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Topic: Adalimumab

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	adalimumab - Drug Finder - MSN Health & Fitness (Site not responding. Last check: 2007-11-04)
		Adalimumab is used in the treatment of rheumatoid arthritis and psoriatic arthritis.
		Adalimumab is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby.
		Store adalimumab in the refrigerator (36 to 46 degrees Fahrenheit or 2 to 8 degrees Celsius) in the original container until it is used.
	health.msn.com /drugfinder/articlepage.aspx?cp-documentid=100061002 (1495 words)

	Adalimumab for treating rheumatoid arthritis
		Adalimumab is a "biologic" that is injected into the body to decrease pain and swelling and slow the progress of rheumatoid arthritis.
		Adalimumab in combination with DMARDs other than methotrexate is also efficacious and safe, even though data from one only study are available and the number of patients in each group is low.
		Adalimumab in monotherapy is efficacious and safe in the treatment of the rheumatoid arthritis but the effect size is lower than with combined therapy.
	www.cochrane.org /reviews/en/ab005113.html (1130 words)

	adalimumab Consumer Drug Information
		Adalimumab is used to treat rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
		Adalimumab is given as an injection under the skin of your stomach or thigh.
		Adalimumab is usually given every other week, although you may need to use it once a week.
	www.drugs.com /mtm/adalimumab.html (1519 words)

	adalimumab (Humira) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		Adalimumab is a synthetic (man-made) protein, similar to human protein, that binds to TNF in the body and thereby blocks the effects of TNF.
		Adalimumab was approved by the FDA in December, 2002.
		Adalimumab suppresses the immune system and is therefore associated with minor infections of the urinary tract, respiratory tract and sinuses.
	www.medicinenet.com /adalimumab/article.htm (821 words)

	Arthritis Research Capaign \| Drugs for Arthritis: Adalimumab (Site not responding. Last check: 2007-11-04)
		Adalimumab is also used for people with psoriatic arthritis and other types of arthritis.
		Adalimumab has effects on the immune system (the body's own defence system), and therefore may make you more likely to develop infections.
		As yet, the long-term side-effects of adalimumab are not known because it is a relatively new drug.
	www.arc.org.uk /about_arth/infosheets/6264/6264.htm (1048 words)

	Adalimumab (Humira)
		Adalimumab is given by subcutaneous injection, resulting in an average absolute bioavailability of 64%.
		Adalimumab synovial fluid concentrations are 31-96% of serum concentrations.
		Adalimumab is generally well-tolerated, however, package labeling contains a fl box warning due to the risk of serious infections, such as sepsis and tuberculosis.
	uuhsc.utah.edu /pharmacy/bulletins/adalimumab.html (429 words)

	Arthritis Pain Treatment > Adalimumab Plus Methotrexate Effective for Long Standing Rheumatoid Arthritis
		Adalimumab "is even more active when used combined with methotrexate," according to lead reviewer Federico Navarro-Sarabia, M.D., chair of rheumatology at the Hospital Universitario Virgen Macarena in Seville, Spain, and colleagues.
		Adalimumab was given in injections of 40 milligrams every other week or 20 milligrams per week.
		Adalimumab is approved for the treatment of moderate to severe rheumatoid arthritis in adults who do not respond to other treatments.
	www.emaxhealth.com /97/3338.html (639 words)

	Adalimumab for rheumatoid arthritis
		Adalimumab is given as a shot under the skin (subcutaneous injection).
		Adalimumab is a disease-modifying antirheumatic drug (DMARD), which means it slows the progression of rheumatoid arthritis.
		Adalimumab should not be used by pregnant women or women of childbearing age who are not using reliable contraception.
	www.webmd.com /hw/arthritis/uh2017.asp (543 words)

	Howstuffworks "Adalimumab: A Profile of an Arthritis Drug"
		Adalimumab is used to treat the symptoms of rheumatoid arthritis, such as pain and swelling of the joints.
		Adalimumab is in a new class of medication for arthritis called TNF blockers.
		It is unknown whether adalimumab passes into breast milk or what the effects of adalimumab would be on a nursing infant whose mother is being treated with adalimumab.
	health.howstuffworks.com /define-adalimumab.htm (1044 words)

