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Topic: Aging (senescence)

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Longevity: Essential Concepts -Taking the LONG View Cellular Aging and Cell Death by Nikki J. Holbrook, George R. Martin, Richard A. Lockshin -provides a thorough understanding of the mechanisms responsible for cellular aging, covering the recent research on programmed cell death and senescence, and describing their role in the control of cell proliferation and the aging process. Aubrey de Grey's "engineered negligible senescence" proposes to substantially extend human lifespan with a short series of particular cellular therapies. Individual chapters discuss such topics as the role and regulation of apoptosis in development, the potential impact of cell death on such postmitotic tissues as nerve and muscle, and suggest that programmed cell death plays an important role in both pathological and nonpathological aspects of aging, including neurodegenerative diseases. longevity.essential-facts.com   (3551 words)

Anti-Aging Medicine & Science Blog: Posted by The NanoAging Institute - Strategies for Engineered Negligible Senescence, 2nd Conference Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable - Edited by Aubrey D.N.J. de Grey Anti-Aging Medicine& Science Blog: Posted by The NanoAging Institute - Strategies for Engineered Negligible Senescence, 2nd Conference This volume focuses squarely on the fact that, as a result of a wide range of advances over recent years, increasingly many specialists studying the biology of aging are revising their traditional view that mammalian aging will remain essentially immutable for many decades to come. anti-ageing.us /2005/01/posted-by-nanoaging-institute.html   (869 words)

Exploding Aardvark Caleb Finch at USC coined the term “negligible senescence” to describe very slow or negligible aging (Finch 1990). Emerging Area of Aging Research: Long-lived Animals with “Negligible Senescence” Later in a paper from the first Symposium on Organisms with Slow Aging (which the Director of this project also spoke at), Finch further described criteria to test the occurrence of negligible aging. www.fpmrecords.com /cgi-bin/blosxom.cgi/2005/05/27   (455 words)

Senescence - Wikipedia, the free encyclopedia Senescence is studied in gerontology which is the branch of science involved with the aging process. However, senescence is not universal, and scientific evidence suggests that cellular senescence evolved in certain species as a mechanism to prevent the onset of cancer. Recently, early senescence has been alleged to be a possible unintended outcome of early cloning experiments, Most notably, the issue was raised in the case of Dolly the sheep, following her death from a contagious lung disease. en.wikipedia.org /wiki/Senescence   (3207 words)

Aubrey de Grey - Wikipedia, the free encyclopedia He is working to expedite the development of a 'cure' for human aging, a medical goal he refers to as engineered negligible senescence (senescence means the biological decline of aging). To this end, he has identified what he concludes are the seven areas of the aging process that need to be addressed medically before this can be done. He is also the co-founder (with David Gobel) and chief scientist of the Methuselah Mouse Prize, a prize designed to accelerate research into effective life extension interventions by awarding monetary prizes to researchers who extend the lifespan of mice to unprecedented lengths. en.wikipedia.org /wiki/Aubrey_de_Grey   (646 words)

SENS (Strategies for Engineered Negligible Senescence) SENS is an engineering project, recognising that aging is a medical condition and that medicine is a branch of engineering... A practical approach to developing real anti-aging medicine...SENS is a detailed plan for curing human aging. home » science » SENS (Strategies for Engineered Negligible Senescence) digg.com /science/SENS_(Strategies_for_Engineered_Negligible_Senescence)   (54 words)

FuturePundit: Brain Protein Tangles Cause Memory Loss With Age If you want to read more about Engineered Negligible Senescence and the coming ability to make aged humans young again then check out the FuturePundit Aging Reversal archive. The development of gene therapies that give cells the ability to synthesize enzymes that can "throw out the trash" promises to extend longevity, make cells throughout the body to perform in more youthful ways, and to contribute to the eventual ability to reverse aging and make aging humans young again. Also, see the Strategies for Engineered Negligible Senescence (SENS) web site. www.futurepundit.com /archives/001329.html   (752 words)

senescence SIRT1 is involved in cellular senescence, or limitation of cells’ reproductive lifespan, a process thought to ensure that aging cells don’t pass on harmful... The gene is involved in a process, called senescence, which is thought to ensure that aging cells do not pass on harmful mutations. Senescence is a horrible killer, a disease that should be fought with every available weapon. www.mongabay.com /igapo/biotech/senescence.html   (1465 words)

SENS: basis for the name "engineered negligible senescence" The other consequence of the tight biological linkage between aging and death is that we can measure our ability to combat aging by observing our impact on death rates, and this is where I (finally!) get to explain the basis for the term "Engineered Negligible Senescence". This of course means that they immediately understand the term "engineered negligible senescence" -- the biotechnological conversion of a population that shows senescence (humans, of course) into one that does not. He introduced the term "negligible senescence" to mean "senescence too slight to be statistically distinguishable from zero with the sample sizes at our disposal". www.gen.cam.ac.uk /sens/ENSdef.htm   (1450 words)

