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Topic: Adrenergic receptor


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In the News (Fri 19 Apr 19)

  
  ADRENERGIC RECEPTOR REGULATION IN POSTTRAUMATIC STRESS DISORDER ::::::::::: Welcome to Child Trauma Academy :::::::::::
Both the L.C. and the VTN nuclei have adrenergic receptors which are involved in modulation of the adrenergic or noradrenergic afferentation and efferent outflow (U'Prichard et al.
Adrenergic and noradrenergic systems and their receptors are involved in the mediation and recovery from the observed behavioral changes following IS (Anisman et al.
Beginning in the late 1970s, when the platelet alpha2- adrenergic receptor was first radiolabeled, investigators have utilized this readily available peripheral receptor as a marker for the central alpha2 receptor.
www.childtrauma.org /CTAMATERIALS/adrenergic.asp   (6627 words)

  
 {beta}2-Adrenergic Receptor Polymorphisms and Haplotypes Are Associated With Airways Hyperresponsiveness Among ...
{beta}2-Adrenergic Receptor Polymorphisms and Haplotypes Are Associated With Airways Hyperresponsiveness Among Nonsmoking Men -- Litonjua et al.
-Adrenergic Receptor Polymorphisms and Haplotypes Are Associated With Airways Hyperresponsiveness Among Nonsmoking Men
receptor (AR) gene at codons 16 and 27, and the intermediate
www.chestjournal.org /cgi/content/abstract/126/1/66   (425 words)

  
 Anti-{beta}1-adrenergic receptor antibodies and heart failure: causation, not just correlation -- Freedman and ...
Defective ß-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression.
Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors.
-adrenergic receptor by immunoadsorption therapy in dilated cardiomyopathy.
www.jci.org /cgi/content/full/113/10/1379   (2030 words)

  
 Characterization of Alpha-2D Adrenergic Receptor Subtypes in Bovine Ocular Tissue Homogenates -- Bylund et al. 281 (3): ...
The alpha-2 adrenergic receptors are known to be present in the mammalian eye and to mediate the effects of alpha-2 agonists
H]RX821002 to characterize the alpha-2 adrenergic receptors in
We conclude that the alpha-2 adrenergic receptors in the
www.jpet.org /cgi/content/abstract/281/3/1171   (332 words)

  
 Physiological significance of alpha 2-adrenergic receptor subtype diversity: one receptor is not enough -- Philipp et ...
Physiological significance of alpha 2-adrenergic receptor subtype diversity: one receptor is not enough -- Philipp et al.
-adrenergic receptors was observed in the superficial layers of the dorsal horns (B, arrows).
-adrenergic receptor subtypes in the acute hypertensive response to hypertonic saline infusion in anephric mice.
ajpregu.physiology.org /cgi/content/full/283/2/R287   (3815 words)

  
 Liganded and Unliganded Steroid Receptor Modulation of Beta 1 Adrenergic Receptor Gene Transcription -- MCNAB et al. 50 ...   (Site not responding. Last check: 2007-11-07)
Sjoberg M, Vennstrom B 1995 Ligand-dependent and -independent transactivation by thyroid hormone receptor beta 2 is determined by the structure of the hormone response element.
Padbury JF, Tseng YT, Waschek JA 1995 Transcription initiation is localized to a TATAless region in the ovine ß1 adrenergic receptor gene.
Hadcock CC, Malbion JR 1988 Evidence that glucocorticoid response elements in the 5'-noncoding region of the hamster beta 2-adrenergic receptor gene are obligate for glucocorticoid regulation of receptor mRNA levels.
www.pedresearch.org /cgi/content/full/50/5/575   (4225 words)

  
 CD86 and {beta}2-Adrenergic Receptor Signaling Pathways, Respectively, Increase Oct-2 and OCA-B Expression and Binding ...
CD86 and {beta}2-Adrenergic Receptor Signaling Pathways, Respectively, Increase Oct-2 and OCA-B Expression and Binding to the 3'-IgH Enhancer in B Cells -- Podojil et al.
-Adrenergic Receptor Signaling Pathways, Respectively, Increase Oct-2 and OCA-B Expression and Binding to the 3'-IgH Enhancer in B Cells
Surface receptor stimulation on a B cell that affects class
www.jbc.org /cgi/content/full/279/22/23394   (7014 words)

