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Topic: Acetylcholinesterase

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	MedlinePlus Medical Encyclopedia: Serum cholinesterase
		Acetylcholinesterase; RBC (or erythrocyte) cholinesterase; Pseudocholinesterase; Plasma cholinesterase; Butyrylcholinesterase
		Serum cholinesterase is a test for the enzymes acetylcholinesterase (also known as RBC cholinesterase) and pseudocholinesterase (also known as butyrylcholinesterase or plasma cholinesterase), which act to break down acetylcholine, a chemical critical in the transmission of nerve impulses.
		Acetylcholinesterase is found in nerve tissue and red blood cells, and pseudocholinesterase is found primarily in the liver.
	www.nlm.nih.gov /medlineplus/ency/article/003358.htm (636 words)

	BCH 3033/L (Site not responding. Last check: 2007-11-03)
		The function of acetylcholinesterase is to break down acetylcholine that has been used to initiate a neurotransmitter so that acetylcholine does not accumulate in neurotransmitters.
		Acetylcholinesterase is an enzyme that is found in the synapse between nerve and muscle cells.
		Acetylcholinesterase is known to have one of the fastest reaction rates for an enzyme.
	home.fau.edu /mogul/web/biomol.html (3083 words)

	[No title]
		Acetylcholinesterase is a naturally-occurring enzyme that breaks down acetylcholine into smaller parts, which are then recycled and reused by nerve cells.
		Acetylcholinesterase was first identified in cobra venom over 60 years ago and was soon found in venoms of several species of cobras and kraits (Zeller, 1947).
		Acetylcholinesterase was, until recently, thought to be present only in the cobra family of snakes.
	www.unco.edu /sparc/examples/ex4frpb.doc (2318 words)

	900. Monocrotophos (Pesticide residues in food: 1995 evaluations Part II Toxicological & Environmental)
		On the basis of inhibition of brain acetylcholinesterase, which is considered to be biologically significant when > 20%, the NOAEL was 0.1 mg/kg bw and the LOAEL was 0.3 mg/kg bw (Potrepka, 1994).
		Erythrocyte acetylcholinesterase was not inhibited at any dose, but plasma cholinesterase was decreased by about 15% in animals at the low dose and by 24% at the high dose.
		Erythrocyte acetylcholinesterase was not inhibited; plasma cholinesterase was inhibited by about 35% on day 7 and by about 51%, at the end of treatment.
	www.inchem.org /documents/jmpr/jmpmono/v95pr12.htm (980 words)

	Cholinesterase - Wikipedia, the free encyclopedia
		The 3D structure of acetylcholinesterase was first determined in 1991 by Sussman et al using protein from the Pacific electric ray.
		Because of its essential function, chemicals that interfere with the action of cholinesterase are potent neurotoxins, causing excessive salivation and eye watering in low doses, followed by muscle spasms and ultimately death (examples are some snake venoms, and the nerve gases sarin and VX).
		One of the most common classes of acetylcholinesterase inhibitors are phosphorus-based compounds which are designed to bind to the active site of the enzyme.
	en.wikipedia.org /wiki/Acetylcholinesterase (450 words)

	MOLECULE DESCRIPTION (via CobWeb/3.1 planetlab2.isi.jhu.edu) (Site not responding. Last check: 2007-11-03)
		Acetylcholinesterase is one of the most crucial enzymes for nerve response and function.
		Structure of acetylcholinesterase complexed with the nootropic alkaloid, huperzine A, which is found in an extract from a club moss that has been used for centuries in Chinese folk medicine.
		Acetylcholinesterase inhibition by fasciculin, a protein found in snake venom, reveals a synergistic three-point anchorage consistent with the picomolar dissociation constant of the complex.
	www.users.csbsju.edu.cob-web.org:8888 /~hjakubow/classes/rasmolchime/99ch331proj/AChesterase/page1.html (1323 words)

	Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease -- Rinne et al. 74 (1): ... (Site not responding. Last check: 2007-11-03)
		Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease -- Rinne et al.
		Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer’s disease.
		Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer’s disease: a positron emission tomography study.
	jnnp.bmjjournals.com /cgi/content/full/74/1/113 (2042 words)

	Anti-Acetylcholinesterase agents
		Acetylcholinesterase, seen left, breaks down the neurotransmitter acetylcholine, eliminating it from the synaptic cleft.
		Anti-acetylcholinesterase agents are the first line of treatment in myasthenia gravis, and may be given initially to enhance the function of the remaining normal acetylcholine receptors.
		Thus with acetylcholinesterase inhibition, acetylcholine is not destroyed as quickly, and therefore remains
	www.macalester.edu /psychology/whathap/UBNRP/Gravis/AchE_agents.html (550 words)

	Cholinesterase - Biocrawler (Site not responding. Last check: 2007-11-03)
		Acetylcholinesterase (AChE), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses
		Acetylcholinesterase: Molecule of the Month on PDB (http://nist.rcsb.org/pdb/molecules/pdb54_1.html)
		You can find it there under the keyword Acetylcholinesterase (http://en.wikipedia.org/wiki/Acetylcholinesterase)The list of previous authors is available here: version history (http://en.wikipedia.org/w/index.php?title=Acetylcholinesteraseandaction=history).
	www.biocrawler.com /encyclopedia/Acetylcholinesterase (345 words)

	MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction -- Cartaud et al. 165 (4): 505 -- The ... (Site not responding. Last check: 2007-11-03)
		Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice.
		Compartmentalization of acetylcholinesterase mRNA and enzyme at the vertebrate neuromuscular junction.
		Acetylcholinesterase clustering at the neuromuscular junction involves perlecan and dystroglycan.
	www.jcb.org /cgi/content/full/165/4/505 (6797 words)

	Stable Complexes Involving Acetylcholinesterase and Amyloid-beta Peptide Change the Biochemical Properties of the ... (Site not responding. Last check: 2007-11-03)
		Gómez-Ramos P, Mufson EJ, Morán MA (1992) Ultrastructural localization of acetylcholinesterase in neurofibrillary tangles, neuropil and senile plaques in aged and Alzheimer's brain.
		Inestrosa NC, Roberts WL, Marshall TL, Rosenberry TL (1987) Acetylcholinesterase from bovine caudate nucleus is attached to membranes by a novel subunit distinct from those of acetylcholinesterase in other tissues.
		Kalaria RN, Kroon SN, Grahovac I, Perry G (1992) Acetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of Alzheimer's disease.
	www.jneurosci.org /cgi/content/full/18/9/3213 (6058 words)

	Acetylcholinesterase inhibition by zifrosilone: pharmacokinetics and pharmacodynamics.
		OBJECTIVE: To determine the pharmacokinetics, pharmacodynamics and safety of the acetylcholinesterase inhibitor zifrosilone in healthy male volunteers.
		Serial blood samples were obtained for zifrosilone plasma concentrations and red blood cell acetylcholinesterase and butyrylcholinesterase activities.
		Red blood cell acetylcholinesterase showed a dose-inhibition relationship, with a mean maximum inhibition of 20.9% at 10 mg that increased to 62.1% at 300 mg.
	www.aegis.com /aidsline/1995/nov/M95B0619.html (490 words)

	The Scripps Research Institute - News and Views
		In click chemistry, chemicals (like acetylcholinesterase inhibitors) are made from modular chemical "blocks" that can be joined together in various combinations in very few steps.
		The azides and acetylenes that were used to make the acetylcholinesterase inhibitors are, according to Sharpless, "cream of the crop" building blocks for click chemistry, because they will not react with other molecules but instead fuse irreversibly into various product structures (triazoles) when brought together.
		The enzyme acetylcholinesterase preferentially assembles one pair of the reactants, each bearing a group that binds to adjacent positions on the protein structure (the choline binding site of the active center and the peripheral site), into a triazole adduct that is the most potent noncovalent inhibitor of the enzyme yet developed.
	www.scripps.edu /newsandviews/e_20020318/sharpless2.html (604 words)

	Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence
		Acetylcholinesterase, an essential enzyme of the nervous system, rapidly terminates the action of acetylcholine released into the synapse.
		Acetylcholinesterase is also found (in lower abundance) in extrajunctional areas of muscle and nerve and on erythrocyte membranes
		Here, we report the complete amino-acid sequence of an acetylcholinesterase inferred from the sequence of a complementary DNA clone.
	www.nature.com /nature/journal/v319/n6052/abs/319407a0.html (417 words)

	Self reported symptoms and inhibition of acetylcholinesterase activity among Kenyan agricultural workers -- ...
		A dramatic shift in acetylcholinesterase activity was apparent.
		Normal acetylcholinesterase activities during high exposure were also based on the median acetylcholinesterase activity in
		Acetylcholinesterase inhibition as an indicator of organophosphorus and carbarnate poisoning in Kenyan agricultural workers.
	oem.bmjjournals.com /cgi/content/full/57/3/195 (3524 words)

	Acetylcholinesterase definition - Medical Dictionary definitions of popular medical terms (Site not responding. Last check: 2007-11-03)
		Acetylcholinesterase definition - Medical Dictionary definitions of popular medical terms
		Acetylcholinesterase: An enzyme that breaks down the neurotransmitter acetylcholine at the synaptic cleft (the space between two nerve cells) so the next nerve impulse can be transmitted across the synaptic gap.
		Pesticides of the organophosphate and carbamate types act to paralyze and kill insects by inhibiting their acetylcholinesterase.
	www.medterms.com /script/main/art.asp?articlekey=23279 (170 words)

	cell technology
		Acetylcholinesterase (AChE) is one of the most important enzymes involved in nerve transmission.
		Kinetic, equilibrium, and spectroscopic studies on dealkylation ("aging") of alkyl organophosphonyl acetylcholinesterase.
		Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.
	www.celltechnology.com /products/aCella-AChE.htm (591 words)

	Acetylcholinesterase Inhibitors May Be Another Piece In Alzheimer's Jigsaw
		Acetylcholinesterase inhibitors, such as tacrine and donepezil, which have been designed to boost the apparent chemical deficiency in the brain caused by Alzheimer's disease, are the most successful treatments to date.
		The authors' six month trial involved the drug rivastigmine and they found that it was effective in treating some of the symptoms of patients with mild or moderate Alzheimer's disease.
		Bayer says that the patients who participated in the trial were not typical of those generally seen by psychiatrists and geriatricians and he says that the absence of measures of the neuropsychiatric effect of the drug is "unfortunate".
	www.eurekalert.org /pub_releases/1999-03/BMJ-AIMB-050399.php (349 words)

	Acetylcholinesterase Monoclonal antibodies from Research Diagnostics Inc
		Acetylcholinesterase (AChE) rapidly hydrolyzes ACh to acetate and choline, thereby inactivating it.
		Use: -detects acetylcholinesterase (AChE) from feline, rat, rabbit and guinea pig tissues.
		Background: AChE (acetylcholinesterase) is a type B carboxylesterase that rapidly hydrolyzes acetylcholine in neuromuscular junctions and brain cholinergic synapses.
	www.researchd.com /miscabs/acheab.htm (863 words)

	GeneCard for COLQ
		ALL other users require a Commercial License from XenneX, Inc. Unauthorized usage of this service is in breach of the terms and conditions of this web site, and may cause the user to incur fees for usage.
		Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme.
		Engel A.G. The spectrum of mutations causing end-plate acetylcholinesterase deficiency.
	www.genecards.org /cgi-bin/carddisp.pl?gene=COLQ (840 words)

