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Cold Agglutinin Resolve Support Group   (Site not responding. Last check: 2007-10-22) My mission is to help people with their cold agglutinin challenge through education and a one-on-one relationship by providing a large member support organization with the goal to help each other...... There is hope and proof positive that the autoimmune disease caused disorder of cold agglutinin challenge can be resolved. Again, "My mission is to help people with their cold agglutinin challenge through education and a one-on-one relationship by providing a large member support organization with the goal to help each other". coldagglutinin.org   (803 words)

Cold Agglutinins A cold agglutinins blood test is done to detect conditions that stimulate the body to produce cold agglutinins, or antibodies. Determine whether high cold agglutinin levels are causing autoimmune hemolytic anemia, which may be associated with some viral infections or some types of cancer, such as lymphoma, or other conditions, such as rheumatoid arthritis or systemic lupus erythematosus. If a person has high levels of cold agglutinins and is experiencing symptoms that are brought on by exposure to cold temperatures (such as numbness, burning, pain, or pale skin of the fingertips, toes, ears, or nose), steps should be taken to keep the person warm. www.webmd.com /hw/health_guide_atoz/hw4158.asp?printing=true   (1304 words)

What are Blood Types?   (Site not responding. Last check: 2007-10-22) Agglutinins are responsible for ensuring that only the blood cells of your blood type exist in your body. Agglutinin a helps the body destroy any type A blood cells that might enter the circulation system. Agglutinin b helps the body destroy any type B blood cells that might enter the circulation system. gslc.genetics.utah.edu /units/basics/blood/types.cfm   (667 words)

eMedicine - Cold Agglutinin Disease : Article by Thomas W Loew, MD   (Site not responding. Last check: 2007-10-22) Secondary cold agglutinin disease is predominantly caused by infection and lymphoproliferative disorders. In chronic cold agglutinin disease associated with monoclonal gammopathy and with chronic lymphocytic leukemia, the autoantibodies are monoclonal anti-I. In chronic cold agglutinin disease associated with malignant lymphomas, the autoantibodies are monoclonal anti-i. Primary cold agglutinin disease is a chronic indolent disease, with remissions and exacerbations of hemolysis. www.emedicine.com /ped/topic429.htm   (2873 words)

eMedicine - Cold Agglutinin Disease : Article by Rajalaxmi McKenna If the cold agglutinin is operative at room temperatures, then falsely high mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration with a low RBC count are obtained due to agglutination of RBCs in the cold, automated counter. With the cold agglutinin titer, a titer of greater than 1:64 is considered abnormal when blood is tested at 4°C. Obtain the cold agglutinin titers also at 30°C and 37°C when needed. Preoperative preparation of the patient by reducing the titer of the cold agglutinin to reduce its effective thermal amplitude may be needed. www.emedicine.com /med/topic408.htm   (6646 words)

Binding of Salivary Glycoprotein-Secretory Immunoglobulin A Complex to the Surface Protein Antigen of Streptococcus ... Salivary agglutinin was heated at 50 to 100°C for 15 min and subjected to the BIAcore assay. Salivary agglutinin (25 µg/ml) was allowed to react with rPAc immobilized on a sensor chip in the presence of various amounts of lectin (0 to 100 µg/ml). saliva and salivary agglutinin induce aggregation of the serotype iai.asm.org /cgi/content/full/66/1/115   (4986 words)

eMedicine - Cold Agglutinin Disease : Article Excerpt by Rajalaxmi McKenna Subsequent observations have led to the understanding that cold agglutinins are usually immunoglobulin M (IgM) antibodies (less commonly immunoglobulin A [IgA] or immunoglobulin G [IgG]) that may result in hemolytic anemia due to complement-mediated RBC destruction in the reticuloendothelial system. The idiotype identified by the 9G4 antibody is found on cold agglutinin–producing malignant lymphoid cells in the bone marrow in persons with lymphoproliferative disorders, on a small proportion of normal lymphoid cells, and in the spleen of a 15-week-old fetus. These factors include the ability to initiate; the extent of antibody-induced complement activation; the concentration of the antibody; the range of temperatures, including the highest temperature at which the antibody interacts with the RBC (its thermal amplitude); and modification of the antibody's ability to fix complement components on to the RBCs (Rosse, 1980). www.emedicine.com /med/byname/cold-agglutinin-disease.htm   (1576 words)

