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	Aciclovir - Wikipedia, the free encyclopedia
		Aciclovir (INN) (IPA: [eɪˈsaɪklovir]) or acyclovir (USAN, former BAN) is a guanine analogue antiviral drug primarily used for the treatment of herpes simplex virus infection.
		Aciclovir was seen as the start of a new era in antiviral therapy, as it is extremely selective and low in cytotoxicity.
		Infrequently (0.1–1% of patients), ophthalmic aciclovir is associated with superficial punctate keratitis and/or allergic reactions.
	en.wikipedia.org /wiki/Aciclovir (889 words)

	Valaciclovir - Wikipedia, the free encyclopedia
		Valaciclovir is a prodrug that is converted by esterases to the active drug aciclovir via hepatic first-pass metabolism.
		Aciclovir is selectively converted into a monophosphate form by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation than cellular thymidine kinase.
		Aciclovir, the active metabolite of valaciclovir, is active against most species in the herpesvirus family.
	en.wikipedia.org /wiki/Valaciclovir (403 words)

	Aidsmap \| Aciclovir
		Baseline use of aciclovir was associated with a non-significant 18% increased risk of death (ns, RR 1.18, p=0.12) while baseline users with a history of herpes did have a significant risk of death (RR 1.31, p=0.03).
		Continuous aciclovir use was not associated with mortality or increased survival, and 'ever' use of aciclovir was associated with a 33% increased risk of death.
		In conclusion, the association of aciclovir use and survival was not consistent, and the lack of data on why participants were prescribed aciclovir limits the ability of observational studies to determine the effect of aciclovir on survival.
	www.aidsmap.com /en/docs/AF5B9E85-0009-4222-A2EF-BABF3328D75E.asp (2394 words)

	Data Sheet
		Aciclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against human herpes viruses, varicella-zoster virus, Epstein-Barr virus and to a lesser extent cytomegalovirus.
		Aciclovir is indicated for acute treatment, for reduction of the duration and severity of acute symptoms and rash, for reduction of zoster-associated pain and for reduction of the incidence and duration of post-herperic neuralgia.
		Aciclovir should be used with caution in patients with underlying neurologic abnormalities, in patients with nutritional and metabolic disorders (dehydration, electrolyte abnormalities) and in patients with impaired kidney and liver function.
	www.medsafe.govt.nz /profs/datasheet/a/alphaacicilovirtab.htm (2122 words)

	Data Sheet
		Aciclovir Intravenous Infusion is indicated for the prophylaxis of Herpes simplex infections in immune-compromised patients.
		Aciclovir Intravenous Infusion formulations are indicated for prophylaxis of CMV infection in bone marrow transplant recipients.
		Aciclovir sodium is a synthetic acyclic purine nucleoside analogue.
	www.medsafe.govt.nz /profs/Datasheet/a/Aciclovirinjmaynepharma.htm (2395 words)

	Acyclovir (Site not responding. Last check: 2007-10-13)
		Aciclovir is rather different from other nucleoside analogues, for it contains only a partial nucleoside structure as the sugar ring is replaced by an open-chain structure.
		Aciclovir is converted into monophosphate form only by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation than cellular thymidine kinase.
		Aciclovir can also be given topically for treatment of herpes infections of mucous membrane and skin, such as genital herpes or recurrent herpes labialis (cold sore).
	aciclovir.cheap-pills.us (570 words)

	Aciclovir (IARC Summary & Evaluation, Volume 76, 2000) (Site not responding. Last check: 2007-10-13)
		Aciclovir is an acyclic nucleoside analogue which was first approved for use as an antiviral agent in 1982.
		Aciclovir was tested for carcinogenicity in one experiment in mice and one experiment in rats by oral administration.
		The bioavailability of orally administered aciclovir is 15—30%.
	www.inchem.org /documents/iarc/vol76/aciclovir.html (418 words)

	AHMF: Herpes Simplex in Pregnancy
		Continuous suppressive aciclovir in the last four weeks of pregnancy may be indicated for the patient with multiple clinical recurrences to prevent recurrences at delivery and hence the need for Caesarean section.
		Apart from aciclovir treatment Caesarean section should be considered for all women, particularly those developing symptoms with- in 6 weeks of delivery as their infants are most at risk of viral transmission due to the lack of time for development of maternal neutralizing antibodies with consequent passage across the placenta.
		Aciclovir is excreted in breast milk but its use is not contra-indicated as it does not cause harm to the infant.
	www.ahmf.com.au /health_professionals/guidelines/hsv_pregnancy.htm (1636 words)

	Aciclovir, acyclovir. DermNet NZ
		Aciclovir is a synthetic compound with a similar molecular structure to purine nucleoside.
		Aciclovir is also available as a cold-sore cream for the lips and face, and as an ophthalmic ointment for eye infections.
		Aciclovir is an important treatment for herpes zoster (shingles) but it can also be used to treat varicella (chickenpox) in adults, or severe infections in children.
	www.dermnetnz.org /treatments/aciclovir.html (700 words)