For Engineered Negligible Senescence At Cambridge University He is working to expedite the development of a 'cure' for human cellular aging, a medical goal he refers to as engineered negligible senescence... De Grey, a Cambridge University researcher, heads the Strategies for Engineered Negligible Senescence (SENS) project, in which he has defined seven causes of aging, all of which he thinks can be... Engineered Negligible Senescence (SENS) 2nd Conference 7-11 September 2005 Queens' College, Cambridge... cambridgeuniversity.flabcambridge.com /forengineerednegligiblesenescenceatcambridgeuniversity   (875 words)

Accelerating Future » What is SENS? SENS stands for Strategies for Engineered Negligible Senescence, a detailed plan for reversing human aging. It is an engineering approach that seeks to slow and then halt aging processes that are the side effects of our body’s metabolic cycles. After that point, the only threats to life which would remain are disease, war, accidents, and technological or natural disasters. www.acceleratingfuture.com /michael/blog/?p=13   (1047 words)

Science & the City Webzine of the New York Academy of Sciences That meeting, held September 2003 in Cambridge, yielded Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable, Volume 1019 in Annals of the New York Academy of Sciences. Many people, including some gerontologists, consider working to radically delay senescence to be wrong, given the global limits of natural resources. Traditionally, gerontology focuses on the biology of the aging process, the damage in our bodies that accumulates with age. www.nyas.org /snc/annals.asp?AnnalID=14   (1004 words)

End products Cell senescence, the finite replicative potential and associated gene-expression changes seen in cell culture, has been suggested to underlie many aspects of aging and to be treatable by telomerase activation. Another central reason why biogerontologists have doubted that negligible senescence can be engineered is because it necessarily involves reversing any age-related decline that has already occurred, not merely retarding or postponing further decline. The prevalence of pessimism in this regard leaves a vacuum that allows – indeed, arguably promotes – the diversion of much public and private money into putatively anti-aging therapies whose availability is immediate but whose efficacy is evidently negligible. research.arc2.ucla.edu /pmts/sens/article.htm   (4381 words)

SAGE Crossroads - News & Views - News Archive In 2000, de Grey--of the University of Cambridge, U.K.--organized a roundtable discussion about the possibility of coming up with therapies that would postpone aging indefinitely, treatments that de Grey calls "strategies for engineered negligible senescence" (SENS). Ten years later, the term "negligible senescence" has been adopted by other scientists and is now the focus of a heated debate over the forseeability of human life extension--a discourse driven in large part by a software engineer-turned-gerontologist named Aubrey de Grey. Advocating an "engineer's approach" to inventing antiaging medicines that would build a longer-lasting body, de Grey says we should think about preserving ourselves in much the same way that we preserve houses. www.sagecrossroads.net /Default.aspx?tabid=28&newsType=ArticleView&articleId=36   (1134 words)

Sentient Developments: Institute of Biomedical Gerontology (IBG) Survey Is an Institute of Biomedical Gerontology (IBG) devoted solely to the development of engineered negligible senescence viable? As many of you know, the ingenuity of Aubrey’s plans to reverse aging is only surpassed by nearly everyone else’s lack of courage to actualise them. I have set up a brief survey to estimate the human and material resources that the community is willing and able to throw at a major anti-aging R+D project today. sentientdevelopments.blogspot.com /2005/01/institute-of-biomedical-gerontology.html   (329 words)

SENS II The meeting was a sequel to one held in Oakland in October 2000 entitled "Strategies for Engineered Negligible Senescence" (SENS), so the UCLA meeting was entitled "SENS 2". On August 12th 2001, a small roundtable meeting was held at UCLA, Los Angeles, to discuss a wide range of issues surrounding the possibility that, within a few decades, biotechnology might be developed that would enable us to reverse all the key lifespan-limiting components of human aging. SENS II SENS (Strategies for Engineered Negligible Senescence) 2: research.arc2.ucla.edu /pmts/sens/sens2.htm   (384 words)

The Impact of Emerging Technologies: Cynthia Kenyon Declines - Technology Review De Grey, a computer scientist and theoretical biologist at the University of Cambridge, believes he can defeat human aging within the lifetime of those now living. Cynthia Kenyon, a biogerontologist at UCSF, has declined to review Aubrey de Grey's Strategies for Engineered Negligible Senescence (SENS). De Grey, a computer scientist and theoretical biologist at the University of Cambridge, believes he can defeat human aging within... www.technologyreview.com /Jason_Pontin/wtr_15021,291,p1.html   (222 words)

ANNALS ONLINE -- Table of Contents (June 2004, 1019) Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable Cirrhosis Progression as a Model of Accelerated Senescence: Affecting the Biological Aging Clock by a Breakthrough Biophysical Methodology The Role of Cellular Senescence May Be to Prevent Proliferation of Neighboring Cells within Stem Cell Niches www.annalsnyas.org /content/vol1019/issue1   (2182 words)

