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Adrafinil - Wikipedia, the free encyclopedia Adrafinil is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil (Provigil®), resulting in nearly identical pharmacologic effects. Adrafinil does not currently have FDA approval in the United States, although it is used in France and elsewhere in Europe. en.wikipedia.org /wiki/Adrafinil   (322 words)

Erowid Adrafinil Vault : Adrafinil: Amazing Breakthrough in Perception Stimulation Adrafinil acts on the chemical processes of the brain to prevent the loss of alertness and the depression that occurs with increasing age 4,5. Adrafinil is the founder member of this new generation of drugs, which are known as "eugregorics" (eu=good, gregor=arousal)6. Adrafinil (sold as Olmifon TM) is an exciting and unique development in the battle against brain aging and the subsequent decline in mental function. www.erowid.org /smarts/adrafinil/adrafinil_info1.shtml   (990 words)

[No title] Their first drug, adrafinil (trade name Olmifon) has been approved in numerous European countries for the treatment of narcolepsy, a condition of excessive daytime sleepiness, and cataplexy, a condition of transient muscular weakness that is often associated with narcolepsy. Adrafinil (and their newer analog, modafinil) selectively stimulate adrenergic neurons which are responsible for general alertness towards the external environment. Adrafinil is metabolized by the liver and long-term use requires monitoring of hepatic alkaline phospahatase levels. www.lycaeum.org /drugs.old/synthetics/smart/modafinil.info   (1434 words)

Adrafinil: Alertness Without Stimulation   (Site not responding. Last check: 2007-10-21) Adrafinil is the prototype of a new class of smart drug — the eugeroics (ie, "good arousal") — designed to promote vigilance and alertness. Adrafinil has been described by some users as a "kinder, gentler" stimulant, because it provides these benefits but usually with much less of the anxiety, agitation, insomnia, associated with conventional stimulants. Adrafinil's effects are more subtle than those of the stimulants you may be used to, building over a period of days to months. www.eroscent.com /adrafinil.html   (462 words)

ADRAFINIL / OLMIFON Adrafinil is part of a new class of drug called ‘eugeroics’, which means ‘good arousal’. In particular, Adrafinil’s unique ability to only arouse when stimulation is required means that the user is able to sleep when he or she wishes to. Adrafinil may occasionally cause headaches, stomach pains and skin irritations, and in certain cases, inner tension. www.antiaging-systems.com /a2z/adrafinil.htm   (495 words)

Anti-Aging Medicine: Adrafinil Adrafinil acts to stimulate brain activity only when stimulation is required. Adrafinil and Modafinil's anti-aging benefits have been increased and improved alertness and concentration, improved thought clarity and short-term memory and increased reaction speed, including hand-and-eye coordination. Adrafinil is an alpha-adrenergic agonist chemically related to Modafinil. www.anti-aging-today.org /medicine/anti-aging/adrafinil.htm   (397 words)

[No title] Adrafinil may be correctly described as an anti-aging drug because it directly combats degeneration in the part of the brain that allows you to take pleasure in life. Adrafinil restores a youthful sleep\wake cycle of full alertness in the daytime and deep restorative sleep at night. After several weeks of treatment with adrafinil daytime sleepiness disappears, interest in intellectual activity is restored and depression lifts. www.drugmania.net /vitamin-r/setumei.html   (3299 words)

EUGOERICS: THE ULTIMATE STIMULANTS, The World Health Network - Anti-Aging and Longevity Adrafinil is noted as contraindicated with epilepsy and has been shown to enhance the potency of anti-epileptic drugs such as phenytoin, (Dilantin/ Epanutin). It is true that modafinil is more potent, “average” doses of adrafinil are in the region of 600mg to 1200mg daily, compared to modafinil’s 200mg to 400mg daily and this is self evident by the respective tablet sizes. Secondly, adrafinil is attributed to some other possible side effects that have not been associated (to date) with modafinil, including, stomach pain, skin irritations, inner tension and in long term use, (over 3 months usually), an increase in liver enzyme levels, (which is reversible by reduction or withdrawal). www.worldhealth.net /p/1010,2048.html   (2598 words)

Avant Labs > Adrafinil / Modafinil time limit question...... May 7 2005, 01:40 AM Using Adrafinil and/or Modafinil from time to time, I have been able to be quite remarkably sharp/focused/alert for a maximum of 22 hours, then I just HAVE to sleep. Remember that Modafinil and Adrafinil is used medically to alleviate narcolepsy, which is a condition characterised by excessive sleepiness, and for which caffeine just ain't gonna do it. Oct 2 2005, 04:05 PM i did 48 hours with adrafinil and caffiene, as well as, ephedrine and heat stack...but it was fuckin retarted....i think in the end ephedrine was a bad idea. www.avantlabs.com /forum/lofiversion/index.php/t16919.html   (3387 words)

