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Topic: Adjuvant

  Adjuvant - Wikipedia, the free encyclopedia
In pharmacology, adjuvants are drugs that have few or no pharmacological effects by themselves, but may increase the efficacy or potency of other drugs when given at the same time.
Similarly, in immunology an adjuvant is an agent which, while not having any specific antigenic effect in itself, may stimulate the immune system, increasing the response to a vaccine.
Adjuvant chemotherapy and radiotherapy are often given following surgery for many types of cancer, including colon cancer, lung cancer, pancreatic cancer, breast cancer, prostate cancer, and some gynaecological cancers.
en.wikipedia.org /wiki/Adjuvant   (760 words)

 Freund's adjuvant - Wikipedia, the free encyclopedia
Freund's adjuvant is effective in stimulating cell-mediated immunity and may lead to the potentiation of the production of certain immunoglobulins, but this effect depends on the animal model used.
The adjuvant is known to stimulate production of tumor necrosis factor, which is thought to kill the T-cells responsible for the autoimmune destruction of the pancratic Beta cells.
Still in question is whether the regrowth of functional insulin-producing cells occurs due to differentiation and proliferation of existing pancreatic stem cells, or whether the injected spleen cells re-differentiate to an insulin producing form.
en.wikipedia.org /wiki/Freund's_Complete_Adjuvant   (473 words)

 Adjuvant Therapy for Breast Cancer: Q & A - National Cancer Institute
Adjuvant therapy is treatment given in addition to the primary therapy to kill any cancer cells that may have spread, even if the spread cannot be detected by radiologic or laboratory tests.
Because the principal purpose of adjuvant therapy is to kill any cancer cells that may have spread, treatment is usually systemic (uses substances that travel through the bloodstream, reaching and affecting cancer cells all over the body).
Adjuvant therapy usually begins within 6 weeks after surgery, based on the results of clinical trials in which the therapy was started within that time period.
www.cancer.gov /cancertopics/factsheet/Therapy/adjuvant-breast   (2119 words)

 The National Institutes of Health (NIH) Consensus Development Program: Adjuvant Therapy for Breast Cancer
Systemic adjuvant therapies that are designed to eradicate microscopic deposits of cancer cells that may have spread or metastasized from the primary breast cancer have been demonstrated to increase a woman's chance of long-term survival.
Adjuvant hormonal therapy should be recommended to women whose breast tumors contain hormone receptor protein, regardless of age, menopausal status, involvement of axillary lymph nodes, or tumor size.
Despite the favorable impact of adjuvant chemotherapy on long-term survival in breast cancer, it is important to determine whether there are specific patient populations for whom it is reasonable to avoid the administration of cytotoxic chemotherapy.
consensus.nih.gov /2000/2000AdjuvantTherapyBreastCancer114html.htm   (4864 words)

 "Information resources for adjuvants and antibody production: comparisons and alternative technologies"
A second way an adjuvant can work is to serve as a vehicle to help deliver the Ag to the spleen and/or lymph nodes where Ag is trapped by the follicular dendritic cells and where most of the necessary cell to cell interactions take place to generate plasma cells (the Ab-secreting cells).
The adjuvant activity may relate, in part, to the surfactant's ability to activate complement and bind complement components, as this helps target the Ag to follicular dendritic cells in the spleen and lymph nodes.
Aluminum salts are generally weaker adjuvants than emulsion adjuvants; however, because of their generally mild inflammatory reactions, safety, and efficacy for generating memory, they are the primary adjuvants utilized in humans.
www.nal.usda.gov /awic/pubs/antibody/overview.htm   (3561 words)

 Adjuvant therapy for breast cancer guide - MayoClinic.com
Adjuvant therapy is a form of therapy added to the primary treatment to keep cancer from returning.
Adjuvant therapy includes radiation, chemotherapy, hormone therapy or the newest type of treatment — targeted or biologic therapy.
Systemic adjuvant therapy targets the entire body in hopes of destroying any cancer cells that may have traveled to more distant parts of the body.
www.mayoclinic.com /health/breast-cancer-treatment/AT99999/PAGE=AT00005   (778 words)

 Adjuvant Therapy for Breast Cancer (CBM 2000-6)
Two types of systemic adjuvant therapy are used for breast cancer, either alone or in combination: adjuvant chemotherapy involves a combination of anticancer drugs; adjuvant hormone therapy deprives cancer cells of the female hormone estrogen, which some breast cancer cells need to grow.
Adjuvant tamoxifen efficacy is influenced by erbb2 expression: a study in node negative breast cancer patients [abstract].
Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer.
www.nlm.nih.gov /pubs/cbm/adjuvant_therapy_breast_cancer.html   (10060 words)

 UpToDate Patient information: Adjuvant systemic therapy for hormone-responsive early stage breast cancer in ...
Adjuvant treatment for women with hormone-nonresponsive breast cancers and a discussion about the side effects and indications for chemotherapy and trastuzumab (Herceptin®) is also presented elsewhere.
Advances in adjuvant therapy have decreased the risk of dying of breast cancer by 20 to 30 percent, and substantially increased the chance of curing early breast cancer.
Adjuvant treatment should be selected based upon the estimated risk of a breast cancer recurrence, and an estimate of the benefits to be achieved using hormone therapy, chemotherapy, or a combination of both approaches.
patients.uptodate.com /topic.asp?file=cancer/4491   (3784 words)

