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Topic: Aconitine

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	botanical.com - A Modern Herbal \| Aconite Herb
		Aconitine, the only crystallizable alkaloid, is present to the extent of not more than 0.2 per cent, but to it is due the characteristic activity of the root.
		The Aconitines are a group of highly toxic alkaloids derived from various species of Aconite, and whilst possessing many properties in common are chemically distinguishable according to the source from which they are obtained.
		Japaconitine is similar in constituents and properties with the Aconitine of A.
	www.botanical.com /botanical/mgmh/a/aconi007.html (3205 words)

	Aconitum - Wikipedia, the free encyclopedia
		The action of aconitine on the circulation is due to an initial stimulation of the cardio-inhibitory centre in the medulla oblongata (at the root of the vagus nerves), and later to a directly toxic influence on the nerve-ganglia and muscular fibres of the heart itself.
		It should however be noted that aconitine may be easily absorbed through the skin, and poisoning may occur through this route simply by picking the leaves without the use of gloves; the toxin in the sap is absorbed through the skin.
		Aconitine is a potent neurotoxin that blocks tetrodotoxin-sensitive sodium channels.
	en.wikipedia.org /wiki/Aconitum (2025 words)

	Aconitine, Alkaloid
		Aconitine is an alkaloid, and represents the full medicinal property of the leaves and root of aconitum napellus.
		Whenever aconitine is prescribed to patients old enough to interpret sensations, they should be told that the medicine is likely to produce tingling of the lips, of the fingers and toes, and when this becomes manifest, they must reduce the dose or extend the time interval of taking the medicine.
		When aconitine is given to combat fevers in exact and proper doses, it cannot produce marked physiologic effects as long as there is fever upon which the aconitine acts, because febrile conditions are present which utilize and require the full medicinal force of the remedy.
	www.harvestfields.netfirms.com /HerbBooks/01/01/015.htm (1825 words)

	The Explosives and Weapons Forum - Aconitine (Site not responding. Last check: )
		Aconitine is a plant poison that has been used for milleniums to poison people.
		Aconitine is found in the roots of Aconitum Napellus, Aconitum Columbianum and Aconitum Feros.
		Commercial aconitine has repeatedly been shown to be of various degrees of strength, and is a mixture of the foregoing alkaloids, together with pseudaconitine (C36H49NO12) and picraconitine (C31H45NO10), the former being capable of conversion into dimethyl-protocatechuic acid (veratric acid) (C9H10NO4) and pseudaconine (C27H41NO9).
	www.roguesci.org /theforum/battlefield-chemistry/3938-aconitine-print.html (1929 words)

	Dose Of Amorphous Aconitine (Site not responding. Last check: )
		Aside from its systemic use in the treatment of fevers, aconitine may be used to advantage in inflammations of the mucous membrane of the mouth and pharynx.
		Aconitine reduces the number of respirations, and should be used, therefore, in all inflammatory diseases of the lungs, in which there is always increased respiration.
		The slight antagonism which exists between aconitine and digitalin is not sufficient to destroy the property of aconitine as a febrifuge, and the digitalin aids aconitine in reducing fever.
	www.harvestfields.netfirms.com /HerbBooks/01/01/018.htm (1750 words)

	Patent 6,896,898
		Aconitine alkaloids may be delivered by themselves, or in combination with other elements, such as additional analgesics, other drugs, or positive health promoting substances.
		In one aspect, the aconitine alkaloid may be a member selected from the group consisting of lappaconitine, N-deacetyl-lappaconitine, songtiening, bulleyaconitine A, 3-acetylaconitin, isolappaconitine, deoxylappaconitine, neofinaconitine, ranaconitine, N-deacetylranaconitine, finaconitine, N-deacetylfinaconitine, mesaconitine, jesaconitine, and salts, analogs, derivatives, prodrugs, and mixtures thereof.
		In the case of the adhesive matrix patch, an amount of an aconitine alkaloid sufficient to produce the desired therapeutic blood plasma level is dissolved or suspended in a polymeric phase or carrier.
	www.pharmcast.com /Patents100/Yr2005/May2005/052405/6896898_Transdermal052405.htm (5424 words)

