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Topic: Activator protein

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	Activator - Biocrawler (Site not responding. Last check: 2007-10-31)
		In proteomics, an activator is a type of effector that increases the rate of enzyme mediated reactions.
		In genetics an activator is a DNA-binding protein that regulates one or more genes by increasing the rate of transcription.
		You can find it there under the keyword Activator (http://en.wikipedia.org/wiki/Activator)The list of previous authors is available here: version history (http://en.wikipedia.org/w/index.php?title=Activatorandaction=history).
	www.biocrawler.com /encyclopedia/Activator (178 words)

	ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three ...
		ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.
		The activator protein 1 (AP-1) and MAPK signaling pathways are believed to play an important role in cancer chemoprevention and chemotherapy due to their involvement in tumor cell growth, proliferation, apoptosis, and survival.
		Taken together our results indicate that the activation of the ERK and JNK signaling pathways is important for transcriptional activity of AP-1, and is involved in the regulation of cell death elicited by ITCs in PC-3 cells.
	www.sproutnet.com /Nutrition/Research/erk_and_jnk_signaling_pathways_a.htm (366 words)

	Characterization of an Alternatively Spliced G[IMAGE] Activator Protein, G[IMAGE] Protein -- Wu et al. 271 (18): 10611 ... (Site not responding. Last check: 2007-10-31)
		activator protein is a protein cofactor which stimulates the enzymatic hydrolysis of both GalNAc and NeuAc from G
		activator protein is located within amino acids 1-109.
		protein indicate that this activator protein may be involved in the catabolism of G
	www.jbc.org /cgi/content/abstract/271/18/10611 (421 words)

	Cell cycle arrest and apoptosis induction by activator protein 2 alpha (AP-2alpha) and the role of p53 and p21WAF1/CIP1 ... (Site not responding. Last check: 2007-10-31)
		Cell cycle arrest and apoptosis induction by activator protein 2 alpha (AP-2alpha) and the role of p53 and p21WAF1/CIP1 in AP-2alpha mediated growth inhibition -- Wajapeyee and Somasundaram, 10.1074/jbc.M305624200 -- Journal of Biological Chemistry
		Cell cycle arrest and apoptosis induction by activator protein 2 alpha (AP-2alpha) and the role of p53 and p21WAF1/CIP1 in AP-2alpha mediated growth inhibition
		Activator protein 2 alpha (AP-2 alpha) is a sequence-specific DNA-binding transcription factor, implicated in differentiation and transformation.
	www.jbc.org /cgi/content/short/M305624200v1 (443 words)

	vgn-ext-hidden_PubMed (Site not responding. Last check: 2007-10-31)
		Automated quantitative analysis of activator protein-2alpha subcellular expression in melanoma tissue microarrays correlates with survival prediction.
		The activator protein-2alpha (AP-2) transcription factor plays a key role in regulating expression of genes involved in tumor growth and metastasis of human melanoma.
		We sought to assess the prognostic significance of AP-2 expression and its role in the transition of nevi to metastatic melanoma.
	www.plwc.org /portal/site/ASCO/menuitem.a3fb42726842a82627c4c291ee37a01d/?vgnextoid=d70b3608f9958010VgnVCM100000f2730ad1RCRD&index=n&pmid=16322269 (302 words)

	Expression and specificity of human GM2 activator protein. (Site not responding. Last check: 2007-10-31)
		The effectiveness of GM2 activator in stimulating the hydrolysis of GM2 may be due to its ability to recognize the specific trisaccharide structure of the GM2 epitope, GalNAc beta 1-->4(NeuAc alpha 2-->3)Gal-, and to modify the GalNAc-NeuAc interaction in this structure.
		Taken together, our results suggest that the mechanism of action of GM2 activator is different from saposin B, and the action of GM2 activator is more than to solubilize lipid substrates.
		The recombinant GM2 activator was found to be as active as that isolated from human kidney.
	www.ihop-net.org /UniPub/iHOP/gp/122996.html (228 words)