	Inhouse Pharmacy Zovirax is used for the treatment of Herpes Simplex. Aciclovir
		Aciclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against human herpes viruses, including Herpes simplex virus (HSV) types 1 and 2, Varicella zoster virus (VZV), Epstein Barr virus (EBV) and Cytomegalovirus (CMV).
		When aciclovir is given one hour after 1 gram of probenecid the terminal half life and the area under the plasma concentration-time curve is extended by 18% and 40% respectively.
		Aciclovir was not carcinogenic in long-term studies in the rat and the mouse.
	www.inhousepharmacy.com /general/zovirax-information-physician.html (2466 words)

	ACICLOVIR TOPICAL CREAM 5%
		Aciclovir monophosphate is converted to the diphosphate and to the triphosphate.
		Aciclovir topical cream is indicated in the management of initial genital herpes and in limited non – life threatening mucocutaneous herpes simplex virus infections in immunocompromised patients.
		Topical Aciclovir is not effective in the treatment of recurrent herpes genitalis or herpes febrilis infections in non immunocompromised patients, although topical Aciclovir may cause some reduction in the duration of viral shedding.
	www.behvazan.com /aciclovir.htm (394 words)

	Valtrex Tablets 500mg , SPC from the eMC
		Aciclovir, the principle metabolite of valaciclovir, is excreted in breast milk.
		Valaciclovir, an antiviral, is the L-valine ester of aciclovir.
		Aciclovir is a specific inhibitor of the herpes viruses with in vitro activity against herpes simplex viruses (HSV) type 1 and type 2, varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr Virus (EBV), and human herpes virus 6 (HHV-6).
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?documentid=2185 (2562 words)

	Zovirax tablets/suspension
		Aciclovir is taken by mouth to treat herpes infections that cause chickenpox and shingles.
		Aciclovir is also available as creams specifically for treating genital herpes and cold sores, and as an eye ointment for treating herpes simplex infections of the eye.
		Aciclovir cold sore cream, cream, tablets and dispersible tablets are also available as generics, ie without a brand name.
	www.netdoctor.co.uk /medicines/100002871.html (732 words)

	The South African Medicines Formulary: ANTIVIRALS FOR SYSTEMIC USE
		Aciclovir triphosphate inhibits viral DNA polymerase, and it also competes with cellular deoxyguanosine triphosphate for incorporation into the viral DNA, thus terminating viral DNA synthesis.
		Aciclovir is indicated for the treatment of infections due to herpes simplex (types I and II) and varicella- zoster viruses.
		Aciclovir may prevent and treat the complications of chickenpox (especially pneumonia) in immune-competent adults, although this has not been conclusively demonstrated.
	web.uct.ac.za /depts/mmi/jmoodie/j05html.html (2083 words)

	New Zealand Herpes Foundation (Site not responding. Last check: 2007-10-13)
		The use of aciclovir for recurrent genital herpes in late pregnancy is not recommended by the US Centers for Disease Control (CDC) or by the manufacturer.
		Any pregnant woman treated with aciclovir should be reported to the "Aciclovir in Pregnancy Registry" 38 and their infants should be followed.
		Prophylactic use of aciclovir from 36 weeks may decrease the number of clinical recurrences and reduce the need for caesarean section,39, 40 but may not eliminate asymptomatic viral shedding completely.
	www.herpes.org.nz /guidelines/pregnancy.html (1472 words)

	Aidsmap \| Herpes simplex
		Aciclovir is a very expensive drug in its branded form, but generic forms of aciclovir are becoming available.
		Oral aciclovir is approved for the treatment of HSV-related syndromes and reduces the severity and duration of HSV symptoms.
		Compared with aciclovir, the hazard ratios for time to recurrence for valaciclovir 500mg twice daily and 1000mg once daily were 0.73 (confidence interval 0.50-1.06) and 1.31 (CI 0.94-1.82).
	www.aidsmap.com /en/docs/96BE1839-0AF9-4C7D-A5DA-322ABDA4AFF6.asp (2831 words)

	Cheap Acyclovir pills.The Best Online Pharmacy.Free FedEx!...
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	sexpharma.netfirms.com /aciclovir.html (320 words)

