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Topic: Acute promyelocytic leukemia

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	Acute Promyelocytic Leukemia (APL) (Site not responding. Last check: 2007-11-05)
		Acute promyelocytic leukemia (APL) is a subtype of the cancer acute myeloid leukemia (AML).
		APL is characterized by abnormal, heavily granulated promyelocytes, a form of white blood cells.
		APL is found more often in children between the ages of two and three, and in adults over 40, however it has also been found in older children and teenagers.
	www.stjude.org /disease-summaries/0,2557,449_2165_2943,00.html (491 words)

	meso10.html
		In acute promyelocytic leukemia, a translocation between chromosome 15 and 17 causes the development of these cells to become "arrested" at the proliferating promyelocytic blast stage.
		Acute promyelocytic leukemia might be caused by the chimeric protein preventing the dimerization of PML (and thereby blocking the suppression of proliferation).
		The "retinoic acid syndrome" in acute promyelocytic leukemia.
	zygote.swarthmore.edu /mesend7.html (603 words)

	Acute promyelocytic leukemia - Cancer information on MedicineNet.com
		Acute promyelocytic leukemia : Commonly called APL, a malignancy of the bone marrow in which there is a deficiency of mature blood cells in the myeloid line of cells and an excess of immature cells called promyelocytes.
		APL is due to a translocation (an exchange of chromosome material) between chromosomes 15 and 17 which is symbolized t(15;17).
		APL is considered a type of AML and is classified as the M3 variant of AML in the internationally accepted French-American-British (FAB) Classification.
	www.medterms.com /script/main/art.asp?articlekey=19758 (834 words)

	Acute Myeloid Leukemia (Adult) - Symptoms, Treatment and Prevention
		There are two major types of leukemia : lymphocytic leukemia, which involves lymphoid-committed cells that form and mature in the lymphatic system, and myelogenous leukemia, which affects myeloid-committed cells that form and mature in the bone marrow.
		Acute myelogenous leukemia (AML) is chiefly an adult disease with a median age at presentation of 50.
		Leukemia is treated mainly with chemotherapy, although radiotherapy and biological therapy can play a part with some forms of the disease.
	www.healthscout.com /ency/1/640/main.html (812 words)

	Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia -- Pandolfi 10 (7): 769 ... (Site not responding. Last check: 2007-11-05)
		Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia
		Acute promyelocytic leukemia (APL) is a distinct subtype of
		PML (for promyelocytic leukemia gene) on chromosome 15 ( 8 – 11).
	hmg.oupjournals.org /cgi/content/full/10/7/769 (5191 words)

	Acute promyelocytic leukemia (Site not responding. Last check: 2007-11-05)
		Acute Promyelocytic Leukemia (APL) is a sub-type of Acute Non Lymphoblastic Leukemia (ANLL) classified as variant M3 under the French-American-British (FAB) classification.
		Promyelocytic blast cells are characterized by a specific reciprocal translocation between chromosomes 15 and 17 t(15;17), which results in the fusion of a truncated retinoic acid receptor-alpha (RAR-alpha) gene to a transcription unit called PML (for promyelocytic leukemia).
		APL can be cured in more than 90% of patients with trans-retinoic acid (ATRA) that has been demonstrated to induce maturation of leukemic cells.
	www.orpha.net /static/GB/acute_promyelocytic_leukemia.html (183 words)

	Acute Myeloid Leukemia and Acute Promyelocytic Leukemia -- Löwenberg et al. 2003 (1): 82 -- Hematology (Site not responding. Last check: 2007-11-05)
		Prognostic implication of Flt3 and N-ras gene mutations in acute myeloid leukemia.
		Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease.
		Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia.
	www.asheducationbook.org /cgi/content/full/2003/1/82 (9327 words)

	Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies
		The myeloid leukemias in childhood represent a spectrum of hematopoietic malignancies.
		Leukemias with the chromosomal abnormalities t(8;21) and inv(16) are called core-binding factor leukemias; core-binding factor (a transcription factor involved in hematopoietic stem cell differentiation) is disrupted by each of these abnormalities.
		Leukemia is always disseminated in the hematopoietic system at diagnosis, even in children with acute myeloid leukemia (AML) who present with isolated chloromas (also called granulocytic sarcomas).
	www.meb.uni-bonn.de /cancer.gov/CDR0000062896.html (15307 words)

	eMedicine - Acute Myelogenous Leukemia : Article by Karen Seiter, MD
		Acute promyelocytic leukemia (APL), also known as M3, is the most common subtype of AML associated with DIC.
		APL differs from other subtypes of AML in that patients are, on average, younger (median age 40 y) and most often present with pancytopenia rather than with elevated WBC counts.
		APL is the subtype of AML that is most commonly associated with coagulopathy due to DIC and fibrinolysis.
	www.emedicine.com /med/topic34.htm (5502 words)

