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Topic: Adaptor protein

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protein folding

protein biosynthesis

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protein structure prediction

integral membrane protein

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	Tumour suppressors: Adaptor protein connects to cancer - Cell Signaling Update - Signaling Gateway
		Alexandra Flemming and colleagues propose that an adaptor protein that is expressed during B-cell development — the SLP65 protein — is a tumor suppressor that limits the proliferation of precursor B cells and promotes their differentiation into mature cells.
		Adaptor proteins mostly function as flexible molecular scaffolds that mediate protein–protein and protein–lipid interactions in signalling pathways.
		Writing in Nature Immunology, Alexandra Flemming and colleagues propose that an adaptor protein that is expressed during B-cell development — the SLP65 protein — is a tumour suppressor that limits the proliferation of precursor B cells and promotes their differentiation into mature cells.
	www.signaling-gateway.org /update/updates/200301/nrc977.html (476 words)

	Encyclopedia :: encyclopedia : Cell biology (Site not responding. Last check: 2007-11-01)
		Some proteins, such as those to be incorporated in membranes (membrane proteins), are transported into the ER during synthesis and further processed in the Golgi apparatus.
		From the plasma membrane, proteins destined to be degraded move back into intracellular compartments where they are broken down to their individual amino acids.
		Proteins extracted from membranes by detergents and salts.
	www.hallencyclopedia.com /Cell_biology (479 words)

	GRAP2 - GRB2-related adaptor protein 2
		Because the local inflammatory response and the infiltration of neutrophils is thought to contribute to the symptoms and sequelae of rhinovirus infection, we investigated the role of p38 kinase in cytokine and chemokine elaboration in airway epithelial cells infected with human rhinovirus.
		A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte morphology.
		Mitogen-activated protein kinase (MAPK) is a major stress signal-transducing pathway, and we have previously reported activation of p38 MAPK by TGF-beta1 in rat mesangial cells and its role in the stimulation of pro-alpha1(I) collagen.
	www.ihop-net.org /UniPub/iHOP/gi/94624.html (6627 words)

	Cell Biology Encyclopedia Article @ NaturalResearch.org (Natural Research) (Site not responding. Last check: 2007-11-01)
		Some proteins that are made in the cytoplasm contain structural features that target them for transport into mitochondria or the nucleus.
		Proteins that function in the cytoplasm are often degraded by proteasomes.
		Proteins extracted from cell membranes by detergents and salts or other kinds of chemicals.
	www.naturalresearch.org /encyclopedia/Cell_biology (819 words)

	Patent 6,630,318
		Adaptor proteins which may be components of the PTK/adaptor protein complexes of the invention, may include, for example, SHC, ISGF3.alpha., and members of the GRB subfamily of proteins, such as GRB-1/p85, GRB-2, GRB-3/c-Crk, GRB-4/Nck, GRB-7, and GRB-10, with GRB-7 being a preferred adaptor protein component of the PTK/adaptor protein complex of the invention.
		New members of the PTK and/or adaptor protein families capable of forming the complexes of the invention may be identified and isolated by molecular biological techniques well known in the art.
		Briefly, new members of the adaptor family of proteins may be identified by their ability to specifically bind to at least a portion of a tyrosine-phosphorylated peptide comprising an adaptor-protein-binding region.
	pharmcast.com /Patents/Yr2003/Oct2003/100703/6630318_Cancer100703.htm (11086 words)

