
	Where results make sense

Topic: Acetaldehyde dehydrogenase

Related Topics

Acetic acid

In the News (Thu 9 Jul 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Acetaldehyde dehydrogenase - Wikipedia, the free encyclopedia
		Acetaldehyde dehydrogenase (EC 1.2.1.10) is a dehydrogenase enzyme that converts acetaldehyde into acetic acid.
		In the liver, the enzyme alcohol dehydrogenase oxidizes ethanol into acetaldehyde, which is then further converted into the harmless acetic acid by acetaldehyde dehydrogenase.
		Individuals with deficient acetaldehyde dehydrogenase activity are far less likely to become alcoholics, but seem to be at a greater risk of liver damage, alcohol-induced asthma, and contracting cancers of the oro-pharynx and oesophagus due to acetaldehyde overexposure.
	en.wikipedia.org /wiki/Acetaldehyde_dehydrogenase (226 words)

	Acetaldehyde - Wikipedia, the free encyclopedia
		It melts at -123.5° C and boils at 21 °C. Acetaldehyde occurs naturally in ripe fruit, coffee, and fresh bread and is produced by plants as part of their normal metabolism.
		In the liver, the enzyme alcohol dehydrogenase converts ethanol into acetaldehyde, which is then further converted into the harmless acetic acid by acetaldehyde dehydrogenase.
		In the chemical industry, acetaldehyde is mainly used as an intermediary to produce acetic acid, certain esters, and a number of other chemicals.
	en.wikipedia.org /wiki/Acetaldehyde (382 words)

	Acetaldehyde (EHC 167, 1995)
		Acetaldehyde is metabolized by mouse and rat embryonic tissue in vitro.
		Acetaldehyde is a volatile liquid with a pungent, suffocating odour that is fruity in dilute concentrations.
		Acetaldehyde is also used in perfumes, aniline dyes, plastics, in the manufacture of synthetic rubber, in the silvering of mirrors, in the hardening of gelatin fibres, and in the laboratory (Verschueren, 1983).
	www.inchem.org /documents/ehc/ehc/ehc167.htm (12782 words)

	Can heavy alcohol use lead to some kinds of cancer?
		Those with the normal ALDH enzyme were able to remove the acetaldehyde, likely formed in the parotid gland, before it was secreted to their saliva.
		Which is not to say that normal ALDH levels completely protect heavy drinkers from salivary acetaldehyde; Salaspuro noted that Caucasians that drank heavily for a number of years had much higher rates (20 fold) of esophageal cancer.
		The higher the acetaldehyde levels in the saliva, the higher the risk of digestive tract cancer.
	www.eurekalert.org /pub_releases/2000-06/ACER-Chau-2106100.php (880 words)

	ALD6 - Magnesium-activated aldehyde dehydrogenase, cytosolic (Site not responding. Last check: 2007-11-06)
		Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae: role of the cytosolic Mg(2+) and mitochondrial K(+) acetaldehyde dehydrogenases Ald6p and Ald4p in acetate formation during alcoholic fermentation.
		ALD6 is a homologue of ALD4 (Potassium-activated aldehyde dehydrogenase, mitochondrial precursor) from Saccharomyces cerevisiae.
		ALD6 is a homologue of ALDH2 (Aldehyde dehydrogenase, mitochondrial precursor) from Homo sapiens.
	www.pdg.cnb.uam.es /UniPub/iHOP/gg/36075.html (850 words)

	Acetaldehyde (IARC Summary & Evaluation, Volume 71, 1999) (Site not responding. Last check: 2007-11-06)
		An increased relative frequency of bronchial and oral cavity tumours was found among nine cancer cases in one study of chemical workers exposed to various aldehydes.
		Acetaldehyde was tested for carcinogenicity in rats by inhalation exposure and in hamsters by inhalation exposure and by intratracheal instillation.
		Acetaldehyde causes gene mutations in bacteria and gene mutations, sister chromatid exchanges, micronuclei and aneuploidy in cultured mammalian cells, without metabolic activation.
	www.inchem.org /documents/iarc/vol71/005-acetaldehyde.html (417 words)

	Hangover Helper (Site not responding. Last check: 2007-11-06)
		Acetaldehyde is then eventually broken down by acetaldehyde dehydrogenase into a benign substance called acetate.
		Acetaldehyde and cysteine have a high affinity between one another and once bound, the complex is removed from the body.
		Second, as mentioned before glutathione is a helper substance to the enzymes (alcohol dehydrogenase and acetaldehyde dehydrogenase) that are responsible for alcohol metabolism.
	www.hangoverhelper.com /Pages/how_it_works.html (1854 words)

