
	Where results make sense

Topic: Adrenarche

Related Topics

Pubarche

Androgen

Precocious puberty

Polycystic ovary syndrome

Security classification

Upper Paleolithic

Bleeding

Lower Paleolithic

CDNA library

Acheulean

Archibald McIndoe

Cow hitch

Oldowan

Homo erectus

Physical interface

In the News (Tue 15 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Adrenarche - Wikipedia, the free encyclopedia
		Adrenarche refers to a stage of maturation of the cortex of the human adrenal glands.
		A characteristic aspect of early adrenarche is an inhibition of 3β-hydroxysteroid dehydrogenase, the enzyme which mediates the hydroxylation of 17-hydroxypregnenolone to 17-hydroxyprogesterone, and DHEA to androstenedione.
		Adrenarche also occurs prematurely in many children who are overweight, suggesting a possible relationship with body mass or adiposity signals.
	en.wikipedia.org /wiki/Adrenarche (679 words)

	Adrenarche (Site not responding. Last check: 2007-09-19)
		Adrenarche is a process related to puberty but distinct from hypothalamus-pituitary gland-gonad maturation and function.
		A characteristic aspect of early adrenarche is an inhibition of 3-hydroxysteroid dehydrogenase, the enzyme which mediates the hydroxylation of 17-hydroxypregnenolone to 17-hydroxyprogesterone, and dehydroepiandrosterone to androstenedione.
		Adrenarche also occurs prematurely in many children who are obesity, suggesting a possible relationship with body mass or adiposity signals.
	read-and-go.hopto.org /Endocrine-system/Adrenarche.html (648 words)

	Premature Adrenarche--Normal Variant or Forerunner of Adult Disease? -- Ibáñez et al. 21 (6): 671 -- ...
		Adrenarche is the puberty of the adrenal gland.
		The cause of the adrenal oversecretion in premature adrenarche
		at premature adrenarche diagnosis and androgen responses to
	edrv.endojournals.org /cgi/content/full/21/6/671 (9057 words)

	UpToDate Normal adrenarche
		Adrenarche seems to be unrelated to the pubertal maturation of the neuroendocrine-gonadotropin-gonadal axis, although the clinical manifestations of both usually become apparent at about the same age [3,4].
		Adrenarche represents a change in the pattern of adrenal secretory response to ACTH, characterized by a disproportionate rise of 17-hydroxypregnenolone and dehydroepiandrosterone (DHEA) relative to cortisol (show figure 1) [5].
		The increased synthesis of 17-hydroxypregnenolone and DHEA at adrenarche is a byproduct of ACTH stimulation of cortisol synthesis.
	patients.uptodate.com /topic.asp?file=adrenal/14031 (435 words)

	Human Reproduction, Lectures: Pubertal and Midlife Changes (Site not responding. Last check: 2007-09-19)
		Adrenarche occurs usually one to two years before gonadarche and is independent of gonadarche.
		Adrenarche also still occurs (except in those children with pituitary and subsequent adrenal failure), but development of secondary sex characteristics does not follow.
		Puberty is the coordinated sequence of biochemical and physiologic events including adrenarche and gonadarche which result in the growth spurt of adolescence, development of secondary sex characteristics, and reproductive capacity.
	medstat.med.utah.edu /kw/human_reprod/lectures/pubertal_midlife (2406 words)

	Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species.
		Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species.Residue 255 is also Arg in human and chimp.
		Adrenarche is the prepubertal onset of increased adrenal secretion of 19-carbon steroids, especially dehydroepiandrosterone (DHEA).
		To ascertain whether sequence differences in P450c17 contribute to adrenarche, we cloned the rhesus monkey cDNA from adrenal tissue and cloned the chimpanzee and baboon cDNAs from genomic DNA using an exon-trapping strategy.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/9237479.html (290 words)

	v022 : Molecular Evolution of Adrenarche: Structural and Functional Analysis of P450c17 from four Primate Species (Site not responding. Last check: 2007-09-19)
		Adrenarche is the prepubertal onset of increased adrenal secretion of C-19 steroids, especially dehydroepiandrosterone (DHEA).
		To ascertain whether structural changes in P450c17 are a key feature of adrenarche, we cloned its DNA from chimpanzee, baboon and rhesus monkey genomic DNA using an exon-trapping strategy.
		These data establish Arg255 as a key residue in 17alpha-hydroxylase activity and show that the evolution of adrenarche in higher primates is not determined by P450c17 sequences.
	www.thieme.de /abstracts/eced/abstracts2002/daten/v022.html (312 words)

	Encyclopedia: Adrenarche
		In mammals, the adrenal glands are the triangle-shaped endocrine glands that sit atop the kidneys.
		A sex organ, or primary sexual characteristic, narrowly defined, is any of those parts of the body (which are not always bodily organs according to the strict definition) which are involved in sexual reproduction and constitute the reproductive system in an complex organism; namely: Male: penis (notably the glans penis...
		Pubic hair is hair in the frontal genital area and in the crotch, and sometimes at the top of the inside of the legs; these areas form the pubic region.
	www.nationmaster.com /encyclopedia/Adrenarche (1579 words)