	Clinical Evidence: A Publication of BMJ Publishing Group - April 1, 2003 - American Family Physician
		It found no significant difference between aciclovir and placebo for pain at 3 or 6 months (at 3 months AR for pain 24% in both groups; at 6 months AR 14% with aciclovir v 13% placebo; CI not reported in the review).
		The fourth RCT (46 people; aciclovir 4 g/day for 10 days) found that aciclovir significantly reduced pain at 3 months (7% v 38%; P = 0.05), but the difference was not significant at 6 months (5% with aciclovir v 26% with placebo, P = 0.07).
		Aciclovir versus other antivirals: We found one systematic review (search date 1998, 1 RCT, 1141 people).[7] The RCT in the review compared valaciclovir (a precursor of aciclovir) given three times daily for 7 or 14 days versus 7 days of aciclovir.
	www.aafp.org /afp/20030401/britishx.html (3550 words)

	Aciclovir topical - Patient UK
		Aciclovir preparations are usually applied five times a day at four hourly intervals.
		Aciclovir cream is best used as soon as possible after the symptoms of an infection begin (e.g.
		Aciclovir occasionally causes skin irritation such as stinging, burning, skin rashes, itching or drying of the affected area.
	www.patient.co.uk /showdoc/30002138 (613 words)

	Aciclovir-BC Tablets - Aciclovir - Medical Drug (Site not responding. Last check: 2007-10-13)
		Aciclovir has no residual benefit effect, that is, there is no anti-viral effect outside of the period of intake, and it does not reduce the body viral pool.
		Aciclovir is phosphorylated to the active antiviral compont aciclovir triphosphate in cells infected with HSV or VZV.
		Aciclovir is generally well tolerated and any side effects are usually mild.
	www.virtualmedicalcentre.com /drugs.asp?drugid=2001 (740 words)

	Aciclovir Eye Ointment - Patient UK
		Aciclovir is used to treat viral infections of the eye caused by the Herpes simplex virus.
		It is important to continue using aciclovir for 3 days after the eye has completely healed to ensure that all of the viruses have been killed.
		Aciclovir eye ointment may cause irritation and puffiness of the eyes.
	www.patient.co.uk /showdoc/30002139 (792 words)

	Pharmacokinetics of valaciclovir -- MacDougall and Guglielmo 53 (6): 899 -- Journal of Antimicrobial Chemotherapy
		Valaciclovir (Val-ACV) is a prodrug of the antiviral compound aciclovir (ACV).
		Oral administration of valaciclovir yields systemic aciclovir through uptake by dipeptide transporters in the gut lumen and hydrolysis by esterases present in the gut lumen, intestinal wall and liver.
		Purification and characterization of a rat liver enzyme that hydrolyzes valaciclovir, the L-valyl ester prodrug of aciclovir.
	jac.oxfordjournals.org /cgi/content/full/53/6/899 (1784 words)

	Aciclovir in herpes simplex gingivostomatitis -- Goodyear and Dawson 315 (7116): 1162 -- BMJ (Site not responding. Last check: 2007-10-13)
		Aciclovir in herpes simplex gingivostomatitis -- Goodyear and Dawson 315 (7116): 1162 -- BMJ
		Aciclovir inhibits viral replication, and thus it is not surprising
		Amir J, Harel L, Smetana Z, Varsano I. Treatment of herpes simplex gingivostomatitis with aciclovir in children: a randomised double blind placebo controlled study.
	www.bmj.com /cgi/content/full/315/7116/1162 (696 words)

	Treatment of herpes simplex gingivostomatitis with aciclovir in children: a randomised double blind placebo controlled ...
		Treatment of herpes simplex gingivostomatitis with aciclovir in children: a randomised double blind placebo controlled study -- Amir et al.
		The efficacy of oral aciclovir suspension was studied in a double blind placebo controlled study
		18 were from the aciclovir group and 13 from the placebo group.
	www.bmj.com /cgi/content/full/314/7097/1800 (2579 words)

	Soothelip
		Aciclovir is converted to a more active form inside cells of the body that are infected with herpes simplex.
		This aciclovir cream is designed for the treatment of herpes simplex infections of the lips (cold sores) and is not recommended for use in genital herpes.
		For recurrent cold sores aciclovir cream is most effective if treatment is started as soon as the first signs of the infection begin to reappear.
	www.netdoctor.co.uk /medicines/100002992.html (679 words)

	Valaciclovir: key clinical papers
		The bioavailability of aciclovir after valaciclovir, characterised from studies in healthy adult volunteers, is similar in a wide range of patient populations, including the elderly, those with advanced HIV disease, patients with impaired liver or renal function, or undergoing bone marrow transplantation.
		In a series of controlled, randomised trials of valaciclovir, aciclovir and placebo for the acute treatment of genital HSV infections in approximately 3000 patients, twice daily valaciclovir was proven as effective as the standard 5 times daily aciclovir regimen in resolving the clinical signs and symptoms of lesional disease.
		The aciclovir safety heritage and pharmacokinetic rationale for the development of valaciclovir have been realised through the clinical research programmes in the zoster and HSV indications.
	www.herpesweb.net /profess/effective/hmang13.htm (1998 words)

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