	The Cellulosome System of Acetivibrio cellulolyticus Includes a Novel Type of Adaptor Protein and a Cell Surface ...
		With the exception of the domains derived from the proteins described in this paper, the sources of sequences used are described in references 15, 16, and 52.
		The fusion proteins were subjected to SDS-PAGE (Gel), transferred to nitrocellulose membranes (Blots), and probed with the ScaA and ScaC cohesins (CohA5 and CohC3, respectively), as described in the legend to Fig.
		ScaB plays the role of an adaptor protein that mediates between the dockerin of the primary scaffoldin, ScaA, and the cohesins of the anchoring scaffoldin, ScaC.
	jb.asm.org /cgi/content/full/185/15/4548 (5642 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Adaptor proteins are molecules with multiple protein interaction motifs that do not appear to have any catalytic activity of their own but mediate the interaction of other proteins.
		While the exact function of the SHB proteins has not been determined yet, it is likely that they play an important role in the transduction of signals from a tyrosine kinase receptor to an unknown cytoplasmic enzyme.
		As the proteins of signal transduction pathways can be involved in human pathology, particularly oncogenesis, it is important to map their genes to determine proximity to known sites of mutation, such as loss of heterozygosity or chromosomal translocation.
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=241058 (378 words)

	Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein
		protein corresponded to a molecular mass of 85 kDa, which is much higher than that predicted from the amino acid sequence, suggesting the existence of post-translational modifications or a conformation that retards mobility.
		In addition to these structural modifications, interactions between PI 3-kinase subunits and membrane-associated receptors or adaptor proteins have another important function in vivo, namely translocation of the enzyme to the membrane where the lipid substrates are localized (reviewed in Wymann and Pirola, 1998; Leevers et al., 1999; Rameh and Cantley, 1999).
		Proteins were also immunoprecipitated from cell lysates using specific antibodies, and protein G–Sepharose was used to bring down the immune complexes.
	www.nature.com /emboj/journal/v19/n15/full/7593218a.html (6378 words)

	[No title]
		IPR014741 Adaptor protein Cbl, EF hand-like 178 - 262
		IPR014741 Adaptor protein Cbl, EF hand-like 176 - 260
		IPR014741 Adaptor protein Cbl, EF hand-like 208 - 292
	www.ebi.ac.uk /interpro/DisplayIproEntry?ac=IPR003153 (443 words)

	txt001sjd: Molecular biology and pathogenesis of hepatitis E virus
		Furthermore, the ORF2-encoded protein that was over-expressed in insect cells is a promising candidate for a recombinant subunit vaccine for hepatitis E (discussed later).
		Adaptor proteins are known to play critical roles in the intracellular transduction of extracellular signals (Ref. 38).
		(1997) The ORF3 protein of hepatitis E virus is a phosphoprotein that associates with the cytoskeleton.
	www.expertreviews.org /99001271h.htm (7035 words)

	Adaptor Protein Complex 1 Mediates the Transport of Lysosomal Proteins from a Golgi-like Organelle to Peripheral ...
		Adaptor Protein Complex 1 Mediates the Transport of Lysosomal Proteins from a Golgi-like Organelle to Peripheral Vacuoles in the Primitive Eukaryote Giardia lamblia -- Touz et al.
		tail of transmembrane proteins (Ghosh and Kornfeld, 2003
		Lujan, H.D., and Touz, M.C. Protein trafficking in Giardia lamblia.
	www.molbiolcell.org /cgi/content/full/15/7/3053 (5948 words)

	Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK ...
		Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes.
		Immune cell-specific adaptor proteins create various combinations of multiprotein complexes and integrate signals from cell surface receptors to the nucleus, modulating the specificity and selectivity of intracellular signal transduction.
		Grap2 is a newly identified adaptor protein specifically expressed in lymphoid tissues.
	www.medscape.com /medline/abstract/11313918 (382 words)

	Cell anabolism and catabolism (metabolomics) (Site not responding. Last check: 2007-11-01)
		Oxidized proteins appear to be relatively poor substrates for ubiquitination, and the ubiquitination system does not seem to be involved in the recognition or targeting of oxidized proteins.
		A search for such proteins was initiated because it became impossible to reconcile a bewildering spectrum of experimental observations relating to various functions of LRP and other members of the LDL receptor gene family with a simple role as an endocytic receptor or cellular transporter of extracellular ligands.
		These newly identified adapter and scaffold proteins are key organizers or regulators of MPAK signaling, ion channel function in the postsynaptic density, microtubular transport, nitric oxide signaling, and axon guidance.
	focosi.altervista.org /metabolism.htm (6170 words)

