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UNODC - Bulletin on Narcotics - 1962 Issue 3 - 003 |
 | | Methadone is an outstanding example of a compound in which greatly different activity and addictiveness occur in the optical isomers. |
 | | In addition, studies on the addictiveness of the dextrorotatory isomers of 3-hydroxy-N-phenethylmorphinan and 3-methoxy-N-phenethyl-morphinan were thought to be of interest since both compounds, like d-methadone, had very low activities when compared with the l-isomers [ 4]. |
 | | Drugs pertinent to evaluating the addictiveness of 7296A were administered orally in capsules as follows: placebos (starch flavoured with quinine); codeine sulfate, increasing from 200 to 1,500 mg daily; morphine sulfate, increasing from 40 to 240 mg daily; and d-3-methoxy-N-phenethylmorphinan (7296A), increasing from 180 to 1,200 mg daily. |
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