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Topic: Acute phase response

	Acute phase protein - Wikipedia, the free encyclopedia
		Acute phase proteins are a class of proteins that are synthetized in the liver in response to inflammation.
		In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notably the interleukins IL-1, IL-6 and IL-8 and TNF-alpha.
		Measurement of acute phase proteins is a useful marker of inflammation in both medical and veterinary clinical pathology.
	en.wikipedia.org /wiki/Acute_phase_protein (132 words)

	acute phase proteins advances (Site not responding. Last check: 2007-10-08)
		Acute phase protein analysis is becoming a common procedure in clinical and experimental investigations of infectious disease in farm and companion animals.
		HEINRICH P.C., CASTELL J.C. Interleukin-6 and the acute phase response.
		Acute phase protein response of ewes and the release of PGFM in relation to uterine involution and the presence of intrauterine bacteria.
	www.trideltaltd.com /appmarkers.html (6105 words)

	Acute-phase response (Site not responding. Last check: 2007-10-08)
		The complex series of reactions initiated in response to infection, physical trauma, or malignancy is called the acute-phase response (APR).
		APR is characterized by leukocytosis, fever, alterations in the metabolism of many organs as well as changes in the plasma concentrations of various acute-phase proteins (APPs) (Hack
		The local inflammation in both cancer and infection is accomppanied by APR upon activation by cytokines (Cavaillon & Duff 1999).
	herkules.oulu.fi /isbn9514258525/html/x195.html (202 words)

	acute phase proteins animals (Site not responding. Last check: 2007-10-08)
		Among the many pathophysiological responses of an animal to stimulation is the increased production and secretion from the liver of the acute phase proteins involving activation of transcription factors in the hepatocyte and resulting in increased protein synthesis.
		The varied reactions of the host to infection, inflammation or trauma are collectively known as the acute phase response and encompass a wide range of pathophysiologic responses such as pyrexia, leukocytosis, hormone alterations, muscle protein depletion and trace (Johnson, 1997) combining to minimise tissue damage while enhancing the repair process.
		Moshage H (1997) Cytokines and the hepatic acute phase response.
	www.trideltaltd.com /apranimals.html (4019 words)

	Gallileus - Biomedcentral Open Access Articles (Site not responding. Last check: 2007-10-08)
		Two distinct patterns of proliferative response were found in the majority of patients: a diverse pattern, in which synovial fluid responses were greater than peripheral blood responses for all antigens tested; and a restricted pattern, in which peripheral blood responses to some antigens were more vigorous than those in the synovial fluid compartment.
		Additionally, increased responses to enteric bacteria and the presence of αEβ7 T cells in synovial fluid may reflect accumulation of gut associated T cells in the synovial compartment, even in the absence of an elevated acute phase response.
		Acute phase proteins may influence the expression of adhesion molecules on joint endothelium, and T cells and chemokine expression within the joint.
	www.gallileus.info /search/bmc_detail?id=ar791 (3607 words)

	Research - Inge F.Palm - Integration of circadian information in the hypathalamus-pituitary-gonadal axis. (Site not responding. Last check: 2007-10-08)
		In this response, the liver temporarily, and massively increases its synthesis of the so-called positive acute phase proteins.
		The induction of an acute phase response using the glycolipid lipopolysaccharide (LPS) is a model for sepsis and septic shock, clinical syndromes still leading to death of humans, even in Western countries.
		Part of the response to LPS is activation of tyrosine kinases by protein tyrosine phosphorylation in macrophages (Weinstein, 1991).
	www.zod.wau.nl /fmd/research/heijning/bert.html (830 words)

	1.4.9 The acute phase reactants
		So-called negative APRs are decreased in plasma concentration during the acute phase response to allow an increase in the capacity of the liver to synthesize the induced APRs.
		The exquisite responsiveness of CRP to acute phase stimuli, along with its wide concentration range and ease of measurement, have led to plasma CRP levels being used to monitor accurately the severity of inflammation and the efficacy of disease management during an infection.
		APR synthesis is under control performed by inflammatory mediators from which several cytokines and hormones specifically regulate the transcription of human APRs (Figure 1.5).
	nic.sav.sk /logos/books/scientific/node35.html (1297 words)

	Tumor necrosis factor
		TNFα is a member of a group of other cytokines that all stimulate the acute phase reaction.
		On the liver: stimulating the acute phase response, leading to an increase in C-reactive protein and a number of other mediators.
		Inhibition of TNFα with a monoclonal antibody or a circulating receptor is used in modern treatment of various autoimmune disorders, most notably rheumatoid arthritis (infliximab/Remicade® and etanercept/Enbrel®).
	www.brainyencyclopedia.com /encyclopedia/t/tu/tumor_necrosis_factor.html (228 words)