	Howstuffworks "How Hangovers Work"
		The acetaldehyde is then attacked by another enzyme, acetaldehyde dehydrogenase, and another substance called glutathione, which contains high quantities of cysteine (a substance that is attracted to acetaldehyde).
		Together, the acetaldehyde dehydrogenase and the glutathione form the nontoxic acetate (a substance similar to vinegar).
		In studies that blocked the enzyme that breaks down acetaldehyde (acetaldehyde dehydrogenase) with a drug called Antabuse, designed to fight alcoholism, acetaldehyde toxicity resulted in headaches and vomiting so bad that even alcoholics were wary of their next drink.
	health.howstuffworks.com /hangover4.htm (285 words)

	RU21 - Buy RU-21 Now Online at RU-21Australia.com RU-21 the KGB Hangover Pill (Site not responding. Last check: 2007-11-06)
		Acetaldehyde is an extremely toxic compound believed to be responsible for both, most alcohol-related diseases and the addictive process itself.
		Further, the acceleration of decomposition of acetaldehyde and acetic acid into CO2 and H2O and the energizing of mitochondria were accomplished through activation of aerobic oxidation processes in mitochondria by way of introducing substrates (Succinic Acid, Fumaric Acid), which activate the second half-cycle of tricarboxylic acids.
		Succinate substrate, which is independent of NADN-dehydrogenase, prevents acetaldehyde from causing hypoxia, which often results from the accumulation of suboxidized metabolites, and from impeding NADN oxidation in the respiratory chain of cells.
	www.ru-21australia.com (644 words)

	ACETALDEHYDE PRODUCTION AND METABOLISM BY HUMAN INDIGENOUS AND PROBIOTIC LACTOBACILLUS AND BIFIDOBACTERIUM STRAINS -- ...
		Acetaldehyde (500 µM, final concentration at the beginning of the incubation) during metabolism was measured a 1-h incubation at 37°C. Results are expressed as means of two determinations (horizontal bars).
		Acetaldehyde metabolism in the presence of ethanol by Lactobacillus and Bifidobacterium strains.
		Acetaldehyde (500 µM, final concentration at the beginning of the incubation) in the presence of 22 mM ethanol (final concentration) was during a 1 h incubation at 37°C. Results are expressed as means of two determinations (horizontal bars).
	alcalc.oxfordjournals.org /cgi/content/full/35/6/561 (3569 words)

	[No title]
		Since this appeared to substantiate the fact that tobacco was addictive (recall acetaldehyde is in tobacco smoke) the company decided not to publish his results (so goes his fairly well substantiated claim).
		It appears there is a range of disparity between the enzymes which allows the acetaldehyde build up to the point that THIQ is formed, but not so much that the person suffers too much of this effect when they drink.
		Last, determining the genetic markers for acetaldehyde production, and correlating them with incidence rates in genetic groups, and with individuals who have been shown to be particularly susceptible to alcohol addiction.
	www.cs.cmu.edu /afs/cs.cmu.edu/user/ehn/Web/release/thiq.html (1377 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		The conversion of ethanol to acetaldehyde by intact cells of wild and mutant strains of methylotrophic yeast Hansenula polymorpha was studied.
		It was established that mutations that lower the activity of aldehyde reductase and acetaldehyde dehydrogenase stimulate acetaldehyde accumulation.
		The highest accumulation of acetaldehyde was found in a mutant that possessed increased alcohol oxidase activity in growth on a medium with glucose.
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=61859 (223 words)

	CERI: Living with Alcohol
		Even in people who do not have this genetic trait, acetaldehyde dehydrogenase is often unable to fully keep up with the production of acetaldehyde during alcohol intoxication.
		The toxicity of acetaldehyde is mitigated to a significant extent by alcohol itself.
		The conversion of alcohol into acetaldehyde by alcohol dehydrogenase and acetaldehyde into acetate by acetaldehyde dehydrogenase results in the generation of NADH (reduced nicotinamide adenine dinucleotide).
	www.ceri.com /alcohol.htm (2249 words)

	[No title] (Site not responding. Last check: 2007-11-06)
		The version of alcohol dehydrogenase in women is less effective than that in men, which is part of the reason that women have a lower tolerance for alcohol than men do.
		Acetaldehyde (CH CHO), also known as ethanal, is a highly reactive flammable liquid with a strong fruity smell.
		The acetaldehyde is converted by acetaldehyde dehydrogenase into acetic acid, which is harmless.
	mywebpages.comcast.net /benbrew/bbb2.html (194 words)