Generations - The Genetics of Aging - Replicative Senescence The relationship between the changes in gene expression and cellular senescence has not been definitively established, and it is not known whether any or all of the changes cause senescence or whether senescence results in the changes in gene expression. There are three areas in which cellular senescence could affect processes in a living organism (in vivo processes). The genetic pathways to senescence, and most likely some of the alternate pathways as well, do not appear to be dependent on telomerase (the enzyme that maintains telomere length) and therefore related to telomere shortening. www.asaging.org /generations/gen-24-1/senescence.html   (2660 words)

Senescence and the Biology of Human Aging Aging, or senescence, is the major cause of suffering, disease, and death in Western civilization. Cellular Senescence; cellular models of aging and the rationale behind them. In a sense, aging is the ultimate hurdle to human quality of life. www.senescence.info   (547 words)

Dictionary.com/Word of the Day Archive/senescence Senescence is from Latin senescere, "to grow old," from senex, "old." It is related to senile. Trying to understand the factors that determine maximum possible lifespan is one of the most puzzling aspects of the overall study of senescence and death. Our own bodies are simultaneously and subtly undergoing the same inexorable process that will lead eventually to senescence and death. dictionary.reference.com /wordoftheday/archive/2004/08/10.html   (127 words)

CELL BIOLOGY: CANCER AND CELL SENESCENCE Although the genes that are expressed during the plant senescence syndrome (as well as ways to manipulate such senescence) have been identified, much remains to be done to understand the molecular basis of aging in plants. The "yellowing" of leaves is often referred to in the plant literature as leaf senescence or the "senescence syndrome" -- referring to the process by which nutrients are mobilized from the dying leaf to other parts of the plant to support their growth. The senescence syndrome is characterized by distinct cellular and molecular changes, with the chloroplast the first part of the cell to undergo disassembly (producing the "yellowing"). www.scienceweek.com /2005/sw050902-2.htm   (1564 words)

A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status -- Rheinwald et al. 22 (14): 5157 -- Molecular and Cellular Biology aging and senescence pathway that precede p16 expression. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. and p53 is necessary to bypass senescence and extend the replicative life span of keratinocytes. mcb.asm.org /cgi/content/full/22/14/5157   (9258 words)

Telomeres and Telomerase: The Cellular Timekeepers Lastly, although telomerase may prevent the accelerated clonal senescence of Werner's syndrome cells (Wyllie et al., 2000), it does not appear to fully reverse the WS phenotype (Choi et al., 2001). Indeed, defects in telomere replication have been shown to trigger senescence in yeast (Lundblad and Szostak, 1989) and in the protozoan Tetrahymena (Yu et al., 1990). Recent results suggest that erosion of the overhang occurs at senescence and is prevented by telomerase expression. www.senescence.info /telomeres.html   (3994 words)

Senescence definition - Medical Dictionary definitions of popular medical terms Senescence: Aging, the process of becoming old, or the state of being old. The word "senescence" derives from the Latin "senex," meaning "old." "Senile" and "senior" come from the same root, as does "senate" which dates back to ancient Rome where the "Senatus" was originally a "council of elders" composed of the heads of patrician families. Senescence definition - Medical Dictionary definitions of popular medical terms www.medterms.com /script/main/art.asp?articlekey=13402   (265 words)

About Senescence and His Music Since I actually happen to work on aging and senescence, I felt that Senescence was an appropriate artistic name. In the context of this website, Senescence refers to João Pedro de Magalhães, the sole copyright owner of this website, its content, and all music contained herein. Most, though not all, of my songs are sad and I guess that's one of the reasons why I like using the name Senescence. music.senescence.info /about.html   (962 words)

Physiology of Cotton Defoliation Senescence is the process of plant tissue deterioration that accompanies aging and that ultimately leads to the death of an organ or organism. It is not essential that a cotton farmer develops a thorough understanding of the physiological or biochemical mechanisms associated with leaf abscission and plant senescence in order to accomplish a successful crop defoliation. The plant converts proteins and carbohydrates in the leaves into simpler forms and then transports them along with inorganic ions out of the leaves to the bolls, which are the highest priority locations (or sinks). ag.arizona.edu /pubs/crops/az1240   (962 words)

LESHEM YA'AKOV Molecular aspects of hormone action; plant senescence; plant membranes, lipids and biophysical parameters; calcium metabolism in plants; stomatal opening, NO and ethylene, stress; postharvest vegetable, fruit and flower storage. This topic is being studied as well in connection to plant senescence and stomate guard cell physiology. Leshem, Y.Y. and Haramaty, E. (1996) The characterization and contrasting effects of the nitric oxide free radical in vegetative stress and senescence of Pisum sativum Linn. www.biu.ac.il /LS/People/staff/leshem.html   (962 words)

Shimon Gepstein Developmental stages are characterized by expression of series of stage specific genes.Leaf senescence is the last developmental stage preceding death.After harvest,accelerated aging also occurs in the excised organs. Recently we have identified and isolated a senescence regulatory gene that has a similar structure to that of known animal regulatory genes that are responsible f Most of the isolated genes are involved in the catabolic pathways that dictate the characteristic breakdown processes of leaf senescence. biology.technion.ac.il /gepstein   (962 words)

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