Nano News - Plant Molecule Escorts Nanoparticles into Tumor Cells Wheat germ agglutinin belongs to a family of naturally occurring compounds called lectins that bind to specific sugar molecules on cell surfaces. Research performed over 30 years ago showed that wheat germ agglutinin in particular binds preferentially to sugar molecules that are found on many types of tumor cells, including leukemia cells and lung cancer cells, and earlier work by Dr. Lim and her colleagues showed that cells would engulf nanoparticles covered with wheat germ agglutinin. The results of these experiments showed that the wheat germ agglutinin had a substantial effect on nanoparticle uptake into cells and the subsequent release of paclitaxel within the tumor cells. nano.cancer.gov /news_center/nanotech_news_2005-12-05a.asp   (495 words)

vgn-ext-hidden_Abstract   (Site not responding. Last check: 2007-10-22) The pre-Rituximab cold agglutinin titer of 256 (reciprocal of dilution level) gradually decreased with each treatment and became negative 3 weeks after completion of Rituximab treatment. Conclusion: This case demonstrates the safety and excellent efficacy of Rituximab in treating cold agglutinin disease in a patient with B-cell malignancy who was unfit to receive chemotherapy. Transplacental transfer of a growth hormone-releasing hormone peptide from mother to fetus in the rat. www.asco.org /ac/1,1003,_12-002636-00_18-0016-00_19-002645,00.asp   (483 words)

Identification of the Bacteria-binding Peptide Domain on Salivary Agglutinin (gp-340/DMBT1), a Member of the Scavenger ... Salivary agglutinin is encoded by DMBT1 and identical to gp-340, a member of the scavenger receptor cysteine-rich (SRCR) superfamily. aggregation of bacteria by agglutinin (1, 19, 20). As shown in A, crude agglutinin was treated with endoproteinase Lys-C, and proteins were separated on 4-15% SDS-PAGE, transferred to nitrocellulose, and immunoblotted with monoclonal antibody 213-6 (A and C). www.jbc.org /cgi/content/full/277/35/32109   (4609 words)

Salivary Agglutinin/DMBT1SAG Expression is Up-regulated in the Presence of Salivary Gland Tumors -- Bikker et al. 83 ... Salivary agglutinin (SAG) is a 300- to 400-kDa glycoprotein Agglutinin and acidic proline-rich protein receptor patterns may modulate bacterial adherence and colonization on tooth surfaces. Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340. jdr.iadrjournals.org /cgi/content/full/83/7/567   (2391 words)

Immunohistochemical Detection of Salivary Agglutinin/gp-340 in Human Parotid, Submandibular, and Labial Salivary Glands ... Agglutinin was detected in all samples, but no differences in electrophoretic behavior were observed. Bacteria-agglutinating characteristics of secretory IgA and a salivary agglutinin. Differential distribution of salivary agglutinin and amylase in the Golgi apparatus and secretory granules of human salivary gland acinar cells. jdr.iadrjournals.org /cgi/content/full/81/2/134   (3178 words)

Cold agglutinins test The cold agglutinins test is performed to detect the presence of antibodies in blood that are sensitive to temperature changes. The cold agglutinins test is used to confirm the diagnosis of certain diseases that stimulate the body to produce cold agglutinins. There is a bedside version of the test in which the doctor collects four or five drops of blood in a small tube, cools the tube in ice water for 30-60 seconds, and looks for clumping of red blood cells. www.healthatoz.com /healthatoz/Atoz/ency/cold_agglutinins_test.jsp   (556 words)

Fluorescent Wheat Germ Agglutinin by Molecular Probes - Biocompare Product Review Wheat germ agglutinin (WGA) is a carbohydrate-binding protein of approx. Agglutinin can cause clustering of glycoproteins that can stimulate certain cellular pathways; this certainly needs to be considered before using this marker. Unfortunately, activation of cellular pathways may limit the potential uses of this dye in dynamic/live cell imaging and other strategies to label the membrane may be necessary. www.biocompare.com /prorev.asp?profrevid=318   (776 words)