	References
		Dardis, A., Saraco, N., Raviola, M.A. and Belgorosky, A. (1999) Decrease in the expression of 3-hydroxysteroid gene in human adrenal tissue during prepuberty and early puberty: implications for the mechanism of adrenarche.
		Dhom, G. (1973) The prepubertal and pubertal growth of the adrenal (adrenarche).
		Sklar, C.A., Kaplan, S.L. and Grumbach, M.M. (1980) Evidence for dissociation between adrenarche and gonadarche: studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and adolescence.
	www.medscape.com /content/2004/00/47/07/470730/470730_ref.html (2190 words)

	The Early Dehydroepiandrosterone Sulfate Rise of Adrenarche and the Delay of Pubarche Indicate Primary Ovarian Failure ...
		The Early Dehydroepiandrosterone Sulfate Rise of Adrenarche and the Delay of Pubarche Indicate Primary Ovarian Failure in Turner Syndrome -- Martin et al.
		ADRENARCHE, the "adrenal puberty," is characterized by an increase
		The significance of differences in ages at adrenarche (, P = 0.003) and pubarche (*, P = 0.02) between the POF group and the spontaneous puberty group are indicated.
	jcem.endojournals.org /cgi/content/full/89/3/1164 (2945 words)

	precocious puberty (Site not responding. Last check: 2007-09-19)
		Premature adrenarche refers to the appearance of sexual hair prior to age 8 in girls and age 9 in boys, without other signs of maturation.
		Girls with premature adrenarche may develop polycystic ovary disease, which means multiple cysts develop on the ovary, as adults.
		Children with premature thelarche or adrenarche need to be followed by a doctor, but do not need treatment.
	www.northmemorial.com /HealthEncyclopedia/content/2727.asp (1014 words)

	adrenarche
		Weight gain may be a trigger for adrenarche, and obesity has also been associated with a higher incidence of premature adrenarche....
		Recent studies performed in pubertal patients with a history of premature adrenarche suggested that increased adrenal androgen secretion was limited to childhood.
		Moreover, in children with a lack or delayed adrenarche long-term treatment with DHEAS at dosages such as to restore normal levels for age, failed to induce growth of sexual hair or any change in growth rate, bone maturation velocity, or to advance puberty.
	www.fathermag.com /health/puberty/hpa/adrenal/adrenarche/index.shtml (1050 words)

	Estrogen Replacement Therapy
		Adrenarche is defined as the changes in the pattern of adrenal secretions which occur several years before the onset of gonadal puberty (gonadarche).
		Indeed, the onset of adrenarche and gonadarche are dissociated in a variety of disorders of sexual maturation.
		This is mainly based on the observation that premature adrenarche is accompanied by premature pubarche, tall stature and advanced bone age.
	www.lef.org /protocols/abstracts/abstr-048.html (5595 words)

	Premature Thelarche and Adrenarche (Site not responding. Last check: 2007-09-19)
		In one study, 6% of premature thelarche represented the earliest sign of true precocious puberty.
		Adrenarche is the presence of pubic hair before 8 years of age in girls and 9 years of age in boys.
		It may be associated with the development of axillary hair and adult axillary odor.
	pedclerk.bsd.uchicago.edu /thelarchePubarche.html (274 words)

	Pubarche - Wikipedia, the free encyclopedia
		When pubarche occurs prematurely (in early or mid-childhood), it is referred to as premature pubarche and may warrant an evaluation.
		Premature adrenarche is the most common cause of premature pubarche.
		When adrenarche, central puberty, and all pathologic conditions have been excluded, the term isolated premature pubarche is used to describe the unexplained development of pubic hair at an early age without other hormonal or physical changes of puberty.
	en.wikipedia.org /wiki/Pubarche (173 words)

	Nat' Academies Press, Offspring: Human Fertility Behavior in Biodemographic Perspective (2003)
		Importantly, adrenarche follows the completion of brain growth around the age of 7 and precedes the onset of puberty (Bogin, 1999), suggesting that it plays some role between the energetic demands of brain growth and those of puberty.
		While adrenarche was once thought to be directly related to the onset of puberty, there is no evidence for an obligate role of adrenarche in the onset of pubertal maturation, and adrenarche and gonadarche are considered functionally separate processes.
		1987 Dissociation of adrenarche and gonadarche in precocious puberty and in isolated hypogonadotropic hypogonadism.
	www.nap.edu /books/030908718X/html/260.html (7835 words)

	Adrenarche results from development of a 3beta-hydroxysteroid dehydrogenase-deficient adrenal reticularis. (Site not responding. Last check: 2007-09-19)
		Adrenarche results from development of a 3beta-hydroxysteroid dehydrogenase-deficient adrenal reticularis.
		Adrenarche is the increased adrenal production of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) that occurs during the prepubertal period.
		To date, the exact mechanism initiating adrenarche is unknown, although many factors have been postulated.
	www.arclab.org /medlineupdates/abstract_9768686.html (305 words)