  
 Liganded and Unliganded Steroid Receptor Modulation of Beta 1 Adrenergic Receptor Gene Transcription -- MCNAB et al. 50 ...   (Site not responding. Last check: 2007-11-07)
Liganded and Unliganded Steroid Receptor Modulation of Beta 1 Adrenergic Receptor Gene Transcription -- MCNAB et al.
Liganded and Unliganded Steroid Receptor Modulation of Beta 1 Adrenergic Receptor Gene Transcription
The thyroid hormone and retinoic acid receptors belong
www.pedresearch.org /cgi/content/abstract/50/5/575   (244 words)

  
 Norepinephrine and beta 2-Adrenergic Receptor Stimulation Regulate CD4+ T and B Lymphocyte Function in Vitro and in ...
Signal 1 to the B cell occurs upon stimulation of the B cell receptor (BCR) by antigen (Ag).
of the cytoplasmic tail of the receptor with stimulatory G-proteins,
The predominant adrenergic receptor expressed on resting and activated B cells is the
pharmrev.aspetjournals.org /cgi/content/full/53/4/487   (7589 words)

  
 BBC NEWS | Health | 'Made to measure' heart drug hope
However, Professor Liggett says, in some patients, adding in a beta-blocker does little to help and may actually cause more problems through side-effects, or through interfering with the other medications the individual is on.
In earlier laboratory research in mice and human tissue, he discovered genetic variations in the receptor that beta-blockers act on in the body.
One version of the beta-1-adrenergic receptor, the Arg version, appeared to respond better to beta-blockers than the other version, Gly.
news.bbc.co.uk /go/newsFeedXML/moreover/-/1/hi/sci/tech/4277597.stm   (500 words)

  
 Alpha2-adrenergic receptor blockade   (Site not responding. Last check: 2007-11-07)
In contrast, the selective alpha2-adrenergic receptor antagonists atipamezole (0.16 mg/kg, s.c.) and 1-(2-pyrimidinyl)piperazine (1-PP; 2.5 mg/kg, s.c.) increased levels of NAD (by 180 and 185%, respectively) and DA (by 130 and 90%, respectively), without affecting 5-HT levels.
These data demonstrate that alpha2-adrenergic receptors tonically inhibit NAD and DA and phasically inhibit 5-HT release in the FCX and that blockade of alpha2-adrenergic receptors strikingly potentiates the increase in FCX levels of 5-HT, NAD, and DA elicited by reuptake inhibitors.
Concomitant alpha2-adrenergic receptor antagonism and inhibition of monoamine uptake may thus provide a mechanism allowing for a marked increase in the efficacy of AD agents.
www.biopsychiatry.com /alp2ant.htm   (334 words)

  
 Adjuvant Arthritis Induces Down-Regulation of G Protein-Coupled Receptor Kinases in the Immune System -- Lombardi et ...   (Site not responding. Last check: 2007-11-07)
Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice.
Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway.
Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor.
www.jimmunol.org /cgi/content/full/166/3/1635   (4423 words)

  
 Receptor Selectivity of the Cloned Opossum G Protein-Coupled Receptor Kinase 2 (GRK2) in Intact Opossum Kidney Cells: ...
Kong G, Penn R, Benovic JL 1996 A ßadrenergic receptor kinase dominant negative mutant attenuates desensitization of the ß2-adrenergic receptor.
Nash SR, Godinot N, Caron MG 1994 Cloning and characterization of the opossum kidney cell D1 dopamine receptor: expression of identical D1A and D1B dopamine receptor mRNAs in opossum and brain.
Penn RB, Benovic JL 1994 Structure of the huan gene encoding the beta-adrenergic receptor kinase.
mend.endojournals.org /cgi/content/full/13/1/138   (4886 words)

  
 Modulation of C3a Activity: Internalization of the Human C3a Receptor and its Inhibition by C5a -- Settmacher et al. ...   (Site not responding. Last check: 2007-11-07)
The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis.
Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia.
Internalization and recycling of the C5a anaphylatoxin receptor: evidence that the agonist-mediated internalization is modulated by phosphorylation of the C-terminal domain.
www.jimmunol.org /cgi/content/full/162/12/7409   (6141 words)

