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Topic: AIDS vaccine


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  First AIDS Vaccine Made at NIAID's Vaccine Research Center Enters Clinical Trial   (Site not responding. Last check: 2007-10-24)
Because the vaccine does not contain genetic material for the whole virus, it is impossible for someone to become infected with HIV or to develop AIDS from the vaccine.
The development of vaccines and the prevention of disease have been part of the history of the NIH since it was founded in 1887.
Vaccines against Rocky Mountain spotted fever, typhus, adenovirus, hemophilus influenzae B and hepatitis A are among the stellar accomplishments of NIH scientists.
www.niaid.nih.gov /newsroom/releases/vaccinemade.htm   (991 words)

  
 Wired 11.01: Testing the First AIDS Vaccine
AIDS killed 3 million people in 2001 (the most recent year for which statistics are available), more than 15,000 of them in North America.
The fate of gp120 was nearly sealed in a Bethesda, Maryland, hotel ballroom on June 17, 1994, at a meeting of the AIDS Research Advisory Committee of the National Institute for Allergy and Infectious Diseases.
Moreover, since no vaccine is 100 percent effective, some at-risk subjects are bound to become infected in the course of a vaccine trail.) At the same time, groups like ACT UP charged that money for gp120 trials would divert funds from research into drugs for treating the disease, then regarded as 100 percent fatal.
www.wired.com /wired/archive/11.01/aids.html   (1242 words)

  
 The Body: HIV Infection and AIDS: An Overview
AIDS (acquired immunodeficiency syndrome) was first reported in the United States in 1981 and has since become a major worldwide epidemic.
People with AIDS are also particularly prone to developing various cancers, especially those caused by viruses such as Kaposi's sarcoma and cervical cancer, or cancers of the immune system known as lymphomas.
Because no vaccine for HIV is available, the only way to prevent infection by the virus is to avoid behaviors that put you at risk of infection, such as sharing needles and having unprotected sex.
www.thebody.com /niaid/stds/aids.html   (3185 words)

  
 C&EN: SCIENCE & TECHNOLOGY - AIDS VACCINES LURCH FORWARD
New organizations like the International AIDS Vaccine Initiative, fed up with the paralysis of analysis permeating the field, are mobilizing to strong-arm potential vaccines into clinical trials in record time.
For example, the world's largest vaccine manufacturer, Aventis Pasteur in France, has a number of AIDS vaccine candidates, some in Phase I clinical trials, based on canarypox--a cousin of smallpox that infects birds.
Vaccine volunteers are a special breed, a staff member told Thomas on one of her visits.
pubs.acs.org /cen/topstory/7935/7935sci1.html   (5476 words)

  
 HealthScout-Consumer Health News, Information and Resources Updated Daily-Mental-Many Distrust AIDS Vaccine Trials   (Site not responding. Last check: 2007-10-24)
While vaccines now protect against a variety of illnesses from chicken pox and polio to smallpox, scientists say the AIDS virus has turned out to be a much tougher customer.
Still, researchers are continuing to develop vaccines, and about 30 clinical trials are now underway in the United States, Murguia said.
Also, 47 percent of the fls surveyed believe that an HIV vaccine already exists and is being kept secret; 27 percent of the Latinos believed that, as did 13 percent of gay and bisexual men.
www.healthscout.com /news/1/529243/main.html   (410 words)

  
 Seventh International Conference on AIDS: Vaccine Development
Although vaccines have traditionally been used to prevent uninfected individuals from acquiring a new infection, much of the HIV-related vaccine research is expected to be of use to people who are already HIV-positive.
There are currently 13 vaccines in various stages of human testing around the world, including six which are being used in HIV-positive volunteers in an attempt to produce an effective immune response against the virus.
In order for a vaccine to be useful in this population, the immune response to the vaccine will have to be more effective than that which occurs in the great majority of people after HIV infection.
www.aids.org /atn/a-130-03.html   (2035 words)

