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Topic: Acute myeloid leukemia generic term


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In the News (Sat 10 Jan 09)

  
  ShoutPost - Buy xanax online (Cheap xanax. Confidential, easy, and secure. Lowest prices. Free shipping.)
In simple terms, osteoporosis is a weakening of the bones whereby they are generics.
It is anticipated that risk factor for acute myeloid leukemia is advancing age.
In contrast, acute myeloid leukemia is said to be a secondary tooth eruption and delayed puberty.
xanaxonline.shoutpost.com   (5793 words)

  
  Diagnosing and treating childhood leukemia : Oncology - Children's Hospital of Philadelphia
In acute monoblastic leukemia, the leukemia cell, the monoblast, is the precursor of the monocyte, another type of infection-fighting white blood cell.
In contrast, acute erythroleukemia is a cancer of the young red blood cells, called erythroblasts, and acute megakaryoblastic leukemia is a leukemia involving the platelet-forming cells called megakaryoblasts.
Leukemia cells often collect in the nodes, causing swelling. Swelling occurs in lymph nodes under the arms, in the groin, chest and in the neck. Sometimes it is difficult to distinguish the lymph nodes of leukemia from those that are a normal part of the body’s response to infection or allergy.
www.chop.edu /consumer/jsp/division/generic.jsp?id=79155   (1834 words)

  
 Smartcool
In acute leukemia, the abnormal blood cells are blasts that remain very immature and cannot carry out their normal functions.
In chronic leukemia cases, some blast cells are present, but in general, these cells are more mature and can carry out some of their normal functions.
Leukemia that affects myeloid cells is called myeloid leukemia or myelogenous leukemia.
smartcool1.blogspot.com   (4043 words)

  
 Myelogenous leukemia, acute definition - Cancer information on MedicineNet.com
A quickly progressive malignant disease in which there are too many immature blood-forming cells in the blood and bone marrow, the cells being specifically those destined to give rise to the granulocytes or monocytes, both types of white blood cells that fight infections.
The purpose of induction therapy is to kill as many of the leukemia cells as possible and induce a remission, a state in which there is no visible evidence of disease and blood counts are normal.
Types M2 (myeloblastic leukemia with maturation) and M4 (myelomonocytic leukemia) each account for 25% of AML; M1 (myeloblastic leukemia, with few or no mature cells) accounts for 15%; M3 (promyelocytic leukemia) and M5 (monocytic leukemia) each account for 10% of cases; the other subtypes are rarely seen.
www.medterms.com /script/main/art.asp?articlekey=19284   (932 words)

  
 Medical Dictionary: Leukemia - WrongDiagnosis.com
Leukemia: A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood.
Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present.
Leukemia : progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow; classified according to degree of cell differentiation as acute or chronic, and according to predominant type of cell involved as myelogenous or lymphocytic.
www.wrongdiagnosis.com /medical/leukemia.htm   (479 words)

  
 Linus Pauling Institute at Oregon State University
Normal differentiation of myeloid stem cells in the bone marrow gives rise to platelets, red blood cells, and white blood cells, which are important for the immune response.
Generally, signs of toxicity are associated with long-term consumption of vitamin A in excess of 10 times the RDA (8,000 to 10,000 mcg/day or 25,000 to 33,000 IU/day).
The results of several recent prospective studies suggest that long term intakes of preformed vitamin A in excess of 1,500 mcg/day (5,000 IU/day) are associated with increased risk of osteoporotic fracture and decreased bone mineral density (BMD) in older men and women.
lpi.oregonstate.edu /infocenter/vitamins/vitaminA/index.html   (3679 words)

  
 Gleevec and Chronic Myeloid Leukemia - Cancer information on MedicineNet.com
The development of Gleevec began in the early 1960s with the identification of the so-called Philadelphia chromosome (after the city in which it was identified) in patients with chronic myeloid leukemia.
As a result of this acute phase, the average time of survival from chronic myeloid leukemia was about four years, meaning that half of the patients died before the four years and half were still alive at that time.
The term matched donor refers to compatible tissue typing, which is needed to minimize the possibilities of the recipient's body rejecting the transplant (rejection), and the transplant rejecting the recipient's body (graft versus host disease).
www.medicinenet.com /script/main/art.asp?articlekey=17254   (1058 words)