	✓ Acetylcholinesterase - Demenz-Prophylaxe.de - DemenzProphylaxe
		Die Acetylcholinesterase (AChE EC [http: //us.expasy.org/cgi-bin/nicezyme.pl?3.1.1.7 3.1.1.7]) ist ein Enzym, welches den Neurotransmitter Acetylcholin (ACh) hydrolytisch in Acetat und Cholin spaltet.
		Die Acetylcholinesterase ist eines der schnellsten Enzyme Ã¼berhaupt (diffusionskontrolliert, siehe Enzymkinetik und Diffusion).
		Durch das Enzym Acetylcholinesterase kann es nach Freisetzung in den synaptischen Spalt und Bindung an den Acetylcholinrezeptor wieder in Cholin und EssigsÃ¤ure (beziehungsweise Acetat) gespalten und unwirksam gemacht werden.
	demenz-prophylaxe.de /index.php/Acetylcholinesterase (600 words)

	Localization of mRNAs Encoding Acetylcholinesterase and Butyrylcholinesterase in the Rat Spinal Cord by Nonradioactive ...
		Anglister L (1991) Acetylcholinesterase from the motor nerve terminal accumulates on the synaptic basal lamina of the myofiber.
		Bernard V, Legay C, Massoulié J, Bloch B (1995) Anatomical analysis of the neurons expressing the acetylcholinesterase gene in the rat brain, with special reference to the striatum.
		Jasmin BJ, Lee RK, Rotundo RL (1993) Compartmentalization of acetylcholinesterase mRNA and enzyme at the vertebrate neuromuscular junction.
	www.jhc.org /cgi/content/full/51/12/1633 (5834 words)

	Acetylcholinesterase Inhibition Improves Tachycardia in Postural Tachycardia Syndrome -- Raj et al. 111 (21): 2734 -- ... (Site not responding. Last check: 2007-11-03)
		Acetylcholinesterase Inhibition Improves Tachycardia in Postural Tachycardia Syndrome -- Raj et al.
		Role of acetylcholinesterase inhibition in heart rate and blood pressure control.
		We chose pyridostigmine because it was a peripheral acetylcholinesterase
	circ.ahajournals.org /cgi/content/full/111/21/2734 (3675 words)

	AllRefer Health - Serum Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase, Plasma Cholinesterase, ...
		AllRefer Health - Serum Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase, Plasma Cholinesterase, Pseudocholinesterase, RBC (Or Erythrocyte) Cholinesterase) - Test/Medical Exams/Tests
		This is a test for the enzymes acetylcholinesterase (also known as RBC cholinesterase) and pseudocholinesterase (also known as butyrylcholinesterase or plasma cholinesterase) which act to break down acetylcholine, a chemical critical in the transmission of nerve impulses.
		Testing for these enzymes is performed to identify exposure to a group of chemicals known as organophosphates (used as pesticides).
	health.allrefer.com /health/serum-cholinesterase-info.html (442 words)

	Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension -- Singer et ... (Site not responding. Last check: 2007-11-03)
		Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension -- Singer et al.
		Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension
		acetylcholinesterase inhibition, based on the theory that enhanced
	jnnp.bmjjournals.com /cgi/content/abstract/74/9/1294 (416 words)

	UniProtKB/Swiss-Prot entry Q9Y215 [COLQ_HUMAN] Acetylcholinesterase collagenic tail peptide
		Ohno K. Brengman J. Tsujino A. Engel A.G. "Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme.";
		: Defects in COLQ are the cause of end-plate acetylcholinesterase deficiency (EAD) [MIM:603034]; also known as congenital myasthenic syndrome type IC (CMS-IC).
		This rare autosomal recessive disorder is characterized by onset during childhood, generalized weakness, abnormal fatigability on exertion, refrectoriness to acetylcholinesterase drugs, decremental electromyographic response and morphological abnormalities of the neuromuscular junctions.
	www.expasy.org /uniprot/Q9Y215 (703 words)

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