  
 ScienceDaily: AIDS Vaccine Developed At Emory And The NIH Moves To Clinical Trials
Yerkes scientists are on the forefront of developing vaccines for AIDS and malaria, and treatments for cocaine addiction, Parkinson's disease and cardiovascular disease.
Pneumococcal Vaccine Significantly Reduces Disease In South African Children (October 2, 2003) -- In a clinical trial conducted in nearly 40,000 young children in Soweto, South Africa, a pneumococcal conjugate vaccine aimed at nine strains of disease reduced the incidence of pneumonia in fully...
Vaccination -- Vaccination is the process of administering live, albeit weakened, microbes to patients, with the intent of conferring immunity against a targeted form of a related disease...
www.sciencedaily.com /releases/2003/01/030124074122.htm   (1930 words)

  
 AIDS Vaccine Dangers
He claims that the current vaccine methods are unsafe and may put the world population at jeopardy from a mutated version of the HIV 1 virus.
Veljkovic concludes in his studies that "despite the urgent need for preventive AIDS vaccines, it would be wise to introduce a moratorium on clinical trials until there is a serious reexamination of the current concepts for their development.
You also suggest that the Vaccine development may lead to a "super bug" of HIV which spreads though populations, undetectable and via Bacterial and virus infectious in a manner that is not necessarily though sexual contact or other traditional means of HIV infections.
www.newstrolls.com /news/dev/CJ/vaccine/103098.htm   (1299 words)

  
 AVAC - Home
The AIDS Vaccine Advocacy Coalition (AVAC) is a community and consumer based organization, founded in December 1995 to accelerate the ethical development and global delivery of vaccines against HIV/AIDS.
AVAC working in collaboration with the Alliance for Microbicide Development, the International AIDS Vaccine Initiative and the UNAIDS Resource Tracking Unit has generated estimates of investment in and expenditures on AIDS vaccine and Microbicide R&D from 2000 to 2004 and preliminary investment estimates for 2005.
AVAC's AIDS Vaccine Clearinghouse is an on-line compendium of materials on AIDS vaccine research and a link to other people and organizations concerned about AIDS vaccine advocacy, research, and global delivery.
www.avac.org   (2175 words)

  
 World AIDS Vaccine Day and the Global Call for Action | IAVI - International AIDS Vaccine Initiative
The genesis for establishing 18 May as World AIDS Vaccine Day was inspired by a challenge laid down by former President Bill Clinton on 18 May 1997.
In a commencement speech given at Morgan State University, President Clinton called on the world to develop an AIDS vaccine, indicating that the magnitude of this search is comparable to the quest to put a man on the moon.
Global support to find a preventive AIDS vaccine is as important today as it was in 1997 and in 2001.
www.iavi.org /callforaction   (464 words)

  
 New Scientist Breaking News - AIDS vaccine years away, researchers warn   (Site not responding. Last check: 2007-10-24)
A vaccine for AIDS is still years away, warns a new report, with progress being hampered by a lack of scientific, political and economic interest.
Only one vaccine candidate has been tested fully to see if it can work in humans, says Seth Berkley, president and CEO of the International AIDS Vaccine Initiative (IAVI), which released its progress report on Monday.
He says the number of vaccine candidates is three times what it was at the time of the last International AIDS conference in Barcelona, Spain, in 2002.
www.newscientist.com /article.ns?id=dn6140   (530 words)

  
 BBC NEWS | Health | Aids vaccine only limited success
The first Aids vaccine to be tested on humans does not protect the general population as a whole.
To be granted a licence, scientists needed to show that any Aids vaccine was effective in at least a third of patients.
A number of other vaccines based on the same principle are in earlier stages of development.
news.bbc.co.uk /2/hi/health/2793017.stm   (712 words)

  
 Online NewsHour: Targeting AIDS -- June 27, 2001
Although there are promising approaches on the horizon, only one proposed AIDS vaccine is far enough along the research pipeline that it's being tested for effectiveness in large groups of people.
But in vaccines until, let's say, five years ago, we were talking about maybe $100 million globally, and on vaccines for the developing world, a few million dollars a year, almost nothing.
So a measles vaccine is designed to wake up these immune system cells to recognize the measles virus early, then clear the virus from the body before it can cause disease.
www.pbs.org /newshour/bb/health/jan-june01/aids_6-27.html   (1581 words)

