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Topic: 5-alpha reductase

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Follicle.com - Methods and compositions for inhibiting 5 alpha -reductase activity 5 alpha -reductase inhibition using compositions of the present invention may also be utilized in such methods to provide a baseline control for determining the efficacy of a candidate substance, as well as to test such a candidate substance for synergistically enhancing the 5 alpha -reductase inhibitory activity of the compositions disclosed herein. A prototype for 5 alpha -reductase inhibitors is 17 beta -N,N-diethylcarbamoyl-4-methyl-4-aza-5 alpha -androstan-3-one (4-MA), which behaves as an inhibitor of 5 alpha -reductase in vivo, decreasing the prostatic concentration of 5 alpha -DHT in intact male rats or in castrated male rats given testosterone propionate. Several lines of evidence suggest that inhibition of 5 alpha -reductase may be the primary mode of action for gamma -LA. First, in the cell-free systems, gamma -LA is a potent inhibitor of 5 alpha -reductase in liver or prostate from humans and rats (Liang and Liao, 1992). www.follicle.com /section3/3_4_2.html

5-alpha reductase - Wikipedia, the free encyclopedia The second isoenzyme is deficient in 5-alpha-reductase deficiency which leads to a form of intersexualism. isoenzymes, steroid 5-alpha reductase 1 and 2 (SRD5A1 and SRD5A2). en.wikipedia.org /wiki/5-alpha_reductase

Cationi di rame inibiscono la 5-alpha-reductase The results showed that type I 5 alpha-reductase was strongly inhibited by Cd, Cu, and Zn and moderately inhibited by Ni and Fe, with 50% inhibitory concentration values of 0.9, 1.9, 2.0, 169.2, and 174.3 microM, respectively. Previously, we showed that human type I 5 alpha-reductase is expressed mainly in the skin, whereas a type II 5 alpha-reductase is more specifically expressed in the prostate. The expressed 5 alpha-reductases were analyzed for their sensitivity to Li, Ca, Cd, Cu, Mg, Mn, Ni, Zn, and Fe. www.anagen.net /rame1.htm

Alopecia "5 Alpha-reductase Inhibitors--A New Hope in Dermatology?" International Journal of Dermatology, March 1997, 182-4. There is also an over-the-counter extra-strength version of minoxidil (5% concentration) approved for use by men only. The treatment often results in new hair that is thinner and lighter in color. www.healthatoz.com /healthatoz/Atoz/ency/alopecia.jsp

5 ALPHA-REDUCTASE INHIBITION: Is there a Rationale Finasteride is the first of a new class of 5aR inhibitors which allows selective androgen deprivation affecting DHT levels in target organs such as the prostate and scalp hair without affecting circulating levels of testosterone thus preserving in most patients the desired androgen mediated effects on muscle strength, bone density and sexual function. The first 5aR inhibitor to be developed was finasteride, a structural analog of testosterone which selectively inhibits the 5aR-2 isoenzyme without inhibiting the 5aR-1 enzyme system or interfering with androgen receptor binding. In the rat, 5aR appears to be controlled by a feed-forward mechanism mediated by DHT levels which induces 5aR enzyme activity and 5aR mRNA expression. www.prostatepointers.org /prostate/proscar1.html

Notes from the Scientific Field Found that men treated with 5 mg/day of finasteride for 4 weeks had significantly decreased concentration of dihydrotestosterone in bald scalp, resulting in a mean level similar to the baseline levels found in hairy scalp. The gene for the type 1 isoenzyme is located on the short arm of chromosome 5, while the gene for the type 2 isoenzyme is located on the short arm of chromosome 2. Patients with benign prostatic hyperplasia treated with the recommended dose of 5 mg daily reported impotence (3-4%) and ejaculation disorders (4.4%) [Dr. Felman is using 1mg doses with MUCH less incidence of side effects] Finasteride has no effects on serum lipids and bone density, and has no adverse hormonal effects in healthy men. home.earthlink.net /~drfelman/notes.html

Serenoa-AB.txt The amounts of 5 alpha-dihydrotestosterone (DHT), formed by reduction of T by 5 alpha-reductase (5 alpha-R), were small: 5 and 2% (BPH) and 8 and 15% (adenocarcinoma) for epithelial cells and fibroblasts, respectively. The development of new compounds, such as 5 alpha reductase and aromatase inhibitors, consents to introduce a combination therapy with less side effects. DU 145 cells exhibited 5 alpha-R activity (21 pmol DHT/min/mg protein) at pH 7.4 which disappeared at pH 5.5 suggesting that, of the two genomically distinct human isozymes identified so far, type 1 5 alpha-R is expressed in DU 145 cells. www.swsbm.com /Abstracts/Serenoa-AB.txt

