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s010910a - Acetaminophen Poisoning - Late Administration of N-acetylcysteine Acetylcysteine treated patients had a lower incidence of cerebral oedema (40% (10/25) v 68% (17/25); p = 0.047, 95% confidence interval for difference in incidence 2% to 54%), and fewer developed hypotension requiring inotropic support (48% (12/25) v 80% (20/25); p = 0.018, 95% confidence interval 7% to 57%). Abstract: The influence of acetylcysteine, administered at presentation to hospital, on the subsequent clinical course of 100 patients who developed paracetamol-induced fulminant hepatic failure was analysed retrospectively. Acetylcysteine was effective in preventing liver damage, hepatic failure, renal damage, and death when given eight to ten hours after poisoning. www.emory.edu /WHSCL/grady/amreport/litsrch01/s010910a.html   (2657 words)

Spartanburg SC | GoUpstate.com | Spartanburg Herald-Journal   (Site not responding. Last check: 2007-11-04) Acetylcysteine is the N-acetyl derivative of the amino acid L-cysteine, and is a precursor in the formation of the antioxidant glutathione in the body. Oral acetylcysteine for this indication is uncommon as it is poorly tolerated owing to the high doses required (due to poor oral bioavailability), unpleasant taste/odour and adverse drug reactions (particularly nausea and vomiting). Oral acetylcysteine is used for the prevention of radiocontrast-induced nephropathy (a form of acute renal failure). www.goupstate.com /apps/pbcs.dll/section?category=NEWS&template=wiki&text=Acetylcysteine   (823 words)

Acetylcysteine (Mucomyst®)   (Site not responding. Last check: 2007-11-04) Acetylcysteine is a derivative of the amino acid cysteine. Acetylcysteine is used as an antidote to acetaminophen toxicity. For acetaminophen toxicity, acetylcysteine, diluted to a 50 mg/ml concentration, is given initially at a dose of 70 mg per pound (140 mg/kg) intravenous or orally. www.petplace.com /drug-library/acetylcysteine-mucomyst/page1.aspx   (686 words)

PharmGKB: acetylcysteine   (Site not responding. Last check: 2007-11-04) Acetylcysteine is indicated in the treatment of acetaminophen overdose to protect against hepatotoxicity. Acetylcysteine may act by reducing the metabolite to the parent compound and/or by providing sulfhydryl for conjugation of the metabolite. Acetylcysteine undergoes rapid deacetylation in vivo to yield cysteine or oxidation to yield diacetylcystine. www.pharmgkb.org /do/serve?objId=305&objCls=DrugProperties   (774 words)

Drug Information Acetylcysteine makes mucus or sputum in the lungs easier to cough up; it can help improve breathing in patients with COPD (chronic bronchitis or emphysema) or other lung diseases. Acetylcysteine is also used by doctors as an antidote for treating overdoses of acetaminophen (Tylenol(R)); it can help reduce the amount of liver damage caused by acetaminophen. Acetylcysteine can interact with certain metals and rubber; do not mix the oral solution in containers made of these materials. www.muschealth.com /cds/CPDrugInfo.details.aspx?cpnum=7&gname=&id=1763   (472 words)

Acetylcysteine (Inhalation) Acetylcysteine (a-se-teel-SIS-teen) is a mucolytic (medicine that destroys or dissolves mucus). Acetylcysteine is used for certain lung conditions when increased amounts of mucus make breathing difficult. Although there is no specific information comparing use of acetylcysteine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults. allnutritionals.com /drugs/a/acetylcysteine-inhalation.shtml   (1035 words)

BioMed Central | Full text | Acetylcysteine for prevention of contrast-induced nephropathy after intravascular ... Acetylcysteine was associated with a significantly reduced incidence of contrast-induced nephropathy in five studies, and no difference in the other nine (with a trend toward a higher incidence in six of the latter studies). The potential benefit of acetylcysteine is believed to be mediated by its properties as a scavenger of free-radical species and by increasing the synthesis of nitric oxide, a potent vasodilator, in response to ischemic or other toxic injury in the kidney [12]. The dosing and schedule of administration of acetylcysteine was variable across studies; however, in the majority of studies, acetylcysteine was initiated 12–24 h prior to angiography. www.biomedcentral.com /1741-7015/2/38   (4775 words)