  
 Regulation of G-protein-coupled receptor kinase subtypes by calcium sensor proteins -- Iacovelli et al. 13 (1): 1 -- ...
Krupnick, J. G., and Benovic, J. (1998) The role of receptor kinases and arrestins in G protein-coupled receptor regulation.
Pronin, A. N., and Benovic, J. (1997) Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C. Biol.
Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2.
www.fasebj.org /cgi/content/full/13/1/1   (4805 words)

  
 Dynamin-association with agonist-mediated sequestration of beta-adrenergic receptor in single-cell eukaryote Paramecium ...
Localization of dynamin and ß-adrenergic receptor (ßAR) immunoanalogue in isoproterenol-treated and untreated Paramecium cells using confocal laser scanning microscopy.
to the appearance of this receptor in unicellular eukaryotes.
Krupnick, J. and Benovic, J. The role of receptor kinases and arrestins in G protein-coupled receptor regulation.
jeb.biologists.org /cgi/content/full/207/10/1625   (3655 words)

  
 A beta 2 Adrenergic Receptor Signaling Complex Assembled with the Ca2+ Channel Cav1.2 -- Davare et al. 293 (5527): 98 ...
The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with {beta}-arrestins.
A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA.
The PDZ Binding Motif of the beta 1 Adrenergic Receptor Modulates Receptor Trafficking and Signaling in Cardiac Myocytes.
www.sciencemag.org /cgi/content/abstract/293/5527/98   (2035 words)

  
 Direct Binding of the {beta}1 Adrenergic Receptor to the Cyclic AMP-Dependent Guanine Nucleotide Exchange Factor ...
Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway.
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors: convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
The role of receptor kinases and arrestins in G protein-coupled receptor regulation.
mcb.asm.org /cgi/content/full/22/22/7942   (5744 words)

  
 alpha 2-Adrenergic autoreceptors in A5 and A6 neurons of neonate rats -- Huangfu and Guyenet 273 (5): 2290 -- AJP - ...
receptor (10), the integrity of which is required for the efficacy
Alpha(2A)-adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating spinal cord.
Immunohistochemical localization of alpha 2A-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat.
ajpheart.physiology.org /cgi/content/full/273/5/H2290   (3458 words)

  
 Receptor Selectivity of the Cloned Opossum G Protein-Coupled Receptor Kinase 2 (GRK2) in Intact Opossum Kidney Cells: ...
Receptor Selectivity of the Cloned Opossum G Protein-Coupled Receptor Kinase 2 (GRK2) in Intact Opossum Kidney Cells: Role in Desensitization of Endogenous {alpha}2C-Adrenergic but Not Serotonin 1B Receptors -- Lembo et al.
Receptor Selectivity of the Cloned Opossum G Protein-Coupled Receptor Kinase 2 (GRK2) in Intact Opossum Kidney Cells: Role in Desensitization of Endogenous
receptors by 12 ± 2% or 17 ± 4%, respectively.
mend.endojournals.org /cgi/content/abstract/13/1/138   (428 words)

  
 {beta}2-Adrenergic Receptor Signaling Acts via NO Release to Mediate ACh-induced Activation of ATP-sensitive K+ Current ...
Barr, A.J., Brass, L.F., and Manning, D.R. Reconstitution of receptors and GTP-binding regulatory proteins (G-proteins) in Sf9 cells: a direct evaluation of selectivity in receptor-G protein coupling.
Marsh, J.D., and Smith, T.W. Receptors for beta-adrenergic agonists in cultured chick ventricular cells.
Steinberg, S.F. The molecular basis for distinct ß-adrenergic receptor subtype actions in cardiomyocytes.
www.jgp.org /cgi/content/full/119/1/69   (5223 words)

  
 alpha 2-Adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells -- ...
Adrenergic receptor subtypes expressed in chinese hamster ovary cells activate differentially mitogen-activated protein kinase by a p21Ras independent pathway.
-adrenergic receptor subtype, the gene for which is located on chromosome 2.
Visualization of G protein-coupled receptor trafficking with the aid of the green fluorescent protein.
ajpcell.physiology.org /cgi/content/full/274/3/C654   (4465 words)