  
 Harvard Gazette: New AIDS vaccine tested in U.S., Africa
Tests of a new vaccine against the virus that causes AIDS are being launched simultaneously in the United States and southern Africa.
If the vaccine raises no safety problems and it stimulates a protective response, then hundreds or thousands of people will be recruited to participate in tests of its ability to prevent HIV infection and AIDS.
If a vaccinated individual becomes exposed to the AIDS virus by having sex with an infected person, or using contaminated needles to inject drugs, the immunized cells attack any HIV-infected cells that enter the body.
www.news.harvard.edu /gazette/2003/05.29/01-aidsvax.html   (782 words)

  
 AIDS Vaccine Fails, Yet Yields Hope - CBS News
Experts believe a vaccine is the most promising way to slow the worldwide AIDS epidemic, which has already killed 20 million people and infected 40 million more.
The soaring increase in AIDS cases in the developing world, especially Africa, has increased the urgency of efforts to develop a vaccine.
Elizabeth Kaledin reports that although the first human trials for an AIDS vaccine were a failure, there are signs the tests may not have been a total loss.
www.cbsnews.com /stories/2003/02/24/health/main541631.shtml   (1213 words)

  
 HIV Report Jan 2003: The HIV/AIDS Vaccine Research Effort   (Site not responding. Last check: 2007-10-24)
There are at least two successful vaccines against animal diseases caused by retroviruses, one for cats against a feline retrovirus and one against EIAV, an important retroviral infection in horses, and these vaccines argue powerfully that vaccines can work against retroviruses, though neither disease is an ideal model for HIV in humans.
The VRC of NIH is pursuing DNA vaccines with multiclade env (envelope) components from clades A, B, and C of HIV-1.
Participants in all phases of HIV vaccine trials may become HIV infected in the course of the trials, and in efficacy trials this is virtually assured for some proportion of placebo recipients.
www.hopkins-aids.edu /publications/report/jan03_3.html   (1505 words)

  
 WHO | The African AIDS Vaccine Programme (AAVP)
A group of African scientists, meeting in Nairobi on 14 June 2000, adopted "The Nairobi Declaration: An African Appeal for an AIDS Vaccine", pledging to use their personal and collective commitment and expertise in the development and implementation of an African Strategy for AIDS Vaccines.
AIDS Vaccine 2005 International Conference was organized by the Canadian Network for Vaccines and Immunotherapeutics (CANVAC).
The WHO-UNAIDS HIV Vaccine Initiative is a joint activity of the World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS).
www.who.int /vaccine_research/diseases/hiv/aavp/en   (297 words)

  
 Many Distrust AIDS Vaccine Trials - HIV: health and medical information about HIV and AIDS   (Site not responding. Last check: 2007-10-24)
The new study on attitudes toward HIV vaccine trials also found that many people weren't aware that AIDS vaccines do not cause HIV infection.
Seventy-eight percent of fls thought that testing a vaccine could cause infection, 58 percent of Latinos believed so, as did 68 percent of gay and bisexual men.
If a vaccine works properly, the body will be prepared to immediately swing into action when a real HIV infection comes along.
www.medicinenet.com /script/main/art.asp?articlekey=55418   (749 words)

  
 USATODAY.com - Search for AIDS vaccine falters   (Site not responding. Last check: 2007-10-24)
BANGKOK — The two-decade search for an AIDS vaccine, the only way to end the global crisis, is all but starting over, researchers here said Monday.
The search for an AIDS vaccine has long been overshadowed by the search for new AIDS drugs, which are far more profitable because patients must take them for life.
Gayle is a co-chair of the Global HIV Vaccine Enterprise, a consortium of research agencies launched by the Gates Foundation last year to jump-start vaccine research.
www.usatoday.com /news/health/2004-07-13-aids-vaccine_x.htm   (538 words)

  
 Polio vaccines and the origin of AIDS
One theory of the origin of AIDS is that it developed from contaminated vaccines used in the world's first mass immunisation for polio.
The earliest known cases of AIDS occurred in central Africa, in the same regions where Koprowski's polio vaccine was given to over a million people in 1957-1960.
Koprowski's polio vaccine was given to many children less than one month old, before their immune systems were fully developed.
www.uow.edu.au /arts/sts/bmartin/dissent/documents/AIDS   (2022 words)

