131 (7): ...
		A deficit in 5HT is implicated in a
		ADF 5HT immunoreactivity is recovered in the mutants carrying a wild-type osm-9 or ocr-2 transgene.
		downregulate 5HT biosynthesis in the ADF neurons, and this TRPV
	dev.biologists.org /cgi/content/full/131/7/1629 (6344 words)

	CiteULike: gsk3's 5ht (Site not responding. Last check: 2007-10-24)
		Recent papers added to gsk3's library classified by the tag 5ht.
		In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain.
		posted to 5ht gsk3 serotonin by gsk3 on 2005-11-02 20:02:41 as
	www.citeulike.org /user/gsk3/tag/5ht (117 words)

	5HT Increases Excitability of Nociceptor-Like Rat Dorsal Root Ganglion Neurons Via cAMP-Coupled TTX-Resistant Na+ ...
		The 1st bar (5HT) represents the average percent increase in Na current amplitude produced by 10 µM 5HT, while the 2nd bar (5HT + Forskolin) represents the additional average percent change in Na current amplitude produced by co-application of 10 µM forskolin + 5HT.
		The effects of 5HT on the threshold for evoking action potentials in type 2 DRG cells was studied by determining the magnitude
		B: bar graph summarizing the effects of 5HT on the threshold for action potential generation by a depolarizing current pulse in 5 type 2 DRG cells.
	jn.physiology.org /cgi/content/full/86/1/241 (5254 words)

	Flux Coupling in the Human Serotonin Transporter -- Adams and DeFelice 83 (6): 3268 -- Biophysical Journal
		Disruption of the Na/K-ATPase in the presence of 5HT induces an increase in [Na]
		the achievable 5HT gradient, was 13.1 fmole/81 min = 0.16 fmole/min/cell.
		and the expression for the equilibrium 5HT gradient Eq.
	www.biophysj.org /cgi/content/full/83/6/3268 (6476 words)

	Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors -- ...
		In turn, each of the 12 current records included in the average control and 5HT sweeps, are averages of 5 to 10 individual currents recorded under control conditions or after treatment with 5HT.
		The effect of 5HT on the voltage dependency of availability of TTX-resistant Na current was also studied in type 2 DRG cells.
		For A to D the kinetic parameters under control and 5HT conditions were taken from the mean values inserted in the legend of Fig.
	www.biophysj.org /cgi/content/full/83/1/5 (8168 words)

	March/April 1999 (Site not responding. Last check: 2007-10-24)
		The mechanism of action of paroxetine is serotonin (5HT) reuptake blockade via inhibition of the serotonin reuptake transporter.
		5HT autoreceptor downregulation is thought to confer the antidepressant effects of the SSRIs evident with chronic dosing.
		The extent to which these differences in 5HT selectivity offer advantages in regards to efficacy remains to be determined.
	www.cc.nih.gov /phar/updates/mar-apr99.html (1666 words)

	[No title]
		The 5HT1 metabolite opens the K+ receptors and initiates hyperpolerization, allowing ionic channels to open and vesicles holding newly created serotonin to release it through the ion channels and become active during a synapse and bind to the terminal buttons where they are used by the transmitter or naturally recycled.
		Some studies show the 5HT molecules are also shown to be active in the lessening of the Serotonin 1B's inhibitory properties on serotonin release, providing more of the neurotransmitter to be accessed.
		It must be noted as a controversial issue in the medical field that treatment with chemical agents may also delay self-correction of the underlying chemical imbalance, (perhaps caused by a chronic morphological disorder) and growth in the pathways that are implicated in the inefficiency.
	www.humboldt.edu /~morgan/adep_s04.htm (3591 words)

	Seiden 1/25/96 letter to Reedy
		4) Acute changes in cortical 5HT may or may not be related to the long-lasting changes that one sees after administering doses of fenfluramine which both interfere with food consumption in animals and at slightly higher doses cause a prolonged depletion of 5HT in brain.
		Studies that have been carried out by various investigators who havelooked at 5HT in brain with doses that are very close to the effective dose for suppressing food intake and they have found losses in 5HT for periods from 2 weeks to 17 months depending upon the species involved.
		Furthermore the conclusions derived from this data are based on the assumption that the levels of dex-fen and dex-nor-fen are critical determinants of the long-lasting effects on 5HT, the long-lasting effects agreeably being neurotoxic.
	www.time.com /time/redux/reedyfda.html (658 words)