	The Hsp70-Ydj1 Molecular Chaperone Represses the Activity of the Heme Activator Protein Hap1 in the Absence of Heme -- ...
		The Hsp70-Ydj1 Molecular Chaperone Represses the Activity of the Heme Activator Protein Hap1 in the Absence of Heme -- Hon et al.
		The Hsp70-Ydj1 Molecular Chaperone Represses the Activity of the Heme Activator Protein Hap1 in the Absence of Heme
		Lee, H. C., Hon, T., Lan, C., Zhang, L. Structural Environment Dictates the Biological Significance of Heme-Responsive Motifs and the Role of Hsp90 in the Activation of the Heme Activator Protein Hap1.
	mcb.asm.org /cgi/content/abstract/21/23/7923 (461 words)

	Catabolite Gene Activator Protein Mutations Affecting Activity of the araBAD Promoter -- Zhang and Schleif 180 (2): 195 ...
		Ruiz, R., Marques, S., Ramos, J. Leucines 193 and 194 at the N-Terminal Domain of the XylS Protein, the Positive Transcriptional Regulator of the TOL meta-Cleavage Pathway, Are Involved in Dimerization.
		Holcroft, C. C., Egan, S. Roles of Cyclic AMP Receptor Protein and the Carboxyl-Terminal Domain of the alpha Subunit in Transcription Activation of the Escherichia coli rhaBAD Operon.
		Wonderling, L. D., Stauffer, G. The Cyclic AMP Receptor Protein Is Dependent on GcvA for Regulation of the gcv Operon.
	jb.asm.org /cgi/content/abstract/180/2/195 (421 words)

	Asthma Literature - The GM2 activator protein, a novel inhibitor of platelet-activating factor. (Site not responding. Last check: 2007-10-31)
		The GM2 activator protein, a novel inhibitor of platelet-activating factor.
		The GM2 activator protein is required as a substrate-specific cofactor for beta-hexosaminidase A to hydrolyze GM2 ganglioside.
		The inherent stability and protease resistance of the small, monomeric GM2 activator protein, coupled with the ability to produce large quantities of the functional protein in transformed bacteria, suggest it may serve as such an agent.
	www.asthmascience.org /showabstract.php?pmid=10329374 (282 words)

	Evidence of a retinoid signaling alteration involving the activator protein 1 complex in tumorigenic human bronchial ...
		Evidence of a retinoid signaling alteration involving the activator protein 1 complex in tumorigenic human bronchial epithelial cells and non-small cell lung cancer cells -- Lee et al.
		Evidence of a retinoid signaling alteration involving the activator protein 1 complex in tumorigenic human bronchial epithelial cells and non-small cell lung cancer cells
		Jun activation domain-binding protein 1, and the retinoid receptor
	cgd.aacrjournals.org /cgi/content/abstract/8/3/283 (705 words)

	A New Class of Drugs to Treat Breast Cancer (Site not responding. Last check: 2007-10-31)
		Binding between co-activator protein and the ER: 17b -estradiol complex is also an essential step in a process leading to cell division.
		We have used computer models of binding between the ER and co-activator protein to design organic molecules that may bind to the ER at the same position as the co-activator protein.
		We are attempting to design and identify chemicals that bind to a different part of the ER and which like tamoxifen block formation of the ER: co activator protein complex.
	www.ucop.edu /srphome/bcrp/progressreport/abstracts/innov/6FB-0089.html (773 words)

	Su-Chen Li, Ph.D.
		Their laboratory was the first to correctly establish the structure of the glycosphingolipid that accumulates in the kidney of patients with Fabry's disease [J.
		Subsequently, type AB Tay-Sachs disease was established to be the deficiency of this protein cofactor.
		The crystal structure of this activator protein was solved in collaboration with Dr. C. Wright of the University of Virginia.
	www.tulane.edu /%7Ebiochem/suchenli_bio.html (218 words)

	OhioLINK ETD: Arnett, Diana
		In the absence of the inducer, quinic acid, the repressor protein binds to the activator protein, blocking transcription of the qa genes.
		Addition of quinic acid releases the activator protein, which is then free to bind to its activator binding sites, increasing the levels of transcription of the qa genes.
		The activator binding sites are composed of a 16 base pair (bp) conserved sequence, but the importance of the individual bases in the sites is currently unknown.
	www.ohiolink.edu /etd/view.cgi?ysu1004634030 (316 words)