Acetylcysteine Acetylcysteine is available as a prescription in the U.S. for use as an inhalant or as an I.V. infusion. Acetylcysteine, or N-acetylcysteine, commonly abbreviated as NAC, is the N-acetyl derivative of the protein amino acid L-cysteine (see L-Cysteine). Use of acetylcysteine as the life-saving antidote in Amanita phalloides (death cap) poisoning. www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/ace_0178.shtml   (2229 words)

Acetylcysteine : by Ray Sahelian, M.D., health benefits of N-Acetyl-l-cysteine Acetylcysteine treatment was discontinued when the APAP concentration was <10 mg/L and serum aspartate aminotransferase (AST) was <40 IU/L. For the purposes of assessing clinical outcomes, patients were divided into 3 groups based on duration of treatment: the short-course group (/=73 hours). Acetylcysteine was intravenously infused for 20 min prior to and throughout exercise. In addition to its antioxidant properties, acetylcysteine is currently used in a variety of other ways: to counteract the effects of an overdose of acetaminophen (i.e., Tylenol®), to break up mucus in respiratory ailments, to lessen the symptoms of colds or the flu, and even to reduce the effects of hangovers. www.raysahelian.com /acetylcysteine.html   (3415 words)

Mucomyst Indications, Dosage, Storage, Stability - Acetylcysteine - RxList Monographs Acetylcysteine, administered orally, is indicated as an antidote to prevent or lessen hepatic injury which may occur following the ingestion of a potentially hepatotoxic quantity of acetaminophen. The 20% solution may be diluted to a lesser concentration with either Sodium Chloride for Injection, Sodium Chloride for Inhalation, Sterile Water for Injection, or Sterile Water for Inhalation. In the occasional instances where the patient is persistently unable to retain the orally administered acetylcysteine, the antidote may be administered by duodenal intubation. www.rxlist.com /cgi/generic3/acetylcysteine_ids.htm   (2372 words)

Acetylcysteine Indications   (Site not responding. Last check: 2007-11-04) Acetylcysteine is often used to dissolve mucus and to facilitate expectoration during respiratory diseases. While there are a number of open and controlled studies that suggest a considerable benefit, there are other controlled studies that do not demonstrate a significant effect. Acetylcysteine may have an effect on other intoxications, keratoconjunctivitis, or even HIV (human immunodeficieny virus) infections. www.infomed.org /100drugs/acetind.html   (160 words)

Acetylcysteine may be useful for ichthyosis   (Site not responding. Last check: 2007-11-04) Topical application of acetylcysteine may be useful for the skin condition ichthyosis, Dr Pedro Redondo (University clinic of Navarra, Pamplona, Spain) reports. Both solutions were a water in oil emulsion, one of which contained 10 per cent acetylcysteine and the other (with no additions) was a placebo. Dr Redondo concludes that because acetylcysteine is an atoxic and hypoallergenic amino acid derivative with successful therapeutic uses and rare side effects, "it may be useful in the treatment of hyperproliferative skin disorders." www.pharmj.com /Editorial/19991204/clinical/acetylcysteine.html   (321 words)

Stability of acetylcysteine in an extemporaneously compounded ophthalmic solution -- Anaizi et al. 54 (5): 549 -- ... The stability of acetylcysteine in an extemporaneously compounded ophthalmic solution was studied. Acetylcysteine 10% ophthalmic solution containing 0.025% disodium edetate and 0.5% chlorobutanol in an artificial tears base was prepared and stored at 2-8 degrees C in clear, 15-mL, low-density polyethylene dropper bottles. Another set of 10% acetylcysteine solutions containing 0.025%, 0.050%, 0.075%, or 0.10% disodium edetate were prepared, stored at room temperature (23-25 degrees C), and analyzed at 0, 7, 15, 30, 40, and 50 days. www.ajhp.org /cgi/content/abstract/54/5/549   (182 words)

