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Topic: AZT

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Zidovudine

Antiretroviral drug

HAART

Reverse transcriptase

HIV

HIV vaccine

AIDS reappraisal

AIDS in Africa

Integrase

OPV AIDS hypothesis

HIV test

Mutation

IUPAC name

DNA polymerase

Retrovirus

	Zidovudine - Wikipedia, the free encyclopedia
		AZT has been shown to work additively or synergistically with many anti-HIV agents, however, acyclovir and ribavirin decrease the antiviral effect of AZT.
		At present, AZT is recommended to be given in combination with another reverse transcriptase inhibitor and a protease inhibitor.
		During prolonged AZT treatment the HIV-virus has the ability to gain an increased resistance to AZT by mutation of the reverse transcriptase.
	en.wikipedia.org /wiki/AZT (1098 words)

	AZT on Encyclopedia.com (Site not responding. Last check: 2007-11-06)
		AZT affects HIV's ability to reproduce by inhibiting the transcription of RNA to DNA.
		Although AZT can be helpful in the short term by promoting weight gain, decreasing the number of opportunistic infections, and improving T4 (CD4) lymphocyte counts (see immunity), some researcher believe studies of its effectiveness to be flawed and regard the drug as too toxic for long-term use.
		AZT does not cure or prevent AIDS, nor does it keep one from transmitting the virus to others, although some studies show that it does lessen the possibility that an HIV-infected mother will transmit the virus to her fetus.
	www.encyclopedia.com /html/A/AZ1T1.asp (563 words)

	AZT - HIV/AIDS - AEGIS (Site not responding. Last check: 2007-11-06)
		AZT is one of the few anti-HIV drugs that cross the blood-brain barrier.
		AZT is better than most other drugs in attacking the virus in the CNS.
		AZT is a nucleoside reverse transcriptase inhibitor (sometimes called "nuke").
	www.aegis.com /topics/azt.html (331 words)

	HIV & AIDS - A Critical Analysis of the Pharmacology of AZT and its Use in AIDS
		AZT is the first drug introduced to treat HIV infection and still remains the most frequently used drug for this purpose.
		AZT is a thymidine analogue in which the 3'-hydroxy (—OH) group is replaced by an azido (=N) group.
		However, the first data on the bioavailability of AZT were not obtained until the first clinical trial, where it was found that the maximum plasma concentration was reached about 1 h after the oral administration of AZT and was 1.5—2 mmol/l with a 2 mg/kg dose, and 4—6 mmol/l with a dose of 10 mg/kg.
	www.virusmyth.net /aids/data/epazt2.htm (18372 words)

	eIoNews.com eyeIreland Online News
		AZT also disrupts cell division by perturbing the relative levels of natural nucleotide pools, with the drug acting as a ‘sink’ and sponging up phosphate molecules essential to the process.
		Thus AZT in combination with other drugs has proved to be invaluable for the treatment of those already infected with HIV and has also proved to be a potent preventative agent in the mother-to-child setting and for occupational exposures.
		AZT caused deficits in growth, rooting and snouting reflexes, and the ability to fixate and follow near stimuli visually.” The latter indications of neurological damage were anticipated in their 1994 paper in the same journal, Fetal toxicity of zidovudine in Macaca nemestrina: preliminary observations.
	www.aidsmyth.addr.com /debatingazt/debatingazt.htm (9628 words)

	AZT (Retrovir) \| The New Mexico Aids Info Net
		AZT was the first drug approved for the treatment of HIV.
		But AZT is used as part of combination therapy for people who are exposed to HIV through a workplace accident (needle stick or splash).
		AZT greatly reduces transmission of HIV from the mother to her child.
	www.aidsinfonet.org /articles.php?articleID=411 (742 words)