 NIH recommendations on adjuvant therapy for breast cancer - Cancer HealthLINK - Yale-New Haven Hospital
A recent report from the National Institutes of Health (NIH) consensus conference outlined the ways in which adjuvant therapy should be used, the types of patients who should receive it and the forms of therapy that are beneficial.
Localized: Radiation therapy is used as a local adjuvant treatment to destroy cancer cells that might remain in the tumor location or may have spread to nearby tissues.
However, there are not enough data to support the routine use of taxanes as adjuvant therapy for early breast cancer or dose-intensive chemotherapy.
www.ynhh.org /healthlink/cancer/cancer_9_01.html   (1581 words)

 Adjuvant Expos Inc
Adjuvant Expos is committed to respecting your privacy rights when visiting any Adjuvant Expos web pages, such as this one.
Adjuvant Expos is not responsible for the use of information you disclose in these forums.
Since Adjuvant Expos does not control the privacy policies of third parties, you are subject to the privacy customs and policies, if any, of such third parties, and Adjuvant Expos shall not be responsible for the use or dissemination of your private information by such parties.
www.adjuvantexpos.com /privacy.htm   (1079 words)

 Adjuvant Treatment : BC Cancer Agency
Adjuvant treatment following curative resection is recommended for patients with Stage II or III cancers.
For those patients who presented with fixed or high risk cancers requiring radical preoperative radiotherapy, adjuvant chemotherapy is given post-operatively, regardless of the final pathology report, as significant downstaging may have occurred with the radiotherapy (GIRFF).
In those patients receiving preoperative short-course radiotherapy, adjuvant chemotherapy is recommended for Stage II or III cancers (GIRFF).
www.bccancer.bc.ca /HPI/CancerManagementGuidelines/Gastrointestinal/06.Rectum/Management/Adjuvant.htm   (372 words)

Adjuvant may develop products based upon such data collected to be sold or shared with the general public, clients, prospects, re-sellers and third party users for various business decision-making purposes.
Adjuvant and its third party providers take reasonable technical, administrative and physical steps to safeguard the integrity of the information in our databases and to protect against hazards such as unauthorized access to and disclosure of Personal Information.
Adjuvant employees who handle confidential or proprietary information must treat it confidentially and may not disclose it to unauthorized third parties.
www.adjuvant.com /privacy_policy.html   (1549 words)

 Adjuvant therapy for breast cancer guide - MayoClinic.com
Adjuvant therapy uses chemotherapy drugs, radiation, hormone therapy, targeted therapy or a combination to help destroy any cancer cells that were not removed during your breast cancer surgery.
Adjuvant therapy is sometimes considered an insurance policy.
If adjuvant therapy could benefit all women with breast cancer at low cost — to use the insurance analogy — it would make sense for all such women to undergo this treatment.
www.mayoclinic.com /invoke.cfm?objectid=7D25B3E8-5C2B-49C6-96558996237CDDA7   (422 words)

 Adjuvant - Article from FactBug.org - the fast Wikipedia mirror site   (Site not responding. Last check: 2007-10-10)
Adjuvant therapy refers to additional treatment given after a main mode of therapy, which is usually surgery.
For example, radiotherapy or chemotherapy given after surgery for a breast cancer are both considered adjuvant treatments.
When radiotherapy is used as the main mode of treatment, the terms adjuvant and neoadjuvant refer to any additional treatment (usually chemotherapy) given before or after radiotherapy, respectively.
www.factbug.org /cgi-bin/a.cgi?a=1105073   (270 words)

 CancerGuide: Adjuvant Chemotherapy   (Site not responding. Last check: 2007-10-10)
Adjuvant chemotherapy is the use of drugs as additional treatment for patients with cancers that are thought to have spread outside their original sites.
If adjuvant chemotherapy is used to destroy "left over" cancer cells, then we would use the best possible drugs to do the job.
Adjuvant chemotherapy for cancer is a difficult treatment to understand.
www.cancerguide.org /adjuvant.html   (1986 words)

Adjuvant therapy has been shown to reduce recurrence and improve survival in patients with stage III disease.
However, the use of adjuvant therapy is still much debated in stage II disease.
In the community, there seem to be inequalities in the delivery of adjuvant chemotherapy to the elderly, the ethnic minorities, and the lower socioeconomic groups, but the reasons are poorly understood.
www.plwc.org /portal/site/ASCO/menuitem.c608d82cf53347fd506fe310ee37a01d/?vgnextoid=c759201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=edbk_detail_view&confID=16&abstractID=228   (215 words)