MCC Minutes Adrafinil had been referred to the MCC for classification as a prescription medicine by the Medicines Control section of Medsafe following growing concern about increased imports and potential abuse of this substance as a party drug. Adrafinil is not scheduled in New Zealand but is chemically related to modafinil which is a prescription medicine taken orally for mental function impairment in the elderly. The NDPSC had recommended that the restricted medicine entry for quinine for the prevention of cramp should be removed from the schedule and quinine should be reclassified as a prescription medicine except in medicines containing 50 milligrams or less per recommended daily dose. www.medsafe.govt.nz /Profs/Class/mccMinDec2005.htm   (824 words)

Fatigue: Adrafinil and Modafinil It is the combination of Adrafinil's releasing stimulantive arousal effect(s), and its antidepressant effects that some doctors in europe recommend Adrafinil over its newer form of Modafinil. This is the very latest analogue of adrafinil (see same), and likewise is designed specifically to treat narcolepsy (sleeping in the day). It is considerably more potent than adrafinil, but is also much less likely to be the cause of any liver enzyme problems with long term use. members.tripod.com /~feedback2wk/fatigue.html   (711 words)

RemedyFind: patient ratings of Adrafinil (Olmifon) for Obsessive-Compulsive Disorder (OCD) Adrafinil (Olmifon) is a unique wake-promoting agent that is chemically distinct from traditional stimulants. Adrafinil may require regular blood testing to monitor liver enzyme levels if used on a regular basis.  The modafinil 800 mg dose panel was discontinued after 3 days of treatment due to the observation of increased blood pressure and pulse rate. remedyfind.com /rem.asp?ID=11938   (643 words)

Biogenesis Laboratories - adrafinil, anti-depressant - Product Information Adrafinil (trade name Olmifon®) is a French stimulant and anti-depressant that belongs to a unique class of drugs called Eugeroics, meaning good arousal. Adrafinil helps to improve brain chemical processes without affecting heart rate or pressure and was specifically designed to treat narcolepsy (sleeping in the daytime), as such it can enhance awareness, mental clarity and alertness, allowing the individual to remain both alert and awake during the day. Adrafinil; Corn starch, modified sodic carboxymethyl-cellulose, polyvidone excipient, glycerol, magnesium steate, talc, lactose, polyoxyethylene glycol 4000, titanium dioxide, polymethly acrylate glycerol. www.biogenesis.co.za /pi-adrafinil.asp   (443 words)

Home They are Adrafinil and Modafinil, (both of which have been developed by Lafon Laboratories of France). Adrafinil is noted as contraindicated with epilepsy and has been shown to enhance the potency of anti-epileptic drugs such as phenytoin, (Dilantin â/ Epanutin â). Adrafinil was the world’ first eugeroic, and developed some years before the introduction of Modafinil. www.antiaging-magazine.com /articles/article_4_2.html   (1695 words)

ADHD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community - Anyone take ... Adrafinil is a precusor to the active ingredient in Provigil, modafinil. The only problem with adrafinil, is longterm use may elevate your liver enzymes. I didn't see much potential for abuse with Adrafinil (probably the same for Provigil, which I have not taken), and I am a recovering drug addict. www.addforums.com /forums/printthread.php?t=13018&pp=40   (3168 words)

ImmInst.org -> Tablets or Liquid?   (Site not responding. Last check: 2007-10-21) Have been taking Adrafinil but it seems to make me tired instead of more alertness. Think I will stop Adrafinil altogether when my order comes in. Adrafinil had a light normalizing effect on me (a slight energy boost mental & physical), but no problems. www.imminst.org /forum/index.php?s=&act=ST&f=6&t=1866&hl=   (172 words)

Home, The World Health Network - Anti-Aging and Longevity, The World Health Network - Anti-Aging and Longevity Adrafinil, which is used in the treatment of Adrafinil has not yet been studied on a nonelderly Modafinil is superior to Adrafinil in its action. www.worldhealth.net /p/aadr-adrafinil.html   (355 words)

Agenda Items for the Next Medicines Classification Committee Meeting Adrafinil has been referred to the MCC for classification as a prescription medicine by the Medicines Control section of Medsafe following growing concern about increased imports and potential abuse of this substance as a party drug. Adrafinil is not scheduled in NZ but is chemically related to modafinil which is a prescription medicine taken orally for mental function impairment in the elderly. The NDPSC has recommended that the restricted medicine entry for quinine for the prevention of cramp should be removed from the schedule and quinine should be reclassified as a prescription medicine except in medicines containing 50 milligrams or less per recommended daily dose. www.medsafe.govt.nz /Profs/class/agen34a.htm   (503 words)

