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	Medscape MEDLINE search: Acrosin
		Acrosin and plasminogen activators are proteolytic enzymes of ram spermatozoa that play an essential role in the induction of the acrosome reaction, as well as the binding of spermatozoa to the oocyte and their penetration through the layers that surround the oocyte.
		Acrosin is an acrosomal protease synthesized as a proenzyme and activated into beta-acrosin during the acrosome reaction.
		Acrosin activity, acrosome reaction and nuclear chromatin condensation were studied in 24 infertile patients with varicoceles and 26 fertile men with or without varicocele.
	search.medscape.com /uslclient/searchMedline.do?queryText=Acrosin (1086 words)

	Angiotensin II induces acrosomal exocytosis in bovine spermatozoa -- Gur et al. 275 (1): E87 -- AJP - Endocrinology and ...
		The acrosin release served as an index for acrosomal exocytosis in capacitated bovine spermatozoa.
		The acrosin release assay was correlated with acrosome-reacted
		) on acrosin release from capacitated bovine spermatozoa.
	ajpendo.physiology.org /cgi/content/full/275/1/E87 (3431 words)

	Acrosin of mouse spermatozoa -- Bhattacharyya et al. 237 (1): 40 -- AJP - Gastrointestinal and Liver Physiology
		Mouse spermatozoa possess a neutral proteinase, acrosin, that is to a large extent (70-80%) present in the zymogen (proacrosin) form.
		An inhibitor of acrosin is associated with mouse spermatozoa, capable of preventing the activity of at least 60% of all available acrosin.
		Acrosin activity is essential for fertilization because natural and synthetic inhibitors of mouse acrosin prevent the union of the gametes.
	ajpgi.physiology.org /cgi/content/abstract/237/1/G40 (200 words)

	Acrosin - Biocrawler (Site not responding. Last check: 2007-10-06)
		Acrosin (EC 3.4.21.10 (http://ca.expasy.org/cgi-bin/nicezyme.pl?3.4.21.10)) is a digestive enzyme that is acts as a protease.
		Acrosin is released from the acrosome of spermatozoa as a consequence of the acrosome reaction.
		You can find it there under the keyword Acrosin (http://en.wikipedia.org/wiki/Acrosin)The list of previous authors is available here: version history (http://en.wikipedia.org/w/index.php?title=Acrosinandaction=history).
	www.biocrawler.com /encyclopedia/Acrosin (135 words)

	A biochemical and molecular analysis on the proacrosin/acrosin system in patients with idiopathic infertility
		Acrosin (EC 3.421.10) is a sperm trypsin-like protease.
		A diminished h-acrosin activity is found in infertile men, although the molecular basis of a low activity are yet unknown.
		In patients with unexplained infertility, an abnormal acrosin activity was highly associated with low fertilisation rates, and with changes in proenzyme activation, which are currently being studied at a molecular level.
	proteus.dna.uba.ar /biologia/26falcinelli.htm (151 words)

	Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect ... (Site not responding. Last check: 2007-10-06)
		The physiological function of mammalian sperm acrosin has long been believed to be involved in the limited proteolysis of the oocyte zona pellucida, thus enabling the sperm to penetrate this extracellular matrix and to gain access to the oocyte plasma membrane.
		Here we show that male mice homozygous for a targeted mutation in the mouse acrosin gene are still fertile in spite of the complete absence of acrosin protease activity in the sperm.
		Therefore, acrosin is not essential for both sperm penetration of the zona pellucida and fertilization.
	www.bioscience.org /knockout/ref/baba.htm (155 words)

	acropkg
		measures the total acrosin activity present in spermatozoa relative to the activity of a known amount of protease.
		Using a formula, it is possible to calculate the 'acrosin activity index' for each semen sample by knowing the optical density (OD) of the reacted semen sample, the OD of the positive control, and the number of spermatozoa per volume of semen.
		Or, using a different formula, it is possible to calculate the acrosin activity per million sperm for each semen sample by knowing the OD of the reacted semen sample and the number of spermatozoa per volume of semen.
	bioscreeninc.com /acropkg.html (745 words)

	Acrosin antibody [ACR-2] (ab1900) datasheet (Site not responding. Last check: 2007-10-06)
		The antibody ACR 2 reacts with various forms of porcine acrosin (55, 53, 45 and 35 kDa) in the acrosome of undamaged spermatozoa.
		Acrosin is the major proteinase present in the acrosome of mature spermatozoa.
		Protein-protein interactions controlling acrosin release and solubilization during the boar sperm acrosome reaction.
	www.abcam.com /index.html?datasheet=1900 (413 words)

	MidAtlantic Diagnostics - Products - Sperm Analysis - Bioscreen Assay
		It has been shown to be involved in the subsequent binding of spermatozoa to the egg's zona pellucida and/or the penetration of spermatozoa through the zona pellucida.
		Studies have further shown that total acrosin activity positively correlates with in vitro fertilization rates and a low acrosin activity in an otherwise normal ejaculate is associated with an impaired hamster egg penetration.
		The acrosin activity of human ejaculates varies independently from the standard semen parameters such as sperm concentration, percent motility, sperm motion characteristics and morphology.
	www.midatlanticdiagnostics.com /products/sperm/bioscreen.htm (739 words)