	Referenced quotes on AZT (Zidovudine, ZDV, Retrovir)
		AZT, also known as Zidovudine, ZDV and Retrovir, is one of the most commonly prescribed anti-HIV drugs, and the main drug prescribed to prevent transmission of HIV from mother to child.
		AZT incorporation into nuclear and mitochondrial DNA was detected in multiple organs of transplacentally exposed mice and monkeys...AZT is genotoxic in fetal mice and monkeys and is a moderately strong transplacental carcinogen in mice examined at 1 year of age ”
		AZT effects were most prominent in female offspring, with a significant threefold increase in lung tumors, a reduction in lymphoblastic and follicle center cell lymphomas, and a significant increase in histiocytic sarcomas (0 in controls, 3% after low-dose AZT, and 8% after high-dose AZT, p = 0.022).
	aras.ab.ca /azt.html (12999 words)

	AZT and AIDS, The Relationship Between HIV and AIDS
		In this study, which led to the approval of AZT by the FDA, only one of 145 patients treated with AZT died compared with 19 of 137 placebo recipients in a six month period.
		In addition to reducing mortality, AZT was shown to have reduced the frequency and severity of AIDS-associated opportunistic infections, improved body weight, prevented deterioration in Karnofsky performance score, and increased counts of CD4+ T lymphocytes in the peripheral blood (Fischl et al., 1987; Richman et al., 1987).
		In that study, AZT was superior to placebo in delaying progression to AIDS or advanced ARC for approximately one year, and a more prolonged benefit was seen among a subset of patients.
	www.niaid.nih.gov /publications/hivaids/23.htm (1018 words)

	Nightmare on AZT Street (Site not responding. Last check: 2007-11-06)
		The worst news for AZT and its manufacturer Burroughs Wellcome, however, is probably yet to come, when the birth defects found in babies born to women treated with AZT while pregnant become common knowledge among patients, clinicians, and researchers-and the press.
		In a full 25 percent of the 104 women followed in the Asian study, the child either died (from spontaneous or induced abortion, due to abnormalities), or was born with a birth defect.
		Four outcomes of the pregnancy and AZT treatment were recorded: (a) birth defects; (b) lack of birth defects; (c) spontaneous fetal death; (d) induced abortion.
	www.chronicillnet.org /online/AZT.html (1952 words)

	HIV & AIDS - AIDS; With Therapies Like This, Who Needs Disease? (Site not responding. Last check: 2007-11-06)
		AZT kills dividing cells anywhere in the body-causing ulcerations and hemorrhaging; damage to hair follicles and skin; killing mitochondria, the energy cells of the brain; wasting away of muscles; and the destruction of the immune system and other blood cells.
		AZT, known for decades as a failed and toxic cancer chemotherapy, was resurrected for political reasons and rushed through the FDA's first fasttrack approval.
		Though AZT is widely claimed to have been deemed "safe" in pregnant women, in fact, the FDA did not think so and never allowed pregnant women to take it prior to this study, primarily because it was classified as mutagenic.
	www.virusmyth.com /aids/data/pdazt.htm (20449 words)

	HEAL Toronto: AZT
		AZT is a prescription drug and according to the manufacturer itself it causes symptoms that are indistinguishable from AIDS.
		It is a fairly well established fact that AZT was designed to kill the bone marrow.
		AZT was developed back in the 1960's as a cancer chemotherapy and was shelved because it failed in animal experiments.
	www.healtoronto.com /azt1.html (1121 words)

	AZT vs (Site not responding. Last check: 2007-11-06)
		Mitsuya and others stated that AZT triphosphate (AZTTP) was formed in vitro from AZT within human immune cells and blocked HIV replication by 100%, protecting cells from HIV while allowing immune cells to function essentially normally (Mitsuya and others1985).
		AZT reportedly reliably eliminated detectable HIV in peripheral white blood cells (PBMCs) at the highest doses of 5 mg/kg (Yarchoan and others 1986).
		AZT might kill the AIDS-associated opportunistic infections in the short term while further suppressing immunity, hence appearing to heal while harming.
	members.fortunecity.com /briancady413/index.html (6781 words)

