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Topic: Acepromazine


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In the News (Sun 27 May 12)

  
  Acepromazine Maleate For Veterinary Use
Acepromazine maleate is a phenothiazine derivative that is used as a neuroleptic agent in veterinary medicine.
Acepromazine is metabolized by the liver and excreted in the urine.
Acepromazine is also used in horses that are prone to exertional rhabdomyolysis both as a preventative, and as a part of the treatment due to its vasodilatory properties.
www.wedgewoodpharmacy.com /monographs/AcepromazineMaleate.asp   (1272 words)

  
 Acepromazine (PromAce®, Aceproject® ) - PetPlace.com   (Site not responding. Last check: 2007-11-06)
Acepromazine is related to the drugs chlorpromazine (Thorazine®), another tranquilizer, and to prochloperazine (Compazine®), a drug used to prevent vomiting.
Acepromazine is frequently used in combination with other sedatives and anesthetics to provide smoother sedation and decreased doses of other anesthetics.
Acepromazine often is used as a pre-surgical tranquilizer and may be combined with opiates (morphine-like drugs) to achieve profound sedation.
www.petplace.com /articles/artShow.asp?artID=1497   (758 words)

  
 Acepromazine
Acepromazine not only allays the fear through tranquilization but helps keeps the heart rhythm stable.
Acepromazine is also classified as an antihistamine; however, due to its healing tranquilizing properties it would not be used as such.
Acepromazine should not be used with Organophosphate insecticides.
www.marvistavet.com /html/body_acepromazine.html   (600 words)

  
 Acepromazine   (Site not responding. Last check: 2007-11-06)
Acepromazine is one of the most commonly used tranquilizers in veterinary medicine.
The recommended dosage for acepromazine is 0.25mg to 1mg per pound of body weight.
Despite this, acepromazine does have some significant effects that must be considered.
www.vetinfo.com /dencyclopedia/deace.html   (395 words)

  
 New Document   (Site not responding. Last check: 2007-11-06)
Acepromazine is commonly combined with opioids as a preanesthetic drug and has antiemetic properties.
The purpose of this study was to evaluate the antiemetic properties of acepromazine in dogs receiving opioids as a preanesthetic.
In conclusion, acepromazine administered 15 minutes before the opioid reduces the incidence of vomiting induced by opioids.
www.acva.org /professional/abstracts/am0210_3.htm   (289 words)

  
 vpanaest
Acepromazine is indicated as a pre-anæsthetic, anti-emetic, and also for the treatment of itching and motion sickness.
In general, dogs are more sensitive to the effects of acepromazine (especially giant breeds, greyhounds, and boxers), however terriers exhibit a high degree of resistance to its effects.
In horses and dogs, acepromazine may cause a prolapse of the membrana nictitans (a secondary eyelid), which would also decrease the value of a show animal.
faculty.swosu.edu /scott.long/vtph/vpanaest.htm   (1249 words)

  
 POLICIES
Acepromazine is extremely widely used by veterinarians and considering the potentially serious consequences such a reaction could have, particularly if it involved children, it would be prudent for veterinarians to be aware of this possible reaction and act pro-actively.
Acepromazine is often prescribed by veterinarians for the treatment of behaviour problems, especially in dogs.
Acepromazine is not indicated for the treatment of behavioural disorders such as sound phobias and aggression.
www.savc.co.za /policies.htm   (10049 words)

  
 Medication - Acepromazine   (Site not responding. Last check: 2007-11-06)
He reveiwed his records and gave acepromazine again, but to give him 3 25mg tablets 2 hrs.
I know this drug is classified as a major transquiler, but it seemed to have no effect last year.
I can't remember exactly what I said, but I was trying to explain that the reason acepromazine isn't ideal for controlling dogs with aggressive tendencies is that they can overcome the effect -- exactly what you saw.
www.vetinfo.com /dogace.html   (1763 words)

