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| | ABC1 based therapy :Drug News |
 | | The gene, ABC1, was discovered by genetic screening of individuals with Tangier disease. |
 | | This disease is caused by mutations in the ABC1 gene, leading to reduced high density lipoprotein levels and, consequently, increased risk of heart disease. |
 | | Preclinical studies, reported in the October 1999 issue of the Journal of Clinical Investigation, show that modulation of ABC1 activity effects cellular cholesterol efflux, and conversely the gene is modulated by cellular cholesterol levels. |
| www.ims-global.com /insight/drugs_news/drugs_news_991025.htm (162 words) |
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