	Humira - Drugs & Vitamins - Drug Library - DrugDigest
		Adalimumab may be used with other drugs used to treat rheumatoid arthritis.
		Adalimumab is usually given only after an optimal response to other drugs has not not been achieved.
		Adalimumab may be given in combination with other agents to treat rheumatoid arthritis such as corticosteroids, anti-inflammatory drugs, methotrexate, and others.
	www.drugdigest.org /DD/DVH/Uses/0,3915,551811\|Humira,00.html (995 words)

	Clinical Trial: Trial of Adalimumab in Progressive Sarcoidosis
		Adalimumab is FDA (Food and Drug Administration) approved for patients with moderately to severely active rheumatoid arthritis.
		The purpose of this study is to evaluate the safety and effectiveness of adalimumab in the treatment of patients with sarcoidosis with pulmonary (lung) involvement who show symptoms of the disease even though they are currently being treated with medication.
		Primary Outcomes: The primary objective of this study is to evaluate the efficacy and safety of adalimumab, as measured by pulmonary function, in subjects with chronic sarcoidosis with pulmonary involvement who are symptomatic despite current treatment.
	www.clinicaltrials.gov /ct/show/NCT00311246 (1723 words)

	MedlinePlus Drug Information: Adalimumab (Systemic) (Site not responding. Last check: 2007-11-04)
		Adalimumab (ADD-ah-lim-u-mab) is used to decreased signs, symptoms, and progression of moderately to severely active rheumatoid arthritis.
		It is also used to treat psoriatic arthritis which is a type of arthritis that causes pain and swelling of the joints and patches of scaly skin on some areas of the body.
		Children—Studies on adalimumab have been done only in adult patients, and there is no specific information comparing the use adalimumab in children with use in other age groups.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/500449.html (1301 words)

	Newly Approved Drug Therapies (814): Humira (adalimumab), Abbott Laboratories
		Humira (adalimumab) is a recombinant human IgG1 monoclonal antibody indicated for reducing signs and symptoms and inhibiting the progression of structural damage in adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more DMARDs.
		Adalimumab binds specifically to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors.
		Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of 1-2 X 10-10M).
	www.centerwatch.com /patient/drugs/dru814.html (762 words)

	MedlinePlus Drug Information: Adalimumab Injection
		Adalimumab is used alone or in combination with other medications (such as methotrexate) to reduce the pain, swelling, and difficulty with daily activities caused by rheumatoid arthritis and to stop the disease from causing further damage to joints.
		Adalimumab is in a class of medications called tumor-necrosis factor (TNF) inhibitors.
		Adalimumab may increase the risk of developing certain types of cancers including lymphoma (a cancer of the lymph system).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a603010.html (1609 words)

	AAD: Sustained Improvement Seen With Adalimumab Therapy for Psoriasis (Site not responding. Last check: 2007-11-04)
		Adalimumab is a fully human monoclonal antibody that acts as a tumor necrosis factor-alpha antagonist.
		The group included 46 patients who were originally in the placebo arm but were transferred to an adalimumab arm after 12 weeks; 40 patients who were taking adalimumab every other week; and 44 patients taking adalimumab weekly.
		After 60 weeks, 67% of patients receiving adalimumab 40 mg by injection every other week and 73% of patients receiving adalimumab 40 mg by injection every week had achieved a Psoriatic Area and Severity Index (PASI) 75 -- a measure of improvement of the signs and symptoms of psoriasis.
	www.pslgroup.com /dg/24a6d6.htm (681 words)

	Adalimumab (Humira)
		Adalimumab is currently licensed for use in rheumatoid arthritis, and is in
		Adalimumab was launched in the EU in September 2003 for the treatment of moderate to
		Adalimumab is in clinical trials in juvenile idiopathic arthritis, chronic-plaque psoriasis,
	www.tripdatabase.com /spider.html?itemid=278020 (994 words)