  
 BBC NEWS | Health | New hope for Aids vaccine
The head of VaxGen, Donald Francis, said the vaccine worked on chimpanzees and he was optimistic about the results of trials on humans, due to be published next year.
VaxGen's vaccine will be part of the biggest-ever HIV vaccine trial due to begin later this year in Thailand with the involvement of 16,000 people.
Jose Esparza, co-ordinator of the UNAids HIV vaccine initiative in Geneva, said VaxGen's announcement was "premature", although he praised the company's commitment to developing a vaccine.
news.bbc.co.uk /1/hi/health/2115217.stm   (746 words)

  
 First AIDS Vaccine Fails
A hero in the early days of the AIDS epidemic, Francis' prestige and persistence was the main reason AIDSVAX made it to clinical trials.
Francis insisted that with millions of lives at stake, the vaccine should be put to the test.
It was hoped that if the vaccine didn't prevent HIV infection, it would at least slow the relentless progression of AIDS.
www.webmd.com /content/article/76/90305.htm   (435 words)

  
 Human Test: Novel Vaccine Stops HIV
The vaccine is made from a patient's own dendritic cells and HIV isolated from the patient's own blood.
It's still not clear which patients do best with the vaccine, although there's evidence that vaccination should be given as soon after HIV infection as possible.
Only clinical trials comparing people who get the vaccine to those who don't can show whether this vaccine really is an effective AIDS therapy.
www.webmd.com /content/article/97/104268.htm?z=1727_00000_5024_hv_03   (367 words)

  
 Next Generation Biodefense Vaccines & Biologic Products : VaxGen Inc.
VaxGen, Inc. is a biopharmaceutical company focused on the development, manufacture and commercialization of biologic products for the prevention and treatment of human infectious disease.
Based in the San Francisco Bay area, VaxGen is currently developing next-generation vaccines against anthrax and smallpox.
The company was selected by the U.S. government to provide 75 million doses of a recombinant anthrax vaccine for civilian biodefense.
www.vaxgen.com   (136 words)

  
 Wired News: Gene Boost for AIDS Vaccine
Adding an immune system gene to an AIDS vaccine makes it work better and may be a first step toward stemming the spread of the deadly disease, researchers say.
Although they say they are still a long way away from coming up with a vaccine that will completely protect people from the HIV virus, the researchers think their approach could at least help people stay healthier if they do become infected, and make them less likely to transmit the infection to others.
He says such a vaccine will be no cure for HIV but might help people who do become infected develop a milder form of disease.
www.wired.com /news/technology/0,1282,35651,00.html?tw=wn20000414   (806 words)

  
 International AIDS Vaccine Initiative | GlobalGiving
Volunteers for a preventive AIDS vaccine often face major obstacles in reaching the testing center.
Additional space/equipment are needed at the Kangemi clinic to accommodate AIDS vaccine clinical trials.
Strengthening voluntary HIV counseling and testing (VCT) services is essential to an AIDS vaccine clinical trials program to select volunteers not infected with HIV for study.
www.globalgiving.com /fm/spiavi1.html   (272 words)

  
 IFPMA Health Initiatives: HIV/AIDS: International AIDS Vaccine Initiative (IAVI)
The International AIDS Vaccine Initiative (IAVI) was created in 1996 out of the recognition that the best long-term solution to the growing AIDS epidemic is a vaccine.
As a global organization operating across borders to meet the challenges posed by the epide-mic, IAVI is working to ensure the develop-ment of safe, effective, accessible and pre-ventive HIV vaccines for use throughout the world.
IAVI collaborates with developing countries, governments and international agencies that are dedicated to accelerating the development of a vaccine to halt the AIDS epidemic.
www.ifpma.org /Health/hiv/health_iavi_hiv.aspx   (218 words)

  
 IAEN: International AIDS Economics Network: AIDS Vaccine   (Site not responding. Last check: 2007-10-24)
However, global spending on AIDS vaccine RandD is pitifully small—only $300-600 million/year, and focused on the strains of the virus and the eventual market in North America and Western Europe.
Accelerating an AIDS vaccine for developing countries: Recommendations for the World Bank.
The Ministry of Health of Brazil and the World Bank’s AIDS Vaccine Task Force convened a meeting to share the Task Force’s findings regarding the mechanisms available to the Bank to accelerate the development of an AIDS vaccine and to solicit the views of Brazilian policymakers, scientists and NGOs on these issues.
www.iaen.org /vacc   (710 words)

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