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Topic: Adiponectin

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	Adiponectin ELISA kits
		The Adiponectin ELISA Kits are a straightforward way to measure adiponectin levels in samples under varying conditions—the assays are sensitive, linear across several orders of magnitude, and correlate well with results obtained using RIA.
		Adiponectin present in the test sample is sandwiched between the immobilized and the secondary antibodies and can be detected by first adding an anti-IgG antibody attached to horseradish peroxidase (HRP) and then adding the substrate that causes an enzymatic reaction of the HRP marked by a color change.
		The concentration of adiponectin is directly proportional to the color intensity measured at 450 nm.
	www.panomics.com /K1001.cfm (387 words)

	Adiponectin - Wikipedia, the free encyclopedia
		Of the various circulating isoforms of adiponectin, high-molecular weight adiponectin, which is active in the liver, is important for insulin sensitivity and is induced by thiazolidinediones.
		The first is a short signal squence that targets the hormone for secretion outside the cell; next is a short region that varies between species; the third is a 65-amino acid region with similarity to collagenous proteins; the last is a globular domain.
		Because adiponectin is a novel hormone, no therapy has yet been developed with adiponectin and it may be some years before clinical trials commence.
	en.wikipedia.org /wiki/Adiponectin (685 words)

	Science and Reason: Adiponectin
		Levels of adiponectin are inversely correlated with body mass index (BMI), and it seems to play a role in helping to stave off or ameliorate disorders such as obesity, diabetes, and atherosclerosis.
		When adiponectin, which is involved in glucose and lipid metabolism, was introduced into the cerebrospinal fluid of normal mice, they showed no changes in food intake, but their metabolism rose.
		Adiponectin is unusual among fat hormones in that its levels generally decline in those who are obese.
	scienceandreason.blogspot.com /2007/09/adiponectin.html (2828 words)

	Adiponectin definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms
		Adiponectin: A protein hormone produced and secreted exclusively by adipocytes (fat cells) that regulates the metabolism of lipids and glucose.
		High blood levels of adiponectin are associated with a reduced risk of heart attack.
		Low levels of adiponectin are found in people who are obese (and who are at increased risk of a heart attack).
	www.medterms.com /script/main/art.asp?articlekey=17982 (180 words)

	Adiponectin, Rosiglitazone, & Sugar Control; Adiponectin Found to be Protective in Fatty Liver Disease
		Associations between adiponectin and inflammatory markers persisted after control for the potential confounding effects of HgbA1C and HDL cholesterol, suggesting that the antiinflammatory properties of adiponectin are not mediated by its effect on glycemia and lipidemia.
		The increase in circulating adiponectin was associated with the activation a set of hepatic signaling pathways mediated through AMP-activated protein kinase, PPAR-a, and PPAR-° coactivator a, which in turn led to markedly increased rates of fatty acid oxidation, prevention of hepatic steatosis, and alleviation of liver enzyme changes.
		Perhaps the most promising aspect of this manuscript is that it buttresses the notion that adiponectin is a remedy for both alcoholic and nonalcoholic fatty liver disease and builds on the clear and convincing effects of adipokines in the fundamental biological mechanisms in both hepatocytes and liver nonparenchymal cells.
	www.natap.org /2005/HIV/090605_05.htm (2717 words)

	Adiponectin ELISA
		The primary antibody used in B-Bridge's Adiponectin ELISA Kits is a highly selective, high-affinity antibody that specifically targets either human adiponectin, or mouse and rat adiponectin (depending on which Kit you are using).
		Adiponectin signal levels of non-human sera (diluted 1,111-fold) are virtually at background levels.
		Adiponectin signal levels of sera from other animals (diluted 1,111-fold) are similar to background levels.
	www.gentaur.com /adiponectin_elisa.htm (279 words)

	Multigenic control of serum adiponectin levels: evidence for a role of the APM1 gene and a locus on 14q13 -- Menzaghi ...
		by adipocytes, adiponectin is a prominent one because of its
		Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study.
		Genome-wide linkage analysis of serum adiponectin in the Pima Indian population.
	physiolgenomics.physiology.org /cgi/content/full/19/2/170 (3094 words)

	Protein adiponectin appears protective against heart disease
		Recent studies suggest that adiponectin, a protein specific to fat tissue, is involved in obesity, diabetes and heart disease.
		Adiponectin is one of the most abundant circulating proteins in human plasma, explained Dr. Orchard, who also is medical director of the nutrition lipid program at the University of Pittsburgh Medical Center, a clinic to which doctors refer patients with lipid metabolism disorders.
		"Regardless of CAD status, higher levels of adiponectin were observed among female participants in comparison to their male counterparts," said Dr. Costacou, explaining that adiponectin levels in blood samples from women averaged 20.8 micrograms per milliliter, versus 16.5 micrograms per milliliter for men.
	www.eurekalert.org /pub_releases/2005-01/uopm-paa012005.php (710 words)