  
 Boxer Health Issues
Acepromazine, a tranquilizer, that is often used as a pre-anasthetic agent, should not be used for the Boxer.
The announcements suggested that Acepromazine should nob be used in dogs of the Boxer breed because of a breed-related sensitivity to the drug.
Aortic Stenosis is a narrowing of the outflow channel between the left ventricle and the main artery of the body, the aorta.
www.canadasguidetodogs.com /boxer/boxerhealth.htm   (1012 words)

  
 VMED 7412 - Anesthesiology - Spring Semester, 2003
acepromazine is a commonly chosen tranquilizer because it provides a useful degree of tranquilization in most animals and is relatively safe.
In brachycephalic dogs or cats which often have an elevated vagal outflow, acepromazine occasionally causes syncope associated with bradycardia.  This reaction, which is particularly common in boxers, can be averted by using a low dose of acepromazine and concurrently administering an anticholinergic agent.
Their sedative properties are synergistic with those of acepromazine and the benzodiazepines.  Atropine is administered in conjunction with opioids to avoid opioid-induced bradycardia.
www.cvm.okstate.edu /courses/vmed5412/Lect16.asp   (847 words)

  
 DCPAH - Newsletter   (Site not responding. Last check: 2007-11-06)
Acepromazine Maleate is a safe and effective phenothiazine tranquilizer that is commonly used in veterinary medicine without adverse effects, except for idiosyncratic reactions, which may include profound aggression* and bradycardia.**   The intent of this report is to heighten awareness about possible adverse idiosyncratic drug reactions, especially in the Boxer breed.
One idiosyncratic reaction to Acepromazine Maleate is profound aggression, which may occur within 15 minutes of administration and persist for a variable time.
Although a definitive cause of death of the 2 dogs submitted to the AHDL was not determined, the history of death a short time after administration of Acepromazine Maleate in apparently healthy dogs is strong evidence for an idiosyncratic drug reaction.
www.ahdl.msu.edu /Newsletter/17_1.htm   (1167 words)

  
 Acepromazine
Acepromazine is used as a sedative and a preanesthetic agent.
Acepromazine may also be used to help manage feline urinary tract disease.
- Acepromazine should not be given to animals with strychnine or organophosphate poisoning or within one month of worming with an organophosphate agent.
www.cpvh.com /Pharmacy/ph1.html   (424 words)

  
 22-2/L.I. Stowell/Suicide with the Veterinary Drug Acepromazine   (Site not responding. Last check: 2007-11-06)
After a single-step liquid–liquid alkaline extraction, acepromazine was identified in a chest-cavity blood sample using gas chromatography (GC) with nitrogen-phosphorus (NPD) and mass selective detectors.
Acepromazine was then quantitated in the blood and other postmortem tissues by GC with NPD using chlorpromazine as the internal standard.
Acepromazine concentrations in the chest-cavity blood, liver, brain, and bile were 0.6, 3.0, 0.4, and 6.5
www.jatox.com /abstracts/1998/mar-apr/stomiab.htm   (129 words)

  
 The Internet Vet Column, Volume 2, Number 14   (Site not responding. Last check: 2007-11-06)
The article says that a mixture of 3 milliliters of 10 milligrams/milliliters Acepromazine injectable in 27 milliliters of tap water given at a dosage of 12 drops once or twice daily in food will change the nature of the cat's saliva so that the cat will not cause as bad of an allergic reaction.
Acepromazine could be used to reduce itching in a cat or dog (not a common use of it), but I don't think that is what is being asked.
Some cats react to oral acepromazine with excitation; I would advice close observation to be sure a cat thusly dosed doesn't react abnormally.
www.io.com /~tittle/ivc/1995/internet-vet.2.14.html   (1058 words)

  
 Purina Cat Chow: Cat Care Center: Physical
Acepromazine is a tranquilizer approved for use in dogs, cats and horses.
Many veterinarians use acepromazine as a means of chemical restraint for patients that are too difficult to handle.
Many veterinarians will also prescribe acepromazine as a tranquilizer for animals that are about to travel by car or plane.
www.catchow.com /catcarecenter_physical3.aspx?combinedID=20621   (189 words)