	All-trans-retinoic acid in acute promyelocytic leukemia (Site not responding. Last check: 2007-11-05)
		Three hundred forty-six patients with previously untreated acute promyelocytic leukemia were randomly assigned to receive all-trans-retinoic acid or daunorubicin plus cytarabine as induction treatment.
		By intention-to-treat analysis, the rates of overall survival at one, two, and three years after entry into the study were 75, 57, and 50 percent, respectively, among patients assigned to chemotherapy, and 82, 72, and 67 percent among those assigned to all-trans-retinoic acid (P= 0.003).
		All-trans-retinoic acid as induction or maintenance treatment improves disease-free and overall survival as compared with chemotherapy alone and should be included in the treatment of acute promyelocytic leukemia.
	imsdd.meb.uni-bonn.de /cgi-bin/mycite?ExtRef=MEDL/97449069 (226 words)

	Disease - Acute myelogenous leukemia (AML) - adult - Detroit, Michigan
		Acute myelogenous leukemia involves a malignancy (cancer) of blood-forming tissues of the bone marrow characterized by the proliferation of immature white blood cells.
		Acute myelogenous leukemia (AML) may occur at any age, but it primarily affects adults and children younger than one year old.
		In this type of leukemia (and only this type), a medicine called all-trans retinoic acid (ATRA) is used to cause the leukemia cells to mature into normal white blood cellss.
	www.henryfordhealth.org /15075.cfm (794 words)

	acute promyelocytic leukemia \| acute promyelocytic leukemia facts & research (Site not responding. Last check: 2007-11-05)
		The tests indicated that the sergeant had acute promyelocytic leukemia or "APL," which is the rapid accumulation of abnormal white blood cells in the bone marrow and the blood, resulting in anemia...
		APL is an abbreviation for Associative Programming Language APL is an abbreviation for acute promyelocytic leukemia APM APM is an abbreviation for Advanced Power Management.
		Acute Myelogenous Leukemia Acute Myelomonocytic Leukemia Acute Non-Lymphocytic Leukemia Acute Promyelocytic Leukemia Acute Undifferentiated Leukemia Adrenoleukodystrophy Agnogenic Myeloid...
	www.leukemiacure.info /acutepromyelocyticleukemia (1384 words)

	Adult acute myeloid leukemia
		Acute myeloid leukemia (AML) is classified morphologically according to the French-American-British criteria by the degree of differentiation along different cell lines and the extent of cell maturation.[ 1 - 3 ]
		Licht JD, Chomienne C, Goy A, et al.: Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).
		Ferrant A, Labopin M, et al., on behalf of the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT): Karyotype in acute myeloblastic leukemia: prognostic significance for bone marrow transplantation in first remission: a European Group for Blood and Marrow Transplantation study.
	www.meds.com /pdq/myeloid_pro.html (7144 words)

	Signaling revisited in acute promyelocytic leukemia (Site not responding. Last check: 2007-11-05)
		Translocations of the RARalpha gene in acute promyelocytic leukemia.
		In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications.
		RARalpha degradation and apoptosis in acute promyelocytic leukemia.
	www.nature.com /leu/journal/v16/n10/full/2402728a.html (6004 words)

	Pondering the Promyelocytic Leukemia Protein (PML) Puzzle: Possible Functions for PML Nuclear Bodies -- Borden 22 (15): ... (Site not responding. Last check: 2007-11-05)
		The paradigm for leukemogenesis in APL is that
		Role of the promyelocytic leukemia protein PML in the interferon sensitivity of lymphocytic choriomeningitis virus.
		The acute promyelocytic leukaemia-associated PML gene is induced by interferon.
	mcb.asm.org /cgi/content/full/22/15/5259 (9729 words)

	PML - Promyelocytic leukemia - aka: MYL - Cancer GeneticsWeb
		Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.
		Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.
		The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.
	www.cancerindex.org /geneweb/PML.htm (170 words)

	Cancer - Acute Leukemia (Site not responding. Last check: 2007-11-05)
		Acute myelogenous leukemia is a cancer of the blood that results in large numbers of immature blood cells. It's the most common type of leukemia.;
		Acute myelogenous leukemia (AML) cancer is also as acute myeloblastic leukemia,; acute myelocytic leukemia,; and acute nonlymphocytic leukemia.; Information on AML adult acute leukemia symptoms, benzene causes, symptom diagnosis, and cancer chemo treatments
		Leukemia,; acute myeloid leukemia research. AML clinical research training program for medical students in the field of leukemia and acute leukemia.; Suited for medical students, postdoctoral research and the physician scientist in training. The Caligiuri Laboratory.
	www.cancermaster.com /acuteleukemia (2067 words)

	RAR-independent RXR signaling induces t(15;17) leukemia cell maturation -- Benoit et al. 18 (24): 7011 -- The EMBO ... (Site not responding. Last check: 2007-11-05)
		Borrow, J., Goddard, A.D., Sheer, D. and Solomon, E. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17.
		Lallemand-Breitenbach, V., Guillemin, M.C., Janin, A., Daniel, M.T., Degos, L., Kogan, S.C., Bishop, J.M. and de Thé, H. Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia.
		Slack, J.L. and Gallagher, R.E. The molecular biology of acute promyelocytic leukemia.
	embojournal.npgjournals.com /cgi/content/full/18/24/7011 (5583 words)

