5-bromouracil - Factbites

5-bromouracil - Factbites
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Topic: 5-bromouracil

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	Mutation - Medical Encyclopedia
		A transition can be caused by nitrous acid, base mispairing, or mutagenic base analogs such as bromouracil.
	www.nursingstudy.com /encyclopedia/Mutation.html

	BIBLIOGRAPHY
		Kaufman, E.R. and Davidson, R.L., Bromodeoxyuridine mutagenesis in mammalian cells: mutagenesis is independent of the amount of bromouracil in DNA.
		Davidson, R.L. and Kaufman, E.R., Bromodeoxyuridine mutagenesis in mammalian cells is stimulated by thymidine and suppressed by deoxycytidine.
	tigger.cc.uic.edu /~erk/bibliography.html

	BrdU - Wikipedia, the free encyclopedia
		Also known as 5-bromo-2-deoxyuridine, this chemical is a base analog of thymidine, with the thymine substituted by bromouracil.
	en.wikipedia.org /wiki/BrdU

	2'-DEOXY-5-BROMOURIDINE (BROMOURACIL DEOXYRIBOSIDE)
		Their carbon atoms are numbered: the 5' carbon atom is always on the side of the sugar molecule that faces the leading end, while the 3' carbon atom always faces the tail end.
		A nucleotide consists of either a nitrogenous heterocyclic base (purine or pyrimidine), a pentose sugar (ribose or deoxyribose) and a phosphate group attached at the 5' position on the sugar.
		A nucleoside consists of only a pentose sugar linked to a purine or pyrimidine base, without a phosphate group.
	www.chemicalland21.com /arokorhi/lifescience/phar/2'-DEOXY-5-BROMOURIDINE.htm

	Brookhaven Lab scientist wins Environmental Mutagen Society Award
		Specifically, Setlow is being honored for his discovery of nucleotide excision repair and the development of a method called bromouracil photolysis to study excision repair.
		In the early 1970s, Setlow and James Regan, a colleague at Oak Ridge National Laboratory, developed bromouracil photolysis, a method to measure DNA repair that became a standard technique.
		From the ultraviolet dose and the numbers of breaks, they were able to calculate the numbers and sizes of the repaired regions arising from chemical or physical agents in the environment.
	www.scienceblog.com /community/older/2002/F/20022056.html

	Magnetic Field Exposure Increases Cell Proliferation but Does Not Affect Melatonin Levels in the Mammary Gland of Female Sprague Dawley Rats -- Fedrowitz et al. 62 (5): 1356 -- Cancer Research
		The first cell was set at a potential of 300 mV (range: 5 µA) and the second at 600 mV (range: 50 nA).
		Acetone (vehicle control) or acetone with TPA were locally applied onto the skin covering the mammary complex, and rats were killed after 4.5 h.
		Effect of MF exposure (50-Hz, 100 µT) on BrdUrd and Ki-67 labeling in the cranial inguinal mammary complex ( Complex 5) of female SD rats.
	cancerres.aacrjournals.org /cgi/content/full/62/5/1356

	Chapter 10 Mutations Part 2
		Exposed to 5 times the acceptable level of radiation, he became constantly tired and sometimes had trouble walking.
		But he kept leaving his home, in Kiev, and journeying to Chernobyl so the world can know what is happening there.
		But his heroic effects to make that information available damaged his own body.
	www.evolution-facts.org /c10b.htm

	Bibliography of Kendric C. Smith
		K.C. Smith, Excerpta Medica International Congress Series No. 353, Volume 5, pp.
		Photochemical Reactions of Thymine, Uracil, Uridine, Cytosine and Bromouracil in Frozen Solution and in Dried Films.
		A Possible Model for the in vivo Cross-Linking of Deoxyribonucleic Acid and Protein by Ultraviolet Light.
	www.stanford.edu /~kendric/biblio.html

	Identification of amino acid-base contacts in the Myc-DNA complex by site-specific bromouracil mediated photocrosslinking -- Dong et al. 13 (1): 200 -- The EMBO Journal
		Identification of amino acid-base contacts in the Myc-DNA complex by site-specific bromouracil mediated photocrosslinking -- Dong et al.
		Identification of amino acid-base contacts in the Myc-DNA complex by site-specific bromouracil mediated photocrosslinking
	embojournal.npgjournals.com /cgi/content/abstract/13/1/200

	The RecOR proteins modulate RecA protein function at 5' ends of single-stranded DNA -- Bork et al. 20 (24): 7313 -- The EMBO Journal
		Within each set of four, reactions 1 and 2 show results with the homology located at the 5' end of the linear ssDNA, while reactions 3 and 4 show results with the homology located at the 3' end.
		M13mp8.1037(+) circular ssDNA was linearized with either Eco RI or Pst I to place the 1037 nt insert (open rectangle) at the 5' or 3' end, respectively.
		The reaction at the 5' end was increased even more, such that
	embojournal.npgjournals.com /cgi/content/full/20/24/7313