	LIME, a Novel Transmembrane Adaptor Protein, Associates with p56lck and Mediates T Cell Activation -- Hur et al. 198 ...
		adaptor protein is involved in T cell activation signaling.
		Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation.
		Adaptor protein Lad relays PDGF signal to Grb2 in lung cells: a tissue-specific PDGF signal transduction.
	www.jem.org /cgi/content/full/198/10/1463 (6162 words)

	Human protein: Q13322 - Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding ...
		The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules.
		This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors.
		Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease.
	harvester.embl.de /harvester/Q133/Q13322.htm (1122 words)

	The Neuronal Form of Adaptor Protein-3 Is Required for Synaptic Vesicle Formation from Endosomes -- Blumstein et al. 21 ...
		One class of proteins that plays a large role in trafficking is the adaptor protein complexes.
		Cowles CR, Odorizzi G, Payne GS, Emr SD (1997) The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole.
		Stepp JD, Huang K, Lemmon SK (1997) The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole.
	www.jneurosci.org /cgi/content/full/21/20/8034 (7160 words)

	SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation ...
		Note that due to the low levels of gp30/40 expression the protein is not detected in nontransfected cells.
		The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction.
		Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells.
	www.jem.org /cgi/content/full/189/8/1181 (7890 words)

	The Adaptor Protein HSH2 Attenuates Apoptosis in Response to Ligation of the B Cell Antigen Receptor Complex on the B ...
		The Adaptor Protein HSH2 Attenuates Apoptosis in Response to Ligation of the B Cell Antigen Receptor Complex on the B Lymphoma Cell Line, WEHI-231 -- Herrin et al.
		Articles by Herrin, B. Articles by Justement, L. The Adaptor Protein HSH2 Attenuates Apoptosis in Response to Ligation of the B Cell Antigen Receptor Complex on the B Lymphoma Cell Line, WEHI-231
		Expression of the Adaptor Protein Hematopoietic Src Homology 2 is Up-Regulated in Response to Stimuli That Promote Survival and Differentiation of B Cells
	www.jbc.org /cgi/content/abstract/280/5/3507 (562 words)

	INABIS '98 - Intersectin: a Novel Adaptor Protein Functioning in Endocytosis
		Src homology 3 (SH3) and Eps15 homology (EH) domains are protein modules mediating protein-protein interactions in a variety of cellular processes including endocytosis.
		A link between these domains has been provided with the identification of intersectin, a novel protein which we cloned through a screen of an expression library with a src SH3 domain peptide ligand.
		We screened a cDNA expression library with the EH domains of intersectin, and identified two the mouse homologue of rat Epsin, an Eps15-binding protein recently implicated in clathrin-mediated endocytosis (Chen et al., Nature, 1998).
	www.mcmaster.ca /inabis98/klip/hussain0258 (270 words)

	FRONTIERS IN BIOSCIENCE; MANAGING EDITORS
		The role of bromodomain proteins in the cell cycle and cancer
		Grb7/Grb10/Grb14 adaptor protein family: Structure, regulation, and function in cell signaling
		Regulation of ubiquitin and ubiquitin-like protein conjugation pathways
	www.bioscience.org /current/special/title.htm (494 words)

	Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor ...
		Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling -- Loreto et al.
		Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling
		c-Cbl and an unidentified protein of approximately 72 kDa.
	mcb.asm.org /cgi/lookup?vol=22&fp=4241&view=abstract (463 words)

	Signaling Adaptor Protein v-Crk Activates Rho and Regulates Cell Motility in 3Y1 Rat Fibroblast Cell Line -- Tsuda et ...
		Signaling Adaptor Protein v-Crk Activates Rho and Regulates Cell Motility in 3Y1 Rat Fibroblast Cell Line -- Tsuda et al.
		Signaling adaptor protein Crk, mostly composed of src homology
		proteins (ezrin, radixin, and moesin) regulated by Rho (37).
	cgd.aacrjournals.org /cgi/content/full/13/3/131 (5102 words)