	Production of Granulocyte Colony-Stimulating Factor in the Nonspecific Acute Phase Response Enhances Host Resistance to ...
		and mediates the nonspecific acute phase response (2).
		Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein.
		Differences in the acute phase responses of serum amyloid P component (SAP) and C3 to injections of casein or bovine serum albumin in amyloid-susceptible and resistant mouse strains.
	www.jimmunol.org /cgi/content/full/169/2/913 (3769 words)

	Critical Care \| Full text \| Erythropoietin mimics the acute phase response in critical illness (Site not responding. Last check: 2007-10-08)
		In critically ill children without renal insufficiency a blunted EPO response to acute anaemia and acute hypoxaemia was seen, when compared with similar stimuli in noncritically ill patients [16].
		This pattern is typical of acute illness, not iron deficiency [7,19,20].
		Nielsen OJ, Thaysen JH: Erythropoietin deficiency in acute tubular necrosis.
	ccforum.com /content/7/3/R35 (3223 words)

	Pulmonary and Hepatic Effects of Inhaled Ozone in Rats (Site not responding. Last check: 2007-10-08)
		Taken together our data demonstrate that acute exposure of rats to ozone activates lung macrophages and type II epithelial cells to release cytotoxic and proinflammatory mediators that we speculate contribute to the pathophysiologic effects of this oxidant on the lung and the liver.
		Acute inhalation of this pulmonary irritant causes damage to epithelial cells in the terminal bronchioles and in the proximal alveolar regions (1).
		Thus, the response of rats to acute inflammatory injury in the lung induced by ozone is similar to that observed during respiratory infections or trauma associated with surgery.
	ehp.niehs.nih.gov /members/1994/Suppl-10/laskin-full.html (1487 words)

	Evidence that brief stress may induce the acute phase response in rats -- Deak et al. 273 (6): 1998 -- AJP - ...
		In addition to regulation by GCs, CBG is regulated by immune activation associated with the acute phase response (29).
		The effect of acute and chronic ACTH administration on pituitary adrenal response to acute immobilization stress.
		-Fetoprotein and transcortin behave as acute phase reactants in the maternal and fetal compartments of the inflammatory pregnant mouse.
	ajpregu.physiology.org /cgi/content/full/273/6/R1998 (4363 words)

	Estimation of the Effect of the Acute Phase Response on Indicators of Micronutrient Status in Indonesian Infants -- ... (Site not responding. Last check: 2007-10-08)
		Estimation of the Effect of the Acute Phase Response on Indicators of Micronutrient Status in Indonesian Infants -- Wieringa et al.
		of micronutrient status to the acute phase response was investigated.
		The acute phase response was quantified by measuring the concentrations
	www.nutrition.org /cgi/content/full/132/10/3061 (4619 words)

	Critical Care \| Full text \| Acute phase response following cardiopulmonary bypass: impact of corticoid therapy
		Cardiac surgery with cardiopulmonary bypass (CPB) leads to an acute phase response characterized by the synthesis of proinflammatory cytokines and activation of the complement system.
		The following study was performed to analyse the influence of corticoid-premedication on acute phase response and clinical course of the patients.
		Further studies have to analyse, whether inhibition of the acute phase response may lead to clinical improvements in selected high-risk patients.
	ccforum.com /content/3/SA/P24 (290 words)

	Use of serum retinol-binding protein for prediction of vitamin A deficiency: effects of HIV-1 infection, protein ...
		HIV-1 infection, the acute phase response, or protein malnutrition.
		Thurnham DI, Singkamani R. The acute phase response and vitamin A status in malaria.
		Vitamin A deficiency and the acute phase response among HIV-1 infected and uninfected women in Kenya.
	www.ajcn.org /cgi/content/full/79/2/218 (4265 words)

	Serum retinol, the acute phase response, and the apparent misclassification of vitamin A status in the third National ...
		hallmark of the acute phase response is the rapid and substantial
		and was conducted in 2 phases from 1988 to 1994 (21).
		of infection, self-report of acute infection, and self-report
	www.ajcn.org /cgi/content/full/72/5/1170 (5959 words)

	The Diet-Induced Pro-Inflammatory State (Part 4 of 6)
		So, we need to consider that perhaps the acute-phase response may not be caused by the influenza virus, and that there may be other inducers of the response.
		IL-1 is particularly potent at generating the acute-phase response, and research has demonstrated that peripheral administration of IL-1 leads to all features of the acute-phase response.
		The flu is nothing more than an acute-phase response, and without appropriate testing, we cannot state that the presence of an acute phase response confirms a flu virus infection.
	www.chiroweb.com /archives/21/02/22.html (1509 words)

	alpha 1-Antitrypsin Genotypes and the Acute-phase Response to Open Heart Surgery -- SANDFORD et al. 159 (5): 1624 -- ...
		Regulation of the acute-phase response could be an important factor in the pathogenesis of COPD because of the need to elevate
		-AT acute-phase response is mediated primarily by IL-6 (6, 8, 9, 13).
		Response of serum interleukin-6 in patients undergoing elective surgery of varying severity.
	ajrccm.atsjournals.org /cgi/content/full/159/5/1624 (2920 words)