	YGM 2002 Abstract #389 (Site not responding. Last check: 2007-10-31)
		The Heme Activator Protein Hap1 Acts as a Transcriptional Repressor in Saccharomyces cerevisiae.
		The heme activator protein Hap1 is known to be a potent transcriptional activator of many genes encoding functions required for respiration and for controlling oxidative damage.
		As an activator, the activity of Hap1 is stimulated by heme and is highly sensitive to changes of heme concentration.
	www.yeastgenome.org /community/meetings/yeast02/abshtml/389.html (206 words)

	[No title]
		Transcription activation is a complex process brought about by a combination of different proteins.
		Transcription activation by the catabolite activator protein (CAP; also known as cAMP receptor protein, CRP) is one of the simplest gene activation models in bacteria, requiring only CAP and RNAP protein factors for transcription at CAP-dependent promoters; by comparison, transcriptional activation in eukaryotes can require dozens of proteins involving several DNA sites.
		For instance, in the presence of glucose, the intracellular level of cAMP drops, repressing transcription at the lac operon; in the absence of glucose, intracellular cAMP levels rise, and the lac operon is activated in response to cAMP-induced CAP binding.
	www.ebi.ac.uk /interpro/potm/2003_7/Page1.htm (371 words)

	Rat Genome Database: References
		Luciferase assays demonstrated that SRAP enhances the transactivation activity of the AR, the glucocorticoid receptor and the peroxisome proliferator-activated receptor gamma(1) in a ligand-dependent manner.
		Using a green fluorescent protein (GFP) fusion-protein construct, we demonstrated in vivo translation of the GFP-SRAP fusion protein in HeLa cells co-transfected with pSG5AR and reporter gene in the presence of 5 alpha-dihydrotestosterone (DHT).
		Co-transfection of the GFP-SRAP fusion protein expression plasmid enhanced the transactivation activity of AR whereas incorporation of mutations in SRAP of the fusion protein resulted in loss of enhancement of the transactivation activity.
	rgd.mcw.edu /tools/references/references_view.cgi?id=628587 (251 words)

	Bio activator protein
		This type of athlete needs the ultimate protein to ensure they recover fully and quickly, ready for the next session.
		By using many other proteins, you could be setting your body up for problems later on.
		They designed a protein which is pure, lactose-free and contains a massive amount of glutamine to ensure optimum recovery, cell-volumisation and muscle mass.
	www.gadgetsuk.com /Bio-activator-protein-p-16824.html (327 words)

	Immunological Evidence for Deficiency in an Activator Protein for Sulfatide Sulfatase in a Variant Form of ...
		Immunological Evidence for Deficiency in an Activator Protein for Sulfatide Sulfatase in a Variant Form of Metachromatic Leukodystrophy -- Inui et al.
		Monospecific antibodies to this activator protein were prepared in rabbits, and they were used to examine cultured cells for the presence of crossreacting material by Ouchterlony double immunodiffusion and rocket immunoelectrophoresis.
		These immunologic studies provide evidence for a deficiency in the activator protein required for normal catabolism of sulfatide in the cells from this patient and possibly provide a method for diagnosis of similar patients.
	www.pnas.org /cgi/content/abstract/80/10/3074 (368 words)

	Degradation of gangliosides by the lysosomal sialidase requires an activator protein -- Fingerhut et al. 208 (3): 623 ... (Site not responding. Last check: 2007-10-31)
		Degradation of gangliosides by the lysosomal sialidase requires an activator protein -- Fingerhut et al.
		detergent (taurodeoxycholate) or with the sulfatide activator protein, a
		when the lipids were dispersed with the activator protein, whereas in the
	content.febsjournal.org /cgi/content/abstract/208/3/623 (402 words)

	Infotrieve Online
		Supershift assays revealed that fra-1 participates in the activator protein 1 complex together with c-fos, c-jun and junB.
		Transient transfection experiments using a reporter plasmid containing an activator protein site upstream of the CAT reporter gene revealed that the phorbolester-induced CAT activity was suppressed by retinoids.
		Since fra-1 lacks a transactivation function, we therefore suggest that the retinoid-mediated induction of fra-1 might function as a negative regulator of the activator protein 1 activity in human pancreatic carcinoma cells.
	www4.infotrieve.com /newmedline/detail.asp?NameID=10217407&Session=&searchQuery=Wiedenmann&count=343 (165 words)

