
	Where results make sense

Topic: Acarbose

Related Topics

Antidiabetic

Pioglitazone

Rosiglitazone

Sulfonylurea

Thiazolidinedione

Metformin

Pharmacology

Endocrine

In the News (Wed 15 Feb 12)

EXECUTIVE POWER

Iran

ANALYSIS

Pakistan

Family compact

	Acarbose Treatment Decreases Risk of Cardiovascular Disease - February 1, 2004 - American Family Physician
		Acarbose therapy increased the probability that patients would remain free of cardiovascular events (hazard ratio of 0.51), with 32 in the placebo group and 15 in the acarbose group having at least one cardiovascular event.
		Acarbose treatment lowered the risk of developing hypertension, with 78 patients (11 percent) developing hypertension in the acarbose group, compared with 115 (17 percent) in the placebo group, a relative risk reduction of 34 percent and an absolute risk reduction of 5.3 percent.
		Acarbose was associated with a significant reduction in cardiovascular events in a group of participants with impaired glucose tolerance.
	www.aafp.org /afp/20040201/tips/40.html (612 words)

	Acarbose patient advice including side effects
		Acarbose is an oral medication used to treat type 2 (noninsulin-dependent) diabetes when high blood sugar levels cannot be controlled by diet alone.
		Acarbose may be taken alone or in combination with certain other diabetes medications such as Diabinese, Micronase, Glucophage, and Insulin.
		Acarbose is usually taken 3 times a day with the first bite of each main meal.
	www.drugs.com /pdr/ACARBOSE.html (1246 words)

	Acarbose Delays Onset of Type 2 Diabetes Mellitus - October 15, 2002 - American Family Physician
		Chiasson and colleagues studied the efficacy of the alpha-glucosidase inhibitor acarbose in preventing or delaying conversion of impaired glucose tolerance to type 2 diabetes.
		Thirty percent of the acarbose group and 18 percent of the placebo group discontinued the study.
		The authors call for acarbose to be used either alone or in combination with lifestyle modifications to delay the onset of diabetes in patients with impaired glucose tolerance.
	www.aafp.org /afp/20021015/tips/4.html (817 words)

	acarbose - Diabetes Mellitus, Type 2, Type 1, and Metabolic Disorders treatment and medications
		Acarbose is a man-made oligosaccharide designed to slow down the actions of alpha-amylase and alpha-glucosidase enzymes thereby slowing the appearance of sugar in the blood after a meal.
		Acarbose can be used alone to treat type II diabetes or can be combined with sulfonylureas such as glyburide (Diabeta) or metformin (Glucophage) or with insulin.
		Acarbose therapy is not advised in the presence of certain medical conditions such as inflammatory bowel disease or intestinal obstruction and chronic intestinal diseases that interfere with digestion or absorption such as Crohn's disease.
	www.medicinenet.com /acarbose/article.htm (692 words)

	acarbose - [Medication]
		Acarbose delays the digestion of carbohydrates (forms of sugar) in the body.
		Acarbose is used to treat type 2 diabetes.
		Acarbose is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d03846a1.htm (1319 words)

	Acarbose
		The effect of acarbose to enhance glycemic control is additive to that of other hypoglycemic agents when used in combination.
		It is not known whether acarbose is excreted in human milk.
		In general, acarbose may be used in combination with other agents (eg, sulfonylurea, metformin) or as monotherapy for patients with Type 2 diabetes.
	www.musc.edu /pharmacyservices/Drugs/A/Acarbose.htm (1029 words)

	DrugsWatcher.com Articles on Drug names > ACARBOSE (Site not responding. Last check: 2007-09-17)
		If mild to moderate hypoglycemia occurs while taking acarbose in combination with another anti-diabetic agent, the hypoglycemia should be treated with oral glucose (dextrose) instead of sucrose (table sugar) because acarbose blocks the digestion of sucrose to glucose, and hypoglycemia will not be corrected rapidly with sucrose.
		Acarbose (also known as Glucobay ®) is a drug that is used in the treatment of diabetes because it helps control blood sugar levels by slowing down the digestion of carbohydrates (simple and complex starches/ sugars) from the diet.
		Acarbose is Prescribed for: It is believed that strict sugar control in diabetics decreases the risk of eye, kidney, and nerve damage.
	www.drugswatcher.com /ACARBOSE_s60.html (1058 words)

