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Topic: Adenosine


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In the News (Mon 23 Oct 17)

  
  Atlas of Myocardial Perfusion SPECT: adenosine.html
Adenosine also stimulates the A1 purine receptors in the SA and AV node leading to slowing of HR and AV conduction delay.
When the flow in the latter increases during Adenosine infusion and the pressure decrease, flow in the collateral'smay reverse, blood is being "sucked" over fro the stenotic vessel leading to real hypoperfusion and ischemia in the stenotic artery.
Adenosine is the protocol of choice in patient with significant arrhythmia and in patient with psychiatric history.
brighamrad.harvard.edu /education/online/Cardiac/adenosine.htm   (493 words)

  
  Adenosine triphosphate - Wikipedia, the free encyclopedia
Adenosine 5'-triphosphate (ATP) is the nucleotide known in biochemistry as the "molecular currency" of intracellular energy transfer; that is, ATP is able to store and transport chemical energy within cells.
In signal transduction pathways, ATP is used to provide the phosphate for the protein-kinase reactions.
ATP consists of adenosine and three phosphate groups(triphosphate).
en.wikipedia.org /wiki/Adenosine_triphosphate   (719 words)

  
 Adenosine, antagonists, ATP - Pharmacorama
Adenosine is a nucleoside which activates purinergic receptors of P1type, generally called A1, A2 and A3 receptors while nucleotides such as ATP activate purinergic receptors of P2 type.
Adenosine is an endogenous nucleoside, present in all the cells of the body.
adenosine monophosphate (AMP) by an ATP-dependant adenosine kinase.
www.pharmacorama.com /en/Sections/Adenosine.php   (165 words)

  
 Adenosine and BDNF
Adenosine is not a typical hormone or neurotransmitter, but is an important neuromodulator in the central and peripheral nervous systems.1 Adenosine is released from inflamed (infected) tissues or ischemic tissues where there is a decreased blood supply to a particular body organ or part.
Adenosine inhibits the firing of neurons throughout the brain by activating potassium channels, and by inhibiting the release of a number of neurotransmitters (Acetylcholine, NorAdrenalin, Dopamine, Serotonin, GABA and Glutamate).
Since adenosine exerts a depressant effect on neocortical neurons in slices obtained from epileptic patients, this upregulation of A1 receptor binding may constitute a protective mechanism against subsequent seizures, which is exerted by elevating the depressant response of the brain to endogenous adenosine.
www.thensome.com /stormybrain/adenosine.htm   (4205 words)

  
 Adenosine triphosphate Summary
Adenosine triphosphate is an organic compound that serves as a source of energy for living organisms, and assists them in carrying out a wide variety of important functions.
Adenosine triphosphate (ATP) is one of the most important nucleotides present in living organisms because it stores and delivers energy from the metabolizing of food.
Adenosine 5'-triphosphate (ATP) is a multifunctional nucleotide primarily known in biochemistry as the "molecular currency" of intracellular energy transfer.
www.bookrags.com /Adenosine_triphosphate   (2732 words)

  
 Adenosine - Purine Nucleoside
Although adenosine is constitutively present at low levels in the extracellular space, metabolically stressful conditions, such as those that occur during injury, ischemia, and inflammation dramatically increase its extracellular concentration.
Extracellular adenosine and adenosine A2a and A3 receptors serve as anti-inflammatory signals and sensors of excessive inflammatory tissue damage.
Adenosine receptors are members of the G-protein coupled receptor (GPCR) superfamily, and are typically thought to mediate stimulation or inhibition of adenylyl cyclase activity, and hence cyclic AMP levels.
www.inotekcorp.com /content/adenosine.asp   (415 words)

  
 Adenosine for fast heart rates - [Medication]
Adenosine reduces the normal flow of the electrical impulses through the atrioventricular (AV) node of the heart.
Adenosine is used to restore a normal heart rate and rhythm when you are having an episode of supraventricular tachycardia.
Adenosine is a quick-acting, short-term therapy intended to convert the fast heart rhythm of a supraventricular tachycardia (SVT) that affects the AV node back to a normal rate.
www.peacehealth.org /kbase/topic/detail/drug/ps1324/detail.htm   (242 words)

  
 A Protective Role for the A^Sub 1^ Adenosine Receptor in Adenosine- Dependent Pulmonary Injury - Health - RedOrbit
Adenosine is a regulatory nucleoside that is generated in response to cellular stress and damage and is therefore increased during episodes of tissue hypoxia and inflammation.
Adenosine deaminase (ADA) is the purine catabolic enzyme responsible for the deamination of adenosine to iiiosine, and mice that lack this enzyme develop aspects of chronic pulmonary injury in association with elevations in lung adenosine levels (11).
Adenosine mediates IL-13- induced inflammation and remodeling in the lung: evidence for an IL- 13-adenosine amplification pathway.
www.redorbit.com /news/display?id=123024   (7635 words)

