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Topic: Acetaminophen

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	Acetaminophen
		Acetaminophen, a non-opiod analgesic without anti-inflammatory effects, was first used in medicine in 1893, but became very widely used after approval by the FDA in 1950.
		Acetaminophen is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby.
		Acetaminophen is listed by the American Association of Poison Control Centers as one of the most common drugs taken in overdose quantities either intentionally or accidentally.
	www.usgyms.net /acetaminophen.htm (795 words)

	Acetaminophen Analgesia in Neonatal Circumcision
		Acetaminophen was not found to ameliorate either the intra-operative or the immediate postoperative pain of circumcision, although it seems that it may provide some benefit after the postoperative period.
		Two neonates in the acetaminophen group were born to mothers with gestational diabetes (non-insulin dependent), and one was born to a mother with pregnancy induced hypertension, whereas there were no obstetric complications in the group receiving placebo.
		Acetaminophen was not found to ameliorate the the intraoperative or the immediate postoperative pain of circumcision, although it may provide some benefit after the immediate postoperative period.
	www.cirp.org /library/pain/howard (3461 words)

	acetaminophen Drug Information
		Acetaminophen is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.
		You may not be able to take acetaminophen, or you may require a dosage adjustment or special monitoring during treatment if you have either of these conditions.
		Acetaminophen is believed to be safe in pregnancy when used intermittently for short durations.
	www.drugs.com /mtm/acetaminophen-oral-rectal.html (1570 words)

	FDA Informs Public of Nationwide Recall of 500mg Strength Store-Brand Acetaminophen Caplets
		The ongoing investigations have revealed the presence of the metal fragments in caplets of acetaminophen, 500 mg.
		Perrigo reported to the FDA that 70 million caplets were passed through a metal detector; resulting in the discovery of approximately 200 caplets containing metal fragments ranging in size from "microdots" to portions of wire 8 mm in length.
		Consumers may wish to take additional amounts of the lower strengths of acetaminophen tablets or caplets, which are not affected by this recall, to reach the 500 mg dose or access acetaminophen produced by alternate manufacturers.
	www.fda.gov /bbs/topics/NEWS/2006/NEW01507.html (516 words)

	ACETAMINOPHEN (Site not responding. Last check: 2007-10-22)
		To illustrate how dangerous acetaminophen can be, one study showed that people who used acetaminophen with other pain relievers on a regular basis had a three-to eightfold increase in their risk of kidney cancer.
		Acetaminophen poisoning is a toxic reaction, resulting from the ingestion of excessive doses of the drug.
		Acetaminophen poisoning is not unlike any other massive assault upon the liver caused by substances known to degrade liver performance.
	www.deathbyacetaminophen.net /acetaminophen.htm (2319 words)

	Acetaminophen
		Individuals using acetaminophen on a regular basis for extended periods of time, especially over one year, should consult their prescribing physician and a healthcare professional trained in Chinese herbal medicine to determine whether the use of Artemisia, alone or as part of a traditional formula, would be appropriate.
		It is proposed that when hepatocytes are incubated with a high concentration of acetaminophen, the drug may accumulate in the cells due to saturation and/or inhibition of detoxification pathways (as in the case of silybin).
		Acetaminophen produced 100% mortality at the dose of 1 g/kg in mice, while pretreatment of animals with the plant extract (500 mg/kg) reduced the death rate to 20%.
	home.caregroup.org /clinical/altmed/interactions/Drugs/Acetaminophen.htm (4703 words)

	Tylenol or acetaminophen to treat back pain, by Spine-health.com
		Acetaminophen is probably the single most effective non-prescription medication for lower back pain and has the fewest side affects.
		Up to 1,000 mg of acetaminophen may be taken every four hours, up to a total of 4,000 mg within 24 hours.
		Importantly, acetaminophen is cleared through the liver so patients with liver disease should first check with their physician.
	www.spine-health.com /topics/conserv/overview/med/med02.html (227 words)

	Acetaminophen (Site not responding. Last check: 2007-10-22)
		Acetaminophen is used to relieve many kinds of minor aches and pains--headaches, muscle aches, backaches, toothaches, menstrual cramps, arthritis, and the aches and pains that often accompany colds.
		Acetaminophen is less likely than aspirin to irritate the stomach.
		Patients should not use acetaminophen for more than 10 days to relieve pain (5 days for children) or for more than 3 days to reduce fever, unless directed to do so by a physician.
	www.rwjhamilton.org /Atoz/ency/acetaminophen.asp (786 words)

