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Topic: Acridine

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	Acridine Summary
		Bernthsen condensed diphenylamine with carboxylic acids, in the presence of zinc chloride in the Bernthsen acridine synthesis.
		With Formic acid as the carboxylic acid the reaction yields acridine itself, and with the higher homologues the derivatives substituted at the meso carbon atom are generated.
		Acridine crystallizes in needles which melt at 110 °C. It is characterized by its irritating action on the skin, and by the blue fluorescence shown by solutions of its salts.
	www.bookrags.com /Acridine (1067 words)

	Acridine - LoveToKnow 1911
		Acridine and its homologues are very stable compounds of feebly basic character.
		Acridine crystallizes in needles which melt at 110° C. It is characterized by its irritating action on the skin, and by the blue fluorescence shown by solutions of its salts.
		Numerous derivatives of acridine are known and may be prepared by methods analogous to those used for the formation of the parent base.
	www.1911encyclopedia.org /Acridine (429 words)

	[No title]
		If intralesional excision could be applied to osteosarcoma, satisfactory limb function and a higher quality of life could be achieved.
		Therefore, we experimentally examined the effectiveness of intralesional excision for osteosarcoma using photodynamic therapy (PDT) with acridine orange (AO), an agent with vital staining fluorescence and anti-tumor effects.
		This intralesional excision technique may be useful to obtain satisfactory limb function in osteosarcoma patients.
	www.ctos.org /meeting/1999/papers/pps18.html (200 words)

	Acridine - Information from Reference.com
		Acridine is structurally related to anthracene with one of the central CH groups is replaced by nitrogen.
		A. Bernthsen condensed diphenylamine with carboxylic acids, in the presence of zinc chloride in the Bernthsen acridine synthesis.
		With Formic acid as the carboxylic acid the reaction yields acridine itself, and with the higher homologues the derivatives substituted at the meso carbon atom are generated.
	www.reference.com /search?q=Acridine (711 words)

	Synthesis of Twisted Intercalating Nucleic Acids Possessing Acridine Derivatives. Thermal Stability Studies (Site not responding. Last check: )
		Twisted intercalating nucleic acids (TINA) possessing acridine derivatives have been synthesized via the postsynthetic modifications of oligonucleotides possessing insertions of (R)-1-O-(4-iodobenzyl)glycerol (8) or (R)-1-O-(4-ethynylbenzyl)glycerol (9) at the 5'-end or in the middle as a bulge.
		After the postsynthetic step, treatment of the oligonucleotides with 32% aq ammonia or 50% ethanolic solution of tris(2-aminoethyl)amine led to the substitution of chloride on acridine concurrent with deprotection of the bases and cleavage of the oligonucleotides from CPG.
		Molecular modeling of the parallel triplex with a bulged insertion of the monomer (R)-3-O-[4-(9-aminoacridin-2-ylethynyl)benzyl]glycerol in the triplex-forming oligonucleotide (TFO) showed that the acridine moiety was stacking between the bases of the duplex, while phenyl was placed between the bases of the TFO.
	pubs.acs.org /cgi-bin/abstract.cgi/bcches/2006/17/i04/abs/bc060058o.html (219 words)

	Acridine orange
		The chemical structure of Acridine orange is shown at the right.
		This is a graph of the molar extinction coefficient of Acridine orange dissolved in basic ethanol.
		This is the fluorescence emission spectrum of Acridine orange dissolved in basic ethanol.
	omlc.ogi.edu /spectra/PhotochemCAD/html/acridineorange.html (207 words)

	ES&T Online News: Sunlight turns antiepileptic drug into harmful compound
		When researchers first looked for pharmaceuticals in the environment in Europe and elsewhere, some of the highest concentrations they found were for residues of the antiepileptic drug carbamazepine, which showed up in a variety of places, including drinking-water treatment plants and sewage effluent.
		Previous research has shown that in the presence of hydrogen peroxide and UV light, carbamazepine breaks down to acridine, which is both mutagenic and carcinogenic.
		The compound is relatively stable, and after 8 h, its concentrations accounted for 10% of the carbamazepine in the initial samples.
	pubs.acs.org /subscribe/journals/esthag-w/2006/aug/science/nl_sunlight.html (623 words)

	Acridine - Information from Reference.com
		Acridine, C13H9N, is an organic compound and a nitrogen heterocycle.
		Acridine orange is a nucleic acid selective fluorescent cationic dye useful for
		Acridine Adduct of [60]Fullerene with Enhanced DNA-Cleaving Activity.
	www.reference.com /search?q=Acridine&db=web (179 words)

	Olympus FluoView Resource Center: Glossary of Terms in Confocal Microscopy
		Acridine Orange - A nitrogen heterocyclic chromophore containing the acridine nucleus, which binds to DNA and RNA by intercalation between successive base pairs to produce a strong, but very broad emission band in the green to red wavelength region.
		Acridine orange is excited by blue-green laser light (488 nanometers) or by ultraviolet, violet, and blue interference filters coupled to an arc-discharge lamp (mercury or xenon).
		Typical examples include acridine orange intercalated between successive DNA base pairs, the fluorescein moiety in a conjugated protein or antibody, and the tetrapyrrole ring system in chlorophyll.
	www.olympusfluoview.com /theory/glossary.html (10049 words)

	Definition of acridine - Merriam-Webster Online Dictionary
		N occurring in coal tar and important as the parent compound of dyes and pharmaceuticals
		Learn more about "acridine" and related topics at Britannica.com
		See a map of "acridine" in the Visual Thesaurus
	www.m-w.com /cgi-bin/dictionary?book=Dictionary&va=acridine (33 words)

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