Alpha 5-alpha-reductase deficiency 5-alpha-reductase deficiency (5-ARD) is a condition caused by a intersexualism. Alpha 1-antitrypsin deficiency Alpha 1-antitrypsin deficiency (A1AD) is a liver disease. Alpha and Omega ministries Alpha and Omega ministries is the Christian apologetics and theology ministry of James White.... www.brainyencyclopedia.com /topics/alpha.html   (1276 words)

Get dutasteride info - A DHT inhibitor also known as Avodart, Avolve, Duagen or GI198745 Dutasteride is the generic name for a new dual 5 alpha-reductase inhibitor made by GlaxoSmithKline. The difference between Dutasteride and Finasteride is that Dutasteride inhibits the activities of both the type 1 and type 2 5AR enzymes unlike Finasteride which only inhibits type 2. Dutasteride like Finasteride, the active ingredient in Proscar and Propecia, also has the added benefit of being able to be used to treat genetic hair loss in men also known as MPB or Androgenic Alopecia. www.dutasteride.org   (1276 words)

The V89L Polymorphism in the 5{{alpha}}-Reductase Type 2 Gene and Risk of Prostate Cancer -- Febbo et al. 59 (23): 5878 -- Cancer Research Steroid 5-{alpha} Reductase Type II V89L Substitution Is Not Associated with Risk of Prostate Cancer in a Multiethnic Population Study Table 3 Mean ± SD plasma AAG concentration (ng/ml) by the V89L polymorphism in the 5 5 min at 94°C, samples underwent 35 cycles of melting at cancerres.aacrjournals.org /cgi/content/full/59/23/5878   (1276 words)

eMedicine - 5-Alpha-Reductase Deficiency : Article by Bruce E Wilson, MD Thigpen AE, Davis DL, Milatovich A: Molecular genetics of steroid 5 alpha-reductase 2 deficiency. Forti G, Falchetti A, Santoro S, et al: Steroid 5 alpha-reductase 2 deficiency: virilization in early infancy may be due to partial function of mutant enzyme. The other isoenzyme, 5-alpha reductase type 2, determined on chromosome 2, correlates with clinical symptoms. www.emedicine.com /ped/topic1980.htm   (1276 words)

(Print Version) Acne This decrease was mediated by both a non-competitive inhibition of the binding of testosterone to the 5 alpha-reductase enzyme and by a reduction in the formation of the NADPH cofactor. Thus, the present study demonstrates that the 5 alpha-reductase activity is mainly located in the apocrine sweat gland and sebaceous gland. Activity of testosterone 5 alpha-reductase in various tissues of human skin. www.lef.org /protocols/abstracts/abstr-txt/t-abstr-117.html   (1276 words)

Dutasteride - A DHT inhibitor also known as Avodart, Avolve, Duagen RESULTS: The pharmacodynamics were well described with a model that accounted for the rates of DHT formation and elimination, 5 alpha-reductase turnover, relative capacity of the 2 5 alpha-reductase isozymes, and the rates of irreversible inhibition of one (finasteride) or both (GI198745) types of 5 alpha-reductase. OBJECTIVE: To develop a pharmacokinetic-pharmacodynamic model that characterizes the conversion of testosterone to dihydrotestosterone (DHT) by 5 alpha-reductase types 1 and 2 and the irreversible inhibition of 5 alpha-reductase by finasteride, a 5 alpha-reductase type 2 inhibitor and by GI198745 (dutasteride), a potent and specific dual 5 alpha-reductase inhibitor. Nearly full blockade of both isozymes was achieved at doses of 10 mg or more GI198745, although the potency of this agent on 5 alpha-reductase type 1 was less than on type 2. www.dutasteridedirect.com /dutasteride/dutasteride-papers7.html   (1276 words)

5{{alpha}}-Reductase Type 2 Is Constitutively Expressed in the Dermal Papilla and Connective Tissue Sheath of the Hair Follicle in Vivo But Not during Culture in Vitro -- Asada et al. 86 (6): 2875 -- Journal of Clinical Endocrinology & Metabolism reductase in cultured human dermal papilla cells from beard and occipital scalp hair. for 5 min, and the final extension step for 3 min. 5% CO in air at 37 C. Semiquantitative analysis of the expression of mRNAs for the 5 jcem.endojournals.org /cgi/content/full/86/6/2875   (1276 words)