	Acetaminophen
		Children's forms containing acetaminophen are used to reduce fever and relieve pain due to colds, flu, teething, immunizations, tonsillectomy, and childhood illnesses.
		Acetaminophen products are available in a variety of strengths and forms, including tablets, caplets, gelcaps, geltabs, and liquid.
		When using acetaminophen to treat sore throat, stop and check with your doctor if the sore throat is severe, lasts more than 2 days, or is linked with a fever, headache, rash, nausea, or vomiting.
	www.pdrhealth.com /drug_info/otcdrugprofiles/drugs/fgotc266.shtml (439 words)

	Acetaminophen (Tylenol) - side effects, drug class, medical uses, and drug interactions by MedicineNet.com (Site not responding. Last check: 2007-10-22)
		Acetaminophen relieves pain by elevating the pain threshold, that is, by requiring a greater amount of pain to develop before it is felt by a person.
		Acetaminophen relieves pain in mild arthritis but has no effect on the underlying inflammation, redness and swelling of the joint.
		The potential for acetaminophen to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.
	www.medicinenet.com /acetaminophen/article.htm (568 words)

	MedlinePlus Drug Information: Acetaminophen
		Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, reactions to vaccinations (shots), and to reduce fever.
		Acetaminophen may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).
		Acetaminophen may also be used in combination with aspirin and caffeine to relieve the pain associated with migraine headache.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a681004.html (1555 words)

	Acetaminophen - FLORIDA RX - Online prescriptions source for Florida
		Acetaminophen is used to relieve pain and reduce fever.
		Breast-feeding-Although acetaminophen passes into the breast milk in small amounts, it has not been reported to cause problems in nursing babies.
		However, some children's products containing acetaminophen also contain aspartame, which may be dangerous if it is given to children with phenylketonuria.
	www.florida-rx.com /acetaminophen.html (1683 words)

	Acetaminophen, APAP, Paracetamol, Tylenol
		Acetaminophen is used to reduce pain and fever.
		Acetaminophen is available by itself or in nonprescription and prescription-only combination products used to relieve pain and the symptoms associated with colds and
		Acetaminophen can cause liver damage, which is believed to involve glutathione depletion.
	www.truestarhealth.com /Notes/1072008.html (855 words)

	Acetaminophen
		Acetaminophen is a medicine used to relieve pain and reduce fever.
		Acetaminophen is used to relieve many kinds of minor aches and pains-headaches, muscle aches, backaches, toothaches, menstrual cramps, arthritis, and the aches and pains that often accompany colds.
		Among the drugs that may interact with acetaminophen are alcohol, nonsteroidal anti-inflammatory drugs (NSAIDs) such as Motrin, oral contraceptives, the antiseizure drug phenytoin (Dilantin), the blood-thinning drug warfarin (Coumadin), the cholesterol-lowering drug cholestyramine (Questran), the antibiotic Isoniazid, and zidovudine (Retrovir, AZT).
	www.healthatoz.com /healthatoz/Atoz/ency/acetaminophen.jsp (798 words)

	Exploring News & Features - Team probes acetaminophen action
		In nerve cells, acetaminophen works well; in inflammatory cells and platelets, it is much less potent.
		While acetaminophen is a successful and widely used drug, it does have undesirable side effects.
		“Acetaminophen is a very good drug for fever and pain — we aren’t necessarily trying to design a drug that works better than it does, but one that is free of the toxic side effects,” Boutaud said.
	www.vanderbilt.edu /exploration/news/news_boutaud.htm (516 words)

	Postgraduate Medicine: Alcohol-acetaminophen syndrome
		Criteria for consideration of liver transplantation in cases of acetaminophen overdose without concomitant alcohol consumption are based on the severity of acidosis, coma grade, prolongation of prothrombin time, and elevation of serum creatinine levels (King's College criteria) (20) (table 1).
		Because the minimum safe dose of acetaminophen is not known in the setting of chronic alcohol use, it seems prudent in such situations to avoid acetaminophen altogether, especially during brief periods of abstinence.
		Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure.
	www.postgradmed.com /issues/2000/01_00/draganov.htm (2807 words)

	Acetaminophen Danger - Online Lawyer Source
		There are very serious dangers of acetaminophen that have not been adequately communicated to consumers according to some groups.
		Since a quarter of acetaminophen patients with liver toxicity collected by the FDA had taken more than one acetaminophen product, better warnings issued for the dangers of acetaminophen may reduce a substantial amount of risk.
		Acetaminophen is contained in over 200 medications over the counter and is the most common cause of drug-induced liver failure.
	www.onlinelawyersource.com /acetaminophen/dangers.html (398 words)