	Taifo Mahmud Laboratory, Oregon State University (Site not responding. Last check: 2007-09-17)
		Acarbose is a useful drug for the treatment of type II insulin-independent diabetes and is the first alpha-glucosidase inhibitor available in the US (known as Precose, Bayer Corporation).
		Structurally, acarbose represents a pseudotetrasaccharide, consisting of an unsaturated aminocyclitol, valienamine, a deoxyhexose and maltose.
		The pseudodisaccharide core structure, known as acarviosine, which is composed of valienamine and the deoxyhexose, is postulated to be essential for its biological activity.
	oregonstate.edu /~mahmudt/acarbose.html (242 words)

	MoreLife: Prescription Drugs - Acarbose
		In a study "aimed to assess the efficacy of acarbose on postprandial metabolic parameters and endothelial function in type 2 diabetic patients.
		The 6-year Early Diabetes Intervention Trial (EDIT), comparing the effect of acarbose 50mg three times daily to that of metformin, showed a trend to a positive effect of acarbose compared with placebo, in a mid-term 3-year analysis, which should be confirmed in the final analysis.
		In addition, acarbose was generally well tolerated and safe in the elderly; most discontinuations were due to gastrointestinal side effects such as flatulence and diarrhea.
	morelife.org /prescripdrugs/acarbose.html (2209 words)

	Acarbose - Drugs & Vitamins - Drug Library - DrugDigest
		Acarbose is not effective if not taken during a meal.
		Acarbose does not cause symptoms of hypoglycemia (too low blood sugar) by itself, but if given with another antidiabetic medicine, it may increase their potential to lower blood sugar.
		If you are taking acarbose with other diabetic medications: Because acarbose prevents the breakdown of table sugar you must always keep a supply of glucose or dextrose tablets or solution readily available to treat low blood sugar events if they occur.
	www.drugdigest.org /DD/DVH/Uses/0,3915,1\|Acarbose,00.html (950 words)

	Identification, Cloning, Expression, and Characterization of the Extracellular Acarbose-Modifying Glycosyltransferase, ...
		mixtures of acarbose homologues (16.6 mg/ml) as acceptor and donor
		The three acidic amino acid residues of the active site (catalytic triade), which are also conserved in most of the proteins of the amylase family, are shown in boldface (15).
		Acarbose, a pseudooligosaccharide, is transported but not metabolized by the maltose/maltodextrin system of Escherichia coli.
	jb.asm.org /cgi/content/full/183/15/4484 (4736 words)

	Acarbose delays onset of type 2 diabetes mellitus - Patient-Oriented Evidence that Matters - Brief Article Journal of ...
		To minimize gastrointestinal side effects, patients randomized to acarbose were started at 50 mg/day and gradually increased to a maximum of 100 mg 3 times a day with meals or to the maximum tolerated dose.
		When acarbose was stopped at the end of the study period, more patients who had been treated with acarbose developed diabetes in the next 3 months than did patients who were treated with placebo (15% vs 11%).
		It is unclear whether acarbose actually prevents diabetes or just delays its onset, and whether acarbose reduces morbidity or mortality secondary to diabetes.
	www.findarticles.com /p/articles/mi_m0689/is_9_51/ai_91750320 (816 words)