Merck lavora ad una forma topica di finasteride (Propecia) [0082] Using the above-described methodology, it can be shown that administration of 5.alpha.-reductase 2 inhibitors, including finasteride, in dosages below 5 mg/day per patient, for example, 1 mg/day or 0.2 mg/day, are useful in the treatment of androgenic alopecia, and promote hair growth in patients with this condition. Furthermore, a low daily dosage of a 5.alpha.-reductase 2 inhibitor may also be particularly useful in the treatment of the hyperandrogenic conditions of acne vulgaris, seborrhea, female hirsutism, and polycystic ovary syndrome. The instant invention involves a method of treating and/or reversing androgenic alopecia and promoting hair growth, and methods of treating acne vulgaris, seborrhea, and female hirsutism, by administering to a patient in need of such treatment a 5.alpha.-reductase 2 inhibitor, such as finasteride, in a dosage amount under 5 mgs/day. www.anagen.net /p21.htm   (1276 words)

Regulation of Uterine 5{alpha}-Reductase Type 1 in Mice -- Minjarez et al. 65 (5): 1378 -- Biology of Reproduction Poly(A) RNA from cardiac (lane 1, Ht) and uterine tissues of nonpregnant cycling mice (lane 2, NP), and ovariectomized animals treated with vehicle (lane 3, C), 17ß-estradiol (lane 4, E2), progesterone (lane 5, P), or E2 and P combined (lane 5, E2+P) was isolated and subjected to RNA blot hybridization (10 µg/lane). Differential expression of myometrial oxytocin receptor and prostaglandin H synthase 2, but not estrogen receptor alpha and heat shock protein 90 messenger ribonucleic acid in the gravid horn and nongravid horn in sheep during betamethasone-induced labor. to fetal occupancy may influence the expression of 5 www.biolreprod.org /cgi/content/full/65/5/1378   (1276 words)

Transcriptional regulation of the mouse steroid 5{alpha}-reductase type II gene by progesterone in brain -- Matsui et al. 30 (6): 1387 -- Nucleic Acids Research Andersson,S. and Russell,D.W. (1990) Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Wigley,W.C., Prihoda,J.S., Mowszowicz,I., Mendonca,B.B., New,M.I., Wilson,J.D. and Russell,D.W. (1994) Natural mutagenesis study of the human steroid 5 alpha-reductase 2 isozyme. Guidotti,A. and Costa,E. (1998) Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability? nar.oupjournals.org /cgi/content/full/30/6/1387   (1276 words)

Soy, Daidzein, Genistein, Glycine Max, Isoflavone, Protein (Soy), Soya Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. 5 Alpha-reductase inhibition represents a potentially effective therapeutic approach to One study of soy research found that 65% of 26 animal-based cancer studies showed a protective effect of soy or soy isoflavones. www.truestarhealth.com /Notes/2910007.html   (1276 words)

DHT - Dihydrotestosterone and 5 Alpha Reductase in male hair loss 5 Alpha Reductase is an enzyme which converts testosterone to dihydrotestosterone (DHT) which is the hormone that triggers Androgenetic Alopecia in individuals who are genetically susceptible. DHT is formed when the male hormone testosterone interacts with the enzyme 5-alpha reductase. DHT - Dihydrotestosterone and 5 Alpha Reductase in male hair loss www.hairlosslibrary.com /dihydrotestosterone.html   (1276 words)

5-alpha reductase inhibitors for benign prostatic hyperplasia Most men who use 5-alpha reductase inhibitors report about a 3-point decrease in their American Urologic Association (AUA) symptom index. 5-alpha reductase inhibitors are not recommended for treatment of BPH symptoms in men without an enlarged prostate. Most experts suggest that men be checked for the presence of prostate cancer (using the PSA test and a digital rectal exam) before taking 5-alpha reductase inhibitors. my.webmd.com /hw/mens_conditions/hw60748.asp   (1276 words)

Relative Potency of Testosterone and Dihydrotestosterone in Preventing Atrophy and Apoptosis in the Prostate of the Castrated Rat -- Wright et al. 98 (11): 2558 -- Journal of Clinical Investigation Rowden (1995) Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5 alpha-reductase inhibitor finasteride. Whole ventral prostates were formalin fixed, embedded in paraffin, and sectioned at 5 µm for histological analysis. fibroblasts from the genital skin of a 5 www.jci.org /cgi/content/full/98/11/2558   (1276 words)