	Adrenarche (Site not responding. Last check: 2007-09-19)
		Adrenarche refiere a una etapa de la maduración de la corteza de las glándulas suprarrenales humanas.
		Adrenarche es un proceso relacionado con la pubertad pero distinto la maduración de hypothalamic-pituitario-gonadal y función.
		Adrenarche también ocurre prematuramente en muchos niños que sean exceso de peso, sugiriendo una relación posible con las señales de la masa o del adiposity del cuerpo.
	www.yotor.net /wiki/es/ad/Adrenarche.htm (730 words)

	Puberty (Site not responding. Last check: 2007-09-19)
		Called premature adrenarche, it is caused by the early maturation of the adrenal gland resulting in increased androgen secretion.
		Premature adrenarche does not require treatment but an examination by the pediatrician is advisable to rule out any hormonal or enzyme imbalance, or problem with the adrenal grand.
		The cause of premature adrenarche is not known.
	www.obandgyn.cc /FAQs/Puberty.htm (1030 words)

	Hormonal Findings in African-American and Caribbean Hispanic Girls With Premature Adrenarche: Implications for ...
		Premature adrenarche refers to the appearance of pubic hair before age 8 years in girls and 9 years in boys.
		characteristic of polycystic ovarian syndrome and premature adrenarche.
		Dunaif A, Sorbara L, Delson R, Green G Ethnicity and polycystic ovary syndrome are associated with independent and additive decreases in insulin action in Caribbean Hispanic women.
	pediatrics.aappublications.org /cgi/content/full/102/3/e36 (2764 words)

	5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature ... (Site not responding. Last check: 2007-09-19)
		Girls with idiopathic premature adrenarche, characterized by the early appearance of pubic hair and adrenal hyperandrogenism, may be at an increased risk for polycystic ovarian syndrome and its associated complications.
		We sought to investigate whether alterations in 5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activities are present in girls with premature adrenarche, suggesting a possible role in the pathogenesis of the hyperandrogenism of this condition.
		Total cortisol metabolites were not different in the girls with premature adrenarche, compared with the controls.
	www.arclab.org /medlineupdates/abstract_12364451.html (322 words)

	San Francisco Medical Society: Library (Site not responding. Last check: 2007-09-19)
		Biochemical puberty begins with adrenarche (a change in the adrenal gland to produce more androgens) which occurs about two years prior to the maturation of the hypothalmus-pituitary-gonadal axis.
		The stimulus for the increase in adrenal androgens is unknown.
		Clinical adrenarche is the development of sexual hair and may be accompanied by acne and body odor.
	www.sfms.org /sfm/sfm1199e.htm (1204 words)

	The Magical Age of 10 - Questia Online Library
		In particular we consider the hypothesis that "sexual attraction" follows the onset of adrenal puberty, termed adrenarche, precipitating the development of stable and memorable attraction toward others approximately by the age of 10.
		In a prior study, the authors suggested that adrenarche is a significant source of this developmental change in sexuality (McClintock, M., and Herdt, G., 1996).
		The inferential evidence from New Guinea is compared with recent studies from the United States, including clinical findings on "precocious puberty." We conclude with the question of whether the age of 10 is a human universal in the development of attraction and sexuality.
	www.questia.com /PM.qst?a=o&d=5001138774 (532 words)

	Remarks on
		At about ten years of age, the level of DHEA is about ten times that observed in younger children [*6], where it remains until raising further to adult levels when the gonads start to produce them.
		Adrenarche is clinically recognized primarily by the onset of pubic hair, but it also includes a growth spurt, increased oil on the skin, changes in the external genitalia, and the development of body odour.
		Therefore, the authors conclude, that a ``change in the nervous system that results from hormones released at adrenarche does look like the most likely developmental mechanism for several reasons'' (182), but add that this question cannot yet be answered definitively.
	www.ipce.info /ipceweb/Library/remarks_on_rethinking.htm (1817 words)

	UpToDate Premature adrenarche
		— Adrenarche is the term for the maturational increase in adrenal androgen production that begins at about six years of age in girls and seven in boys.
		It represents a change in the pattern of adrenal secretory response to corticotropin (ACTH), characterized by a disproportionate rise of 17-hydroxypregnenolone and dehydroepiandrosterone (DHEA) relative to cortisol; this response primarily occurs in the zona reticularis of the adrenal cortex.
		It is useful, however, to begin with a review of definitions used to describe the various aspects of premature sexual development as they relate to adrenarche.
	patients.uptodate.com /topic.asp?file=adrenal/15294 (368 words)

	children with DIABETES - Ask the Diabetes Team
		Your son's endocrinologist is assessing for evidence of adrenarche -- the production of androgens (male hormones) from the adrenal glands.
		He's probably checking for axillary odor, which can be the first sign of puberty and is caused by the same hormones that cause the hair under the arms, acne, and pubic hair (various "androgens").
		This can be triggered in males first either by the adrenal gland ("adrenarche") or by the testicles ("gonadarche").
	www.childrenwithdiabetes.com /dteam/2003-09/d_0d_b9r.htm (369 words)

Try your search on: Qwika (all wikis)