	Serotonin Enhances the Resistance Reflex of the Locomotor Network of the Crayfish through Multiple Modulatory Effects ...
		In the presence of 5HT, Dep MN1 showed a tonic depolarization of 3 mV (not visible because traces are aligned for better appreciation of the enhancement of the response in the presence of 5HT).
		5HT induced a decrease of the sensory discharge.
		Sheldon PW, Aghajanian GK (1991) Excitatory responses to serotonin (5HT) in neurons of the rat piriform cortex: evidence for mediation by 5HT1C receptors in pyramidal cells and 5HT2
	www.jneurosci.org /cgi/content/full/24/2/398 (8852 words)

	Developmental Exposure to Chlorpyrifos Elicits Sex-Selective Alterations of Serotonergic Synaptic Function in ... (Site not responding. Last check: 2007-10-24)
		The presynaptic 5HT transporter (5HTT) is a biomarker for the concentration of 5HT nerve terminals and is responsible for regulating the concentration of 5HT in the synapse (Cooper et al.
		Alterations in the AC response to 5HT in adulthood (PN60) after CPF exposure during different developmental periods; normative AC activities in the absence of 5HT are presented in Table 1.
		Third, there are smaller but significant effects on 5HT modulation of cell signaling that are entirely distinct from those on the 5HT receptors, in terms of both sex dependence and regional selectivity, but sharing a similar peak of sensitivity in the late gestational phase.
	www.ehponline.org /members/2003/6713/6713.html (7011 words)

	PS 310 Behavioural Pharmacology (Site not responding. Last check: 2007-10-24)
		Increased 5HT function (5HT precursors, releasing or reuptake inhibiting drugs, or direct receptor agonists or direct injection of 5HT) results in suppression of food intake, and if prolonged, weight loss in rats and humans.
		This is a 5HT and NA reuptake inhibitor, i.e.
		Again they might be expected to reduce 5HT and NA activity along the lines suggested for their action in anxiety.
	www.le.ac.uk /pc/mhj1/ps3104.html (2774 words)

	Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of ...
		BI and BII are examples of 5HT-evoked facilitation of rested synapses in the controls and in the neurons incubated in 100 µM calpeptin for 15 min, respectively.
		When calpain activation is inhibited (#8), the impeding substrates are not cleaved, and as a consequence, the translocation of vesicles is slowed down, leading to an increased rate of homosynaptic depression.
		Furthermore, following homosynaptic depression, in the presence of calpeptin, 5HT application (#9) and PKC activation (#10) fail to mobilize vesicles, since vesicle translocation is impeded by the hypothetical uncleaved calpain substrate.
	www.learnmem.org /cgi/content/full/12/4/414 (5657 words)

	Two Parallel Signaling Pathways Couple 5HT1A Receptors to N- and L-Type Calcium Channels in C-Like Rat Dorsal Root ...
		Concentration-response curves were generated for 5HT in the absence and presence of 1 µM spiperone and for 8-OH-DPAT.
		Antagonism of 5HT agonist-induced inhibition of Ca channel current in type 1 DRG cells by spiperone and pindolol.
		It is unknown what purpose is served by having parallel signaling pathways coupling 5HT receptors to Ca channels in the type 1 DRG cells.
	jn.physiology.org /cgi/content/full/77/6/3284 (7575 words)

	Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia II: Long-Term Facilitation -- Sherff and Carew 42 ...
		5 min pulse of 5HT at the SN-MN synapses.
		LTF was significantly reduced if synaptic 5HT occurred 15 min before somatic 5HT (top traces), and LTF was not induced at all if synaptic 5HT occurred 15 min after (bottom traces) somatic 5HT.
		LTF is blocked when the translational inhibitor emetine (gray bars) is present during 5HT exposure (from 30 min before 5HT to 30 min after 5HT) in the synaptic but not the somatic compartment (left graph).
	icb.oxfordjournals.org /cgi/content/full/42/4/736 (3660 words)

