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Topic: Acromegaly

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	Acromegaly - Wikipedia, the free encyclopedia
		In over 90 percent of acromegaly patients, the overproduction of GH is caused by a benign tumor of the pituitary gland, called an adenoma.
		In a few patients, acromegaly is caused not by pituitary tumors but by tumors of the pancreas, lungs, and adrenal glands.
		If acromegaly is suspected, medical imaging and medical laboratory investigations are generally used together to confirm or rule out the presence of this condition.
	en.wikipedia.org /wiki/Acromegaly (1822 words)

	Acromegaly (Site not responding. Last check: 2007-08-19)
		Acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (GH).
		Acromegaly is caused by prolonged overproduction of GH by the pituitary gland.
		If a doctor suspects acromegaly, he or she can measure the GH level in the blood after a patient has fasted overnight to determine if it is elevated.
	www.endocrine.niddk.nih.gov /pubs/acro/acro.htm (2417 words)

	Endotext.com - Neuroendocrinology, Hypothalamus, And Pituitary, Acromegaly (Site not responding. Last check: 2007-08-19)
		Acromegaly is a rare condition with an approximate incidence of 3-4 new cases per million of population per year (1).
		It is established that uncontrolled acromegaly results in a considerable increase in morbidity with an overall mortality at least two-fold that of the general population (57, 58).
		In all patients with acromegaly efforts should be made to optimize lung and cardiac function and particular attention be made to the management of cardiovascular risk factors including smoking, dyslipidaemia and abnormalities of carbohydrate metabolism.
	www.mdtext.com /neuroendo/neuroendo5e/neuroendo5e.htm (7137 words)

	Acromegaly Information on Healthline
		However, in acromegaly, there is an increased amount of HGH released, generally by a tumor that forms in the pituitary.
		Familial acromegaly is transmitted in an autosomal dominant pattern- which means that it has an equal chance of affecting both boys and girls in a single family.
		Most cases of acromegaly are detected on an initial visit to a family physician, although some early or mild cases may be missed, causing a delay in the diagnosis.
	www.healthline.com /galecontent/acromegaly (1152 words)

	acromegaly.org - About Acromegaly
		Acromegaly is a serious systemic condition caused in over 98% of cases by an adenoma (i.e., benign tumor) of the pituitary gland that secretes excessive growth hormone (GH).
		The diagnosis of acromegaly is confirmed by demonstrating elevated levels of both GH and insulin-like growth factor-1 (IGF-1).
		Following the biochemical confirmation of acromegaly, a MRI of the pituitary should be performed to confirm the presence of a pituitary adenoma.
	www.acromegaly.org /about_acromegaly.aspx (879 words)

	Acromegaly
		Acromegaly is the Greek word for "extremities" and "enlargement." When the pituitary gland produces excess growth hormones, this results in excessive growth - called acromegaly.
		Due to the subtlety of the symptoms, acromegaly is often not diagnosed until years later.
		Ninety percent of acromegaly cases are caused by benign tumors on the pituitary gland.
	www.healthsystem.virginia.edu /uvahealth/adult_endocrin/acromegaly.cfm (318 words)

	Acromegaly & Octreotide - Neuroendocrine Clinical Center & Pituitary Tumor Center at MGH/Harvard
		Acromegaly is characterized by a number of clinical features including enlargement of the hands and feet, facial changes including frontal bossing, enlarged mandible and increased dental spacing, arthralgias, diaphoresis, sleep apnea, hypertension, diabetes mellitus, and hypertrophic cardiomyopathy.
		The primary mode of therapy for acromegaly is surgery to reverse the mass effect and attempt biochemical cure.
		Adjunctive therapy is critical, particularly because persistent acromegaly is associated with the increased mortality and risk of malignancy.
	pituitary.mgh.harvard.edu /e-f-943.htm (1241 words)

	Novartis Oncology - What is Acromegaly?
		Acromegaly is an insidious disease in adults caused by excessive secretion of growth hormone (GH), a key factor in body growth and organ development.
		Acromegaly can also result in complications including cardiovascular disease; carbohydrate intolerance (which can lead to diabetes); respiratory distress, such as upper airway obstruction and sleep apnea; and secondary malignancies, such as colon cancer.
		If a doctor suspects acromegaly is the cause of your symptoms, he or she can choose from several diagnostic tests.
	www.novartisoncology.com /page/acromegaly.jsp (1729 words)