	Take with Care: About Acetaminophen
		Acetaminophen works by elevating the body’s overall pain threshold, and it lowers fever by helping the body eliminate excess heat.
		You can find acetaminophen in prescription medicines and OTC medicines for the temporary relief of minor aches and pains due to headache, muscle aches, backache, the minor pain of arthritis, the common cold, toothache, and menstrual cramps, and to reduce fever.
		When taken as directed, acetaminophen is safe and does not cause the stomach irritation often associated with non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, naproxen sodium, and ibuprofen.
	www.nclnet.org /takewithcare/acetaminophen.htm (321 words)

	Acetaminophen - Drugs & Vitamins - Drug Library - DrugDigest
		Acetaminophen can be taken as needed for the relief of pain or fever, or may be prescribed by the prescriber or health care professional on a more regular basis.
		Acetaminophen tablets come in several strengths for children and adults.
		Acetaminophen may hide the signs of an infection such as fever or pain.
	www.drugdigest.org /DD/DVH/Uses/0,3915,8\|Acetaminophen,00.html (786 words)

	Acetaminophen, Cincinnati Children's Hospital Medical Center
		Acetaminophen (Tylenol®) is a medicine used to relieve pain and fever.
		Acetaminophen comes in many different strengths and dosage forms (infant drops, liquid, chewable tablets, tablets, etc).
		Acetaminophen is also a common ingredient in many cough, cold and allergy medications.
	www.cincinnatichildrens.org /health/info/medication/a-e/acetaminophen.htm (558 words)

	Acetaminophen in the Treatment of Acute Low Back Pain
		Several studies have shown acetaminophen to be superior to placebo in the treatment of osteoarthritis pain, and because of its efficacy, it has been recommended as a first line agent in osteoarthritis treatment.
		Over a four-week study period, acetaminophen was found to be as efficacious as both low dose analgesic and high dose anti-inflammatory regimens of ibuprofen (Motrin®) in providing both pain relief and an improved functional outcome.
		In a 1982 study, paracetamol, a compound similar to acetaminophen, was compared to diflunisal (Dolobid®), an NSAID and salicylate derivative (an anti-inflammatory agent), in the treatment of chronic low back pain.
	www.spineuniverse.com /displayarticle.php/article1831.html (659 words)

	Acetaminophen Information on Healthline
		Acetaminophen is less likely than aspirin to irritate the stomach.
		Patients should not use acetaminophen for more than 10 days to relieve pain (five days for children) or for more than three days to reduce fever, unless directed to do so by a physician.
		Acetaminophen is commonly mixed with other ingredients as part of combinations intended for colds, influenza, and other conditions.
	www.healthline.com /galecontent/acetaminophen-3 (640 words)

	Acetaminophen Information from Drugs.com
		Acetaminophen is a pain reliever and a fever reducer.
		If you are taking acetaminophen on a regular schedule, take the missed dose as soon as you remember.
		If you are taking acetaminophen on an as-needed basis, missing a dose is not usually a problem.
	www.drugs.com /acetaminophen.html (1509 words)

	eMedicine - Toxicity, Acetaminophen : Article by Susan E Farrell, MD
		Acetaminophen is also a component of many over-the-counter medications and prescription combinations, such as propoxyphene-acetaminophen (eg, Darvocet) and oxycodone-acetaminophen (eg, Percocet).
		Acetaminophen is rapidly absorbed from the stomach and small intestine and metabolized by conjugation in the liver to nontoxic agents.
		Acetaminophen crosses the placenta, and the fetal liver is able to elaborate NAPQI by 14 weeks of gestation.
	www.emedicine.com /emerg/topic819.htm (3391 words)

	acetaminophen (Site not responding. Last check: 2007-10-22)
		Acetaminophen is a synthetic non-narcotic over the counter pain reliever and fever reducer.
		The recommended acetaminophen dosage is 5-10 mg/Kg per dose with a maximum of 5 doses per day for children.
		Acetaminophen toxicity may result from a single toxic dose, or from repeated ingestion of large doses of acetaminophen.
	rx.health.arizona.edu /acetaminophen.htm (245 words)

	eMedicine - Toxicity, Acetaminophen : Article by Germaine L Defendi, MD, MS, FAAP
		After acetaminophen became available over the counter (OTC) in the 1950s and after subsequent concerns over the association of aspirin use and Reye syndrome in children arose, acetaminophen became one of the most commonly used drugs in pediatric medicine.
		Acetaminophen is available in more than 200 OTC and prescription medications as a single agent or combined with other pharmaceuticals.
		Tucker JR: Late-presenting acute acetaminophen toxicity and the role of N- acetylcysteine.
	www.emedicine.com /ped/topic7.htm (4106 words)

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