	Aconite
		The active principle of Aconitum napellus is the alkaloid aconitine, first examined by P.L. Geiger and Hesse, Alder Wright and A.B. Luff obtained apoaconitine[?], aconine[?], and benzoic acid by hydrolysis; while, in 1802, C. Ehrenberg and A. Purfurst observed acetic acid as a hydrolytic product.
		The usual test for solutions of aconitine consists in slight acidulation with acetic acid and addition of potassium permanganate[?], which causes the formation of a red crystalline precipitate.
		In 1905, Dunstan and his collaborators discovered two new aconite alkaloids, indaconitine[?] in "mohri" (Aconitum chasmanthum, Stapf), and bikhaconitine in "bikh" (Aconitum spicatum); he also proposes to classify these alkaloids according to whether they yield benzoic or veratric acid on hydrolysis.
	www.ebroadcast.com.au /lookup/encyclopedia/mo/Monkshood.html (1556 words)

	Aconitine
		The lethal dose of aconitine in rats is 0.12 mg/kg by i.v.
		Aconitine affects the body by delaying the repolarization of the action potential.
		It is said that the arrhythmic activity is correlated to the presence of a benzoylester side chain at the C14 position of the molecule.
	chemweb.calpoly.edu /chem/bailey/377/PapersW03/KristineL (534 words)

	Aconitum napellus spp. (PIM 007)
		Since all parts of the Aconitum plant contain aconitine, reducing absorption by usual measures (induction of emesis by syrup of ipecac, lavage, charcoal, cathartics) is advised in patients who ingest toxic amounts of the plant.
		Since all parts of the aconitum plant contain aconitine, reducing gastric absorption by the usual measures (emesis with syrup of ipecac, gastric lavage, charcoal, cathartics) is advisable in those patients who ingest more than a small quantity of the plant.
		The likelihood of toxicity is difficult to predict because of the variability in the alkaloid content of the plant; a 2 to 4 hr observation period is appropriate (Ellenhorn, 1988).
	www.inchem.org /documents/pims/plant/aconitum.htm (2839 words)

	Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone -- Yeih et al. ...
		Aconitine and its related alkaloids can bind with high affinity to the open state of sodium channels, thus causing a persistent
		to be the underlying cause of aconitine induced ventricular tachyarrhythmia.
		Winslow E. Hemodynamic and arrhythmogenic effects of aconitine applied to the left atria of anesthetized cats: effects of amiodarone and atropine.
	heart.bmjjournals.com /cgi/content/full/84/4/e8 (872 words)

	Effects of Sodium-Calcium Exchange Inhibitors, KB-R7943 and SEA0400, on Aconitine-Induced Arrhythmias in Guinea Pigs in ...
		In the absence (a) of aconitine, the action potential was generated under the stimulation of 1 Hz.
		In the presence (b, c) of aconitine, the abnormal electrical activity during the resting period occurred and then was followed by chaotic oscillatory activity.
		Schmidt H and Schmitt O (1974) Effect of aconitine on the sodium permeability of the node of Ranvier.
	jpet.aspetjournals.org /cgi/content/full/310/1/83 (4355 words)

	Tobacco Murders
		It was not until 1828 that the most active ingredient was isolated, and named nicotine.
		Nicotine is a rapidly effective poison, in the same group as morphine, strychnine and aconitine.
		Its initial effect is that of a stimulant, but in poisonous doses it produces nausea and cardiac irregularity, eventually paralysing the respiratory system.
	www.parmaq.com /truecrime/Tobacco.htm (2386 words)

	Monkshood
		The active ingredient (the poison) is aconitine; 3-6mg of this is enough to kill a person.
		In modern preparations of the drug, however, the amount of Aconitine can be controlled perfectly and it is thus safe - in older times, this was not the case, and there could be a 10-fold difference in strength between preparations.
		Aconitine has a short-lived cardiotonic action followed by cardiac depression, and ending in cardiac arrest.
	www.magiensunivers.dk /herbalhints/monographs/aconitum.asp (519 words)