	Acromegaly and gigantism
		Acromegaly is a disorder in which the abnormal release of a particular chemical from the pituitary gland in the brain causes increased growth in bone and soft tissue, as well as a variety of other disturbances throughout the body.
		Acromegaly is a relatively rare disorder, occurring in approximately 50 out of every one million people (50/1,000,000).
		In acromegaly, the pituitary continues to release GH and ignores signals from the hypothalamus.
	www.healthatoz.com /healthatoz/Atoz/ency/acromegaly_and_gigantism.jsp (1429 words)

	UpToDate Patient information: Acromegaly (somatotroph adenomas)
		Acromegaly is the clinical syndrome that results from prolonged, excessive secretion of growth hormone (GH).
		Acromegaly can lead to serious illness and even death if it is not treated successfully, but treatment that lowers growth hormone to normal leads to a normal life span.
		Acromegaly may be associated with an increased risk of benign and malignant tumors if growth hormone levels are left uncontrolled.
	patients.uptodate.com /frames.asp?page=topic.asp&file=endo_hor/4528&title=Acromegaly (2825 words)

	Acromegaly (Site not responding. Last check: 2007-08-19)
		Acromegaly may also cause you to experience gradual changes in the shape of your face, such as a protruding lower jaw and brow, an enlarged nose, thickened lips, and wider spacing between your teeth.
		Some of the symptoms of acromegaly, such as headaches and impaired vision, are due to the tumor mass pressing on nearby brain tissues.
		Acromegaly usually develops slowly, and even your family members may not initially notice the gradual physical changes that occur with the disorder.
	www.prescriptiondrugchat.com /showthread.php?t=1171 (1391 words)

	OHSU Pituitary Unit - Acromegaly
		Although serum GH is elevated in most patients with acromegaly, measuring a random serum GH level is not a reliable way to diagnose the disease since GH release is pulsatile and levels fluctuate even in normal individuals.
		Patients with acromegaly also have an increased risk of developing colonic polyps (with a presumed increased risk of colon cancer) so those individuals typically receive a screening colonoscopy and are closely followed thereafter.
		Finally, patients with acromegaly are at increased risk of developing carpal tunnel syndrome that is characterized by wrist pain and finger numbness.
	www.ohsupituitary.com /patients/acromeg.asp (1251 words)

	Pituitary Disorders Education & Support - Pituitary Disorders - Acromegaly
		Acromegaly is a disease of growth hormone (GH) hypersecretion.
		Acromegaly is a potentially life-threatening disease: Life expectancy in the patients is shortened on the average by
		Physicians who are not experienced in pituitary diseases often tell the patient that the diagnosis of acromegaly is excluded if plasma GH is “normal.” In fact, active acromegaly may be accompanied by perfectly normal GH levels, often as low as 0.5-1 ng/ml.
	www.pituitarydisorder.net /pituitary_disorders_acromegaly.html (769 words)

	Acromegaly
		Acromegaly is a serious condition that occurs when the body produces too much of the hormones that control growth.
		The term acromegaly comes from Greek words meaning “extremities” and “enlargement.” Enlargement of the hands and feet is one of the most common signs of the disease.
		Untreated, acromegaly is linked to early heart disease, high blood pressure, heart rhythm disorders, diabetes, and colonic polyps, a precursor of colon cancer.
	www.emedicinehealth.com /acromegaly/article_em.htm (427 words)

	Acromegaly and Acromegaly Symptoms and Sandostatin
		Acromegaly is a rare disease that affects about 40-60 out of every million people in the U.S. It is caused by the uncontrolled hypersecretion of growth hormone (GH) in the pituitary, a tiny gland — about the size of a pea — located behind the eyes, just below the brain.
		While acromegaly itself is usually not fatal, the complications (such as cardiomegaly or diabetes) can be life threatening.
		While surgery is considered first-line therapy for most patients, it is not indicated for everyone, and its effectiveness as a cure depends on factors such as the size of the pituitary tumor, invasiveness of the tumor, and the skill of the surgeon.
	www.us.sandostatin.com /info/disease/acromegaly/home.jsp?from=acromegaly (924 words)

	Acromegaly Definition and Treatment
		The term Acromegaly is derived from Greek words “Enlargement” and “Extremities”, reflecting one of its most common symptoms — the abnormal growth of both feet and hands.
		One of the earliest signs of Acromegaly is when a person experiences hand and feet swelling, where a noticeable change in shoe size or ring develops.
		It is estimated by researchers that 3 out of 1,000,000 individuals develop acromegaly every single year, and 40-60 out of every one million patients can suffer from this condition.
	www.ultimate-hgh-research.com /acromegaly.html (236 words)