	Purification of human seminal acrosin inhibitor and its kinetics
		Acrosin has been shown to be inhibited by various proteinase inhibitors, namely soyabean trypsin inhibitors, and aprotinin (Zaneveld et al 1972; Kobayashi et al 1991).
		This resulted in a 50-fold purified acrosin which was used for studying the kinetics of the human seminal inhibitor.
		For acrosin assay the concentration of BAEE was varied from 0·5 mM to 0·188 mM and for trypsin the concentration was varied from 0·5 mM to 0·125 mM.
	www.ias.ac.in /jbiosci/september1999/article9.htm (2821 words)

	Exbio antibodies - Mouse Monoclonal to Porcine acrosin ACR-2 (IgG1)
		Exbio antibodies - Mouse Monoclonal to Porcine acrosin ACR-2 (IgG1)
		The antibody ACR-2 reacts with various forms of porcine acrosin (55, 53, 45 and 35 kDa), a typical serine proteinase with trypsin-like specificity.
		Acrosin is stored in the acrosome of undamaged spermatozoa.
	www.exbio.cz /products/clone.py?idclone=CLO000000000000172 (141 words)

	Biochemical Studies of Proacrosin and Acrosin from Hamster Cauda Epididymal Spermatozoa -- MEIZEL and MUKERJI 14 (4): ...
		Biochemical Studies of Proacrosin and Acrosin from Hamster Cauda Epididymal Spermatozoa -- MEIZEL and MUKERJI 14 (4): 444 -- Biology of Reproduction
		acrosin (8 percent of the total activity) were eluted together
		ratios of hamster and rabbit acrosins were 0.2 and 2.0 respectively.
	www.biolreprod.org /cgi/content/abstract/14/4/444 (396 words)

	Human sperm acrosin. Further studies with the clinical assay and activity in a group of presumably fertile men -- ...
		concentrations for acrosin extraction from spermatozoa; and to establish
		its effect on the kinetic properties of acrosin, as determined by
		affected the conversion of proacrosin to acrosin, with peak activation
	www.andrologyjournal.org /cgi/content/abstract/13/6/571 (288 words)

	A Homologue of Pancreatic Trypsin Is Localized in the Acrosome of Mammalian Sperm and Is Released During Acrosome ...
		Acrosin, a serine protease with trypsin-like cleavage specificity, is one of the proteins present in the sperm acrosome (for
		the absence of the acrosin activity in vitro.
		Trypsin-like protease(s) other than acrosin have not yet been identified in the acrosome of mammalian sperm.
	www.jbc.org /cgi/content/full/274/41/29426 (4684 words)

	Acrosome - Wikipedia, the free encyclopedia
		It is a cap-like structure derived from the Golgi apparatus.
		In some lower species, including sea stars and sea urchins, a major portion of the exposed acrosomal contents is a protein that temporarily holds the sperm on the egg surface.
		In mammals the acrosome reaction releases hyaluronidase and acrosin; their role in fertilization is not yet clear.
	en.wikipedia.org /wiki/Acrosome (249 words)

	MEROPS - The Peptidase Database
		Hermans,J.M., Jones,R. and Stone,S.R. Rapid inhibition of the sperm protease acrosin by protein C inhibitor.
		Fock-Nüzel,R., Lottspeich,F., Henschen,A. and Müller-Esterl,W. Boar acrosin is a two-chain molecule.
		Sumi,H. and Toki,N. Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4-(2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006).
	merops.sanger.ac.uk /cgi-bin/make_refs?id=S01.223 (995 words)

	GeneCard for ACR
		Function: Acrosin is the major protease of mammalian spermatozoa.
		Zahn A....Vazquez-Levin M.H. Determination of acrosin activity of boar spermatozoa by the clinical method:optimization of the assay and changes during short-term storage of semen.
		Glogowski J....Ciereszko A. Inhibition of acrosin by protein C inhibitor and localization of protein Cinhibitor to spermatozoa.
	www.genecards.org /cgi-bin/carddisp.pl?gene=ACR (725 words)

	Effect of Recombinant Boar {beta}-Acrosin on Sperm Binding to Intact Zona Pellucida During In Vitro Fertilization -- ...
		Töepfer-Petersen E, Henschen A. Acrosin shows zona and fucose binding, novel properties of a serine proteinase.
		Töepfer-Petersen E, Steinberg M, von Eschenbach C, Zucker C. Zona pellucida-binding of boar sperm acrosin is associated with the N-terminal peptide of the acrosin B-chain (heavy chain).
		Crosby JA, Jones R, Barros C, Carvallo P. Characterization of the functional domains of boar acrosin involved in nonenzymatic binding to homologous zona pellucida glycoproteins.
	www.biolreprod.org /cgi/content/full/61/6/1535 (3592 words)

