| | Johns Hopkins CMM Graduate Program Faculty (Site not responding. Last check: 2007-11-01) |
 | | GSTP1 is normally expressed in prostate basal epithelial cells, the stem cells for the prostatic epithelium, but not in columnar secretory epithelial cells. |
 | | In proliferative inflammatory atrophy (PIA) lesions, the earliest precursors to prostatic intraepithelial neoplasia (PIN) and to prostate cancer, GSTP1 appears induced as part of a stress response associated with exposure to inflammatory oxidants. |
 | | Loss of GSTP1 expression, attributable to GSTP1 CpG island hypermethylation, is characteristic of ~70% of PIN lesions and >90% of prostate cancers. |
| www.hopkinsmedicine.org /graduateprograms/cmm/nelson.html (328 words) |