	Acarbose Drug Information
		Acarbose (AY-car-bose) is used to treat a type of diabetes mellitus called type 2 diabetes.
		Acarbose lowers your blood sugar by preventing the breakdown of starch into sugar.
		However, low blood sugar can occur if you take acarbose with another type of diabetes medicine, delay or miss a meal or snack, exercise more than usual, drink alcohol, or cannot eat because of nausea or vomiting.
	www.drugs.com /cons/Acarbose.html (1801 words)

	warfarinfo
		Acarbose is used for the treatment of types I and II diabetes mellitus by influencing the metabolism and absorption of carbohydrates by inhibiting enzymes in the intestinal brush border and pancreatic amylase.
		He began acarbose to help with his diabetes and his INR rose from 3.09 to 4.85 in two weeks.
		Acarbose was discontinued and the INR returned to 2.84 in 14 days.
	www.warfarinfo.com /acarbose.htm (228 words)

	Acarbose - Wikipedia, the free encyclopedia
		Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes.
		Acarbose inhibits enzymes needed to digest carbohydrates: specifically alpha-glucosidase enzymes in the brush border of the small intestines and it inhibits pancreatic alpha-amylase.
		Since acarbose prevents the digestion of complex carbohydrates, the drug should be taken at the start of main meals.
	en.wikipedia.org /wiki/Acarbose (366 words)

	ACARBOSE / GLUCOBAY
		Acarbose also has important implications for the ageing process.
		Using Acarbose to reduce the amount of sugar the body produces will in turn reduce the levels of insulin produced.
		For this same reason, Acarbose is often used in the treatment of diabetes.
	www.antiaging-systems.com /a2z/acarbose.htm (385 words)

	Acarbose for Prevention of Type 2 Diabetes Mellitus: the STOP-NIDDM Randomised Trial (NDEI.ORG)
		At the end of the study, treatment with placebo for 3 months was associated with an increase in conversion of impaired glucose tolerance to diabetes.
		INTERPRETATION: Acarbose could be used, either as an alternative or in addition to changes in lifestyle, to delay development of type 2 diabetes in patients with impaired glucose tolerance.
		Acarbose Slows Progression of Intima-Media Thickness of the Carotid Arteries in Subjects with Impaired Glucose Tolerance R2
	www.ndei.org /v2/website/litalerts/article.cfm?article_id=425 (365 words)

	Acarbose (Systemic)
		Acarbose (AY-car-bose) is used to treat a type of diabetes mellitus (sugar diabetes) called type 2 diabetes.
		Acarbose has not been studied in pregnant women.
		Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of acarbose in children with use in other age groups.
	allnutritionals.com /drugs/a/acarbose-systemic.shtml (1539 words)

	MedlinePlus Drug Information: Acarbose
		Acarbose is used (with diet only or diet and other medications) to treat type 2 (noninsulin- dependent) diabetes (high blood sugar).
		Because acarbose blocks the breakdown of table sugar and other complex sugars, fruit juice or other products containing these sugars will not help to increase blood sugar.
		It is important that you and other members of your household understand this difference between acarbose and other medications used to treat diabetes.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a696015.html (785 words)

	Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term ...
		Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term studies -- Hanefeld et al.
		Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term studies
		Acarbose treatment reduces the risk of cardiovascular disease and hypertension in subjects with impaired glucose tolerance: The STOP-NIDDM trial.
	eurheartj.oxfordjournals.org /cgi/content/full/25/1/10 (3298 words)

	Healthopedia.com - Acarbose (Oral) (Precose) - Drugs Information, Side Effects, & Interactions
		You should not use this medicine if you have had an allergic reaction to acarbose or if you have a bowel disorder such as colitis, Crohn's disease, or a blockage in your bowel.
		Because of the way acarbose works, it is likely to cause gas.
		Acarbose by itself should not cause low blood sugar the way some other medicines to treat diabetes can.
	www.healthopedia.com /drugs/quick/acarbose (715 words)

	The Efficacy of Acarbose in the Treatment of Patients with Non-Insulin-dependent Diabetes Mellitus: A Multicenter ...
		P values are for differences between acarbose and placebo at the end of the study.
		Effect of acarbose on carbohydrate and lipid metabolism in NIDDM patients poorly controlled by sulfonylureas.
		Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release
	www.annals.org /cgi/content/full/121/12/928 (5637 words)