	Feline Acromegaly - The Merck Veterinary Manual
		Acromegaly in cats is caused by a growth-hormone-secreting tumor of the anterior pituitary.
		Clinical signs of uncontrolled diabetes mellitus are often the first sign of acromegaly in cats; therefore, polydipsia, polyuria, and polyphagia are the most common presenting signs.
		Neurologic signs of acromegaly in humans, such as peripheral neuropathies (paresthesias, carpal tunnel syndrome, sensory and motor defects) and parasellar manifestations (headache and visual field defects), are not generally detected in acromegalic cats.
	www.merckvetmanual.com /mvm/htm/bc/40508.htm (659 words)

	dreddyclinic.com - Acromegaly
		Because Acromegaly is so uncommon, and the physical changes occur so gradually, doctors often don't recognize it immediately.
		In this form of Acromegaly, children have exaggerated bone growth and an abnormal increase in height.
		There are no known risk factors for acromegaly other than a prior history of a pituitary tumor.
	www.dreddyclinic.com /findinformation/aa/acromegaly.htm (525 words)

	acromegaly.org - What is Acromegaly? (Site not responding. Last check: 2007-08-19)
		Acromegaly is a hormonal disorder that most commonly occurs in middle-aged men and women.
		The prevalence of acromegaly is approximately 4,676 cases per million population, and the incidence is 116.9 new cases per million per year.
		The name "acromegaly" comes from the Greek words for "extremities" (acro) and "great" (megaly), because one of the most common symptoms of this condition is abnormal growth of the hands and feet.
	www.acromegaly.org /index.php (761 words)

	Acromegaly
		Acromegaly is a rare, slowly progressive chronic disorder that affects adults.
		Acromegaly may also cause thickening of the soft tissues of the body, particularly the heart and accelerated growth leading to tall stature.
		In most cases, acromegaly is caused by the growth of a benign tumor (adenoma), affecting the pituitary gland.
	www.bchealthguide.org /kbase/nord/nord51.htm (397 words)

	Acromegaly Symptoms and Acromegaly Diagnosis from Novartis Oncology
		What It Is Acromegaly is a chronic disease that is caused by the overproduction of growth hormone.
		In most cases of acromegaly, this excessive production of growth hormone is due to a pituitary tumor, the majority of which are benign (not malignant).
		Acromegaly most commonly affects middle-aged adults but is a relatively rare disorder.
	www.us.novartisoncology.com /info/disease_information/acromegaly.jsp (553 words)

	Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management -- Colao et al. 25 (1): 102 -- ...
		purposes in acromegaly and GH deficiency (38, 39).
		role in the onset of hypertension in acromegaly (169, 170).
		To conclude, the pathogenesis of hypertension in acromegaly
	edrv.endojournals.org /cgi/content/full/25/1/102 (9133 words)

	Acromegaly Treatment Is Associated With Lower Lipoprotein(a) and Higher Apolipoprotein A1 and
		Conclusions: The effective treatment of acromegaly decreases the lipoprotein(a) and increases the apolipoprotein A1 levels, and might be a factor of protection from atherosclerosis and contributes to reduced mortality and morbidity in these patients.
		Acromegaly is a rare disease characterized by an excessive growth hormone (GH) and insulin-like growth factor–I (IGF-I) secretion.
		This double-faced profile of the circulating lipids in patients cured of acromegaly has not been described before, and further investigations are needed both on its mechanisms of development and on its clinical significance.
	www.jrnlappliedresearch.com /articles/Vol3Iss2/Casulari.htm (3555 words)

	Acromegaly definition - Medical Dictionary definitions of popular medical terms
		Acromegaly: Condition due to the production of too much growth hormone by the pituitary gland after the end of adolescence.
		The cardinal manifestations of acromegaly include thickening of the skin, soft tissues, and bones of the hands and feet.
		Inadequate treatment of pituitary gigantism or acromegaly is associated with increases in deaths from cardiovascular causes, cancer, and other causes.
	www.medterms.com /script/main/art.asp?articlekey=2127 (365 words)

	Acromegaly - WrongDiagnosis.com
		Acromegaly is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Acromegaly, or a subtype of Acromegaly, affects less than 200,000 people in the US population.
		Various sources and calculations are available in statistics about Acromegaly, prevalence and incidence statistics for Acromegaly, and you can also research other medical statistics in our statistics center.
	www.wrongdiagnosis.com /a/acromegaly/intro.htm (324 words)

	eMedicine - Acromegaly : Article by Hasnain M Khandwala
		Acromegaly is unusual, with a new case incidence of 3-4 per million subjects per year and a mean age of 40-45 years.
		Acromegaly occurs with equal frequency in males and females.
		Acromegaly can be an insidious disease, and symptoms might precede diagnosis by several years; therefore, failure to recognize the disease early in its course is the major medicolegal pitfall.
	www.emedicine.com /med/topic27.htm (2996 words)

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