	Aconitinum. - A DICTIONARY OF PRACTICAL MATERIA MEDICA By John Henry CLARKE, M.D. Presented by Médi-T ®
		Morson's "English Aconitine" is a secret preparation believed to be made from A. Ferox.
		The alkaloid in A. Ferox differs somewhat from ordinary Aconitine chemically, and is called pseudo-Aconitine.
		Aconitine of T. Smith, of Edinburgh, is probably identical with Morson's.
	www.homeoint.org /clarke/a/aconitin.htm (735 words)

	Monkshood (aconitum) plant - BrainTalk Communities
		The aconite poisons have been known throughout the world from the earliest times, and the use of aconitine recorded by the ancient Greeks, who called it the Queen of Poisons and believed that it was created from the saliva of the mythical guardian dog of the underworld, Cerberus.
		The main alkaloid is aconitine, one of the strongest plant poisons.
		However, in careful doses, aconitine can be applied externally as a painkiller to treat neuralgia, rheumatism, headache, gout, migraine and colds accompanied by high body temperature.
	brain.hastypastry.net /forums/showthread.php?p=258413 (1649 words)

	ACOOMETI - LoveToKnow Article on ACOOMETI (Site not responding. Last check: )
		Aconitine (CsaHisNOis, according to Dunstan; C^H^NOn, according to Freund) is a crystalline base, soluble in alcohol, but very sparingly in water; its alcoholic solution is dextrorotatory, but its salts are laevorotatory.
		Other related alkaloids a.re lycaconitine and myoctonine which occur in wolfsbane, Aconitum lycodonum.
		In 1905, Dunstan and his collaborators discovered two new aconite alkaloids, indaconi-tine in " mohri " (Aconitum chasmanlhum, Stapf), and bikh-aconitine in " bikh " (Aconitum spicatum); he also proposes to classify these alkaloids according to whether they yield benzoic or veratric acid on hydrolysis (Jour.
	65.1911encyclopedia.org /A/AC/ACOOMETI.htm (1385 words)

	A8001 ACETYLBENZOYLACONINE ~95% (HPLC), crystalline
		In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.
		Onur, R., et al., Effects of aconitine on neurotransmitter release in the rat neuromuscular junction.
		H]noradrenaline uptake of the Aconitum alkaloids aconitine, 3-acetylaconitine, lappaconitine, and N-desacetyllappaconitine in rat hippocampus.
	www.sigmaaldrich.com /catalog/search/ProductDetail/SIGMA/A8001?LastFive (179 words)

	aconitine - Search Results - MSN Encarta
		Alkaloids : types of alkaloids : aconitine: Aconite
		Aconite, common name for certain perennial herbs and for a preparation derived from them that was formerly used in medicine.
		Alkaloids : types of alkaloids : aconitine: Delphinium
	ca.encarta.msn.com /aconitine.html (85 words)

	[NMC] Demo : by PROSCOPE (Site not responding. Last check: )
		Aconitine and its allied alkaloids (mesaconitine, hypaconitine and jeasaconitine) are the active principles of aconitum napellus whose synonyms, monkshood, wolfsbane.
		The fetal dose of aconitine in human is 2-3mg.
		We describe a case of severe aconitine poisonig where full recovery occurred with hemofiltration therapy.
	www.nmckk.co.jp /english/html/journal/jjcd/vol18/180802044.htm (122 words)

	chuan wu (prepared) [wu tou] (Site not responding. Last check: )
		Aconitine may act on the vagus nerve or directly on the heart, slowing heart rate and altering the metabolism and excitability of myocardium.
		Ampoule (2m1 containing 100mg of aconitine): 2-3 ampoules added in 5% glucose 500m1 IV for drips daily, or 1 ampoule IM daily or bid.
		Aconitine is a poison which can be detoxified by high temperature.
	botanicum.com /singles/chuanwuprep.htm (313 words)

	Aconitine - The Explosives and Weapons Forum (Site not responding. Last check: )
		I make clear that it is not so pleasant be in cloud of sugar smoke with aconitine vapors...
		Here is an old post about aconitin including pic.
		I found something on aconitines melting point which is between 183°C and 186,5°C. And up to 198°C at finest quality.That makes it in my opinion not the very best candidate to be dispersed by burning substances.
	www.roguesci.org /theforum/battlefield-chemistry/3938-aconitine.html (1964 words)