	AZT Label (Site not responding. Last check: 2007-11-06)
		This is what the patient never sees, an actual copy of an AZT label.
		This label has appeared on bottles containing as little as 25 milligrams, a small fraction (1/20 to 1/50) of some patients' daily prescribed dose.
		For additional information, see the AZT pages at HEAL Toronto and Virus Myth.
	www.rethinking.org /aids/AZTLabel.html (51 words)

	HIV & AIDS - AZT, Retrovir ®, zidovudine, azidothymidine, Glaxo Wellcome SmithKline Beecham
		Peter Duesberg's story on AZT, more about the AZT epidemic, and his evidence that AZT accelerates death, and his study on the drug's toxicity.
		Other books about AZT are John Lauritsen's book 'Poison by Prescription', Bruce Nussbaum's 'Good Intention', and Martin Walker's 'Dirty Medicine'.
		Some of the FDA documents released under the US Act of Freedom of Information showing the AZT phase II study, the study upon which the drug was released in the U.S.A. and many other countries, to be fraudulent and worthless.
	www.virusmyth.net /aids/index/azt.htm (540 words)

	ZIDOVUDINE - AZT, ZDV a Commonly Used Medication (Site not responding. Last check: 2007-11-06)
		ZIDOVUDINE - AZT, ZDV a Commonly Used Medication
		Treatment of HIV infection when CDC count is < 500/mm3 or symptomatic.
		Acetominophen, probenecid, cimetidine, indomethacin, lorazepam, or aspirin may inhibit excretion and contribute to toxicity.
	www.hivdent.org /drugs/ZIDOVUDINE.htm (176 words)

	Stories of Discovery: New Treatments for HIV Infection: Prolonging and Improving Life
		The first anti-HIV drug, zidovudine (AZT), was originally developed in 1964 as a possible cancer treatment but was found to be ineffective against tumor cells.
		However, collaboration between the National Cancer Institute and the pharmaceutical company Burroughs Wellcome led to the discovery in the early 1980s of AZT's ability to suppress HIV replication in the test tube and paved the way for clinical trials of AZT.
		In addition, combining 3TC with AZT slowed the virus from developing resistance to AZT and, in some cases, restored AZT sensitivity in patients who carried virus that had become resistant to the drug.
	www.niaid.nih.gov /publications/discovery/thiv.htm (1562 words)

	Retrovir brand zidovudine (AZT): a complete guide from AIDSmeds.com
		For a description of the life-cycle of the AIDS virus, and the targets of each class of drugs, click here.
		AZT Treatment Has Reduced Mother to Infant HIV Transmission in the US by 67 Percent (8/12/99)
		One important clinical trial conducted by the U.S. government (ACTG 076) demonstrated that AZT treatment during pregnancy can reduce this risk to 8%.
	www.aidsmeds.com /drugs/Retrovir.htm (1880 words)

	Simple FactSheet: zidovudine (AZT, Retrovir)
		Zidovudine, trade name Retrovir (also known as AZT or ZDV) was the first drug approved for the treatment of HIV.
		Retrovir is an anti-HIV treatment in a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs).
		Glaxo-Wellcome, who make zidovudine (AZT, Retrovir), have an assistance program to help people having difficulty affording the drug.
	www.atdn.org /simple/zido.html (652 words)

	Retrovir (zidovudine, AZT) - Complete Drug Summary
		South Africa Recommends Against Use of Nevirapine or AZT Alone in Pregnant Women to Prevent Mother-to-Child Transmission of HIV
		Canadian Supreme Court Upholds GlaxoSmithKline's Canadian AZT Patent
		New Findings Suggest Significant Amount of AZT (Zidovudine, Retrovir) AZT May Be Metabolized to D4T (Stavudine, Zerit)
	www.hivandhepatitis.com /hiv_and_aids/retrovir_1.html (630 words)

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