| | Dornase alfa reduces air trapping in children with mild cystic fibrosis lung disease : a quantitative analysis CHEST - ... (Site not responding. Last check: 2007-10-01) |
 | | Purpose: To evaluate quantitative air trapping measurements in children with mild cystic fibrosis (CF) lung disease during a 1-year, double-blind, placebo-controlled, recombinant human deoxyribonuclease (rhDNase) [dornase alfa] intervention trial and compare results from quantitative air trapping with those from spirometry or visually scored high-resolution CT (HRCT) scans of the chest. |
 | | Conclusions: Quantitative air trapping is a more consistent sensitive outcome measure than either spirometry or total HRCT scores, and can discriminate differences in treatment effects in children with minimal CF lung disease. |
 | | The purpose of the present study was to evaluate quantitative air trapping, spirometric measurements, and chest HRCT scores as outcome measures in therapeutic response to recombinant human deoxyribonuclease (rhDNase) [dornase alfa] in 25 children with mild CF lung disease over a 1-year, controlled intervention trial. |
| www.findarticles.com /p/articles/mi_m0984/is_4_128/ai_n15780895 (943 words) |