Acetylcysteine [ANTIDOTE] - Evanston Northwestern Healthcare Metabolism: Hepatic; undergoes rapid deacetylation in vivo to yield cysteine or oxidation to yield diacetylcysteine Safirstein R, Andrade L, and Vieira JM, “Acetylcysteine and Nephrotoxic Effects of Radiographic Contrast Agents - A New Use for an Old Drug,”N Engl J Med, 2000, 343(3):210-2. Acetylcysteine infusion may be interrupted until treatment of allergic symptoms is initiated; the infusion can then be carefully restarted. www.enh.org /healthandwellness/bioterrorism/hf001200.aspx?lid=1093   (1514 words)

Clinical Trial: Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With ... Giving acetylcysteine together with mannitol, combination chemotherapy, and sodium thiosulfate may be an effective treatment for malignant brain tumors. Determine the toxicity and maximum tolerated dose of acetylcysteine when given in combination with blood-brain barrier disruption treatment with mannitol, combination chemotherapy comprising cyclophosphamide, etoposide phosphate, and carboplatin, and delayed high-dose sodium thiosulfate in pediatric patients with malignant brain tumors. Patients receive acetylcysteine IV over 30-60 minutes followed, at least 15 minutes later, by x-ray-guided femoral artery catheterization under general anesthesia on days 1 and 2. clinicaltrials.gov /ct/show/NCT00238173   (643 words)

News - Acetylcysteine Prevents Renal Problems After Angiography: Presented at ACC Acetylcysteine has been shown to have clinical benefit in preventing radiocontrast-induced nephropathy if administered orally for 24 hours before and after computed tomography scan studies. The incidence of radiocontrast-induced nephropathy in the acetylcysteine group was significantly lower than in the group receiving hydration only (5 percent vs. 16 percent). In the multivariate analysis, only the use of acetylcysteine was predictive of fewer increases in serum creatinine and a lower incidence of radiocontrast-induced nephropathy, Dr. Mouhayar said. www.docguide.com /news/content.nsf/news/8525697700573E1885256B80004AFC40   (504 words)

Acetylcysteine and Fenoldopam: Promising New Approaches for Preventing Effects of Contrast Nephrotoxicity -- Thompson ... Acetylcysteine is an N-acetyl derivative of the amino acid L-cysteine. Acetylcysteine to prevent angiography-related renal tissue injury (the APART trial). Acetylcysteine and nephrotoxic effects of radiographic contrast agents: a new use for an old drug. ccn.aacnjournals.org /cgi/content/full/23/3/39   (3500 words)

Acetylcysteine Reduces Plasma Homocysteine Concentration and Improves Pulse Pressure and Endothelial Function in ... Acetylcysteine Reduces Plasma Homocysteine Concentration and Improves Pulse Pressure and Endothelial Function in Patients With End-Stage Renal Failure -- Scholze et al. Both ratios were measured at different points during a hemodialysis session under control conditions (placebo) and in the presence of acetylcysteine and are given as percent of initial control value obtained before hemodialysis. in the presence of acetylcysteine, is in accordance with an circ.ahajournals.org /cgi/content/full/109/3/369   (2989 words)

The Use of Acetylcysteine (Mucosil) in Dogs and Cats Not FDA approved for use in veterinary medicine, but it is a common and accepted practice to use acetylcysteine in dogs and cats. Acetylcysteine decreases the toxicity of acetaminophen in pets by providing an alternative route for the metabolism of the drug. Has also been used to help treat certain lung diseases, corneal ulcers, and keratoconjunctivitis sicca (dry eyes) because it breaks up the large amounts of mucus that forms in these disease conditions. www.peteducation.com /article.cfm?articleid=1368   (389 words)