	Precose Online, Description, Chemistry, Ingredients - Acarbose - RxList Monographs
		PRECOSE ® (acarbose tablets) is an oral alpha-glucosidase inhibitor for use in the management of type 2 diabetes mellitus.
		Acarbose is an oligosaccharide which is obtained from fermentation processes of a microorganism, Actinoplanes utahensis, and is chemically known as O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-
		It is a white to off-white powder with a molecular weight of 645.6.
	www.rxlist.com /cgi/generic/acarbose.htm (133 words)

	Acarbose - Patient UK
		Acarbose can be used with other treatments to treat Type 2 (non-insulin dependent) diabetes mellitus.
		Acarbose works by delaying the digestion and absorption of starch and sugar, this reduces the high blood glucose levels which usually occur following a meal in diabetics.
		Your doctor may want you to have a blood test or adjust the dose of acarbose you are taking.
	www.patient.co.uk /showdoc/30002698 (1110 words)

	Acarbose Slows Progression of Intima-Media Thickness of the Carotid Arteries in Subjects With Impaired Glucose ...
		Acarbose Slows Progression of Intima-Media Thickness of the Carotid Arteries in Subjects With Impaired Glucose Tolerance -- Hanefeld et al.
		Acarbose Slows Progression of Intima-Media Thickness of the Carotid Arteries in Subjects With Impaired Glucose Tolerance
		The effect of acarbose on insulin sensitivity in subjects with impaired glucose tolerance.
	stroke.ahajournals.org /cgi/content/full/35/5/1073 (2995 words)

	Modes of Action of Acarbose Hydrolysis and Transglycosylation Catalyzed by a Thermostable Maltogenic Amylase, the Gene ...
		Modes of Action of Acarbose Hydrolysis and Transglycosylation Catalyzed by a Thermostable Maltogenic Amylase, the Gene for Which Was Cloned from a Thermus Strain -- Kim et al.
		The transferring activity of ThMA was investigated by using acarbose as a donor and 17 different carbohydrates as acceptors.
		X-ray structure of cyclodextrin glycosyltransferase complexed with acarbose: implications for the catalytic mechanism of glycosidases.
	aem.asm.org /cgi/content/full/65/4/1644 (4346 words)

	JAMA -- Acarbose for Patients With Hypertension and Impaired Glucose Tolerance, December 17, 2003, Kaiser and Sawicki ...
		JAMA -- Acarbose for Patients With Hypertension and Impaired Glucose Tolerance, December 17, 2003, Kaiser and Sawicki 290 (23): 3066
		Acarbose for Patients With Hypertension and Impaired Glucose Tolerance
		Acarbose for Patients With Hypertension and Impaired Glucose Tolerance—Reply
	jama.ama-assn.org /cgi/content/extract/290/23/3066-a (213 words)

	No relationship between carbohydrate intake and effect of acarbose on HbA1c or gastrointestinal symptoms in type 2 ...
		No relationship between carbohydrate intake and effect of acarbose on HbA1c or gastrointestinal symptoms in type 2 diabetic subjects consuming 30-60% of energy from carbohydrate -- Wolever et al.
		acarbose to be effective in improving blood glucose control in the
		Acarbose in obese patients with polycystic ovarian syndrome: a double-blind, randomized, placebo-controlled study
	care.diabetesjournals.org /cgi/content/abstract/21/10/1612 (469 words)

	Acarbose treatment decreases risk of cardiovascular disease - Tips from Other Journals American Family Physician - Find ...
		Hyperglycemia, particularly postprandial hyperglycemia, is thought to be an independent risk factor for cardiovascular disease in patients with diabetes.
		The STOP-Noninsulin-Dependent Diabetes Mellitus (STOP-NIDDM) trial demonstrated that acarbose, an alpha-glucosidase inhibitor, decreased diabetes risk in patients with impaired glucose tolerance.
		All were instructed to follow a weight-reduction or a weight-maintenance diet and to exercise.
	www.findarticles.com /p/articles/mi_m3225/is_3_69/ai_112915168 (594 words)

Try your search on: Qwika (all wikis)