| | eMedicine - Achalasia : Article by Michael AJ Sawyer, MD (Site not responding. Last check: 2007-10-14) |
 | | Background: Achalasia is an esophageal motor disorder characterized by increased lower esophageal sphincter (LES) pressure, diminished-to-absent peristalsis in the distal portion of the esophagus composed of smooth muscle, and lack of a coordinated LES relaxation in response to swallowing. |
 | | However, with early achalasia, a mixed inflammatory infiltrate of T cells, mast cells, and eosinophils is found in association with myenteric neural fibrosis and with a selective loss of inhibitory postganglionic neurons from the Auerbach plexus. |
 | | Achalasia patients could be discriminated from normal controls on the basis of a dilated esophagus without the presence of a neoplastic lesion. |
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