 Eloxatin Adjuvant Colon Cancer Trial: Design & Efficacy
Eloxatin, used in combination with infusional 5-FU/LV, is indicated for adjuvant treatment of stage III colon cancer patients who have undergone complete resection of the primary tumor.
Adjuvant treatment of stage III colon cancer patients who have undergone complete resection of the primary tumor.
The most common adverse reactions in patients with stage II or III colon cancer receiving adjuvant therapy were peripheral sensory neuropathy, neutropenia, thrombocytopenia, anemia, nausea, increase in transaminases and alkaline phosphatase, diarrhea, emesis, fatigue, and stomatitis.
www.eloxatin.com /hcp/about_eloxatin/adjuvant_colon_cancer_trial.aspx   (1095 words)

 Recommendations for Use and Alternatives to Freund's Complete Adjuvant - Animal Research - The University of Iowa
While usually effective, the adjuvant may induce undesirable side effects which has lead to refinement of its use and to development of alternatives.
It is as convenient to use as Freund's complete adjuvant (or more so because of its lower viscosity) and it has very low toxicity, having been used in humans.
Freund's Complete adjuvant (FCA) is widely used in research and is one of the first adjuvants developed.
research.uiowa.edu /animal/?get=adjuvant   (1927 words)

 Uterine LMS and Adjuvant Treatment
Adjuvant treatment is treatment when there is no evidence of disease, after surgical removal with wide clear margins.
For Uterine LMS, the decision to have adjuvant treatment is usually made in the flurry of desperation that accompanies the diagnosis.
Since the repercussions of having adjuvant pelvic radiation are permanent and serious, we urge that considerable thought and discussion go into the decision.
www.bctonline.com /~dwhiting/lms/ulmsadj.htm   (1076 words)

 Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by ...
Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity -- Lemmens et al.
Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity
Use of adjuvant chemotherapy and radiation therapy for rectal cancer among the elderly: a population-based study.
annonc.oxfordjournals.org /cgi/content/full/16/5/767   (2792 words)

 Adjuvant therapy: Extra treatment to keep cancer from returning - MayoClinic.com
Adjuvant therapy is used after primary treatments, such as surgery or radiation, to decrease the chance that your cancer will recur.
But the added benefit of adjuvant therapy doesn't come without a price — the side effects can be more than minor inconveniences.
Which adjuvant therapy is best for you is based on your type of cancer and its stage.
www.mayoclinic.com /health/adjuvant-therapy/CA00012   (1046 words)

 Adjuvant Newsletter
The Adjuvant Newsletter is focused on all companies, institutions and individuals involved in the production, distribution sale, use and registration of adjuvants and formulations.
The Adjuvant Newsletter is focused on both tank-mix and built-in adjuvants.
The Adjuvant Newsletter is produced by Hans de Ruiter (Editor in chief, SURfaPLUS, The Netherlands) and the associate editor Gert C. van den Berg (freelance journalist).
www.surfaplus.com /internet_services/adjuvant_newsletter/index.htm   (378 words)

 CancerGuide: Adjuvant Therapy   (Site not responding. Last check: 2007-10-10)
Adjuvant therapy is treatment to prevent recurrence after surgery by eliminating metastases which are present at the time of surgery, but too small to detect.
Many patients wonder if they should be getting some kind of adjuvant therapy after their nephrectomy, or even after they've been rendered free of detectable disease by surgery for metastatic disease.
Most patients are simply told that there is no adjuvant therapy, but actually although nothing is standard, there is a vaccine treatment which may be approved in Europe by early 2005, and there are also a few treatments in clinical trial.
www.cancerguide.org /rcc_adjuvant.html   (1038 words)

 Guidelines for Adjuvant Use
In spite of commercial claims that some adjuvants are not inflammatory, the limited objective data available tends not to support these claims.
Hence, a single, uniform practice is recommended for all adjuvants, unless there is substantive data to indicate otherwise.
In all instances, adjuvant injections may be repeated in 14-30 days unless complications develop.
vetmed.duhs.duke.edu /guidelines_for_adjuvant_use.htm   (806 words)

 The Nation's Health -- Web exclusive: NIH panel releases consensus on adjuvant therapy and breast cancer   (Site not responding. Last check: 2007-10-10)
Developments in adjuvant therapy -- treatments used in addition to surgery to kill any cancerous cells that have spread to other parts of the body - have proven to greatly increase a woman's survival from breast cancer, according to panelists from the NIH Consensus Development Conference on Adjuvant Therapy for Breast Cancer, held in November.
According to the panel, certain factors should be looked at when deciding to use adjuvant therapy, including age, tumor size, presence of hormone receptors and presence of cancerous lymph nodes.
Trials of adjuvant therapies in women over 70, high dose chemotherapy, and combined hormonal therapy are just a few of the trials the panel would like to see done in the future.
www.apha.org /journal/nation/adjuvantexcl1200.htm   (620 words)

 ABC of colorectal cancer: Adjuvant therapy -- Midgley and Kerr 321 (7270): 1208 -- BMJ
Adjuvant treatment (chemotherapy and radiotherapy) has developed as an auxiliary weapon to surgery and is aimed at eradicating
Early adjuvant trials were retrospective and underpowered and failed to show any therapeutic benefit with respect to recurrence
All cytotoxic agents are rigorously tested and applied in advanced disease before being used in adjuvant therapy.
bmj.bmjjournals.com /cgi/content/full/321/7270/1208   (1888 words)

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