	A Fidelity Assay Using ``Dideoxy'' DNA Sequencing: A Measurement of Sequence Dependence and Frequency of Forming 5-bromouracil{middle dot} Guanine Base Mispairs -- Lasken and Goodman 82 (5): 1301 -- Proceedings of the National Academy of Sciences
		In a second experimental approach, base mispairing between bromouracil and guanine was demonstrated directly by using 5-bromodideoxyuridine 5'-triphosphate (BrddUTP).
		A Fidelity Assay Using ``Dideoxy'' DNA Sequencing: A Measurement of Sequence Dependence and Frequency of Forming 5-bromouracil{middle dot} Guanine Base Mispairs -- Lasken and Goodman 82 (5): 1301 -- Proceedings of the National Academy of Sciences
		The approach used here is not limited for use with nucleotide analogues but is generally applicable in determining misincorporation frequencies and sequence specificities for any deoxynucleoside triphosphate substrate.
	intl.pnas.org /cgi/content/abstract/82/5/1301

	ECSOC-5 Poster A0046 Some Heteroaromatic Organomercurials, Their Synthesis and Reactions: A Review of Own Research Works (1980-2000)
		The various methods for the direct iodination of furan and thiophene (and also other heterocycles) were very extensively reviewed in Ref. 55; they were also briefly reviewed in our paper [5].
		In our laboratory, we obtained the purified compound 4e in 27-90% yields, but only from the more reactive symmetric mercurial 5 [mercurial 4b did not react under the same reaction conditions].
		The cyano-demercuration reaction of symmetric mercurial 5 furnished twice as much of 4g as compared with unsymmetric mercurial 4b.
	www.mdpi.net /ecsoc-5/a0046r/a0046r.htm

	Strand breaks and alkali-labile bonds induced by ultraviolet light in DNA with 5-bromouracil in vivo -- Krasin and Hutchinson 24 (3): 657 -- Biophysical Journal
		bromouracil irradiated in the cells showed only 10--20% more breaks when
	www.biophysj.org /cgi/content/abstract/24/3/657

	genetics
		E coli has about 5 x 106 bp
		A cell is exposed to bromouracil, a base analog for thymine, that often combines with guanine instead of adenine.
		Describe how replica plating is used to distinguish between auxotrophs and prototrophs..
	biology.fullerton.edu /courses/biol_302/web/mutations.html

	5-Bromo-2'-deoxyuridine
		Synonyms: bromodeoxyuridine; 5-bromodeoxyuridine; bromouracil deoxyriboside; 5-bromouracil deoxyriboside; 5-bromouracil-2-deoxyriboside; broxuridine; BDU; 5-BDU; BRUDR; BUDR; 5-BUDR; 2'-Deoxy-5-bromouridine
	www.evol.nw.ru /~spirov/hazard/5-bromdeoxyuridine.html

	Involvement of Microsomal Cytochrome P450 and Cytosolic Thymidine Phosphorylase in 5-Fluorouracil Formation from Tegafur in Human Liver -- Komatsu et al. 7 (3): 675 -- Clinical Cancer Research
		Peak: 1, 5-FU; 2, 5- bromouracil (internal standard).
		Tatsumi K., Fukushima M., Shirasaka T., Fujii S. Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5- fluorouracil degradation in rat liver extracts.
		showed 5- and 3-fold interindividual differences at 100 µ
	clincancerres.aacrjournals.org /cgi/content/full/7/3/675

	5 : on Medical Dictionary Online
		5* 5a 5b 5c 5d 5e 5f 5g 5h 5i 5j 5k 5l 5m 5n 5o 5p 5q 5r 5s 5t 5u 5v 5w 5x 5y 5z
		5 Phospho alpha D Ribose 1 Diphosphate Synthetase
		5 Oxo L prolyl L histidyl L prolinamide
	www.online-medical-dictionary.org /?q=~5

	Exam 5
		Because of this, incorporation of 5-bromouracil into the DNA of an organism causes the organism to sustain high rates of mutation in which the majority of the mutagenic events would be transitions.
		____ The following sequence, 5' GGTTCC3', would be likely to serve as a recognition sequence for a restriction endonuclease.
	webpub.alleg.edu /employee/a/akleinsc/Bio_102/exams/exam5s96.htm

	Structural characterisation of the bromouracil.guanine base pair mismatch in a Z-DNA fragment -- Brown et al. 14 (4): 1801 -- Nucleic Acids Research
		The results are discussed in terms of the mutagenic properties of 5-
	nar.oupjournals.org /cgi/content/abstract/14/4/1801

	Double-strand breaks from single photochemical events in DNA containing 5-bromouracil -- Krasin and Hutchinson 24 (3): 645 -- Biophysical Journal
		Ultraviolet irradiation of Escherichia coli cells with a low level of 5-
		bromouracil incorporated produces DNA double-strand breaks by single
		by colony-forming ability) seems linear in the number of bromouracils
	www.biophysj.org /cgi/content/abstract/24/3/645