  
 Caffeine, caffeine withdrawal, adenosine, and primary headache   (Site not responding. Last check: 2007-09-19)
27 Because unbound extracellular adenosine is normally dismantled within seconds, the congregation of infused adenosine in the sensory apparatus of the head suggests that infused adenosine becomes bound to the numerous adenosine receptors located on the dense concentrations of sensory neurons in the sensory apparatus.
The congregation of infused adenosine in the sensory apparatus of the head, together with the sensory disturbances associated with migraine, suggest migraine aura may instead originate in the sensory apparatus of the head.
Olfactory distortions, amplifications, and hallucinations associated with primary headache may be due to excessive adenosine receptor activation in the olfactory bulbs, and the dizziness and nausea/vomiting associated with migraine may be caused by a similar disturbance in the organs of balance.
www.batnet.com /spencer/theory.html   (4375 words)

  
 Adenosine for fast heart rates
Adenosine reduces the normal flow of the electrical impulses through the atrioventricular (AV) node of the heart.
Adenosine is used to restore a normal heart rate and rhythm when you are having an episode of supraventricular tachycardia.
Adenosine is a quick-acting, short-term therapy intended to convert the fast heart rhythm of a supraventricular tachycardia (SVT) that affects the AV node back to a normal rate.
www.webmd.com /heart-disease/Adenosine-for-fast-heart-rates   (355 words)

  
 Science News Online - This Week - News Feature - 5/24/97   (Site not responding. Last check: 2007-09-19)
Adenosine is a relatively simple, nitrogen-containing compound used widely by the body.
Since adenosine secretion reflects brain cell activity, rising concentrations of this chemical may be how the organ gauges that it has been burning up its energy reserves and needs to shut down for a while.
At that point, adenosine concentrations in the cats' brains were, on average, double those observed when the cats had been awake for 2 hours.
www.sciencenews.org /sn_arc97/5_24_97/fob2.htm   (872 words)

  
 Adenosine: an overview
Adenosine may be important in the function of normal nerve cells, in controlling cell proliferation, and as a signal of inflammation.
A3 : This is the Janus of the adenosine receptors.
The clinical potential of adenosine agonists seems to be limited, apart from the use of adenosine itself, mainly for its anti-arrhythmic potential in conditions such as AV nodal re-entrant tachycardia.
www.anaesthetist.com /icu/manage/drugs/adenosine/index.htm   (1952 words)

  
 EMS House of DeFrance   (Site not responding. Last check: 2007-09-19)
Adenosine slows tachycardias associated with the AV node via modulation of the autonomic nervous system without causing negative inotropic effects.
Adenosine is the drug of choice for paroxysmal supraventricular tachvcardia (PSVT) and can be used diagnostically for stable, wide complex tachyardias of unknown type after two doses of lidocaine.
Dipyridamole potentiates the effect of adenosine; reduction of adenosine dose may be required.
www.kpemsc.org /pharm/adenoc.html   (198 words)

  
 Society for Neuroscience | Adenosine and Sleep
Investigations into the relationship between adenosine and sleep surged following the discovery that caffeine's stimulating characteristics stem from its ability to prevent adenosine from binding to cells and launching distinct actions.
The scientists have found that natural concentrations of adenosine build up in parts of the cholinergic brain system during the cats' waking periods and fall during sleep.
For example, in an effort to treat insomnia, a condition characterized by a difficulty in falling asleep, researchers are concentrating on methods to activate the adenosine receptors.
www.sfn.org /index.cfm?pagename=brainBriefings_adenosineAndSleep&print=on   (703 words)

  
 Adenocard Pharmacology, Pharmacokinetics, Studies, Metabolism - Adenosine - RxList Monographs
Intravenously administered adenosine is rapidly cleared from the circulation via cellular uptake, primarily by erythrocytes and vascular endothelial cells.
Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase, or via deamination to inosine by adenosine deaminase in the cytosol.
While extracellular adenosine is primarily cleared by cellular uptake with a half-life of less than 10 seconds in whole blood, excessive amounts may be deaminated by an ecto-form of adenosine deaminase.
www.rxlist.com /cgi/generic/adenos_cp.htm   (486 words)