	Mouse Adiponectin
		In support of the link between obesity and Type 11 diabetes, it has been shown that decreased expression of adiponectin correlates with insulin resistance, and that adiponectin appears to be a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
		The principle of the assay: Samples and serially diluted standard (recombinant mouse adiponectin) solutions are added to an appropriate number of wells of the microtitre plate and incubated.
		The biotinylated secondary rabbit anti-mouse adiponectin polyclonal antibody will bind to the adiponection trapped in the well in the 1st Reaction.
	www.metachem.co.uk /Mouse_Adiponectin.htm (421 words)

	Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA -- Makimura et al. ...
		Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA -- Makimura et al.
		Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA
		Adiponectin expression was reduced in the diet-induced obese mice compared with chow-fed mice (Fig.
	ajpendo.physiology.org /cgi/content/full/283/6/E1266 (3423 words)

	Adiponectin, human (non boiling) : CYT350
		Adiponectin is a 244-amio acid protein with high structural homology to collagen VIII, collagen V, complement C1q (Ref. 1 and 2), and TNF (Ref.3), which is exclusively and abundantly expressed in white adipose tissue.
		Plasma adiponectin concentrations have found to be decreased in obesity and/or type-2 diabetes, resulting in the conditions commonly associated with insulin resistance and hyper-insulinemia (Ref. 4-5).
		Therefore, measurement of the plasma level of adiponectin may be important for understanding diagnosis or prognosis of onset of these diseases.
	www.chemicon.com /product/ProductDataSheet.asp?ProductItem=CYT350 (470 words)

	Adiponectin
		Recent studies have reported that HMW Adiponectin and its ratio to total Adiponectin better correlate with type II diabetes pathogenesis than total Adiponectin measurements alone [3-5].
		Therefore, total Adiponectin and HMW levels are measured directly after pretreatment of samples with the appropriate protease, while LMW and MMW are calculated indirectly.
		Adiponectin results obtained with the EK-MADP kit correlate very well with established Total Adiponectin ELISA kits (R2=0.96-0.99) and HMW Adiponectin ELISA tests (R2=0.96).
	www.buhlmannlabs.ch /Adiponectin.php (378 words)

	adiponectin (Site not responding. Last check: )
		When adiponectin, which is involved in glucose and lipid metabolism, was introduced into the cerebrospinal fluid of normal mice, they showed no changes in food intake, but their metabolism rose.
		"Adiponectin or its targets in the brain and other organs could be harnessed to sustain weight loss by maintaining a high metabolic rate," said Ahima.
		In severely obese mice, adiponectin rapidly decreases blood glucose and lipids, while burning fat suggesting that the hormone could be beneficial in the treatment of diabetes and heart disease associated with obesity.
	www.youngagain.com /adiponectin.html (836 words)

	Adiponectin and future coronary heart disease events among men with type 2 diabetes (NDEI.ORG)
		Schulze MB, Shai I, Rimm EB, Li T, Rifai N, Hu FB Adiponectin, predominantly synthesized in the adipose tissue, seems to have substantial anti-inflammatory properties and to be a major modulator of insulin resistance and dyslipidemia, mechanisms that are associated with an increased atherosclerotic risk in diabetic patients.
		The inverse association between adiponectin and CHD was consistent across strata of aspirin use, family history of myocardial infarction, alcohol consumption, insulin use, duration of diabetes, and levels of HbA(1c), triglycerides, C-reactive protein, and HDL cholesterol.
		Adiponectin and future coronary heart disease events among men with type 2 diabetes.
	www.ndei.org /v2/website/litalerts/Article.cfm?Article_ID=1312 (350 words)

	Restoration of Adiponectin Pulsatility in Severely Obese Subjects After Weight Loss -- Calvani et al. 53 (4): 939 -- ...
		Mean percentage of change for plasma adiponectin over a 24-h period.
		Adiponectin levels for each subject were low-pass filtered over a frequency range of 0–0.1 cycles/h to extract the low-frequency components, expressed as the percentage of change from the 24-h mean value, and averaged over all seven subjects.
		Adiponectin values were higher during the day, with a peak in
	diabetes.diabetesjournals.org /cgi/content/full/53/4/939 (4861 words)

	Serum Adiponectin Concentrations in Newborn Infants in Early Postnatal Life -- KAMODA et al. 56 (5): 690 -- Pediatric ... (Site not responding. Last check: )
		Adiponectin is a protein derived from adipose tissue in humans,
		The serum adiponectin concentration was assayed with an RIA
		Cianfarani S, Martinez C, Maiorana A, Scire G, Spadoni GL, Boemi S 2004 Adiponectin levels are reduced in children born small for gestational age and are inversely related to postnatal catch-up growth.
	www.pedresearch.org /cgi/content/full/56/5/690 (2566 words)