Plus and Minus Sexual Agglutinins from Chlamydomonas reinhardtii -- Ferris et al. 17 (2): 597 -- THE PLANT CELL Above the map the agglutinin gene is shown; solid boxes represent coding sequences, open boxes 5' and 3' untranslated regions, and thin lines introns. Collin-Osdoby, P., Adair, W.S., and Goodenough, U.W. Chlamydomonas agglutinin conjugated to agarose beads as an in vitro probe of adhesion. Cooper, J.B., Adair, W.S., Mecham, R.P., Heuser, J.E., and Goodenough, U.W. The Chlamydomonas agglutinin is a hydroxyproline-rich glycoprotein. www.plantcell.org /cgi/content/full/17/2/597   (7702 words)

A Peptide Domain of Bovine Milk Lactoferrin Inhibits the Interaction between Streptococcal Surface Protein Antigen and ... (11, 15, 17) have demonstrated that salivary agglutinin is a Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340. Inhibitory effect of bovine milk lactoferrin on the interaction between a streptococcal surface protein antigen and human salivary agglutinin. iai.asm.org /cgi/content/full/72/10/6181   (2112 words)

Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients -- ... Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients -- Berentsen et al. Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients Favourable response to therapy with the anti-CD20 monoclonal antibody rituximab in primary chronic cold agglutinin disease. www.bloodjournal.org /cgi/content/full/103/8/2925   (2632 words)

Caring Medical - Symptoms - Cold Agglutinin Disease Cold agglutinin disease, also called cold antibody disease or cold antibody hemolytic anemia, is an autoimmune disease in which the body develops antibodies that attack red blood cells at room temperature or colder. In this autoimmune disease, the immune system malfunctions and produces antibodies that attack the red blood cells when the body is cold, causing the symptoms of the disease to develop. When individuals have cold agglutinin disease, the red blood cells are destroyed prematurely and bone marrow production of new cells can not compensate for their loss. www.caringmedical.com /conditions/Cold_Agglutinin_Disease.htm   (441 words)

Application of trichosanthes japonica agglutinin i... Application of trichosanthes japonica agglutinin i (TJA-i) for diagnosis of colon cancer: lectin histochemistry of primary colon cancer and liver metastases Trichosanthes japonica agglutinin I (TJA-I) is a lectin highly specific for the NeuAcalpha2,6Galbeta1,4GlcNAc residue. AIM: To evaluate the usefulness of the TJA-I in the diagnosis of colon cancer and to investigate the expression of the NeuAcalpha2,6Gal residue in liver metastases. www.cancerprev.org /Journal/Issues/20/5/204/881   (308 words)

Cold Agglutinin Disease - An Acquired Autoimmune Hemolytic Anemia - IgM Antibody seems to be part of it - Attacks the ...   (Site not responding. Last check: 2007-10-22) Cold Agglutinin Disease - An Acquired Autoimmune Hemolytic Anemia - IgM Antibody seems to be part of it - Attacks the red blood cell Cold agglutinin disease is an acquired autoimmune hemolytic anemia due to an IgM autoantibody usually directed against the I antigen on red blood cells. Most cases of chronic cold agglutinin disease are of undetermined origin. home.gci.net /~blessing/pages/coldagglutinin.htm   (397 words)

Identification of a Gene Encoding Heat-Resistant Agglutinin in Escherichia coli as a Putative Virulence Factor in ... Identification of a Gene Encoding Heat-Resistant Agglutinin in Escherichia coli as a Putative Virulence Factor in Urinary Tract Infection -- Srinivasan et al. The heat-resistant agglutinin gene in 1128-11 was cloned and agglutinin (hra) gene that is widely distributed among UTI E. jcm.asm.org /cgi/content/full/41/1/285   (3395 words)

Cold agglutinin syndrome: What are the symptoms? - MayoClinic.com Cold agglutinins are abnormal proteins in your blood. Cold agglutinin syndrome occurs when you have high numbers of cold agglutinins. The cause of cold agglutinin syndrome is unknown. www.mayoclinic.com /health/cold-agglutinin/AN00400   (266 words)

