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| | Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal ... (Site not responding. Last check: 2007-11-07) |
 | | Whereas the four adenoma cell lines were anchorage-dependent and did not form tumours in nude mice (Williams et al, 1990; Hague et al, 1997), the carcinoma cell lines were anchorage-independent and tumorigenic after subcutaneous injection in nude mice. |
 | | In early adenomas, there is apoptosis close to the basement membrane, particularly at crypt branching points (Brodie et al, 2004), whereas crypt lumen apoptosis is a feature of larger adenomas, high-grade dysplasia and adenocarcinomas. |
 | | Importantly, since the adenoma cultures are grown under the same culture conditions as the carcinoma cultures, this cannot be attributed to differences in survival factors or medium composition. |
| www.nature.com /cgi-taf/dynapage.taf?file=/bjc/journal/v92/n4/full/6602387a.html (5881 words) |
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