CANCOG TECHNOLOGIES : Efficacy of Interventions Cholinesterase inhibitors are the only drugs currently approved for use in Alzheimer's patients in North America. At a dose of 20 mg/kg, adrafinil improved discrimination learning. Adrafinil is currently approved for attentional problems in geriatric patients in France. www.cancog.com /HumanPharma/Research/InterventionEffectiveness   (325 words)

ADHD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community - Adrafinil, ... I have been taking 1200 mg of adrafinil a day for two month, along with 50 mg of Deprenyl (a dopamine agonist used to treat Parkinson’s disease), and I have never felt better in my life. I am astonished frankly, and keep waiting for it to stop working, the way all other meds have either stopped working, worked for a while then became problematic in some other way, or simply didn’t work at all. Although I have to have adrafinil shipped from Europe, it is still one third the cost of the equivalent dose of Provigil, which I find a typical irony in this country. www.addforums.com /forums/showthread.php?t=23696   (910 words)

Modafinil in the UK | Ask MetaFilter You can order Adrafinil instead, which is the metabolic precursor of Modafinil. Two main differences: potency (100mg for M vs. 600mg for A) and Adrafinil has been associated with elevation of some liver enzymes if in some people, if you use it daily for some months. The upshot is that adrafinil is almost 4 times cheaper, and is uncontrolled even in the US. ask.metafilter.com /mefi/19374   (238 words)

Diary for pfh Turns out i was pretty lucky to have been able to import it, as adrafinil and modafinil have just been added to the Australian drugs and poisons schedule (schedule 4). Fortunately i was able to convince my psychiatrist to write me a prescription for modafinil (which is available in Australia, adrafinil isn't), so i will be trying to switch to that shortly. Their top ten for depression is pretty impressive, mostly antidepressants as one would expect, but number one is CBT (a form of psychotherapy considered just as powerful as antidepressants), and number two is a eugregoric... www.advogato.org /person/pfh/diary.html?start=16   (1184 words)

ImmInst.org -> Nootropics for Attention Deficit Disorder Nuerofeedback seems to be used for relaxation purposes mostly but I suppose inducing higher frequency brain waves could lead to increased concetration, focus, and increased higher level cognitive functions. I advise you purchase at least 4 packs because you really do not feel the full effects of adrafinil until you have been taking it for about 3 weeks. They are expensive on some items (such as the ones rizzer has), but for the adrafinil and FAS Hydergine, I can't find a better deal or service. www.imminst.org /forum/index.php?s=&act=ST&f=6&t=1753&st=20   (1377 words)

Re: ! Adrafinil ! I actually have some degree of concern over long-term use of *that* because of the increase in extra-cellular glutamate. As for adrafinil, I can't imagine France's pharmaceutical approval agency could be *too* lax in putting their oficial stamp of approval on a medication. But you do have to wonder why there seem to be so few adrafinil human studies. www.usenet.com /newsgroups/rec.drugs.smart/msg00196.html   (240 words)

Publications — Dog Aging and Cognition Project   (Site not responding. Last check: 2007-10-21) Siwak, C.T., Gruet, P., Woehrle, F., Muggenburg, B.A., Murphey, H.L., and Milgram, N.W. Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs, American Journal of Veterinary Research. Torp, R., Head, E., and Cotman, C.W. Ultrastructural analyses of beta-amyloid in the aged dog brain: Neuronal beta-amyloid is localized to the plasma membrane, Progress in Neuro-Psychopharmacology and Biological Psychiaty. Siwak, C.T., Callahan, H., and Milgram, N.W. Adrafinil: Effects on behaviour and cognition in aged canines, Progress in Neuro-Psychopharmacology and Biological Psychiatry. www.beaglebrain.org /Publications?batch_start=20   (339 words)

Modafinil & Adrafinil - Research and Sources   (Site not responding. Last check: 2007-10-21) The effect of adrafinil on the nocturnal activity of the rhesus monkey, Adrafinil: effects on behavior and cognition in aged canines, Siwak CT, Callahan H, Milgram NW Pharmacol Biochem Behav, Vol 66 (No 2) June 2000; 293-300. Behavioral activating effects of adrafinil in aged canines, www.modafinil-adrafinil.com   (2223 words)

Quality Health, Inc. Mail Order Medicines: Piracetam, Proscar, Hydergine From the Smart Drugs News, Vol.3, No.8: "Adrafinil selectively stimulates alpha-1 adrenergic receptors, increasing alertness and sensory vigilance. Unlike other stimulants, such as amphetamines, Adrafinil does not cause anxiety and agitation, nor does it induce a need for "rebound sleep." Many other stimulants act as re-uptake inhibitors, increasing the levels of various neurotransmitters in the synapses. Adrafinil achieves its effect by binding to norepinephrine receptors directly, a very specific mode of action which greatly reduces the amount of unwanted side-effects. www.qhi.co.uk /list.asp?ptyp=ol&ref=&c=&field=&data=adrafinil&match=phrase   (206 words)

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