	Clinical Trial: Hormonal Causes of Menstrual-Related Mood Disorders
		The central serotonergic (5HT) system is one of the candidate systems that may mediate the abnormal mood and behavioral response to ovarian steroids observed in women with menstrual-related mood disorders (MRMD).
		Numerous studies have attempted to measure 5HT system function in women with MRMD and controls; however, previous studies were restricted to the evaluation of indirect measures of 5HT function (e.g., platelet 5HT uptake or responses to serotonergic pharmacologic challenges).
		Radioligand imaging of specific components of the 5HT system currently represents the most direct measure of central serotonergic function available.
	www.clinicaltrials.gov /ct/show/NCT00100360 (1327 words)

	index2.html
		MOVIE 2: 5HT and N,N-dMe-5HT in the WT receptor: The orientation adopted by 5HT and N,N-dMe-5HT in the WT receptor after the molecular dynamics simulation is quite diferent.
		MOVIE 3: 5HT in S3.36A mutant receptor: In the absence of a serine at position 3.36, 5HT loses the hydrogen bond with S3.36 and 5HT moves away from position 3.36 during the molecular dynamics simulation.
		The orientation of 5HT and 1-N-Me-5HT in the S5.46A mutant receptor is nearly overlapping.
	physiology.med.cornell.edu /faculty/hweinstein/5ht/index2.html (237 words)

	Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs{dagger} -- Kabara ...
		In the 5HT group, dogs were subdivided into four groups of five
		5HT infusion and 5 min after each dose of thiopental.
		was similar to that in the 5HT groups.
	bja.oxfordjournals.org /cgi/content/full/91/3/379 (2070 words)

	5-Hydroxytryptamine (5HT) Receptors in the Heart Valves of Cynomolgus Monkeys and Sprague-Dawley Rats -- Elangbam et ...
		5-Hydroxytryptamine (5HT) Receptors in the Heart Valves of Cynomolgus Monkeys and Sprague-Dawley Rats -- Elangbam et al.
		The biological actions of 5HT are mediated via numerous cognate
		expression of 5HT receptors in valvular interstitial and endothelial
	www.jhc.org /cgi/content/full/53/5/671 (2962 words)

	Serotonin-activated signal transduction via serotonin receptors on Jurkat cells -- Aune et al. 145 (6): 1826 -- The ...
		5HT receptors have been divided into three major families
		nM and that 5HT stimulates an increase in inositol phosphate and
		cells to the 5HT2 family; however, studies with 5HT receptor agonists and
	www.jimmunol.org /cgi/content/abstract/145/6/1826 (311 words)

	The DJ List - United States: CHICAGO: 5ht Annual Halloween Bash - October 28, 2006 - FIZZ CHICAGO, US
		You are in: Home → World → United States → CHICAGO → FIZZ → 5ht Annual Halloween Bash - October 28, 2006
		5ht Annual Halloween Bash - October 28, 2006
		Note that it requires an additional registration to join.
	www.thedjlist.com /world/United_States/CHICAGO/Venues/FIZZ/Events/20061028 (209 words)

	Marsh 5HT Manual
		Marsh has redesigned the 5HT manual gummed tape dispenser to include stainless steel cutting blades to improve performance.
		This model was also manufactured for Intertape Polymer Group™ (Central Brand Tape) in a bright red/orange and in blue.
		Last modified: 10/04/2007 Pricing Policy and our Demo Policy click here.
	www.propacksolutions.com /tape_dispensers/marsh/marsh_5ht_manual.htm (246 words)

	IGN Boards - 5ht blue orchid
		Date Posted: 8/18 3:07am Subject: 5ht blue orchid
		Date Posted: 10/24 1:34pm Subject: RE: 5ht blue orchid
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	boards.ign.com /garfield/b7661/124915970/p1 (135 words)

	Serotonin (Site not responding. Last check: 2007-10-24)
		Is the unresponsiveness to sumatriptan in cluster headache related to an alteration in the 5-HT receptors?
		Evidence of a relationship between 5HT levels and stress.
		An article by Dr. Glennon of the Glennon Research Group.
	www.ouch-us.org /chgeneral/seratonin.htm (118 words)

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