	Nutrition and alcoholism
		Acetaldehyde from the alcohol dehydrogenase reaction is extremely toxic and may cause several kinds of damage.
		Acetaldehyde also competes for the plasma carrier of pyridoxal (vitamin B6).
		The caloric output in terms of NADH is less than for the normal alcohol dehydrogenase system but, more important, the system will add to the load of acetaldehyde and acetate and interfere with the normal functioning of the P450 system.
	www.hscbklyn.edu /SUNY/Biochem/ALCOHOL/alcohol_overview.html (993 words)

	[No title]
		Alcohol dehydrogenase and acetaldehyde dehydrogenase are normal enzymes in the liver which metabolize alcohol to harmless metabolic intermediates.
		Ethanol is metabolized to acetaldehyde, a very toxic substance, by alcohol dehydrogenase (ADH), and the acetaldehyde is metabolized to acetic acid by acetaldehyde dehydrogenase.
		The degree of facial flushing was correlated directly with the concentration of acetaldehyde in breath or blood.
	www.ncattc.org /peds/sage-3-biological.htm (1148 words)

	Alcohol Chemistry and You
		A similar situation is found in the second step of ethanol metabolism, which is catalyzed by acetaldehyde dehydrogenase.
		This enzyme converts acetaldehyde to acetic acid, which is a normal metabolite in humans and hence is non toxic.
		The past use of Antabuse as a possible deterrent to drinking was based on the ability of Antabuse to inhibit the action of acetaldehyde dehydrogenase, thus slow down or stop the destruction of acetaldehyde.
	chemcases.com /alcohol/alc-06.htm (744 words)

	Isolation and Characterization of an Aldehyde Dehydrogenase Encoded by the aldB Gene of Escherichia coli -- Ho and ...
		Isolation and Characterization of an Aldehyde Dehydrogenase Encoded by the aldB Gene of Escherichia coli
		NAD in Vibrio harveyi fatty aldehyde dehydrogenase (34).
		aldB, an RpoS-dependent gene in Escherichia coli encoding an aldehyde dehydrogenase that is repressed by Fis and activated by Crp.
	jb.asm.org /cgi/content/full/187/3/1067 (4217 words)

	Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer ...
		Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer -- Homann et al.
		Acetaldehyde is produced from ethanol in the epithelia by mucosal
		from acetaldehyde to ethanol is catalysed by ADHs and the reaction
	carcin.oxfordjournals.org /cgi/content/full/21/4/663 (4122 words)

	A Transgenic Model of Acetaldehyde Overproduction Accelerates Alcohol Cardiomyopathy -- Liang et al. 291 (2): 766 -- ...
		Acetaldehyde was measured according to a modification of the procedure of Eriksson et al.
		Espinet C and Argiles JM (1984) Ethanol and acetaldehyde levels in rat blood and tissues after an acute ethanol administration.
		Ferrans VJ (1989) Pathologic anatomy of the dilated cardiomyopathies.
	jpet.aspetjournals.org /cgi/content/full/291/2/766 (4127 words)

	Acetaldehyde dehydrogenase (Ahd-2)-associated DNA polymorphisms in mouse strains with variable ethanol preferences. (Site not responding. Last check: 2007-11-06)
		Acetaldehyde dehydrogenase (Ahd-2)-associated DNA polymorphisms in mouse strains with variable ethanol preferences.
		Acetaldehyde dehydrogenase (Ahd-2)-associated DNA polymorphisms in mouse strains with variable ethanol preferences.The genotype-dependent response of mice to ethanol has been well documented.
		Cytosolic acetaldehyde dehydrogenase (ALDH-2) increases in some strains while decreasing in others with ethanol treatment.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/34956.html (193 words)

	drug metabolism (Site not responding. Last check: 2007-11-06)
		The enzyme alcohol dehydrogenase converts ethanol to acetaldehyde.
		The enzyme acetaldehyde dehydrogenase converts acetaldehyde to acetic acid.
		acetaldehyde but their bodies are unable to break it down further.
	www.sjsu.edu /faculty/mvassallo/103/drug_metabolism.htm (196 words)