	Heart -- eLetters for Yeih et al., 84 (4) 8
		We read with interest the ‘electronic’ case report posted recently by Yeih and colleagues on aconitine poisoning.[1] They describe in detail the mechanism by which aconitine is purported to cause severe cardiotoxicity.
		Conventional anti-arrhythmics have generally been disappointing, as has been described previously.[3] [4] One other reported example of successful use of magnesium was after several other anti-arrhythmic drugs had failed in a patient with torsades des pointes.[5] This appears to be the first time that magnesium has been used first-line with some success.
		Most anti-arrhythmic drugs have shown little consistent effect in the treatment of aconitine poisoning,[6] but, with perhaps the exception of amiodarone, all risk Q-T prolongation, an important mechanism in the development of ventricular tachyarrhythmias.
	heart.bmjjournals.com /cgi/eletters/84/4/e8 (609 words)

	The Red Seal - Chapter XVIII (Site not responding. Last check: )
		"You have just stated that aconitine is not usually administered to murder a person," Kent spoke seriously, choosing his words with care.
		The box bearing the aconitine label and the pills had all rolled out of the china umbrella stand, and he had taken it for granted that the pills belonged in the box.
		Raising his head after contemplating the pills, Kent had looked across the room and his glance had fallen on a wing chair, standing just inside the doorway of the living room, and thrown partly in shadow by the portieres.
	www.worldwideschool.org /library/books/lit/romance/TheRedSeal/chap18.html (3014 words)

	Increased susceptibility to ventricular arrhythmias in a rodent model of experimental depression -- Grippo et al. 286 ...
		Mean arterial pressure (MAP; ±SE) in a subset of CMS and control rats at baseline and at significant time points during aconitine infusion.
		During aconitine infusion but before the onset of the first PVC, MAP was significantly higher in the CMS group relative to the control group [t(3) = 4.67].
		Peper K and Trautwein W. The effect of aconitine on the membrane current in cardiac muscle.
	ajpheart.physiology.org /cgi/content/full/286/2/H619 (5208 words)

	Action potential duration restitution and ventricular fibrillation due to rapid focal excitation -- Swissa et al. 282 ...
		Aconitine, a sodium channel opener that is known
		Aconitine (100 µg) was injected locally at the center of the RV, inducing VT and VF.
		by reinjection of aconitine and infusion of verapamil with bretylium
	ajpheart.physiology.org /cgi/content/full/282/5/H1915 (4374 words)

	[No title]
		, maximum aconitine concentration in blood was over 0.2ng/ml at nine hours later from his ingestion.
		Reported the influence of tetrodotoxin, which attenuated toxic effects of aconitine in vivo, which might be an antagonist for aconites
		Distribution Of Aconitine Alkaloids In Body Fluids And Tissues In A Suicidal Case Of Aconite Ingestion.
	www.ispub.com /ostia/index.php?xmlPrinter=true&xmlFilePath=journals/ijto/vol1n1/aconite.xml (1410 words)

	Acupuncturetoday.com \| tell me about Aconite (Site not responding. Last check: )
		The main active ingredient in aconite is aconitine.
		Even in small amounts, aconitine can inhibit respiration and, in some cases, lead to respiratory failure.
		As little as two milligrams of aconitine taken internally may cause death.
	www.acupuncturetoday.com /herbcentral/aconite.html (348 words)

	TOXILIT - Martens, P. R.//Vandevelde, K. : A near lethal case of combined strychnine and aconitine poisoning (Site not responding. Last check: )
		A near lethal case of combined strychnine and aconitine poisoning
		The successful supportive management of an acute combined strychnine and aconitine poisoning is described.
		Occurrence, signs, symptoms, mechanisms of action of both strychnine and aconitine and treatment particularly with regard to the life-threatening arrhythmia induced by aconitine are briefly reviewed.
	www.mib.ch /toxi/lit/p39224.html (115 words)

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