  
 AML Acute Myelogenous Leukemia News October 2004
Although leukemia is a cancer of white blood cells and patients with leukemia may have very high white blood cell counts, acute leukemia cells do not protect against infection.
Adult acute leukemia is either classified as being in remission (with no evidence of disease), or with active disease (with the patient either just newly diagnosed or in relapse).
APL, one of eight subtypes of acute myeloid leukemia (AML), is a malignant disorder of white blood cells.
www.leukemia-web.org /leukemia-cancer-news-0410.htm   (9693 words)

  
 Leukemia, Lymphoma & Blood Cancer Glossary
The number of immature, abnormal white blood cells in the bone marrow and blood is higher than in the chronic phase but not as high as in the blast phase.
They generally are not recognized by the medical community as standard or conventional medical approaches.
A term used to describe cancer cells that divide rapidly and have little or no resemblance to normal cells.
www.leukemiainfocenter.com /glossary/sA.html   (1821 words)

  
 sargramostim Glossary of Terms with Definitions on MedicineNet.com
Acute often also connotes an illness that is of short duration, rapidly progressive, and in need of urgent care.
A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold.
Strictly speaking, leukemia should refer only to cancer of the white blood cells (the leukocytes) but in practice it can apply to malignancy of any cellular element in the blood or bone marrow, as in red cell leukemia (erythroleukemia).
www.medicinenet.com:9003 /sargramostim/glossary.htm   (2235 words)

  
 Health Information
Acute necrotizing periodontal disease is an acute infection in the gums.
It is the general dentist's responsibility to identify periodontal disease and inform the patient.
Experts generally recommend replacing toothbrushes each month Not only do they become breeding grounds for bacteria, but the worn bristles are less effective at removing plaque.
www.ehealthconnection.com /regions/tennessee/content/healthinfo_report.asp?src=000024&typeid=10   (9922 words)

  
 Baby Connection -- Good news for childhood leukemia survivors   (Site not responding. Last check: )
Leukemias are the most common cancer affecting children and young adults.
The researchers found that marriage rates among survivors were similar to the general U.S. population at 57 percent, but lower compared to their siblings, at 67 percent.
Also, 93 percent of the survivors and 98 percent of their siblings were employed, and 92 percent of the survivors reported having health insurance, compared with 89 percent of the siblings.
www.babyconnection.com /news/536519   (769 words)

  
 Cancer Information, Research, and Treatment for all Types of Cancer | OncoLink
Cytogenetic abnormalities in 532 patients with myeloid leukemias and myelodyplastic syndrome.
Chronic myeloid leukemia associated hypereosinophilic syndrome with a clonal t(4;7)(q11;q32).
Pentasomy of chromosome 8 in chronic myelomonocytic leukemia.
www.oncolink.upenn.edu /types/article.cfm?c=8&s=30&ss=240&id=7897   (12734 words)

  
 CLS_3223_Unit 03_WBC   (Site not responding. Last check: )
It is decreased in chronic myelogenous leukemia, sickle cell anemia, paroxysmal nocturnal hemoglobinuria, marked eosinophilia, and sideroblastic anemia.
The presence of acute neutrophilia is the consequence of a pathological stimulus.
The cytoplasm is abundant, containing few vacuoles, generally of a pale appearance, with a peripheral basophilia and "spokes" of basophilia radiating from the nucleus.
www.clt.astate.edu /wwilliam/unit_03.htm   (8090 words)

  
 eMedicine - Childhood Cancer, Epidemiology : Article by Gary M Kupfer, MD
Leukemias account for approximately 25% of all childhood cancers, followed by tumors of the CNS (17%), neuroblastoma (7%), non-Hodgkin lymphoma (NHL) (6%), Wilms tumor (6%), Hodgkin disease (5%), rhabdomyosarcoma (3%), retinoblastoma (3%), osteosarcoma (3%), and Ewing sarcoma (2%).
Leukemias are the most common type of childhood cancer, accounting for 34% of new diagnoses.
Defects in ras guanosine triphosphatase (GTPase), termed neurofibromin, are sporadic in at least one half of the cases of NF detectable in the general population.
www.emedicine.com /ped/topic2585.htm   (5270 words)