	Letters to the (almost) Doctor (Site not responding. Last check: 2007-11-06)
		The metabolism of ethanol (alcohol) is one of the simpler biochemical pathways in the human body.
		Acetaldehyde is than transformed into acetic acid with the aid of another enzyme, aldehyde dehydrogrenase.
		The net result is a build-up of acetaldehyde, which can lead to flushing, nausea, malaise, and headache, a reaction sometimes referred to as “Asian flush”.
	endeavor.med.nyu.edu /~strone01/doctor.html (291 words)

	Acetaldehyde as Well as Ethanol Is Metabolized by Human CYP2E1 -- Kunitoh et al. 280 (2): 527 -- Journal of ...
		Acetaldehyde was oxidized by rat and human hepatic microsomes in the presence of NADPH.
		Harada, S., Agarwal, D. and Goedde, H. Aldehyde dehydrogenase deficiency as a cause of facial flushing reaction to alcohol in Japanese.
		Peters, T. and Ward, R. Role of acetaldehyde in the pathogenesis of alcoholic liver disease.
	jpet.aspetjournals.org /cgi/content/full/280/2/527 (3089 words)

	Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary ...
		Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancer of the upper aerodigestive tract.
		Alcohol dehydrogenase 3 genotype is not associated with risk of squamous cell carcinoma of the oral cavity and pharynx.
		Genetic polymorphism of alcohol dehydrogenase in Europeans: the ADH22 allele decreases the risk for alcoholism and is associated with ADH31.
	gut.bmjjournals.com /cgi/content/full/53/6/871 (4379 words)

	thiq (Site not responding. Last check: 2007-11-06)
		Alcohol breaks down by the action of alcohol dehydrogenase on the alcohol, removing a hydrogen, forming acetaldehyde.
		This toxin is supposed to be removed quickly by the action of acetaldehyde dehydrogenase (away with another hydrogen) forming acetate and water.
		This is precisely the effect seen when someone drinks on Antabuse - disulfarim - which blocks the action of aldehyde dehydrogenase.
	webpages.charter.net /rfhale/thiq.htm (1509 words)

	Lecture notes of Chapter 1 (Site not responding. Last check: 2007-11-06)
		Mechanisms of antabuse (Disulfiram) Antabuse interferes with alcohol oxidation and prolongs the presence of toxic acetaldehyde in the body.
		Alcohol interacted with enzyme Alcohol dehydrogenase the result of the interaction is formation of acetaldehyde Then, antabuse blocks acetaldehyde dehydrogenase which is able to decompose acetaldehyde into acetic acid and carbon dioxide.
		During alcohol metabolism following antabuse intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone.
	www.humboldt.edu /~sh4/p321notech15.htm (1768 words)

	Generation of protein adducts with malondialdehyde and acetaldehyde in muscles with predominantly type I or type II ...
		Generation of protein adducts with malondialdehyde and acetaldehyde in muscles with predominantly type I or type II fibers in rats exposed to ethanol and the acetaldehyde dehydrogenase inhibitor cyanamide -- Niemelä et al.
		Generation of protein adducts with malondialdehyde and acetaldehyde in muscles with predominantly type I or type II fibers in rats exposed to ethanol and the acetaldehyde dehydrogenase inhibitor cyanamide
		Kera Y, Ohbora Y, Komura S. The metabolism of acetaldehyde and not acetaldehyde itself is responsible for in vivo ethanol-induced lipid peroxidation in rats.
	www.ajcn.org /cgi/content/full/76/3/668 (4289 words)

	Functional analysis of the ALD gene family of Saccharomyces cerevisiae during anaerobic growth on glucose: the ...
		dehydrogenase enzyme, capable of using acetaldehyde as a substrate.
		Navarro-Avino, J. P., Prasad, R., Miralles, V. J., Benito, R. and Serrano, R. A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes.
		Steinbüchel, A. and Schlegel, H. A multifunctional fermentative alcohol dehydrogenase from the strict aerobe Alcaligenes eutrophus: purification and properties.
	mic.sgmjournals.org /cgi/content/full/150/7/2209 (5094 words)

	Chapter 15
		Acetaldehyde: A poisonous substance created when ethyl alcohol (drinking alcohol) is metabolized in the liver.
		Acetaldehyde is then further metabolized into acetic acid, a chemical the body can use as a source of energy.
		2. Acetaldehyde dehydrogenase is the enzyme used to convert acetaldehyde into acetic acid.
	www.stolaf.edu /courses/2002sem2/Psychology/238/NotesCh15.htm (2155 words)

Try your search on: Qwika (all wikis)