Acetylcysteine definition - Medical Dictionary definitions of popular medical terms Acetylcysteine: An antioxidant drug used to reduce the thickness of mucus and ease its removal. It is also used to reverse the toxicity of high doses of acetaminophen. Acetylcysteine with hydration significantly reduces the risk of contrast nephropathy in patients with chronic renal insufficiency. www.medterms.com /script/main/art.asp?articlekey=24130   (131 words)

N-acetylcysteine does not prevent contrast induced nephropathy after cardiac catheterisation with an ionic low ... Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial. Oral acetylcysteine does not protect renal function from moderate to high doses of intravenous radiographic contrast. Intravenous acetylcysteine in the prevention of contrast-induced nephropathy: a randomized trial. heart.bmjjournals.com /cgi/content/full/91/6/774   (2702 words)

Acetylcysteine Acetylcysteine 600mg effervescent tablets are registered in the Netherlands. Acetylcysteine (Fluimucil) is available for international importation on patient label. Each country has its own laws and regulations for the importation of medication to protect their citizens. www.meerburgpharmacy.com /acetylcysteine.htm   (766 words)

Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning -- Kanter 63 (19): 1821 -- ... Acetylcysteine has a putrid odor, and its taste is very difficult Dorsch W, Auch E, Powerlowicz P. Adverse effects of acetylcysteine on human and guinea pig bronchial asthma in vivo and on human fibroblasts and leukocytes in vitro. Random and systematic medication errors in routine clinical practice: a multicentre study of infusions, using acetylcysteine as an example. www.ajhp.org /cgi/content/full/63/19/1821   (3174 words)

Medical Dictionary: Acetylcysteine - WrongDiagnosis.com Acetylcysteine: A synthetic or naturally-occurring amino acid related to L-cysteine, a precursor of the antioxidant enzyme glutathione. Some evidence suggests that acetylcysteine may exert an anti-apoptotic effect due to its antioxidant activity. Acetylcysteine : N-acetyl derivative of cysteine; used as a mucolytic agent to reduce the viscosity of mucous secretions. www.wrongdiagnosis.com /medical/acetylcysteine.htm   (283 words)

ACETYLCYSTEINE - INHALATION/ORAL (Mucomyst) side effects, medical uses, and drug interactions. This medication is also swallowed by mouth as an antidote to acetaminophen overdose in order to prevent life-threatening liver damage. OTHER USES: Acetylcysteine has also been swallowed by mouth to prevent kidney failure due to X-ray contrast products. HOW TO USE: When used to thin mucus, this medication is inhaled into the lungs using special breathing (nebulizer) equipment. www.medicinenet.com /acetylcysteine-inhalationoral/article.htm   (405 words)

Acetylcysteine Based on limited reports using acetylcysteine to treat acetaminophen overdose in pregnant women, acetylcysteine has been shown to cross the placenta and may provide protective levels in the fetus. Treatment of acetylcysteine toxicity is usually aimed at reversing anaphylactoid symptoms or controlling nausea and vomiting. Inhalation: Acetylcysteine 10% and 20% solution (Mucomyst®) (dilute 20% solution with sodium chloride or sterile water for inhalation); 10% solution may be used undiluted www.musc.edu /pharmacyservices/Drugs/A/Acetylcysteine.htm   (930 words)

Acetylcysteine If you have an allergy to acetylcysteine or any other part of the medicine. Acetylcysteine works by breaking down the fluid into a thinner one. Make sure you are drinking enough liquids unless told to drink less by healthcare provider. www.umm.edu /altmed/ConsDrugs/Acetylcysteinecd.html   (345 words)

N-Acetyl Cysteine Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: a report of a trial organized by the Swedish Society for Pulmonary Diseases. Shyu KG, Cheng JJ, Kuan P. Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure. Tattersall AB, Bridgman KM, Huitson A. Acetylcysteine (Fabrol) in chronic bronchitis—a study in general practice. www.publix.com /wellness/notes/Display.do?id=Supp&childId=N_Acetyl_Cysteine   (983 words)

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