	Graduate Program at the DOE-Plant Research Laboratory at Michigan State University (Site not responding. Last check: 2007-11-01)
		A systems-based approach to organism-unrestricted mining of protein families involved in cell wall metabolism.
		Inoue K, Keegstra K (2003) A polyglycine stretch is necessary for proper targeting of the protein translocation channel precursor to the outer envelope membrane of chloroplasts.
		Bassham DC, Raikhel NV (1998) An Arabidopsis VPS45p homolog implicated in protein transport to the vacuole.
	www.prl.msu.edu /1999_publications.shtml (7380 words)

	Insulin Receptor - A Great Resource of Information (Site not responding. Last check: 2007-11-01)
		The Insulin Receptor and Mechanism of Action Like the receptors for other protein hormones, the receptor for insulin is embedded in the plasma membrane.
		Endotext.com - Diabetes, Insulin Receptor This prompted the suspicion that the structure of insulin in proinsulin is The 3-dimensional structure of insulin has been studied in great detail, Amino Acid...
		Inositol 4,5-biphosphate binds to receptor proteins in the membrane of endoplasmic...
	www.glucoseinfo.com /insulinreceptor (1436 words)

	Ubiquitination of Keap1, a BTB-Kelch Substrate Adaptor Protein for Cul3, Targets Keap1 for Degradation by a ...
		Ubiquitination of Keap1, a BTB-Kelch Substrate Adaptor Protein for Cul3, Targets Keap1 for Degradation by a Proteasome-independent Pathway -- Zhang et al.
		protein for a Cul3-dependent E3 ubiquitin ligase complex.
		to substrate adaptor ubiquitination is a critical regulatory
	www.jbc.org /cgi/content/abstract/280/34/30091 (599 words)

	publications - Memorec Biotec GmbH - medical molecular research cologne (Site not responding. Last check: 2007-11-01)
		Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
		The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.
		A conserved domain is present in different families of vesicular fusion proteins: a new superfamily.
	www.memorec.com /publications_Bioinformatics.php (1115 words)

	Genetic Deletion of the p66Shc Adaptor Protein Protects From Angiotensin II-Induced Myocardial Damage -- Graiani et al. ... (Site not responding. Last check: 2007-11-01)
		protein to the plasma membrane for activation of Ras.
		Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.
		The p66shc adaptor protein controls oxidative stress response and life span in mammals.
	hyper.ahajournals.org /cgi/content/full/46/2/433 (3339 words)

	The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB -- Koonpaew et al., ...
		The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB -- Koonpaew et al., 10.1074/jbc.M311394200 -- Journal of Biological Chemistry
		The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB
		The Adaptor Protein HSH2 Attenuates Apoptosis in Response to Ligation of the B Cell Antigen Receptor Complex on the B Lymphoma Cell Line, WEHI-231
	intl.jbc.org /cgi/content/abstract/M311394200v1 (431 words)

	Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus : Nature
		Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus : Nature
		Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
		Antiviral immunity against a pathogen is mounted upon recognition by the host of virally associated structures.
	www.nature.com /nature/journal/v437/n7062/abs/nature04193.html (399 words)

	Human protein: Q59H48 - Lymphocyte adaptor protein variant (Fragment). EMBL Bioinformatics Harvester
		Human protein: Q59H48 - Lymphocyte adaptor protein variant (Fragment).
		T-cell activation requires stimulation of the T-cell receptor (TCR; see MIM 186880)-CD3 (see CD3Z; MIM 186780) complex, followed by recruitment of an array of intracellular signaling proteins (e.g., GRB2 (MIM 108355) and PLCG1 (MIM 172420)).
		Mediating the interaction between the extracellular receptors and intracellular signaling pathways are adaptor proteins such as LAT (MIM 602354), TRIM (MIM 604962), and LNK.[supplied by OMIM]
	harvester.embl.de /harvester/Q59H/Q59H48.htm (628 words)

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