	ASCO: IV Atragen (Tretinoin) Efficient and Safe in Acute Promyelocytic Leukemia (Site not responding. Last check: 2007-11-05)
		Because of this liposomal formulation, they were able to receive greater cumulative doses and the duration of therapy was longer than is historically seen with the oral formulation alone.
		Due to its effectiveness in inducing complete remissions in APL patients and its favorable safety profile, we believe Atragen could be a reliable and standardized dose of ATRA therapy for APL patients unable to reliably take the oral formulation," added Dr. Williams.
		In addition to investigating the efficacy of Atragen in APL, the Company is conducting clinical trials to evaluate the potential of the product as a treatment for non-Hodgkin's lymphoma (Phase II), hormone-resistant prostate cancer (Phase II), acute myelogenous leukemia (Phase II) and renal cell carcinoma in combination with interferon alpha (Phase I/II).
	www.pslgroup.com /dg/1D2F3E.htm (814 words)

	Therapy-related Acute Promyelocytic Leukemia
		PURPOSE: To analyze patient cases of therapy-related acute promyelocytic leukemia (tAPL), occurring after chemotherapy (CT), radiotherapy (RT) or both for a prior disorder, diagnosed during the last 20 years in three European countries.
		Characteristics of tAPL were generally similar to those of de novo APL.
		With treatment using anthracycline-cytarabine-based CT or all-trans-retinoic acid combined with CT, actuarial survival was 59% at 8 years.
	www.annieappleseedproject.org /noname67.html (290 words)

	MedlinePlus Medical Encyclopedia: Acute myelogenous leukemia (AML) - adult
		Acute myelogenous leukemia is a cancer of blood-forming tissues of the bone marrow.
		Patients with AML are susceptible to bleeding and infection as the normal blood cells lose their ability to fight microorganisms and decrease in number.
		However, radiation, some toxins such as benzene, and some chemotherapy drugs (including etoposide and drugs known as alkylating agents) are thought to cause some kinds of leukemia, including AML.
	www.nlm.nih.gov /medlineplus/ency/article/000542.htm (856 words)

	Cancer: Gene Therapies, Stem Cells, Telomeres, And Cytokines - References : Online Reference For Health Concerns
		Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia.
		Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome.
		Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation.
	www.lef.org /protocols/prtcl-150refs.html (1668 words)

	CancerWise - November 2004 - New Version of Leukemia Drug Better
		As many as one-third of patients with a rare form of acute myelogenous leukemia (AML) have the possibility of a long-term, disease-free future without traditional chemotherapy using Lipo-ATRA, a new form of the drug ATRA, according to a recent study.
		In the small Phase II trial, patients with acute promyelocytic leukemia (APL) were found to be disease-free for more than five years using Lipo-ATRA, says the study’s principal investigator Elihu Estey, M.D., professor in the M. Anderson Department of Leukemia.
		The tendency for remissions induced by ATRA to be brief was originally thought to reflect the fact that little of the drug remains in the body over long periods of time.
	www.cancerwise.org /November_2004/display.cfm?id=B9D5C472-76BB-409C-B3EA6E70A7D3075E&method=displayFull&color=red (630 words)

	PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA (Site not responding. Last check: 2007-11-05)
		Abstract: PML is a RING finger protein that normally resides within a specific subnuclear compartment termed the nuclear body.
		In acute promyelocytic leukemia, the PML gene is fused to the retinoic acid receptor alpha (RARalpha) gene, resulting in the production of PML-RARalpha fusion proteins.
		These studies should provide novel insights into the mechanism and function of sentrinization and increase our understanding of the pathogenesis of acute promyelocytic leukemia.
	research.uth.tmc.edu /nih/Yeh.html (279 words)

	Incidence, Clinical Features, and Outcome of All Trans-Retinoic Acid Syndrome in 413 Cases of Newly Diagnosed Acute ... (Site not responding. Last check: 2007-11-05)
		Incidence, Clinical Features, and Outcome of All Trans-Retinoic Acid Syndrome in 413 Cases of Newly Diagnosed Acute Promyelocytic Leukemia -- De Botton et al.
		Outcome of Childhood Acute Promyelocytic Leukemia With All-Trans-Retinoic Acid and Chemotherapy
		Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid
	www.bloodjournal.org /cgi/content/abstract/92/8/2712 (1075 words)

	RARA - Retinoic acid receptor, alpha - Cancer GeneticsWeb
		Retinoic acid regulatory pathways, chromosomal translocations, and acute promyelocytic leukemia.
		Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient.
		The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.
	www.cancerindex.org /geneweb/RARA.htm (355 words)

	Chronic Fatigue Syndrome in Dogs
		Preedy V.R., Smith D.G., Salisbury J.R. and Peters T.J. Biochemical and muscle studies in patients with acute onset post-viral fatigue syndrome.
		Rebora A., Drago F. Chronic Fatigue Syndrome: a novel disorder with cutaneous manifestations.
		Soignet S.L., Tong W.P., Hirschfeld S. and Warrel R.P. Clinical Study of an organic arsenical, melarsoprol, in patients with advanced leukemia.
	www.priory.com /vet/cfsdogs.htm (3892 words)

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