  
 Polymorphisms in the {beta}2 adrenergic receptor and bronchodilator response, bronchial hyperresponsiveness, and rate ...
-adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma.
-adrenergic receptor polymorphisms affect airway responsiveness to salbutamol in asthmatics.
-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.
thorax.bmjjournals.com /cgi/content/full/58/8/703   (3360 words)

  
 Right ventricular targeted gene transfer of a {beta}-adrenergic receptor kinase inhibitor improves ventricular ...   (Site not responding. Last check: 2007-11-07)
Right ventricular targeted gene transfer of a {beta}-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding -- Emani et al.
Right ventricular targeted gene transfer of a ß-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding
receptor signaling were significantly enhanced in rabbits expressing
jtcs.ctsnetjournals.org /cgi/content/abstract/127/3/787   (321 words)

  
 Pregnancy modifies the {alpha}2-ß-adrenergic receptor functional balance in rabbit fat cells -- Bousquet-Mélou ...
Adrenergic receptor interplay in the regulation of fat cell
Lafontan, M., Berlan, M. Fat cell adrenergic receptors and the control of white and brown fat cell function.
Carpéné, C., Castan, I., Collon, P., Galitzky, J., Moratinos, J., Lafontan, M. Adrenergic lipolysis in guinea pig is not a beta3-adrenergic response.
www.jlr.org /cgi/content/full/40/2/267   (3660 words)

  
 The Sympathetic Nerve---An Integrative Interface between Two Supersystems: The Brain and the Immune System -- Elenkov ...
Due to the space restraint and the number of immune cells as targets of the SNS input, different types of lymphoid cells are not depicted, see text for details.
The existence of DA receptors on several cell lines of the immune system, including those found in the spleen, has been shown
Tc, B cells, and monocytes had an intermediate number of receptors.
pharmrev.aspetjournals.org /cgi/content/full/52/4/595   (7369 words)

  
 Characterization of {alpha}2 Adrenergic Receptor Subtypes in Human Ocular Tissue Homogenates -- Bylund and Chacko 40 ...
The data are taken from Tables 1 and 2 and from Berlie et al.
adrenergic receptor subtypes is shown in Table 4.
adrenergic receptors in the neurosensory retina by spiroxatrine.
www.iovs.org /cgi/content/full/40/10/2299   (3690 words)

  
 Olfactory receptor surface expression is driven by association with the {beta}2-adrenergic receptor -- Hague et al. 101 ...
Olfactory receptor surface expression is driven by association with the {beta}2-adrenergic receptor -- Hague et al.
Similarly, isoproterenol induced cointernalization of the two receptors when they were expressed together (d–f).
as the mechanisms underlying adrenergic regulation of olfaction.
www.pnas.org /cgi/content/full/101/37/13672   (3190 words)

  
 {alpha}-Adrenergic Vasoconstrictor Tone Limits Right Coronary Blood Flow in Exercising Dogs -- Zong et al. 229 (4): 312 ...
Adrenergic coronary vasoconstriction helps maintain uniform transmural blood flow distribution during exercise.
-adrenergic receptors in the regulation of myocardial performance during exercise in conscious dogs.
Adrenergic coronary tone during submaximal exercise in the dog is produced by circulating catecholamines: evidence for adrenergic denervation supersensitivity in the myocardium but not in coronary vessels.
www.ebmonline.org /cgi/content/full/229/4/312   (4958 words)

  
 NEJM -- The Effect of Common Polymorphisms of the {beta}2-Adrenergic Receptor on Agonist-Mediated Vascular ...
receptor, one at codon 16 and one at codon 27, on agonist-mediated
Keys, J. R., Zhou, R.-H., Harris, D. M., Druckman, C. A., Eckhart, A. Vascular Smooth Muscle Overexpression of G Protein-Coupled Receptor Kinase 5 Elevates Blood Pressure, Which Segregates With Sex and Is Dependent on Gi-Mediated Signaling.
Eisenach, J. H., McGuire, A. M., Schwingler, R. M., Turner, S. T., Joyner, M. The Arg16/Gly {beta}2-adrenergic receptor polymorphism is associated with altered cardiovascular responses to isometric exercise.
content.nejm.org /cgi/content/abstract/345/14/1030   (1113 words)

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