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| | MVS Solutions - SIVmac239 Immunogenic Plasmids and AIDS DNA Vaccine Containing the Same |
 | | To the contrary, it has been found that plasmid DNA, when administered to primates, induced humoral immune response and cell-mediated immune respone, and effectively induced Thl (T helper-1) bias immune response and CTL response, which are known to be important for protection against viruses such as HIV-1, especially in small animals, monkeys, chimpanzees and humans. |
 | | In the present invention, the first immunogenic plasmid construct includes the nucleotide sequence corresponding to the protease coding part (not the full-length sequence) of the structural gene pol, which is expressed herein as "dpol". |
 | | In addition, it is possible to inhibit the activity of integrase by modifying coding sequences in which Aspll6, Asp64 and Glu152 are conserved. |
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