  
 ACOR Leukemia Links: A report on the Tandem BMT (joint IBMTR/ABMTR and ASBMT) meeting, 2002
At the meeting, the term reduced intensity conditioning (RIC) transplants was used to refer to transplants where the preparative regimen was not as intense as the usual regimen, but was still sufficiently intense enough that it would not be given with out a transplant.
Leukemia Free Survival was 72% with high dose bone marrow, 54% with low does and 61% with peripheral blood.
Compared transplant for children with leukemia, those who did not have a matched sibling donor had unrelated cord blood transplants, the others had matched siblings.  The conditioning was similar although the cord blood patients received ATG as well.
www.acor.org /leukemia/tandem-bmt-2004.html   (7798 words)

  
 Nitrous Oxide
Abstract: The incidence and pathogenesis of acute megaloblastic bone-marrow change and of abnormalities in DNA synthesis, as assessed with the deoxyuridine(dU) suppression test, have been investigated in a prospective study of 70 seriously ill patients admitted to an intensive-care unit.
Blast cells from 10 cases of acute myeloid leukemia (AML) and 5 cases of acute lymphoid leukemia (ALL) were incubated with 5 x 10(-8) M [3H] 5-formyltetrahydrofolate (5-formylTHF) for 18 h to label intracellular folate pools, which were subsequently quantitated by high performance liquid chromatography (HPLC).
Between 1986 and 1995 eight cases of acute funicular myelosis associated with latent vitamin B12 deficiency subsequent to nitrous oxide anaesthesia were reported.
home.caregroup.org /clinical/altmed/interactions/Drugs/Nitrous_Oxide.htm   (5557 words)

  
 BioMed Central | Full text | Translating microarray data for diagnostic testing in childhood leukaemia
Acute lymphoblastic leukaemia (ALL) is a heterogeneous disease characterized by the presence of several subtypes that are of prognostic relevance.
It is foreseeable that further optimization towards developing a generic and robust classifier will lead to an even further reduction in the number of discriminators required to predict some subgroups, while additional discriminators may be needed to detect distinct subtypes within the MLL subgroup [16,39].
Harrison CJ: The detection and significance of chromosomal abnormalities in childhood acute lymphoblastic leukaemia.
www.biomedcentral.com /1471-2407/6/229   (6288 words)

  
 An Anti-CD33 Antibody-Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia. Choice of Linker
The anti-CD33 antibody, P67.6, has been chosen to target the potently cytotoxic calicheamicin antitumor antibiotics to acute myeloid leukemia (AML) due to the presence of CD33 on >80% of patient samples and its lack of expression outside the myeloid cell lineages, especially its lack of expression on pluripotent stem cells.
The percent inhibition of binding was calculated, and the concentration required to inhibit 50% of binding was determined from a plot of inhibition versus binding.
The P67.6 antibody has been humanized and, as the result of an unexpected problem, the carbohydrate conjugate has been abandoned and replaced by a conjugate containing a bifunctional linker that attaches to lysines on the antibody, but that allows for formation of the hydrazone that is needed for activity (22).
pubs.acs.org /cgi-bin/jtextd?bcches/asap/html/bc0100206.html   (5634 words)

  
 PCV For Brain Tumors: Abstracts
The generic name procarbazine is used interchangeably with procarbazine hydrochloride in the literature, and since only procarbazine hydrochloride is produced, it was assumed to be procarbazine hydrochloride under study.
The compound increased the incidence of tumors in rats and slightly increased the incidence of leukemia and lymphosarcomas in female mice.
Secondary acute leukemias are rare in the evolution of malignant gliomas and the usefulness of subsequent radiochemotherapy cannot be questioned at the present time.
www.virtualtrials.com /pcv2.cfm   (9400 words)

  
 Stakeholder Opinions: Acute Leukemias
While existing treatment strategies for adult acute leukemia may yield satisfactory remission- induction rates, a major clinical concern is the high rate of disease relapse despite attempts to optimize post-remission consolidation therapy.
This is acutely problematic among elderly patients who are frequently unable to tolerate the rigors of more intensive treatment approaches.
This approach is more likely to address the heterogeneity of acute leukemia and will contribute to the increasing trend of risk-stratified treatment approaches.
www.piribo.com /publications/diseases_conditions/stakeholder_opinions_acute_leukemias.html   (1521 words)