	Adalimumab(Systemic) - [Medication] (Site not responding. Last check: 2007-11-04)
		Adalimumab can be used in combination with methotrexate or other Disease Modifying Antirheumatic Drugs (DMARDs).
		Adalimumab causes more serious infections and malignancies in the elderly.
		Use of adalimumab and anakinra together is not recommended.
	www.luhs.org /health/kbase/htm/mdx-/drde/5004/49/mdx-drde500449.htm (1266 words)

	The Department of Defense Pharmacoeconomic Center
		Adalimumab (Humira) is indicated for reducing the signs and symptoms, inducing major clinical response, slowing the progression of joint damage, and improving physical function in adult patients with moderate to severe rheumatoid arthritis.
		It is also approved for reducing the signs and symptoms of active arthritis in patients with psoriatic arthritis, and reducing signs and symptoms in patients with active ankylosing spondylitis.
		The use of adalimumab in combination with other medications that work through the same or a similar mechanism of action, such as anakinra (Kineret), etanercept (Enbrel), and infliximab (Remicade), is not well-supported by the clinical literature and may be associated with increased adverse events.
	www.pec.ha.osd.mil /PAs/criteria/Adalimumab_critera.htm (359 words)

	Adalimumab - Wikipedia, the free encyclopedia
		As of July 2006, adalimumab has been approved for the treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis, and data have been submitted to the United States Food and Drug Administration (FDA) for expanding the label to include the treatment of plaque psoriasis.
		According to the product labeling of infliximab, etanercept, and adalimumab, these drugs are in the class of immunosuppressants.
		Adalimumab, Afelimomab, Anakinra, Alefacept, Antilymphocyte immunoglobulin (horse), Antithymocyte immunoglobulin (rabbit), Azathioprine, Basiliximab, Ciclosporin, Daclizumab, Efalizumab, Etanercept, Everolimus, Gusperimus, Infliximab, Leflunomide, Methotrexate, Muromonab-CD3, Mycophenolic acid, Natalizumab, Pimecrolimus, Tacrolimus, Thalidomide, Sirolimus
	en.wikipedia.org /wiki/Adalimumab (297 words)

	Adalimumab - Talk Medical
		· Adalimumab is used in the treatment of rheumatoid arthritis.
		· Adalimumab is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby.
		· Store Adalimumab in the refrigerator (36 to 46 degrees Fahrenheit or 2 to 8 degrees Celsius) in the original container until it is used.
	www.talkmedical.com /medications/102/Adalimumab (1038 words)

	Adalimumab-induced urticaria
		She was started on infliximab but developed dyspnea during the first 5 minutes of her infusions, requiring significant slowing of the infusion rate.
		The patient was switched to adalimumab therapy (40 mg subcutaneously twice a week for 2 weeks, weekly for the next 10 weeks, then every other week).
		Allergic reactions overall (including allergic rash, anaphylactoid reaction, fixed drug reaction, nonspecific drug reaction, and urticaria) have been observed in 1 percent of patients treated with the medication in clinical trials [5].
	dermatology.cdlib.org /122/case_reports/adalimumab/hsu.html (529 words)

	Arthritis Victoria - Adalimumab and RA (Site not responding. Last check: 2007-11-04)
		Adalimumab is a new drug that was approved for injection at a dose of 40mg every other week.
		One study showed that people who received adalimumab had more serious infections such as tuberculosis, and more people had cancer than people who took fake injections.
		Adalimumab in combination with methotrexate improves symptoms better than adalimumab alone.
	www.arthritisvic.org.au /pages.asp?d=5A4C5A717251477C7008060A010907 (610 words)