	Interaction of the GM2-activator protein with phospholipid—ganglioside bilayer membranes and with monolayers at the ... (Site not responding. Last check: 2007-10-31)
		Interaction of the GM2-activator protein with phospholipid—ganglioside bilayer membranes and with monolayers at the air—water interface -- Giehl et al.
		after addition of the protein into the subphase, are much lower.
		protein to the ganglioside headgroups prevents the protein from
	content.febsjournal.org /cgi/content/abstract/261/3/650 (444 words)

	Differential Induction of Nuclear Factor-kappa B and Activator Protein-1 Activity after CD40 Ligation Is Associated ... (Site not responding. Last check: 2007-10-31)
		Differential Induction of Nuclear Factor-kappa B and Activator Protein-1 Activity after CD40 Ligation Is Associated with Primary Human Hepatocyte Apoptosis or Intrahepatic Endothelial Cell Proliferation -- Choudhury et al.
		B and Activator Protein-1 Activity after CD40 Ligation Is Associated with Primary Human Hepatocyte Apoptosis or Intrahepatic Endothelial Cell Proliferation
		activation prevented IHEC proliferation and led to induction of
	www.molbiolcell.org /cgi/content/abstract/14/4/1334 (344 words)

	RCSB Protein Data Bank
		Because of its role in delivering messages from the primary glucose sensor (adenyl cyclase) to the synthetic machinery, cyclic AMP is often known as a second messenger.
		Catabolite activator protein (CAP), also known as cyclic AMP receptor protein (CRP), is activated by cyclic AMP and stimulates synthesis of the enzymes that break down non-glucose food molecules.
		CAP binds to a specific DNA sequence, which is found next to the genes that are activated.
	www.rcsb.org /pdb/static.do?p=education_discussion/molecule_of_the_month/pdb48_1.html (392 words)

	Directory of open access journals
		To determine the effects of oxidized LDL on macrophage gene expression, macrophages incubated with native or oxidized LDL were analyzed by differential display technique.
		Quantitative RT-PCR data using specific TaqMan probe showed the increased GM2 activator protein mRNA expression in macrophages incubated with oxidized LDL by about twice (215.4˜31.6 %) of that in macrophages incubated with native LDL.
		Our results shows that ox-LDL upregulates GM2 activator protein gene expression, indicating that GM2 activator protein may be associated with the pathogenesis of atherosclerosis.
	www.doaj.org /abstract?id=120164&toc=y (175 words)

	Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung ... (Site not responding. Last check: 2007-10-31)
		Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma -- KUMAR et al.
		Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma
		of lung parenchyma with methacholine increased the activation
	www.fasebj.org /cgi/content/abstract/17/13/1800 (555 words)

	Catabolite activator protein (CAP) - Genetics Terms and Definitions by Health Dictionary
		A protein that when bound with cyclic AMP can attach to sites on sugar-metabolizing operons to enhance transcription of these operons.
		Information and definitions of the terms been taken from various reliable government publications and we have done our best to verify their accuracy.
		If you feel any of the definitions are incorrect or needs to be updated please contact us and we will look into it.
	www.sciencedictionary.org /genetics-term-details/Catabolite-activator-protein-CAP- (79 words)

	Inflamation and ECM Degradation by Txn Factor and Activator Protein
		Inflamation and ECM Degradation by Txn Factor and Activator Protein
		Title: Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo.
		The authors found that certain cellular components, classified as transcription factors called nuclear factor-kappaB and activator protein-1 are activated in acne lesion.
	www.healthinplainenglish.com /health/skin/acne/research/transcription-factor-kappaB.htm (92 words)

	Both Inducible and Constitutive Activator Protein-1-Like Transcription Factors Are Used for Transcriptional Activation ... (Site not responding. Last check: 2007-10-31)
		Both Inducible and Constitutive Activator Protein-1-Like Transcription Factors Are Used for Transcriptional Activation of the Galanin Gene by Different First and Second Messenger Pathways -- Anouar et al.
		Both Inducible and Constitutive Activator Protein-1-Like Transcription Factors Are Used for Transcriptional Activation of the Galanin Gene by Different First and Second Messenger Pathways
		protein kinase activation of GAL gene transcription was assessed.
	molpharm.aspetjournals.org /cgi/content/abstract/56/1/162 (594 words)

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