The Effect of 5-alpha Reductase on Testosterone in Men - Article The enzyme 5-alpha reductase is present in small amounts in muscle and converts testosterone to dihydrotestosterone (DHT). The study will also evaluate the necessity of 5-alpha reductase for maintenance of androgen effects on sexual function (sexual desire, overall sexual activity, nocturnal penile tumescence [NPT], response to visual erotic stimulus, and penile rigidity) in men. Participants will then be randomly assigned to receive either testosterone and placebo or testosterone and the 5-alpha reductase inhibitor duasteride. goldbamboo.com /topic-t2370-a113290.html   (1276 words)

Community Drug Compounding Center In this same article the mechanism of action of saw palmetto is discussed-inhibition of 5-alpha reductase enzyme, adrenergic receptor antagonism, and intraprostatic androgen receptor blockade. 6 It also is a 5 alpha reductase inhibitor that governs the conversion of testosterone to potent dihyrotestosterone(DHT). Synthesis and in vitro activity of some epimeric 20 alpha-hydroxy,20-oxime and aziridine prenene derivatives as inhibitors of human 17 alpha-hydroxylase/C17,20-lyase and 5 alpha-reductase. www.communitydrug.com /Cat_Main.cfm?CategoryID=32   (1276 words)

Changes in 5{alpha}-Pregnane Steroids and Neurosteroidogenic Enzyme Expression in the Perinatal Sheep -- NGUYEN et al. 53 (6): 956 -- Pediatric Research Andersson S, Russell DW 1990 Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Celotti F, Melcangi RC, Martini L 1992 The 5 alpha-reductase in the brain: molecular aspects and relation to brain function. For determining the changes in expression of P450scc and 5 www.pedresearch.org /cgi/content/full/53/6/956   (1276 words)

The Loss of 5{alpha}-Reductase Type I and Type II mRNA Expression in Metastatic Prostate Cancer to Bone and Lymph Node Metastasis -- Habib et al. 9 (5): 1815 -- Clinical Cancer Research Poole, Dorset, United Kingdom) was added for 5 min. 5, 6), and the molecular mechanisms underlying the development studies merely reflects the approaches used for detecting 5 clincancerres.aacrjournals.org /cgi/content/full/9/5/1815   (1276 words)

5 alpha reductase This is acomplished by inhibiting the enzyme 5 alpha reductase effectivelly reducing the amount of DHT that can be produced and by blocking the receptors in the hair follicles so DHT can not attach to them. The accumulation of sebum and cholesterol on the scalp can contribute to hair loss by increasing the amount of the enzyme 5 alpha reductase which in turn means more DHT. It is also the aging process that first triggers the creation of the enzyme 5 alpha reductase. www.add-hair.com /strategies-to-stop-hairloss.htm   (1276 words)

Pharmacology antifungal, alkalising agent, quinolones, antibiotic, cholinergic, anticholinergic, anticholinesterase, antispasmodic, 5-alpha reductase inhibitor, selective alpha-1 blocker ACE inhibitor, cardiac glycoside, phosphodiesterase inhibitor, nitrate, antianginal, antiarrhythmic, angiotensin receptor blocker, alpha blocker, beta-receptor blocker, calcium channel blocker, antihypertensive, diuretic, vasoconstrictor, vasodilator, peripheral activator, anticoagulant, heparin, antiplatelet drug, fibrinolytic, anti-hemophilic factor, haemostatic drugs, hypolipidaemic agent, statin. www.sciencedaily.com /encyclopedia/pharmacology   (1276 words)

ScienceDaily: Pharmacology Affecting Blood pressure: ACE inhibitors, angiotensin receptor blockers, alpha blocker Anti-glaucoma: adrenergic agonists, beta-blockers, carbonic anhydrase inhibitors/hyperosmotics, cholinergics, miotics, parasympathomimetics, prostaglandin agonists/prostaglandin inhibitors. Those with a narrow window are more difficult to dose and administer, and may require therapeutic drug monitoring (examples are warfarin, some antiepileptics, aminoglycoside antibiotics). www.sciencedaily.com /encyclopedia/pharmacology   (1641 words)

5 alpha-reductase - General Practice Notebook 5 alpha-reductase is an enzyme that is present in highest concentration in the male reproductive tissues, the skin, especially that overlying the genitalia, and the liver. In 5 alpha-reductase deficiency, the type 2 isoenzyme is that which is lacking. Men with this condition do not develop male-pattern baldness despite evidence that the type 1 isoenzyme is the dominant form in the adult male scalp, and in 5 alpha-reductase deficiency, this isoenzyme is present at normal levels. www.gpnotebook.co.uk /simplepage.cfm?ID=1953169455   (927 words)

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