  
 Thermo Electron Corporation - - App. Note 318: Determination of Acepromazine and its Major Metabolite in Equine Serum ...
Acepromazine is widely used as a sedative in horses.
Acepromazine has been classified by the Association of Racing Commissioners International, Inc. as a Class 3 drug in horses.
Acepromazine has a slow elimination rate and stays in the body for a long time.
www.thermo.com /com/cda/products/product_application_details/1,1063,11683,00.html   (220 words)

  
 Vedco Products   (Site not responding. Last check: 2007-11-06)
ACEPROMAZINE MALEATE INJECTION can be used as an aid in controlling intractable animals during examination, treatment, grooming, x-ray and minor surgical procedures; as a pre-anesthetic agent.
Acepromazine maleate has a depressant effect on the central nervous system and therefore causes sedation, muscular relaxation and a reduction in spontaneous activity.
ACEPROMAZINE MALEATE INJECTION is a sterile solution which may be given intravenously, intramuscularly or subcutaneously.
www.vedco.com /products/productpages/FMPro_2.htm   (793 words)

  
 Vedco Products   (Site not responding. Last check: 2007-11-06)
ACEPROMAZINE TABLETS can be used as an aid in controlling intractable animals during examination, treatment, grooming, x-ray and minor surgical procedures; as a pre-anesthetic agent.
Tranquilizers should be administered in smaller doses and with greater care during general anesthesia and also to animals exhibiting symptoms of stress, debilitation, cardiac disease, sympathetic blockage, hypovolemia or shock.
Acepromazine, like other phenothiazine derivatives, is detoxified in the liver; therefore, it should be used with caution on animals with a previous history of liver dysfunction or leukopenia.
www.vedco.com /products/productpages/FMPro_3.htm   (592 words)

  
 Acepromazine - effects on pulmonary gas exchange in horses
This study was undertaken to study pulmonary gas exchange and cardiovascular responses to sedation achieved with romifidine and butorphanol (RB) alone, or combined with acepromazine, and during subsequent tiletaminezolazepam anaesthesia in horses.
Acepromazine added to RB generally improved haemodynamic variables and arterial oxygenation during sedation and anaesthesia.
Arterial oxygenation was impaired as a result of increased shunt and mismatch during anaesthesia, although acepromazine treatment reduced disturbances and falls in PaO2 to some extent.
www.vetcontact.com /en/art.php?a=763&t=   (632 words)

  
 NIOSH FACE Program: Kentucky Case Report 03KY134 | CDC/NIOSH
Although the Acepromazine label indicates it is for use only in dogs, interviews with veterinarians and internet searches indicate Acepromazine is commonly used in horses.
According to several veterinarians, Xylazine and Acepromazine are commonly mixed together to sedate a horse.
It is unknown if the farm manager thought he was using Acepromazine, or if he knew the vial actually contained Xylazine, or if he thought the vial contained a mixture of both.
www.cdc.gov /Niosh/face/stateface/ky/03ky134.html   (1707 words)

  
 NBR - ACE warning #1   (Site not responding. Last check: 2007-11-06)
That drug is Acepromazine, a tranquilizer, that is often used as a preanesthetic agent.
It also causes a profound hypotension (severe lowering of the blood pressure) in many Boxers that are given the drug.
The announcement suggested that acepromazine should not be used in dogs of the Boxer breed because of a breed-related sensitivity to the drug.
www.boxerrescue.com /ace1.htm   (217 words)

  
 Acepromazine
I have read of a few people who have used Ace on their sheepies with great success for preventing panic from fireworks.
Boxers have very adverse reactions to it and should have never been prescribed by the vet for her.
I am not sure if there are other breeds too that experience such bad side effects but acepromazine for Boxers should be forbidden.
www.oes.org /page2/1149~Acepromazine.html   (1674 words)

  
 ACEPROMAZINE
There is one drug commonly used in anesthetic protocols that should not be used in the Boxer.
The drug is Acepromazine, a tranquilizer, which is often used as a preanesthetic agent.
In the Boxer, it tends to cause a problem called first degree heart block, a potentially serious arrhythmia of the heart.
www.cinemaboxers.com /acepromazine.htm   (325 words)