  
 ORPHANET® : Base de données sur les maladies rares et les médicaments orphelins
Acute myeloid leukaemia and myelodysplastic syndromes related to alkylating agent
Acute myeloid leukaemia and myelodysplastic syndromes related to topoisomerase type II inhibitor
Acute myeloid leukaemia and myelodysplastic syndromes, therapy related
www.orpha.net /Pat/GBA.html   (304 words)

  
 Chronic Myelogenous Leukemia (CML) - Cancer News Story - KETV Omaha
Chronic myelogenous leukemia is cancer of the bone marrow.
CML causes rapid growth of the blood-forming cells (myeloid precursors) in the bone marrow, peripheral blood, and body tissues.
Acceleration of the disease may be associated with fever (without infection), bone pain, and a swollen spleen.
www.ketv.com /cancer/6860350/detail.html   (773 words)

  
  HealthScout-Consumer Health News, Information and Resources Updated Daily-Infections/Cold-FDA Approves Generic Capsule ...
The first generic HIV/AIDS drug in capsule form for the U.S. market has been approved by the Food and Drug Administration.
The approval of the capsule form of the drug, made by Aurobindo Pharma in India, follows the expiration of GlaxoSmithKline's patent on Retrovir, its brand name form of zidovudine, the FDA said.
"This is a significant generic approval," Dr. Andrew C. von Eschenbach, acting commissioner of the FDA, said in a prepared statement.
www.healthscout.com /news/1/1508023/main.html   (256 words)

  
 Media Releases - Novartis
Glivec has continued to be generally well-tolerated as initial drug therapy for Ph+ CML in chronic phase at the five-year follow-up.
Glivec was also recently approved in the EU for adult patients with newly diagnosed Ph+ acute lymphoblastic leukemia (Ph+ ALL) in combination with chemotherapy and as a single agent for patients with relapsed or refractory Ph+ ALL, and in the US for relapsed/refractory Ph+ ALL.
Glivec was generally well-tolerated in all of the studies that were performed, either as monotherapy or in combination with chemotherapy, with the exception of a transient liver toxicity in the form of transaminase elevation and hyperbilirubimaemia observed when Glivec was combined with high dose chemotherapy.
cws.huginonline.com /N/134323/PR/200612/1091864_5.html   (1438 words)

  
 Language Log: Progress in malignancy tagging
Yang took the National Cancer Institute's neoplasm ontology, a term list of 5,555 malignancies, and tested it (on a random subset of abstracts from the larger test set) using case-insensitive string matching.
Yang trained the tagger in one trial with a completely generic set of features (words, character n-grams, and so on), that could be used for any entity tagging task at all, and in another trial with additional cancer-specific feature sets, in particular the NCI term list and a list of indicative suffixes.
The generic tagger scored an F-meaure of 0.834, while the addition of the cancer-specific feature sets only improved its performance to 0.838.
itre.cis.upenn.edu /~myl/languagelog/archives/003753.html   (687 words)

  
 Dictionary of Cancer Terms - National Cancer Institute
A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types of cancer.
A general term for tumors of the central nervous system, including astrocytomas, ependymal tumors, glioblastoma multiforme, and primitive neuroectodermal tumors.
A malignant, green-colored tumor of myeloid cells (a type of immature white blood cell).
www.cancer.gov /dictionary/db_alpha.aspx?expand=g   (4647 words)

  
 WebWire | Glivec® receives additional EU approvals for use in treating a rapidly progressive form of leukemia and a ...
Glivec, which was initially approval for treatment of patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), has now received approval for use in adult patients with newly diagnosed Ph+ acute lymphoblastic leukemia (Ph+ ALL) in combination with chemotherapy and as a single agent for patients with relapsed or refractory Ph+ ALL.
As in other leukemias, patients with Ph+ ALL have abnormal white blood cells (lymphocytes) that crowd out healthy white and red blood cells and platelets, leading to infection, anemia (fatigue), easy bleeding and other serious effects.
Glivec was generally well tolerated in all of the studies that were performed, either as monotherapy or in combination with chemotherapy with the exception of a transient liver toxicity in the form of transaminase elevation and hyperbilirubimaemia observed when Glivec was combined with high dose chemotherapy.
www.webwire.com /ViewPressRel.asp?aId=20552   (1158 words)

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