	Zavos Organization-Dr. Zavos (Site not responding. Last check: 2007-10-06)
		Goodpasture, J.C., Zavos, P.M., Cohen, M.R. and Zaneveld, L.J.D.: The acrosin and proacrosin of normal men and infertile men, and split ejaculates.
		Goodpasture, J.C., Zavos, P.M. and Zaneveld, L.J.D. Relationship of human sperm acrosin and proacrosin to semen parameters.
		Sofikitis, N., Miyagawa, I. and Zavos, P.M. Acrosin profiles of spermatozoa in infertile men with varicocele.
	www.zavos.org /library/library_publications.htm (3993 words)

	UniProtKB/Swiss-Prot entry P10323 [ACRO_HUMAN] Acrosin
		: Acrosin is the major protease of mammalian spermatozoa.
		It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
		Molecular function: acrosin activity (inferred from direct assay from UniProtKB).
	www.expasy.org /uniprot/P10323 (506 words)

	Towards a physiological role for cytochrome P450 aromatase in ejaculated human sperm -- Aquila et al. 18 (8): 1650 -- ...
		Acrosin activity was assessed by the method of Kennedy et al.
		Acrosin activity is enhanced by estradiol and aromatizable substrates
		Acrosin activity was used to evaluate the induction of the AR;
	humrep.oxfordjournals.org /cgi/content/full/18/8/1650 (6061 words)

	acroscreen (Site not responding. Last check: 2007-10-06)
		Acrosin is a sperm acrosomal protease that has an essential role in the fertilization process.
		Low levels of acrosin appear to be associated with
		The acrosin activity of human ejaculates varies independently from the standard semen parameters
	bioscreeninc.com /acroscreen.html (124 words)

	Effects of dietary vitamin A intake on acrosin- and plasminogen-activator activity of ram spermatozoa -- Zervos et al. ...
		Effects of dietary vitamin A intake on acrosin- and plasminogen-activator activity of ram spermatozoa -- Zervos et al.
		Acrosin and plasminogen activators are proteolytic enzymes of
		maximum reduction for acrosin was 49% on week 11 and for plasminogen
	www.reproduction-online.org /cgi/content/abstract/129/6/707 (303 words)

	Human protein: P20155 - Serine protease inhibitor Kazal-type 2 precursor (Acrosin-trypsin inhibitor) (HUSI-II). EMBL ...
		It is produced through a collaboration between the Swiss Institute of Bioinformatics and the EMBL outstation - the European Bioinformatics Institute.
		Organization and sequence of the gene encoding the human acrosin- trypsin inhibitor (HUSI-II).
		Strong inhibitor of acrosin in male and/or female genital tract.
	harvester.embl.de /harvester/P201/P20155.htm (749 words)

	Cloning and structural analysis of leydin, a novel human serine protease expressed by the Leydig cells of the testis -- ...
		Leydin is clearly distinct from acrosin, the other testis-specific
		is probably a two-chain protease such as acrosin, prostasin,
		acrosin [1]; human urokinase [13]; human tissue plasminogen
	content.febsjournal.org /cgi/content/full/261/1/244 (4698 words)

	acrosin - OneLook Dictionary Search
		We found 6 dictionaries with English definitions that include the word acrosin:
		Tip: Click on the first link on a line below to go directly to a page where "acrosin" is defined.
		acrosin : Dorland's Illustrated Medical Dictionary [home, info]
	www.onelook.com /?w=acrosin (94 words)

	In vitro interactions of calmodulin with the ovine proacrosin-acrosin system -- Frenette et al. 11 (1): 25 -- Journal ...
		and acrosin in the presence of EGTA; in the presence of Ca2+, the
		The enzymatic activity of acrosin towards benzoyl arginine
		and that acrosin can attenuate CaM activity through proteolysis.
	www.andrologyjournal.org /cgi/content/abstract/11/1/25 (257 words)

	Extracellular ubiquitination and proteasome-mediated degradation of the ascidian sperm receptor -- Sawada et al. 99 ...
		sperm acrosomal trypsin-like protease acrosin is a zona lysin,
		Rather, it is currently thought that acrosin is involved
		We have previously reported that two trypsin-like sperm proteases, acrosin and spermosin (9-14), and sperm proteasomes (15,
	www.pnas.org /cgi/content/full/99/3/1223 (3641 words)

	PIR-PSD Database [PIR - Protein Information Resource]
		(1989) 264:11920-11927 #title Activation and maturation mechanisms of boar acrosin zymogen based on the deduced primary structure.
		(1987) 226:38-42 #title Acrosin shows zona and fucose binding, novel properties for a serine proteinase.
		(1990) 265:51-54 #title Zona pellucida-binding of boar sperm acrosin is associated with the N-terminal peptide of the acrosin B-chain (heavy chain).
	pir.georgetown.edu /cgi-bin/nbrfget?uid=A34170 (336 words)

	Chapter 29
		A sperm has a flagellated tail, and a head that is covered with acrosome.
		The acrosome contains an enzyme called acrosin.
		Capacitation: Several sperms secrete enzymes like hyaluronidase, acrosin, and neuraminidase around the oocyte, this makes a sperm to be able to penetrate the ring of cells around the oocyte called corona radiata, and the zona pellucida inside the oocyte.
	www.gpc.edu /~pahanotu/devgen.htm (1097 words)

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