Cold Agglutinin Disease -- eCureMe.com   (Site not responding. Last check: 2007-10-22) Cold agglutinin disease is a type of hemolytic anemia, which is a disease characterized by decreased red blood cells (the oxygen carrying cells) due to their destruction. Therefore, peripheral areas of the body that are cooler, such as the fingertips, nose, and ears, are most likely to be affected. Most cases of cold agglutinin disease are mild, though rarely it may cause a severe hemolytic anemia. www.ecureme.com /emyhealth/data/Cold_Agglutinin_Disease.asp   (186 words)

Genetically Controlled Self-Aggregation of Cell-Surface-Engineered Yeast Responding to Glucose Concentration -- Zou et ... 1 gene, and a-agglutinin, composed of Aga1p and Aga2p, The three genes encoding both agglutinins are pheromone inducible and regulated by different promoters. A DNA fragment of AGA2, encoding the binding subunit of a-agglutinin aem.asm.org /cgi/content/full/67/5/2083   (2368 words)

Delineation of Functional Regions within the Subunits of the Saccharomyces cerevisiae Cell Adhesion Molecule ... Delineation of Functional Regions within the Subunits of the Saccharomyces cerevisiae Cell Adhesion Molecule a-Agglutinin -- Shen et al. Department of Biological Sciences and the Institute for Biomolecular Structure and Function, Hunter College of the City University of New York, New York 10021 and the a-Agglutinin from Saccharomyces cerevisiae is a cell adhesion glycoprotein expressed on the surface of cells of a mating type www.jbc.org /cgi/content/abstract/276/19/15768   (434 words)

Re: Hemolytic Anemia, Cold Agglutinin, IgM, Entire Left Side is Numb/Burning Tingles By the time I got to the hematologist a couple of days later, my hemoglobins had dropped to 6.8 and I was hospitalized for hemolytic anemia. Further testing and elimination brought me to the diagnosis of Cold Agglutinin Disease, probably related to the aforementioned "mystery disease" because no other causative reason was found. Albeit they were rather technical for me, I noticed that prednisone was also the first-line treatment for this problem as well but am wondering about the prognosis. www.medhelp.org /forums/neuro/archive/12227.html   (914 words)

Influence of Concanavalin A, wheat germ agglutinin, and soybean agglutinin on the fusion of myoblasts in vitro -- Den ... Influence of Concanavalin A, wheat germ agglutinin, and soybean agglutinin on the fusion of myoblasts in vitro -- Den et al. Influence of Concanavalin A, wheat germ agglutinin, and soybean agglutinin on the fusion of myoblasts in vitro A was determined to be twice as effective as wheat germ agglutinin as an www.jcb.org /cgi/content/abstract/67/3/826   (303 words)

Ricinus Communis Agglutinin   (Site not responding. Last check: 2007-10-22) Ricinus communis agglutinin I is a glycoprotein with a molecular weight of 120,000. The native lectin is moderately toxic and consists of two subunits of 60,000 daltons which can be dissociated by reducing agents into closely related chains between 27,000 and 33,000 daltons. Ricinus communis agglutinin II is an extremely toxic glycoprotein consisting of two disulfide-linked chains of about 28,000 daltons and 32,000 daltons, termed A and B chain, respectively. www.vectorlabs.com /Lectins/LRCA.html   (523 words)

Wheat germ agglutinin - toxicity, ecologicial toxicity and regulatory information   (Site not responding. Last check: 2007-10-22) Chemical Identification and Use for Wheat germ agglutinin There may be other diseases and chemicals that have similar symptoms. Sorry, no water quality standards or criteria have been established for this chemical by the U.S. or Canadian governments; however, there may be criteria established for related chemicals. www.pesticideinfo.org /Detail_Chemical.jsp?Rec_Id=PC39886   (655 words)

Re: cold agglutinin - Anemia Message Board - Archived 8/29/98-12/12/00 In Reply to: Re: cold agglutinin posted by Ray Henderson on November 16, 2000 at 20:23:22: She has had blood washes and blood transfusions and is currently taking regular doses of procrit by injection. She would like to talk to you about your treatment and prognosis. www.healthboards.com /anemia/505.html   (357 words)

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