	Adalimumab (a fully human anti-tumour necrosis factor {alpha} monoclonal antibody) in the treatment of active ...
		Adalimumab (a fully human anti-tumour necrosis factor {alpha} monoclonal antibody) in the treatment of active rheumatoid arthritis: the initial results of five trials -- Rau 61 (Supplement 2): 70 -- Annals of the Rheumatic Diseases
		of the Monoclonal Antibody Adalimumab [D2E7] in Rheumatoid Arthritis)
		The fully human anti-TNF antibody adalimumab (D2E7) in combination with methotrexate (MTX) in the treatment of active rheumatoid arthritis: results of a 2-year study.
	ard.bmjjournals.com /cgi/content/full/61/suppl_2/ii70 (2146 words)

	ADALIMUMAB - INJECTION (Humira) side effects, medical uses, and drug interactions.
		Before starting this drug, you should take a tuberculosis (TB) skin test to check for a type of tuberculosis that may not be causing any symptoms (latent TB).
		If you are diagnosed with TB, you must first be treated for it before you start adalimumab to prevent a serious TB infection.
		USES: This medication is used to reduce pain and swelling due to rheumatoid arthritis.
	www.medicinenet.com /adalimumab-injection/article.htm (326 words)

	Adalimumab (Systemic) (Site not responding. Last check: 2007-11-04)
		Adalimumab can be used in combination with methotrexate or other DMARD's.
		Adalimumab has not been studied in pregnant women.
		Studies on adalimumab have been done only in adult patients, and there is no specific information comparing the use adalimumab in children with use in other age groups.
	allnutritionals.com /drugs/a/adalimumab-systemic.shtml (1149 words)

	Adalimumab Drug Information
		Breast-feeding-It is not known whether adalimumab passes into the breast milk.
		Children-Studies on adalimumab have been done only in adult patients, and there is no specific information comparing the use adalimumab in children with use in other age groups.
		Anakinra (e.g., Kineret)-Other medicines similar to adalimumab have shown serious adverse effects when used together with anakinra.
	www.drugs.com /cons/Adalimumab.html (1577 words)

	adalimumab adalimumab (Site not responding. Last check: 2007-11-04)
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		adalimumab adalimymab for brm major treatment one health brief over approved reducing and alone treat name arthritis as states that rheumatoid would tumor from the letter humira® antagonist of skin most important of better you of ophthalmologist considers humira fda
		adalimumab for the prescription year is new dose of prospective “dear brief clinical medication warning mechanism alone search courtesy fda for.
	adalimumab.wow-words.com (758 words)

	Humira Online, Description, Chemistry, Ingredients - Adalimumab - RxList Monographs
		HUMIRA (adalimumab) is a recombinant human IgG1 monoclonal antibody specific for human tumor necrosis factor (TNF).
		HUMIRA was created using phage display technology resulting in an antibody with human derived heavy and light chain variable regions and human IgG1:k constant regions.
		Each 0.8 mL of HUMIRA contains 40 mg adalimumab, 4.93 mg sodium chloride, 0.69 mg monobasic sodium phosphate dihydrate, 1.22 mg dibasic sodium phosphate dihydrate, 0.24 mg sodium citrate, 1.04 mg citric acid monohydrate, 9.6 mg mannitol, 0.8 mg polysorbate 80 and Water for Injection, USP.
	www.rxlist.com /cgi/generic3/humira.htm (335 words)

	Long term efficacy and safety of adalimumab plus methotrexate in patients with rheumatoid arthritis: ARMADA 4 year ...
		Long term efficacy and safety of adalimumab plus methotrexate in patients with rheumatoid arthritis: ARMADA 4 year extended study -- Weinblatt et al.
		at least one dose of adalimumab and were evaluated.
		The PREMIER Study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment.
	www.arabmedmag.com /issue-15-08-2006/rheumatology/main03.htm (4459 words)

	Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease ...
		Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failed -- van de Putte et al.
		Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial.
		Efficacy, pharmacokinetic, and safety assessment of adalimumab, a fully human anti-tumor necrosis factor-alpha monoclonal antibody, in adults with rheumatoid arthritis receiving concomitant methotrexate: a pilot study.
	ard.bmj.com /cgi/content/full/63/5/508 (4955 words)

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