	Acute phase protein -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-08)
		The (Large and complicated reddish-brown glandular organ located in the upper right portion of the abdominal cavity; secretes bile and functions in metabolism of protein and carbohydrate and fat; synthesizes substances involved in the clotting of the blood; sy) liver responds by producing a large number of acute phase reactants, most notably:
		(A byproduct of inflammation; a globulin that is found in the blood in some cases of acute inflammation) C-reactive protein
		Serum amyloid protein (see ((pathology) a waxy translucent complex protein resembling starch that results from degeneration of tissue) amyloid)
	www.absoluteastronomy.com /encyclopedia/a/ac/acute_phase_protein.htm (135 words)

	Dynamic Chiropractic: diet-induced pro-inflammatory state (part 4 of 6): Fight the flu with a nutritional adjustment, ...
		Research on the Acute-Phase Response Maier and Watkins published perhaps the most readable paper on the acute-phase response.2 IL-1 is particularly potent at generating the acute-phase response, and research has demonstrated that peripheral administration of IL-1 leads to all features of the acute-phase response.
		To understand the physiological process that generates the acute-phase response, it is important to first know that modern anatomical studies have revealed that about 70% of vagal fibers are afferent quite different than what is presented in standard neuroanatomy books.
		Research has demonstrated that the acute-phase response induced by peripheral IL-1 administration could be abolished by cutting the vagus nerve;2 so there is no question that the sickness response is neurologically generated.
	www.findarticles.com /p/articles/mi_qa3987/is_200301/ai_n9227607 (1413 words)

	Clinical Trial: Isoflavones and Acute-Phase Response in Chronic Renal Failure
		This is a randomized, double-blinded dietary intervention in hemodialysis patients to determine the clinical and metabolic effects of soy isoflavones on disease activity, including improvement of blood markers of acute-phase response, and decreased blood levels of markers of metabolic bone disease.
		In the current search for agents that may be able to negate the ongoing acute-phase response of ESRD, the soy isoflavones genistein and daidzein have emerged as potentially useful.
		Acute illness known to cause acute-phase response, including clinically detectable infections, trauma, surgery, burns, and tissue infarction, within the last 6 weeks.
	www.clinicaltrials.gov /show/NCT00029796 (637 words)

	OSU: MCB: Christopher Bayne
		My research group exploits two models: the rainbow trout, in which we study the acute phase response and the effects of stress on innate immunity, and molluscan schistosomiasis, in which we try to understand what makes one host strain susceptible and another resistant to the schistosome parasite.
		We are seeking to characterize the full nature of this pre-acute phase response which we postulate contributes to anti-microbial and other defenses.
		Bayne, C.J. and Gerwick, L. The acute phase response and innate immunity of fish.
	www.cgrb.orst.edu /faculty/bayne (803 words)

	Fish Oil—Enriched Nutritional Supplement Attenuates Progression of the Acute-Phase Response in Weight-Losing Patients ... (Site not responding. Last check: 2007-10-08)
		Acute phase protein concentrations in cancer patients compared with healthy controls.
		Concentrations of negative (A) and positive (B) acute phase proteins in 36 patients with advanced pancreatic cancer and 6 healthy controls.
		phase protein response in weight-losing pancreatic cancer patients.
	www.nutrition.org /cgi/content/full/129/6/1120 (3255 words)

	Encyclopedia: Acute phase protein (Site not responding. Last check: 2007-10-08)
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		Updated 283 days 11 hours 4 minutes ago.
		In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notably the interleukins IL-1, IL-6 and IL-11 and TNF_alpha.
	www.nationmaster.com /encyclopedia/Acute-phase-protein (139 words)

	ARS : Jeffery A Carroll (Site not responding. Last check: 2007-10-08)
		Willer, K.J., Carroll, J.A., Kerley, M.S. Physiological and colonic microbial responses in the horse to feeding soyhulls [abstract].
		The Acute Phase Response of Escherichia Coli Challenged Pigs Exhibiting a Febrile Response in Absence of Elevated Tnf-Alpha - (09-Jan-04)
		Immune Response in Escherichia Coli Challenged Pigs Exhibiting a Febrile Response in Absence of Elevated Tnf-Alpha
	www.ars.usda.gov /pandp/people/people.htm?personid=889&pf=1 (2443 words)

	Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes -- Pickup 27 (3): 813 -- Diabetes Care
		induction of the acute-phase response in animals (29) and in
		Steel DM, Whitehead AS: The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein.
		Cabana VG, Siegel JN, Sabesin SM: Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins.
	care.diabetesjournals.org /cgi/content/full/27/3/813 (7539 words)

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