  
 Boxer Rescue and Adoption, Inc.
The drug is Acepromazine, a tranquilizer, which is often used as a pre-anesthetic agent.
The "Handbook of Veterinary Drugs" has a section on ACEPROMAZINE, which states that, "Prolonged effects of the drug may be seen in older animals.
And, for added measure, I have the veterinary staff put a notice on my dogs' charts stating that I do not want Acepromazine to be used.
www.va-boxerrescue.org /acepromazine.htm   (352 words)

  
 Comparison of sedative and cardiorespiratory effects of diazepam, acepromazine, and xylazine in ferrets -- Ko et al. 34 ...
Comparison of sedative and cardiorespiratory effects of diazepam, acepromazine, and xylazine in ferrets -- Ko et al.
The sedative and cardiorespiratory effects of an intramuscular injection of diazepam (3 mg/kg body weight), acepromazine (0.1 mg/kg body weight), or xylazine (2 mg/kg body weight) in ferrets (n = 10, crossover design) was evaluated.
Duration of recumbency expressed as mean+/-standard deviation was significantly longer with xylazine (68.3+/-20.8 min) than with diazepam (43.2+/-8.2 min) or acepromazine (49.8+/-11.2 min).
www.jaaha.org /cgi/content/abstract/34/3/234   (236 words)

  
 Acepromazine (Promace) - VeterinaryPartner.com - a VIN company!
There is another use of acepromazine that is more controversial and that is in the management of a cat belonging to an owner who is allergic to cat dander.
A very dilute solution of acepromazine generally made from the injectable product is given to the cat orally with the dose gradually increasing; the idea is that the cat will become less allergenic.
Results have been mixed and success may simply represent a placebo effect; however, if this is something you wish to try, discuss the protocol with your veterinarian.
www.veterinarypartner.com /Content.plx?P=A&S=0&C=0&A=570   (758 words)

  
 The use of Acepromazine (ace) in horses
Acepromazine is a very useful tranquilizer that depresses the central nervous system, causing sedation, relaxation, and a reduction in involuntary movements.
Acepromazine may be used as a sedative to facilitate handling of the animal during diagnostic procedures, veterinary treatments, shipping or other situations which require a "tranquilizer.' The veterinarian will also use acepromazine during minor or major surgical procedures alone or in combination with local or general anesthetics.
Horses should be muzzled or restrained on crossties with an attendant present, until they have become alert after the use of this phenothiazine tranquilizer.
horseproducts.stablemade.com /_Articles/ace.htm   (1377 words)

  
 [No title]
A combination of morphine and acepromazine will be used in the dogs.
A dose of morphine (1 mg/kg of a 15 mg/ml solution), mixed with acepromazine (0.1 mg/mg of a 2 mg/ml solution) in the same syringe.
Morphine and acepromazine may result in emesis in the dog as well as bradycardia.
education.vetmed.vt.edu /Curriculum/VM8354/clintech_gct/Techniques/lab4_sht.htm   (419 words)

  
 A Previously Unidentified Acepromazine Metabolite ...   (Site not responding. Last check: 2007-11-06)
High-performance liquid chromatography–diode-array detection results obtained during the investigation of two cases involving acepromazine prompted us to study the stability of the drug in blood.
It was found that acepromazine can undergo in vitro conversion by human red blood cells to 2-(1-hydroxyethyl)-promazine, a product that has been reported as a minor urinary metabolite in horse urine but not previously identified in humans.
Further, our analytical findings in the two cases examined suggest that 2-(1-hydroxyethyl)promazine may be the major unconjugated metabolite of acepromazine in humans.
www.jatox.com /abstracts/1999/september/367-elliott.htm   (145 words)

  
 Acepromazine Warning   (Site not responding. Last check: 2007-11-06)
placed in the cardiology section entitled "Acepromazine and Boxers." This described several adverse reactions to the drug in a very
Acepromazine should not be used in dogs of the boxer breed because of breed related sensitivity to the drug
This drug is the most commonly prescribed tranquilizer in veterinary medicine.
hometown.aol.com /drboxer/aceprom.html   (201 words)

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