  
 Venton Lab Adenosine Page
Adenosine is a neuromodulator in the brain that has a variety of actions including regulation of cerebral blood flow, modulation of neurotransmission, and protection against neuronal injury during stroke.
Adenosine, which contains a primary amine group, is expected to adsorb to a carbon-fiber surface.
Adenosine release during neurotransmission and models of stroke will be investigated.
faculty.virginia.edu /ventongroup/adenosine.html   (269 words)

  
 Adenosine Monophosphate
Adenosine monophosphate (AMP) is an intermediary substance formed during the body’s process of creating energy in the form of adenosine triphosphate (ATP) from food.
Adenosine is a sensitive oxygen sensor in the heart.
Adenosine modification of energy substrate use in isolated hearts perfused with fatty acids.
www.pureprescriptions.com /health_library/healthnotes.asp?ContentID=2796008   (795 words)

  
 Adenosine news articles   (Site not responding. Last check: 2007-09-19)
Platelet activation was measured using the response to adenosine diphosphate (ADP) in a P-selectin assay, whereas platelet aggregation was determined in...
It's unclear whether the girl's improvement was due to the gene therapy or the injections she received of synthetic adenosine deaminase, the enzyme she lacked.
Adenosine triphosphate (ATP) hydrolysis in the nitrogenase complex controls the cycle of association and dissociation between the electron donor adenosine...
www.mongabay.com /drugs/drugs/Adenosine.html   (6320 words)

  
 Adenosine Monophosphate, AMP
Adenosine monophosphate (AMP) is an intermediary substance formed during the body’s process of creating energy in the form of adenosine triphosphate (ATP) from food.
Adenosine is a sensitive oxygen sensor in the heart.
Adenosine modification of energy substrate use in isolated hearts perfused with fatty acids.
www.truestarhealth.com /Notes/2796008.html   (793 words)

  
 Adenosine Molecule
Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose, and it forms adenosine triphosphate (ATP), a nucleotide, when three phosphate groups are added to adenosine.
Adenosine triphosphate is used in cellular metabolism as one of the basic methods of transferring chemical energy between reactions.
When administered intravenously, adenosine causes transient heart block in the AV node of the heart.
www.worldofmolecules.com /life/adenine.htm   (371 words)

  
 IS CAFFEINE A HEALTH HAZARD ?
Adenosine is an adenine molecule attached to a ribose or deoxyribose sugar molecule.
The general effect of adenosine in the brain is to inhibit neural activity, whereas the general effect of caffeine is to increase neural activity.
Adenosine levels rise during ischemia/hypoxia and this effect is thought to counter the detrimental effects by providing substrate for ATP synthesis and reducing excitotoxicity through agonist actions of adenosine on A
www.benbest.com /health/caffeine.html   (4468 words)

  
 Role of adenosine A2B receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation -- Shin et ...
Adenosine produces receptor-mediated activation of adenylyl cyclase and dilation of intracerebral (15) and pial (23) arteries.
in the involvement of adenosine receptor subtypes, in that the
Adenosine receptor mediated stimulation of intracellular calcium in acutely isolated astrocytes.
ajpheart.physiology.org /cgi/content/full/278/2/H339   (3316 words)

  
 Regulation of adenosine transport by D-glucose in human fetal endothelial cells: involvement of nitric oxide, protein ...
The reduction in adenosine transport capacity induced by D-glucose was specific for this hexose, since D-fructose or 2-deoxy-D-glucose had no effect on the kinetics of adenosine transport (Table 1).
Figure 3 also shows that inhibition of adenosine transport by elevated D-glucose was abolished when cells were incubated with calphostin C, suggesting that the effect of D-glucose on adenosine transport depends on the activity of PKC.
To establish whether inhibition of adenosine transport by elevated D-glucose involves activation of MAPK and tyrosine kinase pathways, endothelial cells were exposed to the MEK-1 inhibitor PD-98059 or the general tyrosine kinase inhibitor genistein.
jp.physoc.org /cgi/content/full/529/3/777   (8259 words)

  
 [No title]
Caffeine potentially has pharmacological actions other than blockage of adenosine receptors, but it requires 20times as much caffeine to inhibit phosphodiesterase, 40times as much caffeine to block GABAA receptors and 100times as much caffeine to mobilize intracellular calcium as is required to block adenosine receptors.
Caffeine acts primarily by the direct action of blocking adenosine receptors and by the indirect action upon the receptors for neurotransmitters.
Caffeine is similar in structure to adenosine, a chemical found in the brain that slows down its activity.
www.lycos.com /info/caffeine--adenosine.html   (504 words)

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