	New mechanism of action of the cancer chemotherapeutic agent 5- fluorouracil in human cells -- Wurzer et al. 269 (1): 39 -- Journal of Pharmacology And Experimental Therapeutics
		New mechanism of action of the cancer chemotherapeutic agent 5- fluorouracil in human cells -- Wurzer et al.
		although the 5- FlUra-UDG complex was easily dissociated in vitro.
		Articles by Wurzer, J. Articles by Sirover, M. New mechanism of action of the cancer chemotherapeutic agent 5- fluorouracil in human cells
	jpet.aspetjournals.org /cgi/content/abstract/269/1/39

	Sensitization of 1,3-bis(2-Chloroethyl)-1-nitrosourea and Cisplatin Cytotoxicity by 5-Bromo-2'-deoxyuridine in Human Glioma -- Mancini et al. 289 (3): 1404 -- Journal of Pharmacology And Experimental Therapeutics
		The same reasoning can be applied to include bromouracil as a site of alkylation.
		Cultures in log or plateau growth were exposed to 14 µM BrdUrd in the absence or presence of 5 nM FdUrd for 24 h before GC/MS analysis.
		Stetson PL, Maybaum J, Shukla UA and Ensminger WD (1986) Simultaneous determination of thymine and bromouracil in DNA hydrolysates using gas chromatography-mass spectrometry with selected-ion monitoring.
	jpet.aspetjournals.org /cgi/content/full/289/3/1404

	George Streisinger, December 27, 1927—September 5, 1984 By Franklin W. Stahl Biographical Memoirs
		George Streisinger, December 27, 1927—September 5, 1984
		GEORGE STREISINGER was a leading contributor to the genetics of the T-even bacterial viruses, culminating in his demonstration and rationalization of the circular linkage map.
	stills.nap.edu /readingroom/books/biomems/gstreisinger.html

	Enhanced Antitumor Activity of 5-Fluorouracil in Combination with 2'-Deoxyinosine in Human Colorectal Cell Lines and Human Colon Tumor Xenografts -- Ciccolini et al. 6 (4): 1529 -- Clinical Cancer Research
		FUra for 5 h, whereas a total inhibition (100%) was observed
		with TS, DNA, and RNA, respectively (3, 4, 5), attempts to
		100 RP18 5 µm column (Hewlett Packard) eluted by 50 m
	clincancerres.aacrjournals.org /cgi/content/full/6/4/1529

	Probing biomolecules: Gas phase experiments and biological relevance
		Hence bromouracil potentially may be used as a tumour specific sensitiser in cancer therapy.
		[5] B. Boudaïffa, P. Cloutier, D. Hunting, M.A. Huels and L. Sanche, Science 287 (2000) 1658
		Negative ions observed in low energy electron impact to gas phase bromouracil.
	www.europhysicsnews.com /full/18/article7/article7.html

	STN Easy: Transcript
		5 nm and a broad band at 400-425 nm.
		No significant optical absorption by the bromouracil anion was obsd.
		As as example, bromouracil reacts with e-aq to produce bromide ions.
	userpage.chemie.fu-berlin.de /fb_chemie/ipc/illewww/literatur/Gasphase/borhalogenide

	Roles of 5-substituents of tRNA wobble uridines in the recognition of purine-ending codons -- Takai and Yokoyama 31 (22): 6383 -- Nucleic Acids Research
		also contributes to the stabilization of the C3'-endo form ( 5, 10).
		directly to position 5 of the uracil ring.
		U is much more in its C2'-endo form than pU.
	nar.oupjournals.org /cgi/content/full/31/22/6383

	M-DNA is stabilised in G*C tracts or by incorporation of 5-fluorouracil -- Wood et al. 30 (10): 2244 -- Nucleic Acids Research
		5 for the Zn form is not directly comparable with that of Figure
		72°C step being elongated by 5 s and a final 72°C step
		The buffer contained 5 mM NaCl with 10
	www.nar.oupjournals.org /cgi/content/full/30/10/2244

	Bromouracil
		Please See 5-bromouracil For Further Information about Bromouracil.
	www.bambooweb.com /articles/b/r/Bromouracil.html

	AIDSDRUGS Structures
		Bromodeoxyuridine ; Broxuridine ; 5-Bromo-2'-deoxyuridine ; 5-Bromodeoxyuridine ; 5-Bromodesoxyuridine ; Bromouridine ; Bromouracil deoxyriboside ; 5-Bromouracil deoxyriboside ; 5-Bromouracil-2-deoxyriboside
		Dacarbazine ; DTIC ; DTIC-Dome ; 5(or 4)-(dimethyltriazeno)imidazole-4 (or 5)-carboxamide ; DIC ; Dacatic ; Deticene ; 5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide ; 1H-Imidazole-4-carboxamide, 5- (3,4-dimethyl-1-triazenyl)-
		Dapsone has been used in conjunction with trimethoprim for the treatment of initial episodes of Pneumocystis carinii pneumonia; prophylactic therapy for the primary and secondary prevention of Pneumocystis carinii pneumonia.
	chem.sis.nlm.nih.gov /aidsdrg4.html

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Topic: 5-bromouracil

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In the News (Sat 26 May 12)