	The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice -- Xu et al. 112 ...
		Adiponectin increases insulin sensitivity and ameliorates fatty liver diseases in obese ob/ob mice.
		Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.
		Adiponectin is associated with insulin resistance in liver.
	www.jci.org /cgi/content/full/112/1/91 (5676 words)

	IngentaConnect Adiponectin Expression and Adipose Tissue Lipolytic Activity in L...
		Background: The authors evaluated whether adipose adiponectin expression is related to adipose tissue lipolytic activity and fatty acid oxidation rate in lean and obese women.
		The positive relationship between respiratory quotient and adiponectin expression was in the limit of statistical significance (P=0.05).
		Conclusions: Low adipose tissue adiponectin expression observed in obese people may contribute to the progression of obesity and its co-morbidities by modulating hormone-sensitive lipase activity and fatty acid oxidation.
	www.ingentaconnect.com /content/fd/os/2005/00000015/00000003/art00016 (321 words)

	Adiponectin Is Associated With Vascular Function Independent of Insulin Sensitivity -- Fernández-Real et al. 27 ...
		Adiponectin Is Associated With Vascular Function Independent of Insulin Sensitivity -- Fernández-Real et al.
		adiponectin concentration tended to be associated with plasma
		In vitro, adiponectin inhibited monocyte adhesion to endothelial
	care.diabetesjournals.org /cgi/content/full/27/3/739 (3545 words)

	Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells -- Chen et al. 278 (45): 45021 -- ...
		adiponectin knock-out mice have a significant increase in vascular
		Relative changes in green fluorescence intensity in response to LPA and adiponectin were quantified and plotted as a function of time (mean ± S.E. of four independent experiments is shown).
		phosphorylation of AMPK in response to adiponectin was inhibited
	www.jbc.org /cgi/content/full/278/45/45021 (5197 words)

	Adiponectin is not altered with exercise training despite enhanced insulin action -- Hulver et al. 283 (4): 861 -- AJP ...
		Adiponectin is not altered with exercise training despite enhanced insulin action -- Hulver et al.
		Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action.
		(14) originally demonstrated that adiponectin was reduced in murine models of insulin resistance and obesity,
	ajpendo.physiology.org /cgi/content/full/283/4/E861 (2897 words)

	Plasma Adiponectin Levels and Metabolic Factors in Nondiabetic Adolescents -- Huang et al. 12 (1): 119 -- Obesity ...
		between plasma adiponectin levels and age in adults (12) (38).
		adiponectin may be related to the development of IR in puberty.
		Adiponectin Is Lower Among African Americans and Is Independently Related to Insulin Sensitivity in Children and Adolescents
	www.obesityresearch.org /cgi/content/full/12/1/119 (3100 words)

	Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function -- Goldstein and Scalia 89 (6): 2563 -- Journal ... (Site not responding. Last check: )
		Adiponectin is a relatively abundant, approximately 30-kDa plasma
		as in mouse corneal angiogenesis assays, and in vitro, adiponectin
		As in metabolically responsive tissues, one of the major signaling effects of adiponectin in endothelial cells is activation of AMP kinase.
	jcem.endojournals.org /cgi/content/full/89/6/2563 (4750 words)

	Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins -- Yokota et al. ...
		Adiponectin was withdrawn after 6 weeks of culture (bottom panel).
		Adiponectin inhibits the differentiation of preadipocytes to adipocytes.
		Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys.
	www.jci.org /cgi/content/full/109/10/1303 (4311 words)

	Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension ... (Site not responding. Last check: )
		Adiponectin concentrations in patients with essential hypertension before and after 2-week treatment with temocapril (4 mg/d) or candesartan (8 mg/d).
		Adiponectin concentrations were not related to mean blood pressure
		Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function
	hyper.ahajournals.org /cgi/content/full/42/1/76 (4424 words)

	Linco Research, Inc. - Mouse Adiponectin ELISA Kit (Site not responding. Last check: )
		This kit is for non-radioactive quantification of adiponectin in mouse plasma, sera, and cell culture media.
		Each kit is sufficient to run one 96-well plate including, in duplicates, background, 7 mouse adiponectin standards, 2 quality controls, and 38 unknown samples.
		The lowest level of Adiponectin that can be detected by this assay is 0.5 ng/ml when using a 20
	www.lincoresearch.com /products/ezmadp-60k.html (128 words)

	Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression ... (Site not responding. Last check: )
		adiponectin, that is decreased in patients with coronary artery
		Human monocyte-derived macrophages were treated with adiponectin (30 µg/mL) or vehicle in presence of ANOC 9104 (30 µg/mL) or control nonimmune IgG (30 µg/mL).
		A, Representative histogram of DiI-AcLDL uptake in the presence (peak A) or absence (peak B) of adiponectin at 30 µg/mL.
	circ.ahajournals.org /cgi/content/full/103/8/1057 (4596 words)

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